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Browse our MYD88 Proteins (MYD88)

Full name:
Myeloid Differentiation Primary Response Gene (88) Proteins (MYD88)
On www.antibodies-online.com are 22 Myeloid Differentiation Primary Response Gene (88) (MYD88) Proteins from 7 different suppliers available. Additionally we are shipping MYD88 Antibodies (210) and MYD88 Kits (21) and many more products for this protein. A total of 274 MYD88 products are currently listed.
Synonyms:
CG2078, Dmel\\CG2078, DmMyd88, dMyd88, EP(2)2535, GB12344, irak-2, kra, LD20892, MGC84928, myd88, MYD88D, Myd88F, NV10640, XMyD88, zgc:103541
list all proteins Gene Name GeneID UniProt
MYD88 4615 Q99836
MYD88 301059 Q6Y1S1
MYD88 17874 P22366

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MYD88 Proteins (MYD88) by Origin

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Top referenced MYD88 Proteins

  1. Human MYD88 Protein expressed in Escherichia coli (E. coli) - ABIN1098740 : Kawai, Sato, Ishii, Coban, Hemmi, Yamamoto, Terai, Matsuda, Inoue, Uematsu, Takeuchi, Akira: Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. in Nature immunology 2004 (PubMed)
    Show all 2 references for ABIN1098740

More Proteins for MYD88 Interaction Partners

Fruit Fly (Drosophila melanogaster) Myeloid Differentiation Primary Response Gene (88) (MYD88) interaction partners

  1. a novel function of MyD88 in the regulation of metabolism that appears to be independent of its known roles in immunity and development.

  2. propose that dMyD88 is the functional homolog of TIRAP (show TIRAP Proteins) and that both proteins function as sorting adaptors to recruit downstream signaling adaptors to activated receptors

  3. DmMyD88 encodes an essential component of the Toll (show TLR4 Proteins) pathway in dorsoventral pattern formation.

  4. We show that there is a direct interaction between Kra and Tube presumably mediated by the death domains present in both proteins.

  5. both the heterodimeric and heterotrimeric complexes form kidney-shaped structures and that Tube is bivalent and has separate high affinity binding sites for dMyD88 and Pelle (show IRAK1 Proteins).

Zebrafish Myeloid Differentiation Primary Response Gene (88) (MYD88) interaction partners

  1. DrIRF1 works in concert with MyD88 to activate zebrafish IFNvarphi3 but not IFNvarphi1. These results provide insights into the evolving function of IRF1 (show IRF1 Proteins) as a positive IFN regulator.

  2. MyD88 signaling has an important protective role during early pathogenesis.

  3. MyD88-dependent signaling is involved in the innate immune response of the developing zebrafish embryo, a model for the study of vertebrate innate immunity.

Human Myeloid Differentiation Primary Response Gene (88) (MYD88) interaction partners

  1. Study showed that MyD88 Toll/interleukin-1 receptor (TIR) domain interacted with TLR5TIR but not with TLR6TIR. The solubility of both TLR5TIR and TLR6TIR were influenced by its binding partner MyD88TIR.

  2. MyD88 was expressed at a higher level in NSCLC tissues and was closely associated with poor prognosis.

  3. Results indicate that harboring MYD88 mutation is associated with increased risk of disease progression and poor prognosis in PCMZL.

  4. MYD88 gene analysis is a helpful ancillary tool for diagnosing vitreoretinal lymphoma (VRL (show TRPV2 Proteins))

  5. Knockdown of MyD88 significantly inhibited matrix metalloproteinase (show MMP20 Proteins) expression in chondrocytes.

  6. Our findings suggest that miRNA-149 mediates the susceptibility of paclitaxel by regulating MyD88 expression in ovarian cancer cells.

  7. these results suggest that targeting the COX-2/PGE2 pathway together with TLR/MyD88 signaling, which would suppress the inflammatory microenvironment and maintenance of stemness, could be an effective preventive or therapeutic strategy for gastric cancer

  8. CARMA1 (show CARD11 Proteins)- and MyD88-dependent activation of Jun (show JUN Proteins)/ATF-type AP-1 (show FOSB Proteins) complexes is a hallmark of ABC (show ABCB6 Proteins) diffuse large B-cell lymphomas.

  9. the MYD88 mutation is a fairly consistent genetic feature in testicular diffuse large B-cell lymphoma

  10. MyD88s is positively regulated by IKKbeta and CREB and negatively regulated by ERK1/2 signaling pathways.

Pig (Porcine) Myeloid Differentiation Primary Response Gene (88) (MYD88) interaction partners

  1. These results suggest that porcine circovirus 2 induces IL-8 (show IL8 Proteins) secretion via the TLR2/MyD88/NF-kappaB (show NFKB1 Proteins) signalling pathway.

  2. At 30 days after autotransplantation of a pig kidney, mRNA expression increases for MyD88.

  3. These results suggest that an MyD88-dependent signaling pathway is present in newborn as well as in adult swine and that it is involved in the innate immune system of these animals.

Cow (Bovine) Myeloid Differentiation Primary Response Gene (88) (MYD88) interaction partners

  1. Modulated cytokine expression in Bovine viral diarrhea virus type 2 infected macrophages was associated with decreased MyD88 expression.

  2. The study demonstrates that in cattle, animals heterozygous at the MyD88 A625C polymorphic marker have a 5-fold reduced risk for active pulmonary tuberculosis.

  3. MyD88 plays a functional role in transducing LPS (show IRF6 Proteins) signaling from TLR-4 (show TLR4 Proteins) to downstream effector molecules involved in NF-kappaB (show NFKB1 Proteins) activation

Atlantic Salmon (Salmo salar) Myeloid Differentiation Primary Response Gene (88) (MYD88) interaction partners

  1. MyD88 interacts with interferon (show IFNA Proteins) regulatory factor (IRF) 3 (show IRF3 Proteins) and IRF7 (show IRF7 Proteins) in Atlantic salmon (Salmo salar)

  2. the salmon MyD88 was cloned and its expression was analysed.

Mouse (Murine) Myeloid Differentiation Primary Response Gene (88) (MYD88) interaction partners

  1. Attenuated inflammation through down-regulating the levels of MyD88 by decreasing TLR4 (show TLR4 Proteins) expression.

  2. The authors demonstrate that, in addition to MyD88, Yersinia pseudotuberculosis inhibits TRIF (show RNF138 Proteins) signaling through the type III secretion system effector YopJ.

  3. that motor deficits emerge rapidly during a narrow age window in Spinocerebellar ataxia (show USP14 Proteins) type 6 (84Q) mice

  4. Severity of sodium dodecyl sulfate-induced colitis is reduced in Ido1 (show IDO1 Proteins)-deficient mice with down-regulation of TLR-MyD88-NF-kB transcriptional networks.

  5. MyD88 contributes to the generation of innate and adaptive immune responses during the pathogenesis of Atopic dermatitis in a mouse model.

  6. These results suggest that MyD88 signaling mediates instructive signals in DCs and secretion of IL-1beta (show IL1B Proteins) and type 1 immune cytokines.

  7. These results expand on our knowledge of the roles for TLR2 and TLR4 (show TLR4 Proteins) in C. burnetii infection and suggest various roles for these receptors that are dictated by the site of infection.

  8. IL-1R1/MyD88 signaling negatively regulates bone regeneration via impairment of mesenchymal stem cell proliferation, migration and differentiation by inhibiting the Akt (show AKT1 Proteins)/GSK-3beta/beta-catenin (show CTNNB1 Proteins) pathway.

  9. Suggest role for MyD88 in lung resident cells for regulating ciliary motility, wound repair and inflammatory responses to organic dust extract.

  10. In 2 models of Klebsiella pneumonia sepsis, platelet MyD88 did not impact on bacterial growth or dissemination. It did not influence hallmark sepsis responses such as thrombocytopenia, coagulation or endothelial activation, or distant organ injury.

MYD88 Protein Profile

Protein Summary

This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants.

Alternative names and synonyms associated with MYD88

  • myeloid differentiation primary response gene (88) (myd88-b)
  • CG2078 gene product from transcript CG2078-RB (Myd88)
  • myeloid differentiation primary response gene (88) (myd88)
  • myeloid differentiation primary response factor 88 (Myd88)
  • myeloid differentiation primary response 88 (myd88)
  • myeloid differentiation primary response gene 88 (Myd88)
  • MyD88 adaptor (myd88)
  • myeloid differentiation factor 88 (myd88)
  • myeloid differentiation response protein 88 (myd88)
  • myeloid differentiation primary response gene 88 (myd88)
  • interleukin-1 receptor-associated kinase 2 (IRAK2)
  • interleukin-1 receptor-associated kinase 2 (irak2)
  • interleukin-1 receptor-associated kinase 2 (LOC100228175)
  • myeloid differentiation primary response 88 (MYD88)
  • myeloid differentiation primary response 88 (Myd88)
  • myeloid differentiation primary response gene (88) (MYD88)
  • CG2078 protein
  • Dmel\\CG2078 protein
  • DmMyd88 protein
  • dMyd88 protein
  • EP(2)2535 protein
  • GB12344 protein
  • irak-2 protein
  • kra protein
  • LD20892 protein
  • MGC84928 protein
  • myd88 protein
  • MYD88D protein
  • Myd88F protein
  • NV10640 protein
  • XMyD88 protein
  • zgc:103541 protein

Protein level used designations for MYD88

myeloid differentiation primary response protein MyD88-B , Toll/IL-1 receptor binding protein MyD88-B , CG2078-PA , CG2078-PB , Myd88-PA , Myd88-PB , Myd88F , krapfen , myeloid differentiation primary response factor 88 , myeloid differentiation primary response protein MyD88 , zMyD88 , myeloid differentiation primary response gene (88) , myeloid differentiation primary response gene 88 , myeloid differentiation factor 88 , myeloid differentiation response protein 88 , interleukin-1 receptor-associated kinase-like 2 , interleukin-1 receptor-associated kinase 2 , myeloid differentiation primary response protein 88

GENE ID SPECIES
734302 Xenopus laevis
35956 Drosophila melanogaster
403145 Danio rerio
413194 Apis mellifera
549591 Xenopus (Silurana) tropicalis
100118553 Nasonia vitripennis
100134853 Takifugu rubripes
100136123 Oncorhynchus mykiss
100305041 Ictalurus punctatus
100616081 Amphimedon queenslandica
416118 Gallus gallus
493227 Xenopus (Silurana) tropicalis
100228175 Taeniopygia guttata
4615 Homo sapiens
301059 Rattus norvegicus
477024 Canis lupus familiaris
460269 Pan troglodytes
420420 Gallus gallus
396646 Sus scrofa
444881 Bos taurus
678682 Ovis aries
696494 Macaca mulatta
100169859 Salmo salar
17874 Mus musculus
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