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Browse our MYD88 Proteins (MYD88)

Full name:
Myeloid Differentiation Primary Response Gene (88) Proteins (MYD88)
On www.antibodies-online.com are 23 Myeloid Differentiation Primary Response Gene (88) (MYD88) Proteins from 7 different suppliers available. Additionally we are shipping MYD88 Antibodies (268) and MYD88 Kits (25) and many more products for this protein. A total of 335 MYD88 products are currently listed.
Synonyms:
CG2078, Dmel\\CG2078, DmMyd88, dMyd88, EP(2)2535, GB12344, irak-2, kra, LD20892, MGC84928, myd88, MYD88D, Myd88F, NV10640, XMyD88, zgc:103541
list all proteins Gene Name GeneID UniProt
MYD88 4615 Q99836
MYD88 301059 Q6Y1S1
MYD88 17874 P22366

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MYD88 Proteins (MYD88) by Origin

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Top referenced MYD88 Proteins

  1. Human MYD88 Primary Antibody for SDS - ABIN1098740 : Kawai, Sato, Ishii, Coban, Hemmi, Yamamoto, Terai, Matsuda, Inoue, Uematsu, Takeuchi, Akira: Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. in Nature immunology 2004 (PubMed)
    Show all 2 references for ABIN1098740

More Proteins for MYD88 Interaction Partners

Fruit Fly (Drosophila melanogaster) Myeloid Differentiation Primary Response Gene (88) (MYD88) interaction partners

  1. a novel function of MyD88 in the regulation of metabolism that appears to be independent of its known roles in immunity and development.

  2. propose that dMyD88 is the functional homolog of TIRAP (show TIRAP Proteins) and that both proteins function as sorting adaptors to recruit downstream signaling adaptors to activated receptors

  3. DmMyD88 encodes an essential component of the Toll (show TLR4 Proteins) pathway in dorsoventral pattern formation.

  4. We show that there is a direct interaction between Kra and Tube presumably mediated by the death domains present in both proteins.

  5. both the heterodimeric and heterotrimeric complexes form kidney-shaped structures and that Tube is bivalent and has separate high affinity binding sites for dMyD88 and Pelle (show IRAK1 Proteins).

Zebrafish Myeloid Differentiation Primary Response Gene (88) (MYD88) interaction partners

  1. Fish IRF6 (show IRF6 Proteins) is distinguished from the homolog of mammals by being a positive regulator of IFN transcription and phosphorylated by MyD88 and TBK1 (show TBK1 Proteins), suggesting that differences in the IRF6 (show IRF6 Proteins) regulation pattern exist between lower and higher vertebrates.

  2. DrIRF1 works in concert with MyD88 to activate zebrafish IFNvarphi3 but not IFNvarphi1. These results provide insights into the evolving function of IRF1 (show IRF1 Proteins) as a positive IFN regulator.

  3. MyD88 signaling has an important protective role during early pathogenesis.

  4. MyD88-dependent signaling is involved in the innate immune response of the developing zebrafish embryo, a model for the study of vertebrate innate immunity.

Human Myeloid Differentiation Primary Response Gene (88) (MYD88) interaction partners

  1. homo-dimerization and restrains the dynamics of the MyD88-TIR domain

  2. Epistatic interaction between MyD88 and TIRAP (show TIRAP Proteins) against Helicobacter pylori.

  3. It was found that HP1437 forms dimers in solution similar to other bacterial Toll (show TLR4 Proteins)/IL-1 (show IL1A Proteins) receptor domain proteins. Furthermore, glutathione S-transferase (show GSTa2 Proteins) pull down assays identified an interaction between HP1437 and human Toll (show TLR4 Proteins)/IL-1 (show IL1A Proteins) receptor domain adaptor MyD88.

  4. Findings suggest that high mobility group box 1/toll-like receptor 4/myeloid differentiation factor 88 signaling pathway may contribute to the development and progression of gastric cancer via the nuclear factor kappa B pathway.

  5. Non-IgM Lymphoplasmacytic lymphomas are a clinically and pathologically heterogeneous group and often harbor MYD88 L265P mutation

  6. DENV replication and IFNalpha/beta, TNF-alpha (show TNF Proteins), IL-12 (show IL12A Proteins) and IL-18 (show IL18 Proteins) in infected cultures at 24h were found. All of these parameters were significantly decreased after TRIF (show TRIM69 Proteins), MYD88 or NF-kB inhibition

  7. The -938C>A polymorphism in MYD88 is associated with susceptibility to tuberculosis.

  8. Knockdown of MyD88 reduced the proliferation, migration, and invasion of MCF-7 cells and increased the sensitivity of MCF-7 cells to paclitaxel treatment through the inhibition of activation of NF-kappaB (show NFKB1 Proteins) via PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins).

  9. Methicillin-resistant Staphylococcus aureus infection can enhance non small cell lung cancer cell metastasis by up-regulating TLR4 (show TLR4 Proteins)/MyD88 signaling.

  10. hotspot mutations of CD79B (show CD79B Proteins) Y196 and MYD88 L265 may serve as a genetic hallmark for primary central nervous system lymphoma

Pig (Porcine) Myeloid Differentiation Primary Response Gene (88) (MYD88) interaction partners

  1. These results suggest that porcine circovirus 2 induces IL-8 (show IL8 Proteins) secretion via the TLR2/MyD88/NF-kappaB (show NFKB1 Proteins) signalling pathway.

  2. At 30 days after autotransplantation of a pig kidney, mRNA expression increases for MyD88.

  3. These results suggest that an MyD88-dependent signaling pathway is present in newborn as well as in adult swine and that it is involved in the innate immune system of these animals.

Cow (Bovine) Myeloid Differentiation Primary Response Gene (88) (MYD88) interaction partners

  1. L. rhamnosus GR-1 ameliorates the E. coli-induced disruption of cellular ultrastructure, subsequently reducing the percentage of bovine endometrial epithelial cells apoptosis and limiting inflammatory responses, partly via attenuation of MyD88-dependent and MyD88-independent pathway activation

  2. Modulated cytokine expression in Bovine viral diarrhea virus type 2 infected macrophages was associated with decreased MyD88 expression.

  3. The study demonstrates that in cattle, animals heterozygous at the MyD88 A625C polymorphic marker have a 5-fold reduced risk for active pulmonary tuberculosis.

  4. MyD88 plays a functional role in transducing LPS (show IRF6 Proteins) signaling from TLR-4 (show TLR4 Proteins) to downstream effector molecules involved in NF-kappaB (show NFKB1 Proteins) activation

Atlantic Salmon (Salmo salar) Myeloid Differentiation Primary Response Gene (88) (MYD88) interaction partners

  1. MyD88 interacts with interferon (show IFNA Proteins) regulatory factor (IRF) 3 (show IRF3 Proteins) and IRF7 (show IRF7 Proteins) in Atlantic salmon (Salmo salar)

  2. the salmon MyD88 was cloned and its expression was analysed.

Mouse (Murine) Myeloid Differentiation Primary Response Gene (88) (MYD88) interaction partners

  1. The authors report that microbial stimulation triggers Mincle (Clec4e (show CLEC4E Proteins)) expression through the myeloid differentiation primary response gene 88 (MyD88) pathway; a process that does not require MCL (Clecsf8 (show CLEC4D Proteins), Clec4d (show CLEC4D Proteins)). Conversely, they show that MCL (show CLEC4D Proteins) is constitutively expressed but retained intracellularly until Mincle (show CLEC4E Proteins) is induced, whereupon the receptors form heterodimers which are translocated to the cell surface.

  2. that increased hepcidin (show HAMP Proteins) expression caused by inflammation prevents brain iron efflux via inhibition of the intracellular iron efflux of brain microvascular endothelial cells entering into circulation and aggravating oxidative brain injury and cognition impairment

  3. Paraquat poisoning activates the MyD88-dependent pathway causing acute lung injury. MyD88 gene knockout attenuates paraquat-induced acute lung injury.

  4. beta-elemene anti-inflammatory effect is due to the down-regulation of TLR4 (show TLR4 Proteins)/MyD88 signaling pathway

  5. Myeloid Differentiation Factor 88 Signaling in Bone Marrow-Derived Cells Promotes Gastric Tumorigenesis by Generation of Inflammatory Microenvironment.

  6. Attenuated inflammation through down-regulating the levels of MyD88 by decreasing TLR4 (show TLR4 Proteins) expression.

  7. The authors demonstrate that, in addition to MyD88, Yersinia pseudotuberculosis inhibits TRIF (show RNF138 Proteins) signaling through the type III secretion system effector YopJ.

  8. that motor deficits emerge rapidly during a narrow age window in Spinocerebellar ataxia (show USP14 Proteins) type 6 (84Q) mice

  9. Severity of sodium dodecyl sulfate-induced colitis is reduced in Ido1 (show IDO1 Proteins)-deficient mice with down-regulation of TLR-MyD88-NF-kB transcriptional networks.

  10. MyD88 contributes to the generation of innate and adaptive immune responses during the pathogenesis of Atopic dermatitis in a mouse model.

MYD88 Protein Profile

Protein Summary

This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants.

Alternative names and synonyms associated with MYD88

  • myeloid differentiation primary response gene (88) (myd88-b)
  • CG2078 gene product from transcript CG2078-RB (Myd88)
  • myeloid differentiation primary response gene (88) (myd88)
  • myeloid differentiation primary response factor 88 (Myd88)
  • myeloid differentiation primary response 88 (myd88)
  • myeloid differentiation primary response gene 88 (Myd88)
  • MyD88 adaptor (myd88)
  • myeloid differentiation factor 88 (myd88)
  • myeloid differentiation response protein 88 (myd88)
  • myeloid differentiation primary response gene 88 (myd88)
  • interleukin-1 receptor-associated kinase 2 (IRAK2)
  • interleukin-1 receptor-associated kinase 2 (irak2)
  • interleukin-1 receptor-associated kinase 2 (LOC100228175)
  • myeloid differentiation primary response 88 (MYD88)
  • myeloid differentiation primary response 88 (Myd88)
  • myeloid differentiation primary response gene (88) (MYD88)
  • CG2078 protein
  • Dmel\\CG2078 protein
  • DmMyd88 protein
  • dMyd88 protein
  • EP(2)2535 protein
  • GB12344 protein
  • irak-2 protein
  • kra protein
  • LD20892 protein
  • MGC84928 protein
  • myd88 protein
  • MYD88D protein
  • Myd88F protein
  • NV10640 protein
  • XMyD88 protein
  • zgc:103541 protein

Protein level used designations for MYD88

myeloid differentiation primary response protein MyD88-B , Toll/IL-1 receptor binding protein MyD88-B , CG2078-PA , CG2078-PB , Myd88-PA , Myd88-PB , Myd88F , krapfen , myeloid differentiation primary response factor 88 , myeloid differentiation primary response protein MyD88 , zMyD88 , myeloid differentiation primary response gene (88) , myeloid differentiation primary response gene 88 , myeloid differentiation factor 88 , myeloid differentiation response protein 88 , interleukin-1 receptor-associated kinase-like 2 , interleukin-1 receptor-associated kinase 2 , myeloid differentiation primary response protein 88

GENE ID SPECIES
734302 Xenopus laevis
35956 Drosophila melanogaster
403145 Danio rerio
413194 Apis mellifera
549591 Xenopus (Silurana) tropicalis
100118553 Nasonia vitripennis
100134853 Takifugu rubripes
100136123 Oncorhynchus mykiss
100305041 Ictalurus punctatus
100616081 Amphimedon queenslandica
416118 Gallus gallus
493227 Xenopus (Silurana) tropicalis
100228175 Taeniopygia guttata
4615 Homo sapiens
301059 Rattus norvegicus
477024 Canis lupus familiaris
460269 Pan troglodytes
420420 Gallus gallus
396646 Sus scrofa
444881 Bos taurus
678682 Ovis aries
696494 Macaca mulatta
100169859 Salmo salar
17874 Mus musculus
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