Browse our MYD88 Proteins (MYD88)

Full name:
Myeloid Differentiation Primary Response Gene (88) Proteins (MYD88)
On www.antibodies-online.com are 23 Myeloid Differentiation Primary Response Gene (88) (MYD88) Proteins from 7 different suppliers available. Additionally we are shipping MYD88 Antibodies (267) and MYD88 Kits (25) and many more products for this protein. A total of 336 MYD88 products are currently listed.
Synonyms:
CG2078, Dmel\\CG2078, DmMyd88, dMyd88, EP(2)2535, GB12344, irak-2, kra, LD20892, MGC84928, myd88, MYD88D, Myd88F, NV10640, XMyD88, zgc:103541
list all proteins Gene Name GeneID UniProt
MYD88 4615 Q99836
MYD88 301059 Q6Y1S1
MYD88 17874 P22366

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MYD88 Proteins (MYD88) by Origin

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Top referenced MYD88 Proteins

  1. Human MYD88 Protein expressed in Escherichia coli (E. coli) - ABIN1098740 : Kawai, Sato, Ishii, Coban, Hemmi, Yamamoto, Terai, Matsuda, Inoue, Uematsu, Takeuchi, Akira: Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. in Nature immunology 2004 (PubMed)
    Show all 2 references for 1098740

More Proteins for MYD88 Interaction Partners

Fruit Fly (Drosophila melanogaster) Myeloid Differentiation Primary Response Gene (88) (MYD88) interaction partners

  1. a novel function of MyD88 in the regulation of metabolism that appears to be independent of its known roles in immunity and development.

  2. propose that dMyD88 is the functional homolog of TIRAP (show TIRAP Proteins) and that both proteins function as sorting adaptors to recruit downstream signaling adaptors to activated receptors

  3. DmMyD88 encodes an essential component of the Toll (show TLR4 Proteins) pathway in dorsoventral pattern formation.

  4. We show that there is a direct interaction between Kra and Tube presumably mediated by the death domains present in both proteins.

  5. both the heterodimeric and heterotrimeric complexes form kidney-shaped structures and that Tube is bivalent and has separate high affinity binding sites for dMyD88 and Pelle (show IRAK1 Proteins).

Zebrafish Myeloid Differentiation Primary Response Gene (88) (MYD88) interaction partners

  1. Fish IRF6 (show IRF6 Proteins) is distinguished from the homolog of mammals by being a positive regulator of IFN transcription and phosphorylated by MyD88 and TBK1 (show TBK1 Proteins), suggesting that differences in the IRF6 (show IRF6 Proteins) regulation pattern exist between lower and higher vertebrates.

  2. DrIRF1 works in concert with MyD88 to activate zebrafish IFNvarphi3 but not IFNvarphi1. These results provide insights into the evolving function of IRF1 (show IRF1 Proteins) as a positive IFN regulator.

  3. MyD88 signaling has an important protective role during early pathogenesis.

  4. MyD88-dependent signaling is involved in the innate immune response of the developing zebrafish embryo, a model for the study of vertebrate innate immunity.

Human Myeloid Differentiation Primary Response Gene (88) (MYD88) interaction partners

  1. Data indicate that 64 patients (57.1%) carried the myeloid differentiation factor 88 protein (MYD88) L265P mutation and 14 patients (12.5%) carried the chemokine (C-X-C motif) receptor 4 (CXCR4) WHIM (show CXCR4 Proteins)-like mutation.

  2. HCK (show HCK Proteins) represents a novel target for therapeutic development in MYD88-mutated Waldenstrom macroglobulinemia and activated-B cell diffuse large B-cell lymphoma, and possibly other diseases driven by mutated MYD88.

  3. We found an that enhanced expression of the TLR4 (show TLR4 Proteins)-MyD88-NF-kB pathway occurs in GDM placentae, which positively correlates with heightened local IR in placentae and higher maternal hyperglycemia. The TLR4 (show TLR4 Proteins)/MyD88/NF-kB pathway may play a potential role in the development of IR in placentae of GDM.

  4. We found that over-expression of CRNDE in astrocytes increased the expression of key factors in the toll (show TLR4 Proteins)-like receptor signaling pathway, especially toll-like receptor-3 (show TLR3 Proteins)-mediated MyD88-independent pathway.We speculated that CRNDE might trigger inflammation to regulate tumorigenesis and tumor development through the toll (show TLR4 Proteins)-like receptor pathway

  5. Data suggest that, in monocytes and macrophages, the interleukin-1B- (IL1B (show IL1B Proteins))-stimulated trans-autophosphorylation of IRAK4 (interleukin-1 receptor-associated kinase 4 (show IRAK4 Proteins)) is initiated by MYD88-induced dimerization of IRAK4 (show IRAK4 Proteins). In contrast, IRAK1 (interleukin-1 receptor-associated kinase 1 (show IRAK1 Proteins)) is inactive in unstimulated monocytes/macrophages and is converted to an active protein kinase (show CDK7 Proteins) in response to IL1B (show IL1B Proteins).

  6. our data suggest a new role of MyD88 in the development of glucose intolerance and hepatic steatosis.

  7. In patient population from Southeast Serbia Myd 88 L265 mutation was not responsible for the development of diffuse large B-cell non Hodgkin lymphoma.

  8. FSTL1 (show FSTL1 Proteins) displays anti-inflammatory effects against oxidized low-density lipoprotein-induced pro-inflammatory cytokine production via a mechanism that involves the TLR4 (show TLR4 Proteins)/MyD88/NF-kappaB (show NFKB1 Proteins) and MAPK (show MAPK1 Proteins) signaling pathways.

  9. The incidence of MYD88 and CD79B (show CD79B Proteins) mutations in patients with CD5 (show CD5 Proteins)(+) DLBCL is lower than that in patients with DLBCL-SS, suggesting that CD5 (show CD5 Proteins)(+) DLBCL is not the same disease as DLBCL-SS in terms of gene mutation status.

  10. NEDDylation of MyD88 regulates NF-kappaB (show NFKB1 Proteins) activity through antagonizing its ubiquitination, suggesting a novel mechanism of modulating NF-kappaB (show NFKB1 Proteins) signaling pathway.

Pig (Porcine) Myeloid Differentiation Primary Response Gene (88) (MYD88) interaction partners

  1. These results suggest that porcine circovirus 2 induces IL-8 (show IL8 Proteins) secretion via the TLR2/MyD88/NF-kappaB (show NFKB1 Proteins) signalling pathway.

  2. At 30 days after autotransplantation of a pig kidney, mRNA expression increases for MyD88.

  3. These results suggest that an MyD88-dependent signaling pathway is present in newborn as well as in adult swine and that it is involved in the innate immune system of these animals.

Cow (Bovine) Myeloid Differentiation Primary Response Gene (88) (MYD88) interaction partners

  1. L. rhamnosus GR-1 ameliorates the E. coli-induced disruption of cellular ultrastructure, subsequently reducing the percentage of bovine endometrial epithelial cells apoptosis and limiting inflammatory responses, partly via attenuation of MyD88-dependent and MyD88-independent pathway activation

  2. Modulated cytokine expression in Bovine viral diarrhea virus type 2 infected macrophages was associated with decreased MyD88 expression.

  3. The study demonstrates that in cattle, animals heterozygous at the MyD88 A625C polymorphic marker have a 5-fold reduced risk for active pulmonary tuberculosis.

  4. MyD88 plays a functional role in transducing LPS (show IRF6 Proteins) signaling from TLR-4 (show TLR4 Proteins) to downstream effector molecules involved in NF-kappaB (show NFKB1 Proteins) activation

Atlantic Salmon (Salmo salar) Myeloid Differentiation Primary Response Gene (88) (MYD88) interaction partners

  1. MyD88 interacts with interferon (show IFNA Proteins) regulatory factor (IRF) 3 (show IRF3 Proteins) and IRF7 (show IRF7 Proteins) in Atlantic salmon (Salmo salar)

  2. the salmon MyD88 was cloned and its expression was analysed.

Mouse (Murine) Myeloid Differentiation Primary Response Gene (88) (MYD88) interaction partners

  1. Autophagy contributes to macrophage resistance to Leishmania major. Data, including data from studies in knockout mice, suggest a key resistance mechanism involves endosomal signaling via Tlr3 (show TLR3 Proteins)/7/9 in macrophages; macrophages deficient for Tlr3 (show TLR3 Proteins)/7/9, Unc93b1, or MyD88 fail to undergo L. major-induced autophagy. (TLR = Toll (show TLR4 Proteins)-like receptor; Unc93b1 = unc-93 homolog B1; MyD88 = myeloid differentiation primary response gene 88)

  2. MyD88 inhibitor ST2825 attenuates acute cardiac rejection and promotes donor-specific hyporesponsiveness in stringent skin transplant models

  3. MyD88 has a divergent requirement for cell survival in non-Tregs and Tregs, and a yet-to-be defined survival-independent requirement for Treg function during the response to alloantigen

  4. The aim of this study was to examine the role of the common TLR adaptor protein myeloid-differentiation factor (MyD) 88 in lung epithelium during host defense against K. pneumoniae-induced pneumonia.

  5. TLR2, TLR4 (show TLR4 Proteins) AND MyD88 mediate allergic airway disease (AAD) and Streptococcus pneumoniae-induced suppression of AAD.

  6. miR-23a-5p modulated the innate host defense by promoting mycobacteria survival and inhibiting the activation of autophagy against Mycobacterium tuberculosis through TLR2/MyD88/NF-kappaB pathway by targeting TLR2.

  7. results indicate that the R753Q polymorphism alters TLR2 signaling competence, leading to impaired MyD88-TLR2 assembly, reduced phosphorylation of IRAK-1 (show IRAK1 Proteins), diminished activation of MAPKs and NF-kappaB (show NFKB1 Proteins), and deficient induction of cytokines in macrophages infected with M. smegmatis.

  8. our data suggest a new role of MyD88 in the development of glucose intolerance and hepatic steatosis.

  9. this study shows that MyD88-dependent mechanisms are critical for orchestrating lung inflammatory responses, in terms of IL-17A (show IL17A Proteins) production, as well as eosinophil and neutrophil recruitment

  10. a deficiency in MyD88 or CybB (show CYBB Proteins) is associated with impaired bacterial clearance and increased granuloma formation in the lung.

MYD88 Protein Profile

Protein Summary

This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants.

Alternative names and synonyms associated with MYD88

  • myeloid differentiation primary response gene (88) (myd88-b)
  • CG2078 gene product from transcript CG2078-RB (Myd88)
  • myeloid differentiation primary response gene (88) (myd88)
  • myeloid differentiation primary response factor 88 (Myd88)
  • myeloid differentiation primary response 88 (myd88)
  • myeloid differentiation primary response gene 88 (Myd88)
  • MyD88 adaptor (myd88)
  • myeloid differentiation factor 88 (myd88)
  • myeloid differentiation response protein 88 (myd88)
  • myeloid differentiation primary response gene 88 (myd88)
  • interleukin-1 receptor-associated kinase 2 (IRAK2)
  • interleukin-1 receptor-associated kinase 2 (irak2)
  • interleukin-1 receptor-associated kinase 2 (LOC100228175)
  • myeloid differentiation primary response 88 (MYD88)
  • myeloid differentiation primary response 88 (Myd88)
  • myeloid differentiation primary response gene (88) (MYD88)
  • CG2078 protein
  • Dmel\\CG2078 protein
  • DmMyd88 protein
  • dMyd88 protein
  • EP(2)2535 protein
  • GB12344 protein
  • irak-2 protein
  • kra protein
  • LD20892 protein
  • MGC84928 protein
  • myd88 protein
  • MYD88D protein
  • Myd88F protein
  • NV10640 protein
  • XMyD88 protein
  • zgc:103541 protein

Protein level used designations for MYD88

myeloid differentiation primary response protein MyD88-B , Toll/IL-1 receptor binding protein MyD88-B , CG2078-PA , CG2078-PB , Myd88-PA , Myd88-PB , Myd88F , krapfen , myeloid differentiation primary response factor 88 , myeloid differentiation primary response protein MyD88 , zMyD88 , myeloid differentiation primary response gene (88) , myeloid differentiation primary response gene 88 , myeloid differentiation factor 88 , myeloid differentiation response protein 88 , interleukin-1 receptor-associated kinase-like 2 , interleukin-1 receptor-associated kinase 2 , myeloid differentiation primary response protein 88

GENE ID SPECIES
734302 Xenopus laevis
35956 Drosophila melanogaster
403145 Danio rerio
413194 Apis mellifera
549591 Xenopus (Silurana) tropicalis
100118553 Nasonia vitripennis
100134853 Takifugu rubripes
100136123 Oncorhynchus mykiss
100305041 Ictalurus punctatus
100616081 Amphimedon queenslandica
416118 Gallus gallus
493227 Xenopus (Silurana) tropicalis
100228175 Taeniopygia guttata
4615 Homo sapiens
301059 Rattus norvegicus
477024 Canis lupus familiaris
460269 Pan troglodytes
420420 Gallus gallus
396646 Sus scrofa
444881 Bos taurus
678682 Ovis aries
696494 Macaca mulatta
100169859 Salmo salar
17874 Mus musculus
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