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|Application / Reactivity||Human||Mouse (Murine)||Rat (Rattus)|
|Western Blotting (WB)||254 Antibodies||115 Antibodies||95 Antibodies|
|Intracellular Staining (ICS)||4 Antibodies||2 Antibodies|
|Immunoprecipitation (IP)||51 Antibodies||14 Antibodies||10 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||49 Antibodies||29 Antibodies||22 Antibodies|
|Immunohistochemistry (IHC)||121 Antibodies||73 Antibodies||69 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||5 Antibodies||3 Antibodies||3 Antibodies|
|Antigen||Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This NFKBIA antibody is un-conjugated Alternatives|
Flow Cytometry (FACS)
|3 references available|
|Supplier||Log in to see|
Product Details anti-NFKBIA AntibodyTarget Details NFKBIA Application Details Handling References for anti-NFKBIA Antibody (ABIN2664012) Images
|Purification||This antibody was purified by antigen-affinity chromatography.|
Target Details NFKBIAProduct Details anti-NFKBIA Antibody Application Details Handling References for anti-NFKBIA Antibody (ABIN2664012) Images back to top
|Alternative Name||IkB-alpha (NFKBIA Antibody Abstract)|
|Background||IκB-α is an inhibitory protein that binds the NFκB complex and retains this complex in the cytoplasm where it cannot activate transcription. Upon cellular stimulation, the IκB proteins are phosphorylated and degraded via the ubiquitin pathway allowing nuclear translocation of NFκB. The NFκB complex binds DNA to activate gene expression of a number of a variety of proteins involved in inflammation, cellular proliferation, differentiation, and apoptosis. Poly6249 recognizes the C-terminal region of human, mouse, rat IKB-α and has been shown to be useful for Western blotting, immunoprecipitation, and immunohistochemistry.|
|Pathways||NF-kappaB Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway|
Application DetailsProduct Details anti-NFKBIA Antibody Target Details NFKBIA Handling References for anti-NFKBIA Antibody (ABIN2664012) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-NFKBIA Antibody Target Details NFKBIA Application Details References for anti-NFKBIA Antibody (ABIN2664012) Images back to top
|Buffer||phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % gelatin.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Do not freeze.|
|Storage Comment||The antibody solution should be stored undiluted between 2°C and 8°C.|
References for anti-NFKBIA Antibody (ABIN2664012)Product Details anti-NFKBIA Antibody Target Details NFKBIA Application Details Handling Images back to top
Hoffmann, Levchenko, Scott et al.: "The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation." in: Science (New York, N.Y.), Vol. 298, Issue 5596, pp. 1241-5, 2002 (PubMed).
Baeuerle: "IkappaB-NF-kappaB structures: at the interface of inflammation control." in: Cell, Vol. 95, Issue 6, pp. 729-31, 1999 (PubMed).
Ito, Adey, Bautch et al.: "Structure and evolution of the human IKBA gene." in: Genomics, Vol. 29, Issue 2, pp. 490-5, 1996 (PubMed).
ImagesProduct Details anti-NFKBIA Antibody Target Details NFKBIA Application Details Handling References for anti-NFKBIA Antibody (ABIN2664012) back to top