Browse our NFKBIA Proteins (NFKBIA)

Full name:
Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha Proteins (NFKBIA)
On www.antibodies-online.com are 10 Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA) Proteins from 7 different suppliers available. Additionally we are shipping NFKBIA Antibodies (504) and NFKBIA Kits (34) and many more products for this protein. A total of 567 NFKBIA products are currently listed.
Synonyms:
AI462015, ECI-6/IKBA, IKBA, MAD-3, NFKBI, RL/IF-1
list all proteins Gene Name GeneID UniProt
NFKBIA 18035 Q9Z1E3
NFKBIA 4792 P25963
Rat NFKBIA NFKBIA 25493 Q63746

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NFKBIA Proteins (NFKBIA) by Origin

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Top referenced NFKBIA Proteins

  1. Human NFKBIA Protein expressed in Escherichia coli (E. coli) - ABIN2004994 : Scherer, Brockman, Chen, Maniatis, Ballard: Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination. in Proceedings of the National Academy of Sciences of the United States of America 1995 (PubMed)
    Show all 5 references for 2004994

  2. Human NFKBIA Protein expressed in Escherichia coli (E. coli) - ABIN667968 : Simpson, Morris: Regulation of neuronal cell adhesion molecule expression by NF-kappa B. in The Journal of biological chemistry 2000 (PubMed)
    Show all 2 references for 667968

More Proteins for NFKBIA Interaction Partners

Mouse (Murine) Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA) interaction partners

  1. Mechanistic analysis suggest that USP12 may be required for the activation of NFkappaB pathway as knockdown of USP12 reduced the inhibitory phosphorylation of IkappaBalpha, a well characterized inhibitor of NFkappaB nuclear translocation.

  2. SM22alpha (show TAGLN Proteins) is a phosphorylation-regulated (show PHAX Proteins) suppressor of IKK (show CHUK Proteins)-IkappaBalpha-NF-kappaB (show NFKB1 Proteins) signaling cascades.

  3. We found potential links between the alterations in expression of Tsc22d3 (show TSC22D3 Proteins), Nfkbia and Pdyn (show PDYN Proteins), and different aspects of susceptibility to stress.

  4. Specific and constitutive deletion of the inhibitor of NF-kappaB (show NFKB1 Proteins) (IkappaBalpha) in eosinophils in vivo reduced apoptosis during helminth infection

  5. GRK6 (show GRK6 Proteins) directly phosphorylates Nfkbia at Ser32/Ser36. Knockdown of GRK6 (show GRK6 Proteins) suppresses TNF-alpha (show TNF Proteins)-induced NF-kappaappaB signaling.

  6. Results demonstrate novel roles of TNFRII (show TNFRSF1B Proteins) in the regulation of Abeta (show APP Proteins) production, suggesting a potential therapeutic strategy for Alzheimer's disease by up-regulating TNFRII (show TNFRSF1B Proteins) levels and elevating phosphorylated IkappaBalpha by SUMOylation.

  7. Defective lymphoid organogenesis underlies the immune deficiency caused by a heterozygous S32I mutation in IkappaBalpha.

  8. Dengue virus protease interacts with both NF-kappaB inhibitor alpha (IkappaBalpha) and NF-kappaB (show NFKB1 Proteins) inhibitor beta (IkappaBbeta (show NFKBIB Proteins)), cleaving them in a mouse hemorrhage model.

  9. The results indicate that following heat shock treatment, HuR (show ELAVL1 Proteins) translocates from the nucleus to the cytoplasm, forming stress granules and regulating the translation of IkBalpha mRNA without affecting the half-life.

  10. Data show that inhibition of nuclear factor-kappaB (NF-kappaB (show NFKB1 Proteins)) in IKBM protects the mice from monocrotaline (MCT (show MCAT Proteins))-induced pulmonary arterial hypertension and right ventricular hypertrophy.

Human Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA) interaction partners

  1. The results showed that NFKB1 (show NFKB1 Proteins) and NFKBIA single-nucleotide polymorphisms and gastric cancer are related and that the combined effects of polymorphisms in two genes and the NFKBIA gene monomer increased the risk of gastric cancer, and it was found that in different types of gastric cancer (the cardia and non-cardia cancer), susceptible polymorphism sites and combined effects are different.

  2. Double phosphorylation-induced structural changes in the signal-receiving domain of IkappaBalpha in complex with NF-kappaB (show NFKB1 Proteins) have been described.

  3. Here, the authors report amide hydrogen/deuterium exchange data that reveal long-range allosteric changes in the NFkappaB (show NFKB1 Proteins) (RelA (show NFkBP65 Proteins)-p50 (show CD40 Proteins)) heterodimer induced by DNA or IkappaBalpha binding.

  4. Sam68 (show KHDRBS1 Proteins) is essential for DNA damage-induced NF-kappaB (show NFKB1 Proteins) activation and colon tumorigenesis.

  5. Specifically, BCA2 (show RNF115 Proteins) serves as an E3 SUMO ligase in the SUMOylation of IkappaBalpha, which in turn enhances the sequestration of NF-kappaB (show NFKB1 Proteins) components in the cytoplasm. Since HIV-1 utilizes NF-kappaB (show NFKB1 Proteins) to promote proviral transcription, the BCA2 (show RNF115 Proteins)-mediated inhibition of NF-kappaB (show NFKB1 Proteins) significantly decreases the transcriptional activity of HIV-1.

  6. This study found that NFKBIA mRNAs was significantly expressed in normal tissues compared with glioma specimens.

  7. Findings indicate the prognostic value of NFKB inhibitor alpha (NFKBIA) in lower-grade gliomas (LGGs).

  8. W346 effectively inhibited tumor necrosis factor (TNF-a (show TNF Proteins))-induced NF-kappaB (show NFKB1 Proteins) activation by suppressing IKK (show CHUK Proteins) phosphorylation, inhibiting IkB (show NFKBIB Proteins)-a degradation, and restraining the accumulation of NF-kappaB (show NFKB1 Proteins) subunit p65 (show GORASP1 Proteins) nuclear translocation. W346 also affected NF-kappaB (show NFKB1 Proteins)-regulated downstream products involved in cycle arrest and apoptosis.

  9. treating cells with SZC014 resulted in a decrease in phosphorylation of IkBa and NF-kappaB (show NFKB1 Proteins)/p65 (show GORASP1 Proteins) and NF-kappaB (show NFKB1 Proteins)/p65 (show GORASP1 Proteins) nuclear translocation. The cytotoxic activities of seven OA derivatives were generally stronger than that of OA, among which, SZC014 possessed the most potent anticancer activity in SGC7901 cells and would be a promising chemotherapic agent for the treatment of gastric cancer

  10. Network analysis identified NFKBIA as pathogenic gene in childhood asthma.

Cow (Bovine) Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA) interaction partners

  1. IkappaB-alpha protein was stabilized by COMMD1 (show COMMD1 Proteins), which attenuated NF-kappaB (show NFKB1 Proteins) signaling during Toll (show TLR4 Proteins)-like receptor ligand and tumor necrosis factor alpha (show TNF Proteins) treatment and enhanced HIV-1 latency in latently HIV-1-infected cells.

  2. NFKBIA has a role as a marker of NF-kappaB (show NFKB1 Proteins)/p65 (show SYT1 Proteins) activation in the early embryo.

  3. NF-kappaB (show NFKB1 Proteins) has a role in increasing PDGF-B (show PDGFB Proteins) transcription

  4. AIP1 (show PDCD6IP Proteins) is a novel transducer in TNF (show TNF Proteins)-induced TRAF2 (show TRAF2 Proteins)-dependent activation of ASK1 (show MAP3K5 Proteins) that mediates a balance between JNK (show MAPK8 Proteins) versus NF-kappaB (show NFKB1 Proteins) signaling

  5. GRK5 overexpression causes nuclear accumulation of IkappaB alpha, leading to the inhibition of NFkappaB transcriptional activity.

NFKBIA Protein Profile

Protein Summary

This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.

Alternative names and synonyms associated with NFKBIA

  • nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (NFKBIA)
  • nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (LOC100220015)
  • nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (LOC100357341)
  • nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha (Nfkbia)
  • nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (Nfkbia)
  • AI462015 protein
  • ECI-6/IKBA protein
  • IKBA protein
  • MAD-3 protein
  • NFKBI protein
  • RL/IF-1 protein

Protein level used designations for NFKBIA

NF-kappa-B inhibitor alpha , nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha , I(Kappa)B(alpha) , I-kappa-B-alpha , I-kappaBalpha , ikB-alpha , ikappaBalpha , nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha , nuclear factor of kappa light polyp gene enhancer in B-cell 1 , IkappaBalpha , major histocompatibility complex enhancer-binding protein MAD3 , nuclear factor of kappa light chain gene enhancer in B-cells , ECI-6 , I kappa B-alpha , IKB-alpha , NF-kappaB inhibitor alpha , REL-associated protein pp40 , Rel-associated pp40 , IkappaB alpha , Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells alpha , Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells, alpha

GENE ID SPECIES
780520 Ovis aries
100220015 Taeniopygia guttata
100357341 Oryctolagus cuniculus
18035 Mus musculus
4792 Homo sapiens
406188 Sus scrofa
396093 Gallus gallus
480291 Canis lupus familiaris
282291 Bos taurus
25493 Rattus norvegicus
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