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Browse our NFKBIA Proteins (NFKBIA)

Full name:
Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha Proteins (NFKBIA)
On www.antibodies-online.com are 10 Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA) Proteins from 7 different suppliers available. Additionally we are shipping NFKBIA Antibodies (486) and NFKBIA Kits (28) and many more products for this protein. A total of 544 NFKBIA products are currently listed.
Synonyms:
AI462015, ECI-6/IKBA, IKBA, MAD-3, NFKBI, RL/IF-1
list all proteins Gene Name GeneID UniProt
NFKBIA 18035 Q9Z1E3
NFKBIA 4792 P25963
Rat NFKBIA NFKBIA 25493 Q63746

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NFKBIA Proteins (NFKBIA) by Origin

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Top referenced NFKBIA Proteins

  1. Human NFKBIA Protein expressed in Escherichia coli (E. coli) - ABIN2004994 : Scherer, Brockman, Chen, Maniatis, Ballard: Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination. in Proceedings of the National Academy of Sciences of the United States of America 1995 (PubMed)
    Show all 5 references for ABIN2004994

  2. Human NFKBIA Protein expressed in Escherichia coli (E. coli) - ABIN667968 : Simpson, Morris: Regulation of neuronal cell adhesion molecule expression by NF-kappa B. in The Journal of biological chemistry 2000 (PubMed)
    Show all 2 references for ABIN667968

More Proteins for NFKBIA Interaction Partners

Mouse (Murine) Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA) interaction partners

  1. SM22alpha (show TAGLN Proteins) is a phosphorylation-regulated (show PHAX Proteins) suppressor of IKK (show CHUK Proteins)-IkappaBalpha-NF-kappaB (show NFKB1 Proteins) signaling cascades.

  2. We found potential links between the alterations in expression of Tsc22d3 (show TSC22D3 Proteins), Nfkbia and Pdyn (show PDYN Proteins), and different aspects of susceptibility to stress.

  3. Specific and constitutive deletion of the inhibitor of NF-kappaB (show NFKB1 Proteins) (IkappaBalpha) in eosinophils in vivo reduced apoptosis during helminth infection

  4. GRK6 (show GRK6 Proteins) directly phosphorylates Nfkbia at Ser32/Ser36. Knockdown of GRK6 (show GRK6 Proteins) suppresses TNF-alpha (show TNF Proteins)-induced NF-kappaappaB signaling.

  5. Results demonstrate novel roles of TNFRII (show TNFRSF1B Proteins) in the regulation of Abeta (show APP Proteins) production, suggesting a potential therapeutic strategy for Alzheimer's disease by up-regulating TNFRII (show TNFRSF1B Proteins) levels and elevating phosphorylated IkappaBalpha by SUMOylation.

  6. Defective lymphoid organogenesis underlies the immune deficiency caused by a heterozygous S32I mutation in IkappaBalpha.

  7. Dengue virus protease interacts with both NF-kappaB inhibitor alpha (IkappaBalpha) and NF-kappaB (show NFKB1 Proteins) inhibitor beta (IkappaBbeta (show NFKBIB Proteins)), cleaving them in a mouse hemorrhage model.

  8. The results indicate that following heat shock treatment, HuR (show ELAVL1 Proteins) translocates from the nucleus to the cytoplasm, forming stress granules and regulating the translation of IkBalpha mRNA without affecting the half-life.

  9. Data show that inhibition of nuclear factor-kappaB (NF-kappaB (show NFKB1 Proteins)) in IKBM protects the mice from monocrotaline (MCT (show MCAT Proteins))-induced pulmonary arterial hypertension and right ventricular hypertrophy.

  10. Wedelolactone inhibited lipopolysaccharide -induced NF-kappaB (show NFKB1 Proteins) p65 (show NFkBP65 Proteins) activation via the degradation and phosphorylation of IkappaB-alpha and subsequent translocation of the NF-kappaB (show NFKB1 Proteins) p65 (show NFkBP65 Proteins) subunit to the nucleus.

Human Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA) interaction partners

  1. Activated Rac1 regulates the degradation of IkappaBalpha and the nuclear translocation of STAT3-NFkappaB complexes in starved cancer cells

  2. DAT (show SLC6A3 Proteins) stabilized IkBa by inhibiting the phosphorylation of Ika by the IkB (show NFKBIB Proteins) kinase (IKK (show CHUK Proteins)) complex. DAT (show SLC6A3 Proteins) induced proteasomal degradation of TRAF6 (show TRAF6 Proteins), and DAT (show SLC6A3 Proteins) suppressed IKKb (show IKBKB Proteins)-phosphorylation through downregulation of TRAF6 (show TRAF6 Proteins)

  3. the rs3138053 polymorphism of NFKBIA gene is a candidate for susceptibility to overall cancers, while rs696 plays a protective role [meta-analysis]

  4. Identify a novel BCR-ABL (show ABL1 Proteins)/IkappaBalpha/p53 (show TP53 Proteins) network, whereby BCR-ABL (show ABL1 Proteins) functionally inactivates a key tumor suppressor in chronic myeloid leukemia (show BCL11A Proteins).

  5. Study demonstrates an association between functional polymorphisms of IkappaBalpha rs696 and smoking with the risk of defective spermatogenesis, suggesting some interaction between the NF-kappaB (show NFKB1 Proteins) signalling pathway and smoking-related ROS (show ROS1 Proteins) in human spermatogenesis.

  6. MicroRNA-19a mediates gastric carcinoma cell proliferation through the activation of IkappaBalpha.

  7. No association was observed between NFKBIA variants and risk of liver cancer.

  8. Data indicate the involvement of the p38 MAPK (show MAPK14 Proteins)/NF-kappaB (show NFKB1 Proteins)/IkappaBalpha pathway in Newcastle disease virus (NDV) infection and subsequent induction of apoptosis in clear cell renal cell carcinoma (show MOK Proteins) (ccRCC) cells.

  9. SM22alpha (show TAGLN Proteins) is a phosphorylation-regulated (show PHAX Proteins) suppressor of IKK (show CHUK Proteins)-IkappaBalpha-NF-kappaB (show NFKB1 Proteins) signaling cascades.

  10. This study aimed to examine the association between NFKB19-4 ATTG ins-->del, NFKBIA 3' UTR A-->G, -826CT and -881AG polymorphisms and prostate cancer risk among Chinese.

Cow (Bovine) Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA) interaction partners

  1. IkappaB-alpha protein was stabilized by COMMD1 (show COMMD1 Proteins), which attenuated NF-kappaB (show NFKB1 Proteins) signaling during Toll (show TLR4 Proteins)-like receptor ligand and tumor necrosis factor alpha (show TNF Proteins) treatment and enhanced HIV-1 latency in latently HIV-1-infected cells.

  2. NFKBIA has a role as a marker of NF-kappaB (show NFKB1 Proteins)/p65 (show SYT1 Proteins) activation in the early embryo.

  3. NF-kappaB (show NFKB1 Proteins) has a role in increasing PDGF-B (show PDGFB Proteins) transcription

  4. AIP1 (show PDCD6IP Proteins) is a novel transducer in TNF (show TNF Proteins)-induced TRAF2 (show TRAF2 Proteins)-dependent activation of ASK1 (show MAP3K5 Proteins) that mediates a balance between JNK (show MAPK8 Proteins) versus NF-kappaB (show NFKB1 Proteins) signaling

  5. GRK5 overexpression causes nuclear accumulation of IkappaB alpha, leading to the inhibition of NFkappaB transcriptional activity.

NFKBIA Protein Profile

Protein Summary

This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.

Alternative names and synonyms associated with NFKBIA

  • nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (NFKBIA)
  • nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (LOC100220015)
  • nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (LOC100357341)
  • nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha (Nfkbia)
  • nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (Nfkbia)
  • AI462015 protein
  • ECI-6/IKBA protein
  • IKBA protein
  • MAD-3 protein
  • NFKBI protein
  • RL/IF-1 protein

Protein level used designations for NFKBIA

NF-kappa-B inhibitor alpha , nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha , I(Kappa)B(alpha) , I-kappa-B-alpha , I-kappaBalpha , ikB-alpha , ikappaBalpha , nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha , nuclear factor of kappa light polyp gene enhancer in B-cell 1 , IkappaBalpha , major histocompatibility complex enhancer-binding protein MAD3 , nuclear factor of kappa light chain gene enhancer in B-cells , ECI-6 , I kappa B-alpha , IKB-alpha , NF-kappaB inhibitor alpha , REL-associated protein pp40 , Rel-associated pp40 , IkappaB alpha , Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells alpha , Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells, alpha

GENE ID SPECIES
780520 Ovis aries
100220015 Taeniopygia guttata
100357341 Oryctolagus cuniculus
18035 Mus musculus
4792 Homo sapiens
406188 Sus scrofa
396093 Gallus gallus
480291 Canis lupus familiaris
282291 Bos taurus
25493 Rattus norvegicus
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