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IkappaBbeta has essential functions within the Rel-NFkappaB generation module, specifically for the RelA:RelA homodimer, which controls a subset of NFkappaB target genes.
these results mechanistically link the innate immune response mediated by IkappaBbeta/NF-kappaB (show NFKB1 Proteins) to ET-1 (show EDN1 Proteins) expression and potentially reveal therapeutic targets for patients with Gram-negative septic shock.
Dengue virus protease interacts with both IkappaBalpha (show NFKBIA Proteins) and IkappaBbeta cleaving them in a mouse hemorrhage model.
sustained NF-kappaB (show NFKB1 Proteins) activity mediated by IkappaBbeta protects against hyperoxic lung injury through increased expression of antiapoptotic genes
Findings represent a necessary but not sufficient role of IkappaBbeta in preventing oxidant stress-induced cell death.
IkappaBbeta is an essential co-activator for LPS (show TLR4 Proteins)-induced IL-1beta (show IL1B Proteins) transcription in vivo.
IkappaBbeta acts through p65 (show NFkBP65 Proteins):c-Rel (show NFkBP65 Proteins) dimers to maintain prolonged expression of TNF-alpha (show TNF Proteins)
data suggest that RelA (show NFkBP65 Proteins) is liberated during LPS (show TLR4 Proteins)-induced pulmonary inflammation by the regulated degradation of both IkappaB-alpha (show NFKBIA Proteins) and IkappaB-beta
temporal control of NF-kappaB (show NFKB1 Proteins) activation by the coordinated degradation and synthesis of IkappaB proteins
beta-TrCP1 (show BTRC Proteins) contributes to, but is not absolutely required for, the degradation of I kappa B and beta-catenin (show CTNNB1 Proteins)
our data establish the importance of a novel tumor suppressive IKBB gene in abrogating angiogenesis in NPC (show NPC1 Proteins) via the NF-kappaB (show NFKB1 Proteins) signalling pathway.
IkappaBbeta may be a novel target for transcription factors of the HMG (show SSRP1 Proteins)-box SRY (show SRY Proteins)/Sox (show PIPOX Proteins) family and imply a potential role for NF-kappaB (show NFKB1 Proteins)/IkappaBbeta in spermatogenesis
Data show that increased nuclear factor-kappaB (NF-kB) activity in the amnion during labor is associated with an increase in the expression of NF-kBp65 and of the NF-kB binding proteins IkBa (show NFKBIA Proteins), IkBb-1 and IkBb-2.
VEGF (show VEGFA Proteins) increased Mn-superoxide dismutase (show SOD2 Proteins) promoter activity, an effect that was dependent on a second intronic NF-kappaB (show NFKB1 Proteins) consensus motif.
data indicate that inhibition of NFkappa-B activity by the hepatitis C virus core protein might be related to its physical interaction with and interrupted nuclear localization of IKKbeta (show IKBKB Proteins)
None of the NFKBIB SNPs are associated with pneumococcal susceptibility.
NF-kappaB (show NFKB1 Proteins), IkappaB-alpha (show NFKBIA Proteins), IkappaB-beta mRNA decreased significantly after weight loss.
increased I-kappaBbeta expression reversed NF-kappaB (show NFKB1 Proteins) activation in cancer cells, compensating for the loss of I-kappaBalpha (show NFKBIA Proteins) via TGase 2 (show TGM2 Proteins) polymerization.
NFKBIA (show NFKBIA Proteins) and NFKBIB are not likely to harbor ovarian cancer risk alleles.
The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
, NF-kappa-B inhibitor beta
, nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, beta
, TR-interacting protein 9
, thyroid receptor-interacting protein 9