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The basic residues Lys (show LYZ ELISA Kits)-717 and Lys (show LYZ ELISA Kits)-719 in the C-terminal region of ANK7 contribute to IkappaBzeta (show NFKBIZ ELISA Kits) binding to the Lcn2 (show LCN2 ELISA Kits) promoter, probably via interaction with the cytosine-rich element required for Lcn2 (show LCN2 ELISA Kits) activation; glutamate (show GRIN1 ELISA Kits) substitution for both lysines results in a loss of transcriptionally active complex formation without affecting direct contact of IkappaBzeta (show NFKBIZ ELISA Kits) with p50 (show LSP1 ELISA Kits).
The data imply that regulation of these c-Rel (show NFkBP65 ELISA Kits)-dependent lymphoid responses is a non-redundant function of IkappaBepsilon.
temporal control of NF-kappaB (show NFKB1 ELISA Kits) activation by the coordinated degradation and synthesis of IkappaB proteins
IkappaBepsilon deficiency in mice leads to neonatal death, elevated kappaB binding activity, overexpression of NF-kappaB (show NFKB1 ELISA Kits) target genes, and disruption of lymphocyte production.
Neither IkappaBalpha (show NFKBIA ELISA Kits) nor IkappaBepsilon deficiency had major effects on natural killer cell generation while their combined absence led to NF-kappaB (show NFKB1 ELISA Kits) hyperactivation.
An important role is proposed for I kappa B epsilon in the differential regulation of nuclear NF-kappa B (show NFKB1 ELISA Kits) activity in stimulated B cells.
In vivo degradation rate constants were measured for NF-kappaB (show NFKB1 ELISA Kits)-bound & -unbound IkappaB. Models suggest differential degradation rates of free & bound IkappaB may be a new cross-regulation mechanism imparting functional robustness to the signaling module.
We suggest that the impairment of NFKBIE gene function can reduce the uptake of methotrexate into cells, suggesting that the gene is an important factor for rheumatoid arthritis outcome
A NFKBIE polymorphism was associated with increased risk of pneumococcal meningitis.
results show that Gal-1 (show LGALS1 ELISA Kits) acts by inhibiting the stimulation of the LPS (show IRF6 ELISA Kits)-induced IkappaBzeta (show NFKBIZ ELISA Kits) expression, an NF-kappaB (show NFKB1 ELISA Kits) regulator involved in IL-6 (show IL6 ELISA Kits) gene transcription.
Newly identified alterations included recurrent promoter mutations of NFKBIE, encoding NF-kappaB (show NFKB1 ELISA Kits) inhibitor varepsilon (IkappaBvarepsilon), in 14.5% of samples of desmoplastic melanoma
IkappaBepsilon has a role in NF-kappaB (show NFKB1 ELISA Kits) regulation in aggressive chronic lymphocytic leukemia
Vitamin C forestalls cigarette smoke induced NF-kappaB (show NFKB1 ELISA Kits) activation in alveolar epithelial cells.
we identified two gene loci associated with rheumatoid arthritis susceptibility- NFKBIE and RTKN2
Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon
An NFKBIE SNP associated with susceptibility to pneumococcal disease but not pneumococcal empyema.
Expression levels of GGT1 (show GGT1 ELISA Kits) and possibly NFKBIE might be useful as biomarkers of genetic susceptibility to arsenite.
The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus.
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
, NF-kappa-B inhibitor epsilon
, solute carrier family 35, member B2