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|Application / Reactivity||Human|
|Confocal Microscopy (CM)||2 Antibodies|
|Enzyme Immunoassay (EIA)||5 Antibodies|
|Flow Cytometry (FACS)||79 Antibodies|
|Fluorescence Microscopy (FM)||1 Antibodies|
|Immunochromatography (IC)||5 Antibodies|
|Immunocytochemistry (ICC)||35 Antibodies|
|Immunofluorescence (IF)||59 Antibodies|
|Immunofluorescence (Cultured Cells) (IF (cc))||11 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||13 Antibodies|
|Immunohistochemistry (IHC)||70 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||13 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||46 Antibodies|
|Immunoprecipitation (IP)||37 Antibodies|
|Intracellular Flow Cytometry (ICFC)||6 Antibodies|
|Antigen||Nerve Growth Factor Receptor (NGFR) Antibodies|
|Conjugate||This NGFR antibody is conjugated to PE Alternatives|
Flow Cytometry (FACS), Intracellular Flow Cytometry (ICFC)
|7 references available|
|Supplier||Log in to see|
Product Details anti-NGFR AntibodyTarget Details NGFR Application Details Handling References for anti-NGFR Antibody (ABIN2663264) Images
|Cross-Reactivity||Monkey, Raccoon (Procyon lotor), Sheep (Ovine), Cat (Feline), Dog (Canine), Pig (Porcine), Rabbit|
|Purification||The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.|
Target Details NGFRProduct Details anti-NGFR Antibody Application Details Handling References for anti-NGFR Antibody (ABIN2663264) Images back to top
|Alternative Name||CD271 (NGFR Antibody Abstract)|
|Background||CD271, also known as p75NTR, TNFRSF16, p75(NTR), Gp80-LNGFR, and NGFR, is a type I transmembrane protein with a MW of 75 kD. It is expressed by many cell types including neurons, Schwann cells, mesenchymal stem/stromal cells, follicular dendritic cells and melanocytes. The extracellular portion contains four TNFR-Cys repeats that form the binding domain for its ligands (NGF, BDNF, NTF3, and NTF4). The intracellular portion of CD271 contains a death domain, which interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9, to promote cell apoptosis, and to regulate cell differentiation and neurogenesis.|
|Pathways||NF-kappaB Signaling, Neurotrophin Signaling Pathway|
Application DetailsProduct Details anti-NGFR Antibody Target Details NGFR Handling References for anti-NGFR Antibody (ABIN2663264) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-NGFR Antibody Target Details NGFR Application Details References for anti-NGFR Antibody (ABIN2663264) Images back to top
|Buffer||Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Protect from prolonged exposure to light. Do not freeze.|
|Storage Comment||The antibody solution should be stored undiluted between 2°C and 8°C.|
References for anti-NGFR Antibody (ABIN2663264)Product Details anti-NGFR Antibody Target Details NGFR Application Details Handling Images back to top
Friedman, Li, Li: "Activation of gene transcription by heat shock protein 27 may contribute to its neuronal protection." in: The Journal of biological chemistry, Vol. 284, Issue 41, pp. 27944-51, 2009 (PubMed).
Rock, Onaitis, Rawlins et al.: "Basal cells as stem cells of the mouse trachea and human airway epithelium." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 31, pp. 12771-5, 2009 (PubMed).
Kidd, Anderson, Schneider: "Postnatal lead exposure alters expression of forebrain p75 and TrkA nerve growth factor receptors." in: Brain research, Vol. 1195, pp. 113-9, 2008 (PubMed).
Peters, Liotiri, Bodó et al.: "Probing the effects of stress mediators on the human hair follicle: substance P holds central position." in: The American journal of pathology, Vol. 171, Issue 6, pp. 1872-86, 2007 (PubMed).
Jansen, Giehl, Nyengaard et al.: "Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury." in: Nature neuroscience, Vol. 10, Issue 11, pp. 1449-57, 2007 (PubMed).
Kamke, Brown, Irvine: "Origin and immunolesioning of cholinergic basal forebrain innervation of cat primary auditory cortex." in: Hearing research, Vol. 206, Issue 1-2, pp. 89-106, 2005 (PubMed).
Cattoretti, Schiró, Orazi et al.: "Bone marrow stroma in humans: anti-nerve growth factor receptor antibodies selectively stain reticular cells in vivo and in vitro." in: Blood, Vol. 81, Issue 7, pp. 1726-38, 1993 (PubMed).
ImagesProduct Details anti-NGFR Antibody Target Details NGFR Application Details Handling References for anti-NGFR Antibody (ABIN2663264) back to top