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|Antigen||Protein Kinase C, zeta (PRKCZ) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This PKC zeta antibody is conjugated to Cy5.5 Alternatives|
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
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Product Details anti-PKC zeta AntibodyTarget Details PKC zeta Application Details Handling Images
|Purification||Purified by Protein A.|
|Immunogen||KLH conjugated synthetic phosphopeptide derived from human PRKCZ around the phosphorylation site of Thr410|
Target Details PKC zetaProduct Details anti-PKC zeta Antibody Application Details Handling Images back to top
|Alternative Name||Prkcz (PRKCZ Antibody Abstract)|
Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Synonyms: PRKCZphospho T410, PRKCZphospho Thr410, p-PRKCZT410, rotein Kinase C, AAG6, Aging associated gene 6, MGC129900, MGC129901, MGC41878, MGC57564, PKC B, PKC beta, PKC zeta, PKC2, PKCB, PKCC, PKCD, PKCE, PKCG, PRKACA, PRKC A, PRKC G, PRKCA, PRKCB, PRKCB1, PRKCB2, PRKCD, PRKCE, PRKCG, PRKCZ , Protein kinase C alpha, Protein kinase C alpha type, Protein Kinase C, Protein kinase C beta 1, Protein kinase C beta 1 polypeptide, Protein kinase C beta, Protein kinase C beta type, Protein kinase C delta, Protein kinase C epsilon, Protein kinase C gamma, Protein kinase C gamma type, Protein kinase C zeta, SCA14, Spinocerebellar ataxia 14.
|Pathways||NF-kappaB Signaling, RTK Signaling, Myometrial Relaxation and Contraction, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Synaptic Membrane, Production of Molecular Mediator of Immune Response, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling|
Application DetailsProduct Details anti-PKC zeta Antibody Target Details PKC zeta Handling Images back to top
|Application Notes||IF(IHC-P) 1:50-200|
|Restrictions||For Research Use only|
HandlingProduct Details anti-PKC zeta Antibody Target Details PKC zeta Application Details Images back to top
|Buffer||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.|
|Storage Comment||Store at 4°C|
|Expiry Date||12 months|