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Browse our PKC zeta Proteins (PRKCZ)

Full name:
Protein Kinase C, zeta Proteins (PRKCZ)
On www.antibodies-online.com are 14 Protein Kinase C, zeta (PRKCZ) Proteins from 8 different suppliers available. Additionally we are shipping PKC zeta Antibodies (196) and PKC zeta Kits (41) and many more products for this protein. A total of 265 PKC zeta products are currently listed.
Synonyms:
14-3-3-zetaisoform, AI098070, aPKCzeta, C80388, PKC-ZETA, PKC2, pkcz, PKCzeta, PRKCZ, prkcz-A, r14-3-3, R74924, si:ch211-150o23.4, TPKC, zetaPKC
list all proteins Gene Name GeneID UniProt
PRKCZ 5590 Q05513
PRKCZ 18762 Q02956
PRKCZ 25522 P09217

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PKC zeta Proteins (PRKCZ) by Origin

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More Proteins for PKC zeta Interaction Partners

Xenopus laevis Protein Kinase C, zeta (PRKCZ) interaction partners

  1. Protein kinase c activity restricts dendritic arborization during embryonic brain circuit development through synaptotropic stabilization of dynamic processes.

Human Protein Kinase C, zeta (PRKCZ) interaction partners

  1. The PKC-zeta - induced phosphorylation of GSK-3 beta stimulates GSK-3 beta activity.

  2. Over-expression of PRKCZ results in gene and/or protein expression alterations of insulin-like growth factor 1 receptor (IGF1R (show IGF1R Proteins)) and integrin beta 3 (ITGB3 (show ITGB3 Proteins)) in SKOV3 and OVCAR3 cells.

  3. PKCzeta inhibition prevented alternative cleavage and release of TROP2 (show TACSTD2 Proteins), suggesting that these events require endocytic uptake and exosomal release of the corresponding microvesicles.

  4. Data show that aPKC scaffold protein (show HOMER1 Proteins) p62 (show GTF2H1 Proteins) tethers Atypical protein kinase C (aPKC) in an active conformation.

  5. PRKCZ methylation is associated with sunlight exposure

  6. Neuronal NF1 (show NF1 Proteins)/RAS regulation of cyclic AMP (show APRT Proteins) requires atypical PKC zeta activation, which is perturbed in neurofibromatosis type 1 (show NF1 Proteins).

  7. The results indicate that induction and activation of PKCzeta promote TNBC growth, invasion and metastasis.

  8. PKCzeta and PKMzeta are overexpressed in TCF3 (show TCF3 Proteins)-rearranged paediatric acute lymphoblastic leukaemia and may have a role in thiopurine sensitivity

  9. Results indicate that PKCzeta regulates survivin (show BIRC5 Proteins) expression levels and inhibits apoptosis in colon cancer cells.

  10. These data indicate for the first time that HIV-1 Gag phosphorylation on Ser487 is mediated by atypical PKC and that this kinase may regulate the incorporation of Vpr into HIV-1 virions and thereby supports virus infectivity.

Mouse (Murine) Protein Kinase C, zeta (PRKCZ) interaction partners

  1. androstenedione administration increased Akt1 (show AKT1 Proteins) and PKC zeta phosphorylation in the muscle tissue of C57BL6 mice.

  2. studies support a model wherein an alternative mechanism regulates PKCzeta-mediated insulin (show INS Proteins) signalling that does not utilize conventional activation via agonist-evoked phosphorylation at the activation loop

  3. PKCzeta/p62 (show GTF2H1 Proteins) activation stimulated inflammatory cytokine production and enhanced IGF-I (show IGF1 Proteins)-stimulated VSMC proliferation

  4. Neuronal NF1 (show NF1 Proteins)/RAS regulation of cyclic AMP (show TMPRSS5 Proteins) requires atypical PKC zeta activation, which is perturbed in neurofibromatosis type 1 (show NF1 Proteins).

  5. Asymmetric division and CD8+ T lymphocyte fate specification is regulated by protein kinase Czeta and protein kinase Clambda.

  6. Data indicate that pseudosubstrate arginine residues are key regulators of atypical protein kinase C-lambda (show PRKCI Proteins) and atypical protein kinase C-zeta.

  7. Lgl1 (show Klra7 Proteins) forms two distinct complexes in vivo, Lgl1 (show Klra7 Proteins)-NMIIA and Lgl1 (show Klra7 Proteins)-Par6alpha (show PARD6A Proteins)-aPKCzeta, and that the formation of these complexes is affected by the phosphorylation state of Lgl1 (show Klra7 Proteins).

  8. Either depleting PKC-zeta or inhibiting NADPH oxidase (show NOX1 Proteins).

  9. KIBRA (show WWC1 Proteins) levels in the rodent hippocampus correlate closely both to spatial memory performance in rodents and to PKMzeta

  10. Phosphatidylinositol-3,4,5-triphosphate but not phosphatidylinositol-4,5-biphosphate plays an important role in GLUT4 (show SLC2A4 Proteins) upregulation and glucose metabolism mediated by AKT (show AKT1 Proteins)/PKCzeta/lambda phosphorylation.

Cow (Bovine) Protein Kinase C, zeta (PRKCZ) interaction partners

  1. These data identify atypical PKC isozymes as STAT and ERK activators that mediate c-fos and collagenase expression.

  2. chronic exposure to hypoxia leads to the emergence of cells lacking anti-replication activity of PKCzeta in the pulmonary artery adventitia.

  3. inhibition of NO production by Ang-1 (show ANGPT1 Proteins), via phosphorylation of eNOS (show NOS3 Proteins) on Thr (show TRH Proteins)(497) by PKC zeta, is responsible, at least in part, for inhibition of VEGF (show VEGFA Proteins)-stimulated endothelial permeability by Ang-1 (show ANGPT1 Proteins).

Pig (Porcine) Protein Kinase C, zeta (PRKCZ) interaction partners

  1. ceramide as a potent physiological modulator of the Na(+)-ATPase, participating in a regulatory network in kidney cells and counteracting the stimulatory effect of PKA via PKCzeta.

Zebrafish Protein Kinase C, zeta (PRKCZ) interaction partners

  1. Zebrafish pronephros tubulogenesis and epithelial identity maintenance are reliant on the polarity proteins Prkc iota and zeta.

PKC zeta (PRKCZ) Protein Profile

Protein Summary

Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms.

Alternative names and synonyms associated with PKC zeta (PRKCZ)

  • protein kinase C, zeta (prkcz)
  • protein kinase C, zeta (PRKCZ)
  • protein kinase C, zeta (Prkcz)
  • 14-3-3-zetaisoform protein
  • AI098070 protein
  • aPKCzeta protein
  • C80388 protein
  • PKC-ZETA protein
  • PKC2 protein
  • pkcz protein
  • PKCzeta protein
  • PRKCZ protein
  • prkcz-A protein
  • r14-3-3 protein
  • R74924 protein
  • si:ch211-150o23.4 protein
  • TPKC protein
  • zetaPKC protein

Protein level used designations for Protein Kinase C, zeta Proteins (PRKCZ)

protein kinase C, zeta , protein kinase c type Z , protein kinase C zeta type , protein kinase C zeta type-like , nPKC-zeta , atypical protein kinase C , protein kinase C zeta subspecies , 14 - 3 - 3 - zeta isoform , atypical protein kinase C zeta

GENE ID SPECIES
373768 Xenopus laevis
743533 Pan troglodytes
100101769 Xenopus (Silurana) tropicalis
100174126 Pongo abelii
100394749 Callithrix jacchus
100585698 Nomascus leucogenys
5590 Homo sapiens
18762 Mus musculus
25522 Rattus norvegicus
479577 Canis lupus familiaris
286877 Bos taurus
100009538 Oryctolagus cuniculus
100533200 Sus scrofa
419399 Gallus gallus
100734946 Cavia porcellus
555737 Danio rerio
101122295 Ovis aries
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