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Protein kinase c activity restricts dendritic arborization during embryonic brain circuit development through synaptotropic stabilization of dynamic processes.
Here we provide the first evidence that PKC-zeta is a potential target for the treatment of COPD (show ARCN1 Proteins) by selective small molecules
Study provides evidence for a novel PKC-zeta to p47phox interaction that is required for cell transformation from blebbishields and ROS (show ROS1 Proteins) production in cancer cells.
FRET-based translocation assays reveal that insulin (show INS Proteins) promotes the association of both p62 (show GTF2H1 Proteins) and aPKC with the insulin (show INS Proteins)-regulated scaffold IRS-1 (show IRS1 Proteins).
data suggest that the interaction between this novel region in Galphaq (show GNAQ Proteins) and the effector PKCzeta is a key event in Galphaq (show GNAQ Proteins) signaling.
The PKC-zeta - induced phosphorylation of GSK-3 beta stimulates GSK-3 beta activity.
Over-expression of PRKCZ results in gene and/or protein expression alterations of insulin-like growth factor 1 receptor (IGF1R (show IGF1R Proteins)) and integrin beta 3 (ITGB3 (show ITGB3 Proteins)) in SKOV3 and OVCAR3 cells.
PKCzeta inhibition prevented alternative cleavage and release of TROP2 (show TACSTD2 Proteins), suggesting that these events require endocytic uptake and exosomal release of the corresponding microvesicles.
Data show that aPKC scaffold protein (show HOMER1 Proteins) p62 (show GTF2H1 Proteins) tethers Atypical protein kinase C (aPKC) in an active conformation.
PRKCZ methylation is associated with sunlight exposure
Neuronal NF1 (show NF1 Proteins)/RAS regulation of cyclic AMP (show APRT Proteins) requires atypical PKC zeta activation, which is perturbed in neurofibromatosis type 1 (show NF1 Proteins).
Data (including data from studies in transgenic and knockout mice) suggest that Pkcz (protein kinase C zeta) activation is key for early compensatory pancreatic beta-cell proliferation in insulin (show INS Proteins) resistance (overweight and diabetes type 2) by regulating downstream signal transduction components mTOR (mammalian target of rapamycin (show FRAP1 Proteins) protein) and Ccnd2 (cyclin-D2 (show CCND2 Proteins)).
androstenedione administration increased Akt1 (show AKT1 Proteins) and PKC zeta phosphorylation in the muscle tissue of C57BL6 mice.
studies support a model wherein an alternative mechanism regulates PKCzeta-mediated insulin (show INS Proteins) signalling that does not utilize conventional activation via agonist-evoked phosphorylation at the activation loop
PKCzeta/p62 (show GTF2H1 Proteins) activation stimulated inflammatory cytokine production and enhanced IGF-I (show IGF1 Proteins)-stimulated VSMC proliferation
Neuronal NF1 (show NF1 Proteins)/RAS regulation of cyclic AMP (show TMPRSS5 Proteins) requires atypical PKC zeta activation, which is perturbed in neurofibromatosis type 1 (show NF1 Proteins).
Asymmetric division and CD8+ T lymphocyte fate specification is regulated by protein kinase Czeta and protein kinase Clambda.
Data indicate that pseudosubstrate arginine residues are key regulators of atypical protein kinase C-lambda (show PRKCI Proteins) and atypical protein kinase C-zeta.
Lgl1 (show Klra7 Proteins) forms two distinct complexes in vivo, Lgl1 (show Klra7 Proteins)-NMIIA and Lgl1 (show Klra7 Proteins)-Par6alpha (show PARD6A Proteins)-aPKCzeta, and that the formation of these complexes is affected by the phosphorylation state of Lgl1 (show Klra7 Proteins).
Either depleting PKC-zeta or inhibiting NADPH oxidase (show NOX1 Proteins).
KIBRA (show WWC1 Proteins) levels in the rodent hippocampus correlate closely both to spatial memory performance in rodents and to PKMzeta
These data identify atypical PKC isozymes as STAT and ERK activators that mediate c-fos and collagenase expression.
chronic exposure to hypoxia leads to the emergence of cells lacking anti-replication activity of PKCzeta in the pulmonary artery adventitia.
inhibition of NO production by Ang-1 (show ANGPT1 Proteins), via phosphorylation of eNOS (show NOS3 Proteins) on Thr (show TRH Proteins)(497) by PKC zeta, is responsible, at least in part, for inhibition of VEGF (show VEGFA Proteins)-stimulated endothelial permeability by Ang-1 (show ANGPT1 Proteins).
ceramide as a potent physiological modulator of the Na(+)-ATPase, participating in a regulatory network in kidney cells and counteracting the stimulatory effect of PKA via PKCzeta.
Zebrafish pronephros tubulogenesis and epithelial identity maintenance are reliant on the polarity proteins Prkc iota and zeta.
Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms.
protein kinase C, zeta
, protein kinase c type Z
, protein kinase C zeta type
, protein kinase C zeta type-like
, atypical protein kinase C
, protein kinase C zeta subspecies
, 14 - 3 - 3 - zeta isoform
, atypical protein kinase C zeta