Browse our RANK Proteins (CD265)

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RANK Proteins (CD265)
On are 11 RANK (CD265) Proteins from 2 different suppliers available. Additionally we are shipping RANK Antibodies (86) and RANK Kits (15) and many more products for this protein. A total of 112 RANK products are currently listed.
list all proteins Gene Name GeneID UniProt
CD265 21934 O35305
CD265 8792 Q9Y6Q6
Rat CD265 CD265 498206  

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RANK Proteins (CD265) by Origin

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Top referenced RANK Proteins

  1. Human RANK Protein expressed in HEK-293 - ABIN2666569 : Anderson, Maraskovsky, Billingsley, Dougall, Tometsko, Roux, Teepe, DuBose, Cosman, Galibert: A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. in Nature 1997 (PubMed)
    Show all 8 references for 2666569

More Proteins for RANK Interaction Partners

Mouse (Murine) RANK (CD265) interaction partners

  1. The persistence of bone erosion and synovial osteoclasts in Rank-deficient mice, and the ability of TNF (show TNF Proteins)/IL-6 (show IL6 Proteins) to induce osteoclastogenesis, suggest that more than one cytokine pathway exists to generate these bone-resorbing cells in inflamed joints.

  2. Muscle RANK deletion had no significant effects on the sham or denervated slow-twitch soleus muscles. These data identify a novel role for RANK as a key regulator of Ca(2 (show CA2 Proteins)+)storage and SERCA (show ATP2A3 Proteins) activity, ultimately affecting denervated skeletal muscle function.

  3. present study shows that ginsenoside Rg3 protects against LPS (show TLR4 Proteins)-induced acute lung injury through inactivating the NF-kappaB (show NFKB1 Proteins) signaling

  4. In palmatine-treated mice, RANKL (show TNFSF11 Proteins) and OPG (show TNFSF11 Proteins) expression decreased. In the culture supernatant of MC3T3-E1 cells, RANKL (show TNFSF11 Proteins) and OPG (show TNFSF11 Proteins) levels were significantly reduced by palmatine addition.

  5. Results show that moderate increases in affinity for RANK lead to a substantial augmentation of osteoclast formation, signaling, and bone resorption suggesting a biphasic relationship between RANKL (show TNFSF11 Proteins)/RANK affinity and osteoclastogenic capacity.

  6. Dissection of the mechanism by which this occurs indicates that mCripto-1 activates receptor activator NF-kappaB (show NFKB1 Proteins)/receptor activator NF-kappaB (show NFKB1 Proteins) ligand, and NF-kappaB (show NFKB1 Proteins) signaling pathways.

  7. We also show that R-spondin1 (show RSPO1 Proteins) is depleted in RANK-null progenitors, and that its exogenous administration rescues key aspects of RANK deficiency by reinstating a WNT (show WNT2 Proteins) response and mammary cell expansion

  8. findings have uncovered a tumorigenic role for RANKL (show TNFSF11 Proteins)/RANK in the salivary gland and suggest that targeting this pathway may represent a novel therapeutic intervention approach in the prevention and/or treatment of this understudied head and neck cancer

  9. results indicate that the RANK IVVY motif cooperates with the TRAF (show TRAF1 Proteins)-binding motifs to promote osteoclastogenesis, which provides novel insights into the molecular mechanism of RANK signaling in osteoclastogenesis.

  10. findings suggest CCN2 (show CTGF Proteins) as a candidate of the fourth factor in the RANK/RANKL/OPG (show TNFSF11 Proteins) system for osteoclastogenesis, which regulates OPG (show TNFSF11 Proteins) and RANK via direct interaction

Human RANK (CD265) interaction partners

  1. RANK/RANKL (show TNFSF11 Proteins) signaling is involved in the androgen deprivation therapy-induced acceleration of bone metastasis in castration-insensitive prostate cancer and is inhibited by osteoprotegerin (show TNFRSF11B Proteins) to prevent bone metastasis.

  2. In histologically normal tissue of BRCA1-mutation carriers and showed that RANK(+) cells are highly proliferative, have grossly aberrant DNA repair and bear a molecular signature similar to that of basal-like breast cancer.

  3. In this review, we will provide a summary of the biological functions of RANK signaling pathway (receptor activator of nuclear factor kappaB ligand RANKL (show TNFSF11 Proteins) and its receptor RANK ) and downstream pathways in bone remodeling, immunity and epithelial homeostasis, with a particular emphasis on cancer

  4. Our results suggest that the polymorphism of the RANKL (show TNFSF11 Proteins), RANK, and OPG (show TNFRSF11B Proteins) genes does not make a significant genetic contribution to heel ultrasound measurements in a population of young Caucasian adults. Further studies replicating the results in independent populations are needed to support these initial findings.

  5. Vav3 (show VAV3 Proteins) is a novel TRAF6 (show TRAF6 Proteins) interaction partner that functions in the activation of cooperative signaling between T6BSs and the IVVY motif in the RANK signaling complex.

  6. OPG (show TNFRSF11B Proteins) rs2073618, RANK rs75404003, and RANKL (show TNFSF11 Proteins) rs9594782 single nucleotide poymorphisms may predispose LVH in thalassemia patients.

  7. Twenty-one single-nucleotide polymorphisms (SNPs) of TNFSF11, TNFRSF11A, and TNFRSF11B were genotyped. This study suggests that TNFRSF11B but not TNFSF11 and TNFRSF11A genetic polymorphisms are associated with Type 2 Diabetes Mellitus in Southern Han Chinese women.

  8. the OPG/RANKL (show TNFSF11 Proteins)/RANK system might be directly influenced by genetic variants of NOTCH1 (show NOTCH1 Proteins) in aortic valve calcification.

  9. Postmenopausal women with Rheumatoid Arthritis, carrying either the RANKL (show TNFSF11 Proteins)-290T allele or possessing the RANK 575CC genotype were more likely to develop osteoporosis.

  10. The RANK/RANKL (show TNFSF11 Proteins) system induces chemoresistance.

RANK (CD265) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus.

Alternative names and synonyms associated with RANK (CD265)

  • tumor necrosis factor receptor superfamily, member 11a (Tnfrsf11a)
  • tumor necrosis factor receptor superfamily, member 11a, NFKB activator (TNFRSF11A)
  • tumor necrosis factor receptor superfamily, member 11a, NFKB activator (Tnfrsf11a)
  • CD265 protein
  • FEO protein
  • LOH18CR1 protein
  • Ly109 protein
  • mRANK protein
  • ODFR protein
  • OFE protein
  • OPTB7 protein
  • OSTS protein
  • PDB2 protein
  • RANK protein
  • RGD1563614 protein
  • TRANCE-R protein
  • TRANCER protein

Protein level used designations for RANK Proteins (CD265)

osteoclast differentiation factor receptor , receptor activator of NF-KB , receptor activator of NF-kappaB , tumor necrosis factor receptor superfamily member 11A , loss of heterozygosity, 18, chromosomal region 1 , receptor activator of nuclear factor-kappa B

21934 Mus musculus
8792 Homo sapiens
498206 Rattus norvegicus
483957 Canis lupus familiaris
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