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Browse our SLC39A3 Proteins (SLC39A3)

Full name:
Solute Carrier Family 39 (Zinc Transporter), Member 3 Proteins (SLC39A3)
On are 3 Solute Carrier Family 39 (Zinc Transporter), Member 3 (SLC39A3) Proteins from 2 different suppliers available. Additionally we are shipping SLC39A3 Antibodies (28) and SLC39A3 Kits (1) and many more products for this protein. A total of 38 SLC39A3 products are currently listed.
A170, AI845814, OSIL, p60, p62, p62B, PDB3, Zip3
list all proteins Gene Name GeneID UniProt
SLC39A3 8878 Q13501
SLC39A3 106947 Q99K24
Rat SLC39A3 SLC39A3 314637 Q5U1X7

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SLC39A3 Proteins (SLC39A3) by Origin

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More Proteins for SLC39A3 Interaction Partners

Human Solute Carrier Family 39 (Zinc Transporter), Member 3 (SLC39A3) interaction partners

  1. These results demonstrated that p62-dependent mitophagy has an immunosuppressive role to innate immune response and might serve as a potential immunomodulatory target for inflammation-associated diseases.

  2. siRNA-mediated knockdown of p62 clearly increased the efficiency of transfection of murine embryonic stem (mES) cells and human HeLa cells. These data indicate that p62 acts as a key regulator of gene delivery.

  3. These studies suggest that p62 is involved in the genesis of nuclear factor kappaB-induced proinflammatory and prolabor mediators.

  4. In this review, we discuss p62-mediated signaling pathways and their roles in liver pathophysiology, especially nonalcoholic steatohepatitis and hepatocellular carcinoma

  5. findings expand the SQSTM1 (show SQSTM1 Proteins)-associated phenotypic spectrum and lend further support to the concept of disturbed selective autophagy pathways in neurodegenerative diseases

  6. Aldo was revealed to induce autophagy, as indicated by the increased conversion from microtubuleassociated protein 1A/1Blight chain 3 (LC3)I to LC3II, the increased expression levels of autophagyrelated gene 7 (Atg7) and the increased degradation of p62, which was accompanied by MC proliferation

  7. Results demonstrate that p62 (show GTF2H1 Proteins) facilitates activation of NRF2 (show GABPA Proteins) and mTORC1 and is essential for hepatocellular carcinomas (HCC (show FAM126A Proteins)) initiation. High levels of p62 (show GTF2H1 Proteins) accumulation in non-tumor liver tissue in early-stage HCC (show FAM126A Proteins) patients.

  8. Results show that Nrf2 (show GABPA Proteins) prevents TM-induced apoptotic cell death and that TM promotes p62 (show GTF2H1 Proteins)-dependent autophagic Keap1 (show KEAP1 Proteins) degradation, leading to Nrf2 (show GABPA Proteins) activation. In addition, we identified that p62 (show GTF2H1 Proteins) is essential to protect cells against TM-mediated oxidative damage through Nrf2 (show GABPA Proteins) activation.

  9. Spinal stenosis emerges as a prominent phenotype in SQSTM1 (show SQSTM1 Proteins) P392L-positive men with aging

  10. p62 is a crucial positive regulator of HIF1alpha, which is a facilitating factor in p62-enhanced tumorigenesis.

Mouse (Murine) Solute Carrier Family 39 (Zinc Transporter), Member 3 (SLC39A3) interaction partners

  1. ZnT3 (show Slc30a3 Proteins) KO mice showed abnormality in trace fear conditioning is involved in associative fear memory and extinction, but not in innate fear.

  2. Znt-3-deficient mice lacking synaptic Zn also show less hippocampal cell damage following kainic acid injection. Zip transporters may provide selective therapeutic targets to protect these neurons from early Zn-induced neurodegeneration following injury.

  3. The expression of zinc transporter 3 (ZnT3 (show Slc30a3 Proteins)) starts early in development, lasts throughout embryonic life, and is detected in proliferative and differentiating areas of the brain in distinct chelatable vesicular zinc pools.

  4. ZnT3 (show Slc30a3 Proteins)-immunoreactive ependymal cells possess secretory activity directed towards the central canal.

  5. ZIP1 (show SLC39A1 Proteins), ZIP2 and ZIP3 may play cell-specific roles in zinc homeostasis rather than primary roles in the acquisition of dietary zinc

  6. ZIP1 (show SLC39A1 Proteins) and ZIP3 zinc uptake transporter activity is controlled by zinc-stimulated endocytosis

  7. Reduced expression of Zip3 ultimately resulted in cell death, indicating that mammary epithelial cells have a unique requirement for Zip3-mediated Zn(2+) import.

  8. Knockout mice lacking Zip3 were generated and characterized.

  9. Mutations in the ZIP1 (show SLC39A1 Proteins) and ZIP3 zinc transporter genes are silent when dietary intake of zinc is normal, but can dramatically compromise the success of pregnancy when dietary intake of zinc is limiting.

  10. temporal and spatial patterns of expression of the mouse ZIP1 (show SLC39A1 Proteins), 3, 4, and 5 genes in the developing intestine and the effects of maternal dietary zinc deficiency on these patterns of expression were examined

SLC39A3 Protein Profile

Protein Summary

This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.

Alternative names and synonyms associated with SLC39A3

  • sequestosome 1 (SQSTM1)
  • solute carrier family 39 (zinc transporter), member 3 (SLC39A3)
  • solute carrier family 39 (zinc transporter), member 3 (Slc39a3)
  • A170 protein
  • AI845814 protein
  • OSIL protein
  • p60 protein
  • p62 protein
  • p62B protein
  • PDB3 protein
  • Zip3 protein

Protein level used designations for SLC39A3

EBI3-associated protein of 60 kDa , EBI3-associated protein p60 , EBIAP , oxidative stress induced like , phosphotyrosine independent ligand for the Lck SH2 domain p62 , phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa , sequestosome-1 , ubiquitin-binding protein p62 , ZIP-3 , solute carrier family 39 member 3 , zinc transporter ZIP3 , zrt- and Irt-like protein 3

8878 Homo sapiens
29985 Homo sapiens
106947 Mus musculus
314637 Rattus norvegicus
505294 Bos taurus
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