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ZnT3 (show Slc30a3 Proteins) KO mice showed abnormality in trace fear conditioning is involved in associative fear memory and extinction, but not in innate fear.
Znt-3-deficient mice lacking synaptic Zn also show less hippocampal cell damage following kainic acid injection. Zip transporters may provide selective therapeutic targets to protect these neurons from early Zn-induced neurodegeneration following injury.
The expression of zinc transporter 3 (ZnT3 (show Slc30a3 Proteins)) starts early in development, lasts throughout embryonic life, and is detected in proliferative and differentiating areas of the brain in distinct chelatable vesicular zinc pools.
ZnT3 (show Slc30a3 Proteins)-immunoreactive ependymal cells possess secretory activity directed towards the central canal.
ZIP1 (show SLC39A1 Proteins), ZIP2 and ZIP3 may play cell-specific roles in zinc homeostasis rather than primary roles in the acquisition of dietary zinc
ZIP1 (show SLC39A1 Proteins) and ZIP3 zinc uptake transporter activity is controlled by zinc-stimulated endocytosis
Reduced expression of Zip3 ultimately resulted in cell death, indicating that mammary epithelial cells have a unique requirement for Zip3-mediated Zn(2+) import.
Knockout mice lacking Zip3 were generated and characterized.
Mutations in the ZIP1 (show SLC39A1 Proteins) and ZIP3 zinc transporter genes are silent when dietary intake of zinc is normal, but can dramatically compromise the success of pregnancy when dietary intake of zinc is limiting.
temporal and spatial patterns of expression of the mouse ZIP1 (show SLC39A1 Proteins), 3, 4, and 5 genes in the developing intestine and the effects of maternal dietary zinc deficiency on these patterns of expression were examined
These results support a concept that downregulation of RREB-1 causes downregulation of ZIP3, which results in decreased zinc in pancreatic premalignant and carcinoma cells
The metallothionein (show MT Proteins) gene had a higher expression in the blood, when compared to zinc transporters ZnT-1, Zip-1 (show SLC39A1 Proteins), and Zip-3 (p=0.01 in obese patients.
Data show that the combination of concurrent zinc, ZIP3, and RREB-1 changes represent early events in the development of adenocarcinoma.
ZiP2 and Zip3 are down regulated in malignant cells
This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.
, solute carrier family 39 member 3
, zinc transporter ZIP3
, zrt- and Irt-like protein 3