Browse our SLC39A3 Proteins (SLC39A3)

On are 3 Solute Carrier Family 39 (Zinc Transporter), Member 3 (SLC39A3) Proteins from 2 different suppliers available. Additionally we are shipping SLC39A3 Antibodies (29) and SLC39A3 Kits (1) and many more products for this protein. A total of 39 SLC39A3 products are currently listed.
A170, AI845814, OSIL, p60, p62, p62B, PDB3, Zip3
list all proteins Gene Name GeneID UniProt
SLC39A3 8878 Q13501
SLC39A3 106947 Q99K24
Rat SLC39A3 SLC39A3 314637 Q5U1X7

SLC39A3 Proteins (SLC39A3) by Origin

More Proteins for SLC39A3 Interaction Partners

Human Solute Carrier Family 39 (Zinc Transporter), Member 3 (SLC39A3) interaction partners

  1. SQSTM1-Nup214, although mostly cytoplasmic, also forms nuclear bodies and inhibits nuclear protein but not poly(A)(+) RNA export.

  2. autophagy upregulation by Sequestosome 1 (p62 (show SQSTM1 Proteins)/SQSM1) knockdown ameliorated this cell injury and relieved insulin (show INS Proteins) resistance

  3. This work suggests that UVA-induced p62 (show GTF2H1 Proteins) acts through COX-2 to promote skin tumor growth and progression.

  4. we provide evidence that p62 (show GTF2H1 Proteins) is implicated in the activation of NF-kappaB (show NFKB1 Proteins) signaling that is partly dependent on RIP1 (show UQCRFS1 Proteins)

  5. In this study, we first observed that p62-positive intranuclear aggregates also appeared in controls and were not specific for the Neuronal Intranuclear Hyaline Inclusion Disease cases.

  6. Data suggest that phosphorylation of SQSTM1 (show SQSTM1 Proteins) by AMP-activated protein kinase (AMPK (show PRKAA2 Proteins)) and translocation of SQSTM1 (show SQSTM1 Proteins) to mitochondria drives autophagic cell death in adult hippocampal neural stem cells; activation of AMPK (show PRKAA1 Proteins) promotes autophagic cell death; inhibition of AMPK (show PRKAA1 Proteins) (by enzyme inhibitor or RNA interference) suppresses autophagic cell death. (SQSTM1 (show SQSTM1 Proteins) = sequestosome 1 (show SQSTM1 Proteins))

  7. Authors found that p62/SQSTM1 (show SQSTM1 Proteins), a protein upregulated in liver parenchymal cells but downregulated in HCC (show FAM126A Proteins)-associated HSCs, negatively controls hepatic stellate cells activation.

  8. necessary for retinal pigmented epithelial cytoprotection under oxidative stress; NFkappaB p65 activity may be critical upstream initiator of p62 expression in retinal pigmented epithelial cells under oxidative stress

  9. p62/SQSTM1 (show SQSTM1 Proteins), which accumulates in autophagy-defective cells, directly binds to and inhibits nuclear RNF168 (show RNF168 Proteins), an E3 ligase essential for histone H2A ubiquitination and DNA damage responses. As a result, DNA repair proteins such as BRCA1, RAP80 (show UIMC1 Proteins), and Rad51 (show RAD51 Proteins) cannot be recruited to the sites of DNA double-strand breaks (DSBs), which impairs DSB repair.

  10. propose that the interplay between LRRK2 (show LRRK2 Proteins) and p62 (show GTF2H1 Proteins) may contribute to the pathophysiological function and homeostasis of LRRK2 (show LRRK2 Proteins) protein

Mouse (Murine) Solute Carrier Family 39 (Zinc Transporter), Member 3 (SLC39A3) interaction partners

  1. ZnT3 (show Slc30a3 Proteins) KO mice showed abnormality in trace fear conditioning is involved in associative fear memory and extinction, but not in innate fear.

  2. Znt-3-deficient mice lacking synaptic Zn also show less hippocampal cell damage following kainic acid injection. Zip transporters may provide selective therapeutic targets to protect these neurons from early Zn-induced neurodegeneration following injury.

  3. The expression of zinc transporter 3 (ZnT3 (show Slc30a3 Proteins)) starts early in development, lasts throughout embryonic life, and is detected in proliferative and differentiating areas of the brain in distinct chelatable vesicular zinc pools.

  4. ZnT3 (show Slc30a3 Proteins)-immunoreactive ependymal cells possess secretory activity directed towards the central canal.

  5. ZIP1 (show SLC39A1 Proteins), ZIP2 and ZIP3 may play cell-specific roles in zinc homeostasis rather than primary roles in the acquisition of dietary zinc

  6. ZIP1 (show SLC39A1 Proteins) and ZIP3 zinc uptake transporter activity is controlled by zinc-stimulated endocytosis

  7. Reduced expression of Zip3 ultimately resulted in cell death, indicating that mammary epithelial cells have a unique requirement for Zip3-mediated Zn(2+) import.

  8. Knockout mice lacking Zip3 were generated and characterized.

  9. Mutations in the ZIP1 (show SLC39A1 Proteins) and ZIP3 zinc transporter genes are silent when dietary intake of zinc is normal, but can dramatically compromise the success of pregnancy when dietary intake of zinc is limiting.

  10. temporal and spatial patterns of expression of the mouse ZIP1 (show SLC39A1 Proteins), 3, 4, and 5 genes in the developing intestine and the effects of maternal dietary zinc deficiency on these patterns of expression were examined

SLC39A3 Protein Profile

Protein Summary

This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.

Alternative names and synonyms associated with SLC39A3

  • sequestosome 1 (SQSTM1)
  • solute carrier family 39 (zinc transporter), member 3 (SLC39A3)
  • solute carrier family 39 (zinc transporter), member 3 (Slc39a3)
  • A170 protein
  • AI845814 protein
  • OSIL protein
  • p60 protein
  • p62 protein
  • p62B protein
  • PDB3 protein
  • Zip3 protein

Protein level used designations for SLC39A3

EBI3-associated protein of 60 kDa , EBI3-associated protein p60 , EBIAP , oxidative stress induced like , phosphotyrosine independent ligand for the Lck SH2 domain p62 , phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa , sequestosome-1 , ubiquitin-binding protein p62 , ZIP-3 , solute carrier family 39 member 3 , zinc transporter ZIP3 , zrt- and Irt-like protein 3

8878 Homo sapiens
29985 Homo sapiens
106947 Mus musculus
314637 Rattus norvegicus
505294 Bos taurus
Selected quality suppliers for SLC39A3 Proteins (SLC39A3)
Did you look for something else?