Transforming growth factor (TGF-alpha, TGF-a, EGF-like TGF) is a polypeptide growth factor that shares significant structural and functional homology with epidermal growth factor (EGF). TGF is synthesized as a 160 amino acid transmembrane precursor molecule from which the mature 50 amino acid TGF alpha peptide is secreted following proteolytic cleavage by specific elastase-like enzymes. All the biological properties of TGF alpha and EGF are likely elicited by the binding of these ligands to the EGF receptor, therefore the biochemical cascade that follows activation of the EGF receptor tyrosine kinase is likely to be the same following activation of the receptor by either ligand.
Each vial contains 0.1 mg IgG in 0.1 mL of PBS pH7.4 with 0.09% sodium azide.
Precaution of Use
Warning: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.