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TGF-alpha contributes to the progression of diabetic kidney disease.
c-Myc (show MYC Proteins) and transforming growth factor alpha enhance the development of hepatic lesions due to mutant beta-catenin (show CTNNB1 Proteins) in transgenic mice.
Reverse transcriptase polymerase chain reaction studies showed that three members, Tgfa, Hbegf,and Nrg1 of the EGF family were expressed in the epithelium cultured with FGF7 + LPA as well as in the epithelium freshly isolated from the rudiments.
findings suggest that elevated PHD4 (show P4HTM Proteins) levels disturb the angiogenic balance in osteosarcoma via induction of the TGF-alpha pathway and inhibit tumor growth by reducing the expression of HIF-2alpha (show EPAS1 Proteins)
Interaction between IRF6 (show IRF6 Proteins) and TGFA genes contribute to the risk of nonsyndromic cleft lip/palate.
These results imply that TGFalpha stimulates proliferation of endometrial stromal cells through multiple mechanisms, including its regulation of Igfbp3 (show IGFBP3 Proteins) and Mmp3 (show MMP3 Proteins) transcription.
ADAM-17 (show ADAM17 Proteins) and TGF-alpha are strongly and locally upregulated following adult mice cortical damage.
Different mechanisms regulate neurogenesis in neonatal and adult olfactory epithelium; fibroblast growth factor (FGF)2 (show FGF2 Proteins) and TGFalpha may have different roles throughout development.
beta-catenin (show CTNNB1 Proteins) controlled both cell-autonomous and non-cell-autonomous hepatocyte proliferation, through direct transcriptional and complex control of cyclin D1 (show CCND1 Proteins) gene expression and of the expression of a new target gene, Tgfalpha.
variable TGF-alpha expression may explain, in part, the genetic susceptibility to chronic kidney disease (CKD) progression.
results therefore demonstrate cancer epigenetics induces a loop of cancer-stroma-cancer interaction in omental microenvironment that promotes peritoneal metastasis of ovarian cancer cells via TNFalpha (show TNF Proteins)-TGFalpha-EGFR (show EGFR Proteins).
In conclusion, we identified four novel loci (TGFA, PIK3R1, FGFR3 (show FGFR3 Proteins) and TREH (show TREH Proteins)) and confirmed two loci known to be associated with cartilage thickness.The identified associations were not caused by rare exonic variants. This is the first report linking TGFA to human Osteoarthritis, which may serve as a new target for future therapies.
Our study showed that TGFA/TGFB3 (show TGFB3 Proteins)/MSX1 (show MSX1 Proteins) gene polymorphisms were associated with congenital NSHI. The distribution of genotype frequencies and allele frequencies of TGFA rs3771494, TGFB3 (show TGFB3 Proteins) rs3917201 and rs2268626, and MSX1 (show MSX1 Proteins) rs3821949 and rs62636562 were significantly different between the case and the control groups
TGFA gene expression is regulated by MiR (show MLXIP Proteins)-374a in lung adenocarcinoma.TGFA plays role in lung adenocarcinoma cell proliferation and invasion.
Overall, our findings indicated that intratumoral administration of TGFalphaL3-SEB effectively inhibited the growth of breast tumors through induction of necrosis and suppressing proliferation and angiogenesis without systemic toxicity.
TGFA expression decreased after 10 and 30min of treatment even when transcription was not inhibited. We found that activation of PI3K (show PIK3CA Proteins) was necessary for triiodothyronine to modulate HIF1A (show HIF1A Proteins) and TGFA expression
This is the first demonstration that miR (show MLXIP Proteins)-490-3P might act as a suppressor in endometrial cancer tumorigenesis and progression by targeting TGFalpha.
miR (show MLXIP Proteins)-505 acts as tumor suppressor in endometrial cancer by regulating TGF-alpha.
findings strongly suggest that phosphorylated HSP20 (show HSPB6 Proteins) inhibits TGF-alpha-induced HCC (show FAM126A Proteins) cell migration and invasion via suppression of the JNK (show MAPK8 Proteins) signaling pathway
miR (show MLXIP Proteins)-205 may function as a tumor suppressor via targeting TGF-alpha in Osteosarcoma
upregulation of TGFalpha or FGF2 (show FGF2 Proteins) expression is not a pre-requisite for enhanced testicular growth and increased Sertoli cell proliferation that occurs subsequent to hemicastration in the neonatal boar
This gene encodes a growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types of cancers, and it may also be involved in some cases of cleft lip/palate. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
transforming growth factor, alpha
, transforming growth factor alpha
, protransforming growth factor alpha
, transforming growth factor-alpha
, waved 1
, TGF alpha