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Human TNFRSF13C ELISA Kit for Sandwich ELISA - ABIN414961
Deng, Zhang, Wang, Xu, Zhang, Yang, Mao, Gao, Song, Kong, Qu: Soluble BAFF-R produced by decidual stromal cells plays an inhibitory role in monocytes and macrophages. in Reproductive biomedicine online 2012
Inhibition of ADAM10 (show ADAM10 ELISA Kits) augments BAFF (show TNFSF13B ELISA Kits)-dependent survival of primary human B cells, whereas inhibition of ADAM17 (show ADAM17 ELISA Kits) increases BAFFR expression levels.
Relationships between serum BAFF (show TNFSF13B ELISA Kits) and BBR expression [(BAFFR, calcium signal modulating cyclophilic ligand interactor (TACI (show TNFRSF13B ELISA Kits)) and B cell maturation antigen (BCMA (show TNFRSF17 ELISA Kits))] were determined on B cell subsets, defined using immunoglobulin (Ig)D/CD38. Twenty pre-RTX and 18 rheumatoid arthritis patients relapsing after B cell depletion were included.
Among the BAFF (show TNFSF13B ELISA Kits) receptors in a cohort of rheumatoid arthritis (RA) patients, the AA have shown, by fluorescence activated cell sorter (FACS) analysis of median fluorescence intensity (MFI), that transmembrane activator and calcium-modulating cyclophilin ligand (show CAMLG ELISA Kits) interactor (TACI (show TNFRSF13B ELISA Kits)) and B cell maturation antigen (BCMA (show TNFRSF17 ELISA Kits)) do not change
The expression levels of serum BAFF (show TNFSF13B ELISA Kits) and the three receptors (TACI (show TNFRSF13B ELISA Kits), BCMA (show TNFRSF17 ELISA Kits) and BAFF-R) in non-Hodgkin lymphoma patients were significantly higher than in healthy controls.
Variants in BAFF-R gene is associated with chronic lymphocytic leukemia.
BAFF-R, as the principal receptor of BAFF (show TNFSF13B ELISA Kits), not only decreased the apoptosis of B cells and CD8 (show CD8A ELISA Kits)+ T cells by upregulating the expression of Bcl-2 (show BCL2 ELISA Kits) and BclxL (show BCL2L1 ELISA Kits), but also promoted B-cell proliferation in immune thrombocytopenia.
BAFF (show TNFSF13B ELISA Kits) and BAFF-R are expressed in the thyrocytes derived from patients with either autoimmune thyroid disorders or multinodular goiter, as well in the infiltrating immune cells of Graves' disease and Hashimoto's thyroiditis
There is an increased prevalence of the BAFF-R His159Tyr mutation in patients with Sjogren's syndrome (SS), particularly in those with SS complicated by MALT lymphoma whose disease onset occurred at a younger age.
Expression of mutant caspase-9 (show CASP9 ELISA Kits) correlated with a downregulation of BAFFR (B-cell-activating factor (show TNFSF13B ELISA Kits) belonging to the TNF (show TNF ELISA Kits) family (BAFF) receptor) in B cells and ICOS (inducible T-cell costimulator (show ICOS ELISA Kits)) in T cells.
Variants of TNFRSF13C were associated with common variable immunodeficiency.
B cell-activating factor (BAFF (show TNFSF13B ELISA Kits)) upregulates CD28 (show CD28 ELISA Kits)/B7 and CD40 (show CD40 ELISA Kits)/CD154 (show CD40LG ELISA Kits) expression, and promotes the interactions between T and B cells in a BAFF receptor-dependent manner.
conclude that P44S BAFFR mutation does not hinder BAFFR function or enhance B cell activity in MRL/Lpr (show FAS ELISA Kits) and MRL mice and that other susceptibility loci on the MRL background contributed to the hyperactivity of these cells
Results from this study suggest blockade of CXCL13 (show CXCL13 ELISA Kits) and BAFFR together may be an effective therapeutic strategy in preventing salivary hypofunction and reducing autoantibody titers and sialadenitis in patients with Sjogren's syndrome
Heteromers consisting of one BAFF (show TNFSF13B ELISA Kits) and two APRIL bind to receptor TACI (show TNFRSF13B ELISA Kits), BCMA (show TNFRSF17 ELISA Kits) but not to BAFFR.
Syk (show SYK ELISA Kits)-deficient B cells require BAFF receptor and CD19 (show CD19 ELISA Kits)/PI3K signaling for their long-term survival.
In conclusion, BAFFR signaling affects both innate and adaptive immune activation during viral infections.
BAFF (show TNFSF13B ELISA Kits) controls neural cell survival through BAFF receptor.
BAFF receptor deficiency limits Murid herpesvirus 4 infection.
Although we have found that TACI is dispensable for controlling B. hermsii infection, mice deficient in BAFFR or BAFF exhibit impairment in B. hermsii-specific IgM responses and clearance of bacteremia.
tnfrsf13c is dispensable for the development of SLE in NZM mice.
B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival.
tumor necrosis factor receptor superfamily, member 13C
, tumor necrosis factor receptor superfamily member 13C
, B cell-activating factor receptor
, B-cell-activating factor receptor
, BAFF receptor
, BLyS receptor 3
, B-cell maturation defect 1
, b cell-activating factor receptor