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anti-Human TNFRSF1A antibody for Functional Studies

Recommended TNFRSF1A Antibody (supplied by: Log in to see )

Antigen
Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) Antibodies
  • cd120a
  • CD120a
  • fpf
  • FPF
  • MS5
  • p55
  • p55-R
  • p55-r
  • p60
  • TBP1
  • tbp1
  • TNF-alphaR1
  • TNF-R
  • tnf-r
  • TNF-R-I
  • TNF-R1
  • TNF-R55
  • TNFalpha-R1
  • tnfar
  • TNFAR
  • Tnfr-2
  • tnfr1
  • Tnfr1
  • TNFR1
  • TNFR1-d2
  • tnfr55
  • TNFR55
  • TNFR60
  • tnfr60
  • TNFR I
  • TNFRI
  • TNFRp55
  • TNFRSF1A
  • wu:fj65b10
  • xtnfr1
  • zgc:85914
Reactivity
Human
324
163
82
39
34
32
28
15
10
9
9
8
7
4
4
2
2
1
1
Host
Mouse
258
109
18
17
16
14
1
Clonality
Monoclonal
Conjugate
This TNFRSF1A antibody is un-conjugated
32
30
29
13
10
9
5
5
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Application
Functional Studies (Func), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
260
166
150
114
102
68
52
34
31
23
21
12
11
10
7
2
2
2
2
2
1
1
1
1
1
1
1
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Catalog No. ABIN111939
$ 1,424.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.00087626296 ABIN1105792 Func EIA IHC (fro) FACS IP WB Mouse IgG2a Log in to see H398 5
0.00087626296 ABIN1981872 Func IHC (f) FACS IP IHC (p) Mouse IgG2a Log in to see H398 1
0.00087626296 ABIN2749013 Func IHC (f) FACS IP IHC (p) Mouse IgG2a Log in to see H398 2
0.00087626296 ABIN116277 EIA Func WB Rabbit Log in to see Polyclonal
0.00087626296 ABIN116278 EIA Func WB Rabbit Log in to see Polyclonal
0.00087626296 ABIN1105787 Func EIA IHC (fro) Mouse IgG1 Log in to see MR1-2 1
0.00087626296 ABIN2478294 Func FACS RIA ELISA Mouse IgG2a Log in to see H398 4
0.00087626296 ABIN2478295 Func IHC (fro) FACS IP Mouse IgG2a Log in to see H398 2
0.00087626296 ABIN299012 Func FACS IHC (fro) IP Mouse IgG2a Log in to see H398
0.00087626296 ABIN3199428 FACS Func IHC IP Mouse IgG2a Log in to see H398
0.00087626296 ABIN3199429 FACS Func IHC IP Mouse IgG2a Log in to see H398
0.00087626296 ABIN3036630 Func FACS IP IHC Mouse IgG2a full length Log in to see
0.00087626296 ABIN3036629 Func FACS IP IHC Mouse IgG2a full length Log in to see

Top referenced anti-TNFRSF1A antibody for Functional Studies

Similar anti-TNFRSF1A Antibodies

Application / Reactivity Human
Agonist (Agon) 1 Antibodies
Blocking Antibody (Inhibition) 1 Antibodies
Cell Culture (CC) 2 Antibodies
Cytotoxicity Test (CyTox) 1 Antibodies
Dot Blot (DB) 1 Antibodies
ELISA 111 Antibodies
Enzyme Immunoassay (EIA) 18 Antibodies
Flow Cytometry (FACS) 122 Antibodies
Functional Studies (Func) 14 Antibodies
Immunoassay (IA) 4 Antibodies
Immunocytochemistry (ICC) 28 Antibodies
Immunofluorescence (IF) 35 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 11 Antibodies
Immunohistochemistry (IHC) 94 Antibodies
Immunohistochemistry (Acetone-fixed) (IHC (af)) 1 Antibodies
Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) 2 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 44 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 61 Antibodies

General

Antigen Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) Antibodies
Reactivity Human
(324), (163), (82), (39), (34), (32), (28), (15), (10), (9), (9), (8), (7), (4), (4), (2), (2), (1), (1)
Host Mouse
(258), (109), (18), (17), (16), (14), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This TNFRSF1A antibody is un-conjugated
(32), (30), (29), (13), (10), (9), (5), (5), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Functional Studies (Func), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
(260), (166), (150), (114), (102), (68), (52), (34), (31), (23), (21), (12), (11), (10), (7), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Pubmed 6 references available
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Product Details anti-TNFRSF1A Antibody

Target Details TNFRSF1A Application Details Handling References for anti-TNFRSF1A Antibody (ABIN111939) Images
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Affinity Chromatography on Protein G.
Immunogen Partially purified preparation of TNF binding protein from HL-60 cells.
Clone Htr9
Isotype IgG1

Target Details TNFRSF1A

Product Details anti-TNFRSF1A Antibody Application Details Handling References for anti-TNFRSF1A Antibody (ABIN111939) Images back to top
Antigen
Alternative Name CD120a / TNFR1 (TNFRSF1A Antibody Abstract)
Background Tumor Necrosis Factor (TNF) is a cytokine whose function is mediated through two distinct cell surface receptors (TNF Receptor I and TNF Receptor II) that are included in the TNF Receptor superfamily along with FAS antigen and CD40. TNF Receptors I and II are 55 and 75 kDa members, respectively, of a family of cell surface molecules including nerve growth factor receptor, Fas/Apo1, CD30, OX40, and 41BB, which are characterized by cysteine rich motifs in the extracellular domain. While TNF Receptor I and TNF Receptor II share 28 % sequence homology in the extracellular domains, their intracellular domains lack sequence homology, suggesting that they differ in their internal signal transduction pathways. TNF Receptor I contains an approximately 80 amino acid death domain near its carboxy terminus capable of transmitting an apoptotic signal through its interaction with TRADD (TNF Receptor I associated death domain protein), and subsequent interactions with FADD. TNF Receptor I can also activate the transcription factor NFkB via TRAF2 (TNF Receptor associated factor 2). The cytoplasmic domain of TNF Receptor I can directly interact with Jak kinase, thereby activating the JAK/STAT signal transduction cascade. TNF Receptor I is expressed by virtually all nucleated mammalian cells, including hepatocytes, monocytes and neutrophils, cardiac muscle cells, endothelial cells, and CD34 + hematopoietic progenitors. Both TNF alpha and TNF beta bind to TNF Receptor I.Synonyms: TNF-R1, TNF-RI, TNFR-I, Tnfrsf1a, Tumor necrosis factor receptor 1, Tumor necrosis factor receptor superfamily member 1A, Tumor necrosis factor receptor type I, p55, p60
Gene ID 9606
UniProt P19438
Research Area CD Antigens, Surface Receptors of Immune Cells
Pathways NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis

Application Details

Product Details anti-TNFRSF1A Antibody Target Details TNFRSF1A Handling References for anti-TNFRSF1A Antibody (ABIN111939) Images back to top
Application Notes Flow Cytometry: 10 μg/mL. Immunohistochemistry on Frozen Sections: 2-5 μg/mL on Cryostat Sections. Concentrations < 25 μg/mL may give non specific staining of discrete cells. This putativecross reactivity with nuclear (?) antigens cannot be abrogated by pre- or coincubation withTNF. Fixation: Acetone 5 min 4 °C or 2 % paraformaldehyde-lysine sodium periodate.
Restrictions For Research Use only

Handling

Product Details anti-TNFRSF1A Antibody Target Details TNFRSF1A Application Details References for anti-TNFRSF1A Antibody (ABIN111939) Images back to top
Concentration 1.0 mg/mL (by Absorbance at 280 nm)
Buffer PBS, pH 7.2 without stabilizers and preservatives.
Preservative Without preservative
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store lyophilized (preferably in a desiccator) at 2-8 °C and reconstituted (in aliquots) at -20 °C.

References for anti-TNFRSF1A Antibody (ABIN111939)

Product Details anti-TNFRSF1A Antibody Target Details TNFRSF1A Application Details Handling Images back to top
Background publications

Gehr, Gentz, Brockhaus, Loetscher, Lesslauer: "Both tumor necrosis factor receptor types mediate proliferative signals in human mononuclear cell activation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 149, Issue 3, pp. 911-7, 1992

Vandenabeele, Declercq, Vercammen, Van de Craen, Grooten, Loetscher, Brockhaus, Lesslauer, Fiers: "Functional characterization of the human tumor necrosis factor receptor p75 in a transfected rat/mouse T cell hybridoma." in: The Journal of experimental medicine, Vol. 176, Issue 4, pp. 1015-24, 1992

Hohmann, Brockhaus, Baeuerle, Remy, Kolbeck, van Loon: "Expression of the types A and B tumor necrosis factor (TNF) receptors is independently regulated, and both receptors mediate activation of the transcription factor NF-kappa B. TNF alpha is not needed for induction of a biological effect via TNF receptors." in: The Journal of biological chemistry, Vol. 265, Issue 36, pp. 22409-17, 1991

Brockhaus, Schoenfeld, Schlaeger, Hunziker, Lesslauer, Loetscher: "Identification of two types of tumor necrosis factor receptors on human cell lines by monoclonal antibodies." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 8, pp. 3127-31, 1990

Espevik, Brockhaus, Loetscher, Nonstad, Shalaby: "Characterization of binding and biological effects of monoclonal antibodies against a human tumor necrosis factor receptor." in: The Journal of experimental medicine, Vol. 171, Issue 2, pp. 415-26, 1990

Shalaby, Sundan, Loetscher, Brockhaus, Lesslauer, Espevik: "Binding and regulation of cellular functions by monoclonal antibodies against human tumor necrosis factor receptors." in: The Journal of experimental medicine, Vol. 172, Issue 5, pp. 1517-20, 1990