|Antigen||Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) Antibodies|
|Conjugate||This TNFRSF1A antibody is un-conjugated Alternatives|
Blocking Antibody (Inhibition), ELISA, Western Blotting (WB)
|Supplier||Log in to see|
Product Details anti-TNFRSF1A AntibodyTarget Details TNFRSF1A Application Details Handling Images
|Immunogen||TNF receptor type I antibody was raised in rabbit using highly pure recombinant human sTNF-receptor as the immunogen.|
Target Details TNFRSF1AProduct Details anti-TNFRSF1A Antibody Application Details Handling Images back to top
|Alternative Name||TNF Receptor Type I (TNFRSF1A Antibody Abstract)|
|Background||TNFR1 belongs to the TNFR superfamily of transmembrane proteins, and is expressed in most cell types. Binding of either TNF-alpha or TNF-beta to TNFR1 initiates a signal transduction pathway that results in the activation of the transduction factor NF kb, whose target genes are involved in the regulation of inflammatory responses, and, in certain cells induce apoptosis. Soluble TNF Receptor I (sTNFR1) is capable of inhibiting TNF-alpha and TNF-beta activities by acting as a decoy receptor that serves as a sink for the TNF ligands.|
|Molecular Weight||18.3 kDa (predicted detection band MW)|
|Pathways||NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, Hepatitis C|
Application DetailsProduct Details anti-TNFRSF1A Antibody Target Details TNFRSF1A Handling Images back to top
ELISA: 0.5-2 µg/mL, Inhibition: 0.9-1.1 µg/mL, WB: 0.1-0.2 µg/mL
Optimal conditions should be determined by the investigator.
|Restrictions||For Research Use only|
HandlingProduct Details anti-TNFRSF1A Antibody Target Details TNFRSF1A Application Details Images back to top
|Buffer||Lyophilized from PBS, pH 7.2.|
Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.
|Storage Comment||Store at -20 °C until reconstitution. Following reconstitution product may be stored at 4 °C in the short term. For long term storage aliquot and freeze at -20 °C.|