|Application / Reactivity||Mouse (Murine)|
|Blocking Reagent (BR)||1 Antibodies|
|Enzyme Immunoassay (EIA)||6 Antibodies|
|Flow Cytometry (FACS)||34 Antibodies|
|Functional Studies (Func)||8 Antibodies|
|Immunoassay (IA)||3 Antibodies|
|Immunocytochemistry (ICC)||21 Antibodies|
|Immunofluorescence (IF)||21 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||11 Antibodies|
|Immunohistochemistry (IHC)||45 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||7 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||20 Antibodies|
|Immunoprecipitation (IP)||62 Antibodies|
|Intracellular Flow Cytometry (ICFC)||1 Antibodies|
|Mass Cytometry (CyTOF)||2 Antibodies|
|Neutralization (Neut)||4 Antibodies|
|Antigen||Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) Antibodies|
|Reactivity||Mouse (Murine) Alternatives|
|Conjugate||This TNFRSF1A antibody is un-conjugated Alternatives|
Intracellular Flow Cytometry (ICFC)
|5 references available|
|Supplier||Log in to see|
Product Details anti-TNFRSF1A AntibodyTarget Details TNFRSF1A Application Details Handling References for anti-TNFRSF1A Antibody (ABIN2665527) Images
|Purification||The LEAF™ (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.|
|Sterility||0.2 μm filtered|
Endotoxin level is <0.1 EU/μg of the protein (<0.01 ng/μg of the protein) as determined by the LAL test.
Target Details TNFRSF1AProduct Details anti-TNFRSF1A Antibody Application Details Handling References for anti-TNFRSF1A Antibody (ABIN2665527) Images back to top
|Alternative Name||CD120a (TNFRSF1A Antibody Abstract)|
|Background||CD120a is a 55 kD Type I transmembrane protein, also known as Tumor Necrosis Factor Receptor Type I (TNFRI) or p55. It is expressed on a variety of cells at low levels. Resting T cells and erythrocytes express very little to no CD120a. This receptor binds both TNF-α and LT-α (also known as TNF-β). In association with TRADD and RIP, the receptor crosslinking induced by TNF-α or LT-α trimers is critical for signal transduction, leading to apoptosis, NF-kB activation, increased expression of proinflammatory genes, tumor necrosis, and cell differentiation depending on cell type and differentiation state. The 55R-170 antibody has been shown to block in vitro and in vivo receptor signaling initiated by ligand binding.|
|Research Area||CD Antigens, Surface Receptors of Immune Cells|
|Pathways||NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis|
Application DetailsProduct Details anti-TNFRSF1A Antibody Target Details TNFRSF1A Handling References for anti-TNFRSF1A Antibody (ABIN2665527) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-TNFRSF1A Antibody Target Details TNFRSF1A Application Details References for anti-TNFRSF1A Antibody (ABIN2665527) Images back to top
|Handling Advice||This LEAF™ solution contains no preservative, handle under aseptic conditions|
|Storage Comment||The antibody solution should be stored undiluted between 2°C and 8°C.|
References for anti-TNFRSF1A Antibody (ABIN2665527)Product Details anti-TNFRSF1A Antibody Target Details TNFRSF1A Application Details Handling Images back to top
Chan, Chun, Zheng et al.: "A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling." in: Science (New York, N.Y.), Vol. 288, Issue 5475, pp. 2351-4, 2000 (PubMed).
Rothe, Lesslauer, Lötscher et al.: "Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes." in: Nature, Vol. 364, Issue 6440, pp. 798-802, 1993 (PubMed).
Sheehan, Pinckard, Arthur et al.: "Monoclonal antibodies specific for murine p55 and p75 tumor necrosis factor receptors: identification of a novel in vivo role for p75." in: The Journal of experimental medicine, Vol. 181, Issue 2, pp. 607-17, 1995 (PubMed).
Aggarwal, Eessalu, Hass: "Characterization of receptors for human tumour necrosis factor and their regulation by gamma-interferon." in: Nature, Vol. 318, Issue 6047, pp. 665-7, 1986 (PubMed).
Loetscher, Pan, Lahm et al.: "Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor." in: Cell, Vol. 61, Issue 2, pp. 351-9, 1990 (PubMed).
ImagesProduct Details anti-TNFRSF1A Antibody Target Details TNFRSF1A Application Details Handling References for anti-TNFRSF1A Antibody (ABIN2665527) back to top