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|Antigen||Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) Antibodies|
|Reactivity||Mouse (Murine) Alternatives|
|Conjugate||This TNFRSF1A antibody is un-conjugated Alternatives|
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
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Product Details anti-TNFRSF1A AntibodyTarget Details TNFRSF1A Application Details Handling Images
|Specificity||This antibody reacts to Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A).|
Species reactivity (expected):Bovine, Canine, Drosophila, Xenopus, Hamster, Human, Monkey, Porcine, Rabbit, Rat, Sheep, Yeast.
Species reactivity (tested):Mouse.
|Immunogen||TNFRSF1A antibody was raised against synthetic peptide derived from the sequence of mouse TNF-R11.|
Target Details TNFRSF1AProduct Details anti-TNFRSF1A Antibody Application Details Handling Images back to top
|Alternative Name||CD120a / TNFR1 (TNFRSF1A Antibody Abstract)|
|Background||TNFRI is a 55 kD transmembrane glycoprotein that also exists as a secreted protein. TNF receptors self assemble through a distinct functional extracellular domain termed PLAD in the absence of ligand. Efficient TNFA binding depends on receptor self assembly. TNFR1 associates with MADD protein through a death domain-death domain interaction. MADD is thought to provide a link to MAP Kinase activation. TNFR1 can also activate NFKbeta via TNF receptor associated factor 2 and the cytoplasmic domain can interact with the JAK/STAT pathway.Synonyms: TNF-R1, TNF-RI, TNFR-I, Tnfrsf1a, Tumor necrosis factor receptor 1, Tumor necrosis factor receptor superfamily member 1A, Tumor necrosis factor receptor type I, p55, p60|
|Research Area||CD Antigens, Surface Receptors of Immune Cells|
|Pathways||NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, Hepatitis C|
Application DetailsProduct Details anti-TNFRSF1A Antibody Target Details TNFRSF1A Handling Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-TNFRSF1A Antibody Target Details TNFRSF1A Application Details Images back to top
|Buffer||PBS containing 0.09 % sodium azide as preservative and 50 % glycerol|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
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