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anti-Rat (Rattus) TNFRSF1A antibody for Functional Studies

Recommended TNFRSF1A Antibody (supplied by: Log in to see )

Antigen
Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) Antibodies
  • cd120a
  • CD120a
  • fpf
  • FPF
  • MS5
  • p55
  • p55-R
  • p55-r
  • p60
  • TBP1
  • tbp1
  • TNF-alphaR1
  • TNF-R
  • tnf-r
  • TNF-R-I
  • TNF-R1
  • TNF-R55
  • TNFalpha-R1
  • tnfar
  • TNFAR
  • Tnfr-2
  • tnfr1
  • Tnfr1
  • TNFR1
  • TNFR1-d2
  • tnfr55
  • TNFR55
  • TNFR60
  • tnfr60
  • TNFR I
  • TNFRI
  • TNFRp55
  • TNFRSF1A
  • wu:fj65b10
  • xtnfr1
  • zgc:85914
Reactivity
Human, Rat (Rattus)
290
147
78
36
32
29
26
13
9
7
7
6
5
4
4
2
1
1
1
Host
Mouse
253
81
17
16
13
5
1
Clonality
Monoclonal
Conjugate
This TNFRSF1A antibody is un-conjugated
31
28
27
13
9
9
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Application
Functional Studies (Func), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Immunoprecipitation (IP), Western Blotting (WB)
239
136
124
97
97
44
34
32
31
22
21
11
10
10
7
2
2
2
2
1
1
1
1
1
1
1
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Catalog No. ABIN1105792
$ 566.50
Plus shipping costs $45.00

Top referenced anti-TNFRSF1A antibody for Functional Studies

Similar anti-TNFRSF1A Antibodies

Application / Reactivity Rat (Rattus) Human
ELISA 11 Antibodies 110 Antibodies
Enzyme Immunoassay (EIA) 3 Antibodies 18 Antibodies
Flow Cytometry (FACS) 2 Antibodies
Functional Studies (Func) 1 Antibodies
Immunocytochemistry (ICC) 22 Antibodies
Immunofluorescence (IF) 21 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 11 Antibodies
Immunohistochemistry (IHC) 39 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 4 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 13 Antibodies
Immunoprecipitation (IP) 22 Antibodies
Western Blotting (WB) 57 Antibodies
Agonist (Agon) 1 Antibodies
Blocking Antibody (Inhibition) 1 Antibodies
Cell Culture (CC) 2 Antibodies
Cytotoxicity Test (CyTox) 1 Antibodies
Dot Blot (DB) 1 Antibodies

General

Antigen Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) Antibodies
Reactivity Human, Rat (Rattus)
(290), (147), (78), (36), (32), (29), (26), (13), (9), (7), (7), (6), (5), (4), (4), (2), (1), (1), (1)
Host Mouse
(253), (81), (17), (16), (13), (5), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This TNFRSF1A antibody is un-conjugated
(31), (28), (27), (13), (9), (9), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Functional Studies (Func), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Immunoprecipitation (IP), Western Blotting (WB)
(239), (136), (124), (97), (97), (44), (34), (32), (31), (22), (21), (11), (10), (10), (7), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Pubmed 5 references available
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Product Details anti-TNFRSF1A Antibody

Target Details TNFRSF1A Application Details Handling References for anti-TNFRSF1A Antibody (ABIN1105792) Images
Cross-Reactivity (Details) Species reactivity (tested):Human, Rat.
Purification Protein G
Clone H398
Isotype IgG2a

Target Details TNFRSF1A

Product Details anti-TNFRSF1A Antibody Application Details Handling References for anti-TNFRSF1A Antibody (ABIN1105792) Images back to top
Antigen
Alternative Name CD120a / TNFR1 (TNFRSF1A Antibody Abstract)
Background TNF-RI (~55-60 kDa) is present on most cell types and is considered to play a prominent role in cell stimulation by TNF-alpha. TNF-alpha activates inflammatory responses, induces apoptosis, regulates cellular proliferation, and may even promote cancer progression. The effects of TNF-alpha are mediated by TNF-RI and TNF-RII, which have both distinct and overlapping downstream signaling cascades. Induction of cytotoxicity and other functions are mediated largely via TNF-RI. TNF-RI is equally well activated by both the 17 kDa soluble and 26 kDa membrane-bound form, whereas TNF-RII is efficiently activated only by the membrane bound form of TNF-alpha. TNF-RI signaling is initiated when trimeric TNF-alpha binds TNF-RI receptors. Subsequent TNF-RI trimerization promotes the recruitment of a proximal signaling complex composed of TNF Receptor Associated protein with a Death Domain (TRADD), Receptor Interacting Protein (RIP), cellular Inhibitor of Apoptosis Protein 1 (cIAP1), TNF Receptor Associated Factor 2 (TRAF2), and likely TRAF5. Studies with TNF-RI-deficient mice indicate that TNF-RI mediates most of the proliferation, pro-inflammatory, and apoptosis-activating pathways.Synonyms: TNF-R1, TNF-RI, TNFR-I, Tnfrsf1a, Tumor necrosis factor receptor 1, Tumor necrosis factor receptor superfamily member 1A, Tumor necrosis factor receptor type I, p55, p60
Gene ID 9606
UniProt P19438
Research Area CD Antigens, Surface Receptors of Immune Cells
Pathways NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis

Application Details

Product Details anti-TNFRSF1A Antibody Target Details TNFRSF1A Handling References for anti-TNFRSF1A Antibody (ABIN1105792) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-TNFRSF1A Antibody Target Details TNFRSF1A Application Details References for anti-TNFRSF1A Antibody (ABIN1105792) Images back to top
Concentration 0.1 mg/mL
Buffer PBS, 0.1 % BSA
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Prior to reconstitution store at -70 °C. Following reconstitution store the antibody (in aliquots) at -20 °C for 6 month.
Expiry Date 6 months

References for anti-TNFRSF1A Antibody (ABIN1105792)

Product Details anti-TNFRSF1A Antibody Target Details TNFRSF1A Application Details Handling Images back to top
Background publications

Leccardi, Decarli, Lorenzelli, Milani, Mettala, Orava, Barborini: "Long-term outdoor reliability assessment of a wireless unit for air-quality monitoring based on nanostructured films integrated on micromachined platforms." in: Sensors (Basel, Switzerland), Vol. 12, Issue 6, pp. 8176-92, 2012

Kontermann, Münkel, Neumeyer, Müller, Branschädel, Scheurich, Pfizenmaier: "A humanized tumor necrosis factor receptor 1 (TNFR1)-specific antagonistic antibody for selective inhibition of tumor necrosis factor (TNF) action." in: Journal of immunotherapy (Hagerstown, Md. : 1997), Vol. 31, Issue 3, pp. 225-34, 2008

Grell, Scheurich, Meager, Pfizenmaier: "TR60 and TR80 tumor necrosis factor (TNF)-receptors can independently mediate cytolysis." in: Lymphokine and cytokine research, Vol. 12, Issue 3, pp. 143-8, 1993

Thoma, Grell, Pfizenmaier, Scheurich: "Identification of a 60-kD tumor necrosis factor (TNF) receptor as the major signal transducing component in TNF responses." in: The Journal of experimental medicine, Vol. 172, Issue 4, pp. 1019-23, 1990

Product cited in:

Krippner-Heidenreich, Grunwald, Zimmermann, Kühnle, Gerspach, Sterns, Shnyder, Gill, Männel, Pfizenmaier, Scheurich: "Single-chain TNF, a TNF derivative with enhanced stability and antitumoral activity." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 180, Issue 12, pp. 8176-83, 2008