anti-Rat (Rattus) TNFRSF1A antibody for Immunohistochemistry (Frozen Sections)

Recommended TNFRSF1A Antibody (supplied by: Log in to see )

Antigen
Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) Antibodies
  • fpf
  • p55
  • tbp1
  • p55-r
  • tnf-r
  • tnfar
  • tnfr1
  • cd120a
  • tnfr55
  • tnfr60
  • xtnfr1
  • TNFR I
  • TNFRSF1A
  • TNFR1
  • CD120a
  • FPF
  • MS5
  • TBP1
  • TNF-R
  • TNF-R-I
  • TNF-R55
  • TNFAR
  • TNFR1-d2
  • TNFR55
  • TNFR60
  • p55-R
  • p60
  • TNF-R1
  • TNF-alphaR1
  • TNFRI
  • TNFRp55
  • TNFalpha-R1
  • Tnfr-2
  • Tnfr1
  • wu:fj65b10
  • zgc:85914
  • tumor necrosis factor receptor superfamily, member 1A
  • tumor necrosis factor receptor superfamily, member 1a
  • tnfrsf1a
  • TNFRSF1A
  • Tnfrsf1a
Reactivity
Human, Rat (Rattus)
405
186
111
61
55
52
47
16
14
9
9
8
8
4
3
2
1
1
Host
Mouse
264
160
22
19
16
15
1
Clonality
Monoclonal
Conjugate
This TNFRSF1A antibody is conjugated to Biotin
32
28
28
14
12
10
9
8
8
8
8
6
6
6
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Western Blotting (WB)
303
205
149
114
109
84
45
43
32
22
22
22
13
11
7
7
7
5
4
2
2
2
2
1
1
1
1
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Catalog No. ABIN1105795
$ 456.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN1105792 Func EIA IHC (fro) FACS IP WB Mouse IgG2a Log in to see H398 5

General

Antigen Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) Antibodies
Reactivity Human, Rat (Rattus)
(405), (186), (111), (61), (55), (52), (47), (16), (14), (9), (9), (8), (8), (4), (3), (2), (1), (1)
Host Mouse
(264), (160), (22), (19), (16), (15), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This TNFRSF1A antibody is conjugated to Biotin
(32), (28), (28), (14), (12), (10), (9), (8), (8), (8), (8), (6), (6), (6), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Western Blotting (WB)
(303), (205), (149), (114), (109), (84), (45), (43), (32), (22), (22), (22), (13), (11), (7), (7), (7), (5), (4), (2), (2), (2), (2), (1), (1), (1), (1)
Pubmed 5 references available
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Product Details anti-TNFRSF1A Antibody

Target Details TNFRSF1A Application Details Handling References for anti-TNFRSF1A antibody (ABIN1105795) Images
Cross-Reactivity (Details) Species reactivity (tested):Human, rat
Purification Protein G
Clone H398
Isotype IgG2a

Target Details TNFRSF1A

Product Details anti-TNFRSF1A Antibody Application Details Handling References for anti-TNFRSF1A antibody (ABIN1105795) Images back to top
Antigen
Alternative Name CD120a / TNFR1 (TNFRSF1A Antibody Abstract)
Background TNF-RI (~55-60 kDa) is present on most cell types and is considered to play a prominent role in cell stimulation by TNF-alpha. TNF-alpha activates inflammatory responses, induces apoptosis, regulates cellular proliferation, and may even promote cancer progression. The effects of TNF-alpha are mediated by TNF-RI and TNF-RII, which have both distinct and overlapping downstream signaling cascades. Induction of cytotoxicity and other functions are mediated largely via TNF-RI. TNF-RI is equally well activated by both the 17 kDa soluble and 26 kDa membrane-bound form, whereas TNF-RII is efficiently activated only by the membrane bound form of TNF-alpha. TNF-RI signaling is initiated when trimeric TNF-alpha binds TNF-RI receptors. Subsequent TNF-RI trimerization promotes the recruitment of a proximal signaling complex composed of TNF Receptor Associated protein with a Death Domain (TRADD), Receptor Interacting Protein (RIP), cellular Inhibitor of Apoptosis Protein 1 (cIAP1), TNF Receptor Associated Factor 2 (TRAF2), and likely TRAF5. Studies with TNF-RI-deficient mice indicate that TNF-RI mediates most of the proliferation, pro-inflammatory, and apoptosis-activating pathways.Synonyms: TNF-R1, TNF-RI, TNFR-I, Tnfrsf1a, Tumor necrosis factor receptor 1, Tumor necrosis factor receptor superfamily member 1A, Tumor necrosis factor receptor type I, p55, p60
Gene ID 9606
UniProt P19438
Research Area CD Antigens, Surface Receptors of Immune Cells
Pathways NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, Hepatitis C

Application Details

Product Details anti-TNFRSF1A Antibody Target Details TNFRSF1A Handling References for anti-TNFRSF1A antibody (ABIN1105795) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-TNFRSF1A Antibody Target Details TNFRSF1A Application Details References for anti-TNFRSF1A antibody (ABIN1105795) Images back to top
Concentration 0.1 mg/mL
Buffer PBS, 0.02 % sodium azide, 1 % bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Prior to reconstitution store at -70 °C. Following reconstitution store the antibody (in aliquots) at -20 °C for 6 month.
Expiry Date 6 months

References for anti-TNFRSF1A antibody (ABIN1105795)

Product Details anti-TNFRSF1A Antibody Target Details TNFRSF1A Application Details Handling Images back to top
Background publications

Leccardi, Decarli, Lorenzelli, Milani, Mettala, Orava, Barborini: "Long-term outdoor reliability assessment of a wireless unit for air-quality monitoring based on nanostructured films integrated on micromachined platforms." in: Sensors (Basel, Switzerland), Vol. 12, Issue 6, pp. 8176-92, 2012

Kontermann, Münkel, Neumeyer, Müller, Branschädel, Scheurich, Pfizenmaier: "A humanized tumor necrosis factor receptor 1 (TNFR1)-specific antagonistic antibody for selective inhibition of tumor necrosis factor (TNF) action." in: Journal of immunotherapy (Hagerstown, Md. : 1997), Vol. 31, Issue 3, pp. 225-34, 2008

Grell, Scheurich, Meager, Pfizenmaier: "TR60 and TR80 tumor necrosis factor (TNF)-receptors can independently mediate cytolysis." in: Lymphokine and cytokine research, Vol. 12, Issue 3, pp. 143-8, 1993

Thoma, Grell, Pfizenmaier, Scheurich: "Identification of a 60-kD tumor necrosis factor (TNF) receptor as the major signal transducing component in TNF responses." in: The Journal of experimental medicine, Vol. 172, Issue 4, pp. 1019-23, 1990

Product cited in:

Krippner-Heidenreich, Grunwald, Zimmermann, Kühnle, Gerspach, Sterns, Shnyder, Gill, Männel, Pfizenmaier, Scheurich: "Single-chain TNF, a TNF derivative with enhanced stability and antitumoral activity." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 180, Issue 12, pp. 8176-83, 2008