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|Application / Reactivity||Mouse (Murine)|
|ELISA (Capture)||2 Antibodies|
|Enzyme Immunoassay (EIA)||6 Antibodies|
|Flow Cytometry (FACS)||21 Antibodies|
|Functional Studies (Func)||10 Antibodies|
|Immunoassay (IA)||4 Antibodies|
|Immunochromatography (IC)||1 Antibodies|
|Immunocytochemistry (ICC)||6 Antibodies|
|Immunofluorescence (IF)||8 Antibodies|
|Immunohistochemistry (IHC)||13 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||9 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||13 Antibodies|
|Immunoprecipitation (IP)||27 Antibodies|
|Intracellular Flow Cytometry (ICFC)||1 Antibodies|
|Neutralization (Neut)||2 Antibodies|
|Western Blotting (WB)||61 Antibodies|
|Antigen||Tumor Necrosis Factor Receptor Superfamily, Member 1B (TNFRSF1B) Antibodies|
|Reactivity||Mouse (Murine) Alternatives|
|Conjugate||This TNFRSF1B antibody is conjugated to PE Alternatives|
ELISA (Capture), Neutralization (Neut)
|7 references available|
|Supplier||Log in to see|
Product Details anti-TNFRSF1B AntibodyTarget Details TNFRSF1B Application Details Handling References for anti-TNFRSF1B Antibody (ABIN2662981) Images
|Purification||The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.|
Target Details TNFRSF1BProduct Details anti-TNFRSF1B Antibody Application Details Handling References for anti-TNFRSF1B Antibody (ABIN2662981) Images back to top
|Alternative Name||CD120b (TNFRSF1B Antibody Abstract)|
|Background||CD120b is a 75 kD type I transmembrane protein, also known as Tumor Necrosis Factor Receptor Type II (TNFRII) or p75. It is expressed on a variety of cells at low levels, the expression is upregulated upon activation. This receptor binds both TNF-α and LT-α (also known as TNF-β). In association with TRAF1 and TRAF2, the receptor crosslinking induced by TNF-α or LT-α trimers is critical for signal transduction, leading to apoptosis, NF-kB activation, increased expression of proinflammatory genes, tumor necrosis, and cell differentiation depending on cell type and differentiation state.|
|Pathways||NF-kappaB Signaling, Apoptosis|
Application DetailsProduct Details anti-TNFRSF1B Antibody Target Details TNFRSF1B Handling References for anti-TNFRSF1B Antibody (ABIN2662981) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-TNFRSF1B Antibody Target Details TNFRSF1B Application Details References for anti-TNFRSF1B Antibody (ABIN2662981) Images back to top
|Buffer||Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Protect from prolonged exposure to light. Do not freeze.|
|Storage Comment||The antibody solution should be stored undiluted between 2°C and 8°C.|
References for anti-TNFRSF1B Antibody (ABIN2662981)Product Details anti-TNFRSF1B Antibody Target Details TNFRSF1B Application Details Handling Images back to top
Bell, Herrera, Li et al.: "Role of ADAM17 in the ectodomain shedding of TNF-alpha and its receptors by neutrophils and macrophages." in: Journal of leukocyte biology, Vol. 82, Issue 1, pp. 173-6, 2007 (PubMed).
Schlaepfer, Hou, Lim et al.: "Tumor necrosis factor-alpha stimulates focal adhesion kinase activity required for mitogen-activated kinase-associated interleukin 6 expression." in: The Journal of biological chemistry, Vol. 282, Issue 24, pp. 17450-9, 2007 (PubMed).
Chan, Chun, Zheng et al.: "A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling." in: Science (New York, N.Y.), Vol. 288, Issue 5475, pp. 2351-4, 2000 (PubMed).
Rothe, Lesslauer, Lötscher et al.: "Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes." in: Nature, Vol. 364, Issue 6440, pp. 798-802, 1993 (PubMed).
Sheehan, Pinckard, Arthur et al.: "Monoclonal antibodies specific for murine p55 and p75 tumor necrosis factor receptors: identification of a novel in vivo role for p75." in: The Journal of experimental medicine, Vol. 181, Issue 2, pp. 607-17, 1995 (PubMed).
Aggarwal, Eessalu, Hass: "Characterization of receptors for human tumour necrosis factor and their regulation by gamma-interferon." in: Nature, Vol. 318, Issue 6047, pp. 665-7, 1986 (PubMed).
Loetscher, Pan, Lahm et al.: "Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor." in: Cell, Vol. 61, Issue 2, pp. 351-9, 1990 (PubMed).
ImagesProduct Details anti-TNFRSF1B Antibody Target Details TNFRSF1B Application Details Handling References for anti-TNFRSF1B Antibody (ABIN2662981) back to top