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|Application / Reactivity||Rat (Rattus)||Mouse (Murine)|
|ELISA||6 Antibodies||32 Antibodies|
|Enzyme Immunoassay (EIA)||1 Antibodies||2 Antibodies|
|Immunocytochemistry (ICC)||3 Antibodies||5 Antibodies|
|Immunofluorescence (IF)||3 Antibodies||12 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||22 Antibodies||22 Antibodies|
|Immunohistochemistry (IHC)||4 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||2 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||12 Antibodies|
|Immunoprecipitation (IP)||1 Antibodies|
|Western Blotting (WB)||18 Antibodies|
|Blocking Antibody (Inhibition)||1 Antibodies|
|Flow Cytometry (FACS)||28 Antibodies|
|Functional Studies (Func)||2 Antibodies|
|Antigen||Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) Antibodies|
|Epitope||AA 270-317 Alternatives|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This TNFSF11 antibody is un-conjugated Alternatives|
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|7 references available|
|Supplier||Log in to see|
Product Details anti-TNFSF11 AntibodyTarget Details TNFSF11 Application Details Handling References for anti-TNFSF11 Antibody (ABIN672696) Images
|Purification||Purified by Protein A.|
|Immunogen||KLH conjugated synthetic peptide derived from human RANKL|
Target Details TNFSF11Product Details anti-TNFSF11 Antibody Application Details Handling References for anti-TNFSF11 Antibody (ABIN672696) Images back to top
|Alternative Name||RANKL (TNFSF11 Antibody Abstract)|
Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.
Subcellular location: Extracellular
Synonyms: ODF, OPGL, sOdf, CD254, OPTB2, RANKL, TRANCE, hRANKL2, Tumor necrosis factor ligand superfamily member 11, Osteoclast differentiation factor, Osteoprotegerin ligand, Receptor activator of nuclear factor kappa-B ligand, TNF-related activation-induced cytokine, TNFSF11
|Research Area||Immunology, Adaptive Immunity, Atherosclerosis, Innate Immunity, Cytokines, Extracellular Matrix|
Application DetailsProduct Details anti-TNFSF11 Antibody Target Details TNFSF11 Handling References for anti-TNFSF11 Antibody (ABIN672696) Images back to top
|Application Notes||WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)|
|Restrictions||For Research Use only|
HandlingProduct Details anti-TNFSF11 Antibody Target Details TNFSF11 Application Details References for anti-TNFSF11 Antibody (ABIN672696) Images back to top
|Buffer||Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||Store at -20°C|
|Expiry Date||12 months|
References for anti-TNFSF11 Antibody (ABIN672696)Product Details anti-TNFSF11 Antibody Target Details TNFSF11 Application Details Handling Images back to top
|Product cited in:||
Ota, Urakawa, Kozawa et al.: "Expression of colony-stimulating factor 1 is associated with occurrence of osteochondral change in pigmented villonodular synovitis." in: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, Vol. 36, Issue 7, pp. 5361-7, 2015 (PubMed).
Li, Wu, Ma et al.: "Oral administration of 5-hydroxytryptophan aggravated periodontitis-induced alveolar bone loss in rats." in: Archives of oral biology, Vol. 60, Issue 5, pp. 789-98, 2015 (PubMed).
Zhang, Liu, Li et al.: "Mycobacterium tuberculosis 10-kDa co-chaperonin regulates the expression levels of receptor activator of nuclear factor-?B ligand and osteoprotegerin in human osteoblasts." in: Experimental and therapeutic medicine, Vol. 9, Issue 3, pp. 919-924, 2015 (PubMed).
Yu, Lv, Zhang et al.: "Expression of neuropeptides and bone remodeling-related factors during periodontal tissue regeneration in denervated rats." in: Journal of molecular histology, Vol. 46, Issue 2, pp. 195-203, 2015 (PubMed).
Sun, Wang, Fu et al.: "A Crucial Role of IL-17 in Bone Resorption During Rejection of Fresh Bone Xenotransplantation in Rats." in: Cell biochemistry and biophysics, 2014 (PubMed).
Yang, Li, Yang et al.: "Efficacy and safety of echinacoside in a rat osteopenia model." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2013, pp. 926928, 2013 (PubMed).
Lescarbeau, Seib, Prewitz et al.: "In vitro model of metastasis to bone marrow mediates prostate cancer castration resistant growth through paracrine and extracellular matrix factors." in: PLoS ONE, Vol. 7, Issue 8, pp. e40372, 2012 (PubMed).
ImagesProduct Details anti-TNFSF11 Antibody Target Details TNFSF11 Application Details Handling References for anti-TNFSF11 Antibody (ABIN672696) back to top