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|Application / Reactivity||Mouse (Murine)||Human|
|ELISA||21 Antibodies||124 Antibodies|
|Enzyme Immunoassay (EIA)||1 Antibodies||9 Antibodies|
|Flow Cytometry (FACS)||12 Antibodies||60 Antibodies|
|Functional Studies (Func)||3 Antibodies||9 Antibodies|
|Immunocytochemistry (ICC)||6 Antibodies|
|Immunofluorescence (IF)||2 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||11 Antibodies|
|Immunohistochemistry (IHC)||10 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||1 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||8 Antibodies|
|Immunoprecipitation (IP)||3 Antibodies|
|Western Blotting (WB)||35 Antibodies|
|Blocking Antibody (Inhibition)||3 Antibodies|
|ELISA (Capture)||1 Antibodies|
|Antigen||Tumor Necrosis Factor (Ligand) Superfamily, Member 13b (TNFSF13B) Antibodies|
|Epitope||AA 254-269, C-Term Alternatives|
|Reactivity||Human, Mouse (Murine) Alternatives|
|Conjugate||This TNFSF13B antibody is un-conjugated Alternatives|
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Product Details anti-TNFSF13B AntibodyTarget Details TNFSF13B Application Details Handling Images
|Specificity||This antibody recognizes CD257/BAFF.|
Species reactivity (expected):Mouse.
Species reactivity (tested):Human.
|Purification||Protein G Chromatography.|
|Immunogen||Synthetic peptide corresponding to amino acids 254-269 (C-terminal) of Human BAFF.|
Target Details TNFSF13BProduct Details anti-TNFSF13B Antibody Application Details Handling Images back to top
|Alternative Name||CD257 / BAFF (TNFSF13B Antibody Abstract)|
|Background||Simultaneously four different laboratories identified a new member of the tumor necrosis factor (TNF) family. This has been named as TALL-1, THANK (TNF homologue that activates apoptosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase, BAFF (for B cell activating factor belonging to the TNF family) and Blys (B lymphocyte stimulator). Membrane-bound BAFF is processed and secreted through the action of a protease whose specificity matches that of the furin family of proprotein convertases. Secreted BLyS/BAFF/THANK acts as a potent B cell growth factor. This protein is expressed abundantly in peripheral blood lymphocytes, specifically in monocytes and macrophages. Its regulation is upregulated by interferon gamma. Overexpression of BLyS/BAFF in transgenic mice lead to increased numbers of mature B and effector T cells. These mice also develop autoimmune like symptoms, such as, high levels of rheumatoid factors, anti-DNA autoantibodies, etc. Two receptors for BLyS/BAFF have been identified and termed as BCMA and TACI.Synonyms: B cell-activating factor, B lymphocyte stimulator, BAFF, BLYS, Dendritic cell-derived TNF-like molecule, TALL1, TNF- and APOL-related leukocyte expressed ligand 1, TNFSF13B, TNFSF20, Tumor necrosis factor ligand superfamily member 13B, ZTNF4|
Application DetailsProduct Details anti-TNFSF13B Antibody Target Details TNFSF13B Handling Images back to top
Immunohistochemistry on Paraffin Sections: 10 μg/mL. Western blot: 0.5-2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-TNFSF13B Antibody Target Details TNFSF13B Application Details Images back to top
|Buffer||0.2 mLPBS containing 0.05 % BSA as stabilizer and 0.05 % Sodium Azide as preservative.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.|
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