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These data for the first time identifies miR (show MLXIP ELISA Kits)-485-5p/TRADD axis in hydrogen sulfide protecting against TNF-alpha (show TNF ELISA Kits)-induced neuronal cell apoptosis.
By reducing the levels of TRADD, wild type CFTR suppresses downstream proinflammatory NFkappaB signaling.
NPM (show NPM1 ELISA Kits)-RAR (show RARA ELISA Kits) binding to TRADD selectively inhibits caspase (show CASP3 ELISA Kits) activation, while allowing activation of NFkappaB (show NFKB1 ELISA Kits) and JNK (show MAPK8 ELISA Kits)
The release of extracellular vesicles was triggered by TNFA (show TNF ELISA Kits) from BEAS-2b cells.TNFA-triggered extracellular vesicles contained TNFR1 (show TNFRSF1A ELISA Kits) and TRADD.
MicroRNA-30c-2-3p negatively regulates NF-kappaB (show NFKB1 ELISA Kits) signaling and cell cycle progression through downregulation of TRADD and CCNE1 (show CCNE1 ELISA Kits) in breast cancer.
domains of calmodulin (show CALM1 ELISA Kits) mediate FADD (show FADD ELISA Kits) and TRADD interaction
PA induced the apoptosis of HUVECs by initiating the death pathway (TNF-R1 (show TNFRSF1A ELISA Kits)/TRADD/caspases 8 pathway), whereas AA enhanced cell survival to protect vascular endothelial cells by activating the survival pathway (TNF-R1 (show TNFRSF1A ELISA Kits)/RIP (show HRB ELISA Kits)/NF-kappaB (show NFKB1 ELISA Kits) 50/NF-kappaB (show NFKB1 ELISA Kits) 65).
Biologic assessment found that NPM (show NPM1 ELISA Kits)-RAR (show RARA ELISA Kits) expression impaired TNF (show TNF ELISA Kits)-induced signaling through TRADD, blunting TNF (show TNF ELISA Kits)-mediated activation of caspase-3 (CASP3 (show CASP3 ELISA Kits)) and caspase-8 (CASP8 (show CASP8 ELISA Kits)), to ultimately block apoptosis.
TRADD gene expression was knocked down by an antisense oligonucleotide.
structure-based mutations of TNFR-1 (show TNFRSF1A ELISA Kits) (P367A and P368A), TRADD (F266A), and RIP1 (M637A and R638A) disrupted formation of the death domain (DD) complex and prevented stable interactions among those DDs
TRADD knockout blunts pressure overload-induced cardiac hypertrophy through mediating TAK1 (show NR2C2 ELISA Kits)/p38 MAPK (show MAPK14 ELISA Kits) but not AKT (show AKT1 ELISA Kits) phosphorylation
Data indicate that ASK1 (show MAP3K5 ELISA Kits) activation stimulated the activity of the transcription factor FoxO3a (show FOXO3 ELISA Kits), which increased the abundance of the apoptosis-promoting adaptor protein TRADD, leading to activation of caspase 8 (show CASP8 ELISA Kits).
data indicate that TRADD shuttles dynamically from the cytoplasm into the nucleus to modulate the interaction between p19(Arf) and its E3 ubiquitin ligase ULF, thereby promoting p19(Arf) protein stability and tumour suppression
Data suggest that deficiency of TRADD sensitizes cells to TRAIL-induced apoptosis, and that enhanced cell death in TRADD(-/-) MEFs is associated with defective NF-kappaB (show NFKB1 ELISA Kits) activation.
TRADD is required for recruitment of receptor interacting protein 1 (show RIPK1 ELISA Kits) and TNFR (show TNFRSF1A ELISA Kits)-associated factor 2 to the DR3 (show TNFRSF25 ELISA Kits) signaling complex and for the ubiquitination of receptor interacting protein 1 (show RIPK1 ELISA Kits)
We show that TRADD is recruited to the TRAIL-receptor complex, and RIP1 (show RALBP1 ELISA Kits) recruitment is mediated by TRADD.
TRADD may be involved in IFN-gamma (show IFNG ELISA Kits) signaling by forming a complex with STAT1 (show STAT1 ELISA Kits)-alpha within the nucleus and regulating IFN-gamma (show IFNG ELISA Kits)-mediated STAT1 (show STAT1 ELISA Kits)-alpha activation.
Tradd activates distinct mechanisms of apoptosis from the nucleus and the cytoplasm.
silencing TRADD expression with small-interfering RNA reduced neuronal apoptosis and subsequent microglial and astroglial activation
TRADD is a multifunctional protein crucial both for TNFR1 (show TNFRSF1A ELISA Kits) signaling and other signaling pathways relevant to immune responses.
TNF (show TNF ELISA Kits) binding induces release of AIP1 (DAB2IP (show DAB2IP ELISA Kits)) from TNFR1 (show TNFRSF1A ELISA Kits), resulting in cytoplasmic translocation and concomitant formation of an intracellular signaling complex comprised of TRADD, RIP1 (show RALBP1 ELISA Kits), TRAF2 (show TRAF2 ELISA Kits), and AIPl.
The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway.
TNFRSF1A-associated via death domain
, conjugal transfer protein D
, TNFR1-associated death domain protein
, tumor necrosis factor receptor type 1 associated death domain protein
, tumor necrosis factor receptor type 1-associated DEATH domain protein
, tumor necrosis factor receptor-1-associated protein
, TNF receptor 1 associated signal transducer
, TNFR1-associated DEATH domain protein
, Tumor necrosis factor receptor type 1-associated DEATH domain protein
, TNFRSF1A-associated via death domain protein