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Browse our TRADD Proteins (TRADD)

Full name:
TNFRSF1A-Associated Via Death Domain Proteins (TRADD)
On www.antibodies-online.com are 14 TNFRSF1A-Associated Via Death Domain (TRADD) Proteins from 5 different suppliers available. Additionally we are shipping TRADD Antibodies (108) and TRADD Kits (3) and many more products for this protein. A total of 135 TRADD products are currently listed.
Synonyms:
9130005N23Rik, AA930854, Hs.89862, tradd, wu:fc59e02, zgc:103556
list all proteins Gene Name GeneID UniProt
TRADD 8717 Q15628
TRADD 71609 Q3U0V2
TRADD 246756  

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TRADD Proteins (TRADD) by Origin

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More Proteins for TRADD Interaction Partners

Human TNFRSF1A-Associated Via Death Domain (TRADD) interaction partners

  1. NPM (show NPM1 Proteins)-RAR (show RARA Proteins) binding to TRADD selectively inhibits caspase (show CASP3 Proteins) activation, while allowing activation of NFkappaB (show NFKB1 Proteins) and JNK (show MAPK8 Proteins)

  2. The release of extracellular vesicles was triggered by TNFA (show TNF Proteins) from BEAS-2b cells.TNFA-triggered extracellular vesicles contained TNFR1 (show TNFRSF1A Proteins) and TRADD.

  3. MicroRNA-30c-2-3p negatively regulates NF-kappaB (show NFKB1 Proteins) signaling and cell cycle progression through downregulation of TRADD and CCNE1 (show CCNE1 Proteins) in breast cancer.

  4. domains of calmodulin (show CALM1 Proteins) mediate FADD (show FADD Proteins) and TRADD interaction

  5. PA induced the apoptosis of HUVECs by initiating the death pathway (TNF-R1 (show TNFRSF1A Proteins)/TRADD/caspases 8 pathway), whereas AA enhanced cell survival to protect vascular endothelial cells by activating the survival pathway (TNF-R1 (show TNFRSF1A Proteins)/RIP (show HRB Proteins)/NF-kappaB (show NFKB1 Proteins) 50/NF-kappaB (show NFKB1 Proteins) 65).

  6. Biologic assessment found that NPM (show NPM1 Proteins)-RAR (show RARA Proteins) expression impaired TNF (show TNF Proteins)-induced signaling through TRADD, blunting TNF (show TNF Proteins)-mediated activation of caspase-3 (CASP3 (show CASP3 Proteins)) and caspase-8 (CASP8 (show CASP8 Proteins)), to ultimately block apoptosis.

  7. TRADD gene expression was knocked down by an antisense oligonucleotide.

  8. structure-based mutations of TNFR-1 (show TNFRSF1A Proteins) (P367A and P368A), TRADD (F266A), and RIP1 (show UQCRFS1 Proteins) (M637A and R638A) disrupted formation of the death domain (DD) complex and prevented stable interactions among those DDs

  9. Data indicate that the (show MAP3K5 Proteins)ASK1-FoxO3a-TRADD-caspase 8 pathway is present in neural tube defects (show FOXO3 Proteins)(NTDs)-affected tissues.

  10. we demonstrated that the association between DR6 (show TNFRSF21 Proteins) and TRADD was enhanced upon DQM3 stimulation and TRADD was involved in DR6 (show TNFRSF21 Proteins)-induced signaling activation

Mouse (Murine) TNFRSF1A-Associated Via Death Domain (TRADD) interaction partners

  1. Data indicate that ASK1 (show MAP3K5 Proteins) activation stimulated the activity of the transcription factor FoxO3a (show FOXO3 Proteins), which increased the abundance of the apoptosis-promoting adaptor protein TRADD, leading to activation of caspase 8 (show CASP8 Proteins).

  2. data indicate that TRADD shuttles dynamically from the cytoplasm into the nucleus to modulate the interaction between p19(Arf) and its E3 ubiquitin ligase ULF, thereby promoting p19(Arf) protein stability and tumour suppression

  3. Data suggest that deficiency of TRADD sensitizes cells to TRAIL-induced apoptosis, and that enhanced cell death in TRADD(-/-) MEFs is associated with defective NF-kappaB (show NFKB1 Proteins) activation.

  4. TRADD is required for recruitment of receptor interacting protein 1 (show RIPK1 Proteins) and TNFR (show TNFRSF1A Proteins)-associated factor 2 to the DR3 (show TNFRSF25 Proteins) signaling complex and for the ubiquitination of receptor interacting protein 1 (show RIPK1 Proteins)

  5. We show that TRADD is recruited to the TRAIL-receptor complex, and RIP1 (show RALBP1 Proteins) recruitment is mediated by TRADD.

  6. TRADD may be involved in IFN-gamma (show IFNG Proteins) signaling by forming a complex with STAT1 (show STAT1 Proteins)-alpha within the nucleus and regulating IFN-gamma (show IFNG Proteins)-mediated STAT1 (show STAT1 Proteins)-alpha activation.

  7. Tradd activates distinct mechanisms of apoptosis from the nucleus and the cytoplasm.

  8. silencing TRADD expression with small-interfering RNA reduced neuronal apoptosis and subsequent microglial and astroglial activation

  9. TRADD is a multifunctional protein crucial both for TNFR1 (show TNFRSF1A Proteins) signaling and other signaling pathways relevant to immune responses.

Cow (Bovine) TNFRSF1A-Associated Via Death Domain (TRADD) interaction partners

  1. TNF (show TNF Proteins) binding induces release of AIP1 (DAB2IP (show DAB2IP Proteins)) from TNFR1 (show TNFRSF1A Proteins), resulting in cytoplasmic translocation and concomitant formation of an intracellular signaling complex comprised of TRADD, RIP1 (show RALBP1 Proteins), TRAF2 (show TRAF2 Proteins), and AIPl.

TRADD Protein Profile

Protein Summary

The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway.

Alternative names and synonyms associated with TRADD

  • TNFRSF1A-associated via death domain (TRADD)
  • TNFRSF1A-associated via death domain (LOC100337888)
  • conjugal transfer protein D (traDd)
  • TNFRSF1A-associated via death domain (Tradd)
  • TNFRSF1A-associated via death domain (tradd)
  • tnfrsf1a-associated via death domain (tradd)
  • tnfrsf1a-associated via death domain protein (LOC100136668)
  • 9130005N23Rik protein
  • AA930854 protein
  • Hs.89862 protein
  • tradd protein
  • wu:fc59e02 protein
  • zgc:103556 protein

Protein level used designations for TRADD

TNFRSF1A-associated via death domain , conjugal transfer protein D , TNFR1-associated death domain protein , tumor necrosis factor receptor type 1 associated death domain protein , tumor necrosis factor receptor type 1-associated DEATH domain protein , tumor necrosis factor receptor-1-associated protein , TNF receptor 1 associated signal transducer , TNFR1-associated DEATH domain protein , Tumor necrosis factor receptor type 1-associated DEATH domain protein , TNFRSF1A-associated via death domain protein

GENE ID SPECIES
415700 Gallus gallus
454154 Pan troglodytes
100337888 Oryctolagus cuniculus
7369642 Agrobacterium radiobacter K84
8717 Homo sapiens
71609 Mus musculus
246756 Rattus norvegicus
611262 Canis lupus familiaris
504707 Bos taurus
733418 Xenopus laevis
58130 Danio rerio
100136668 Oncorhynchus mykiss
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