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Rbf1-induced apoptosis activates a compensatory proliferation mechanism which also depends on Slipper and TRAF1, indicating that these two proteins seem to be key players of compensatory proliferation in Drosophila.
Traf4 is expressed throughout development, and is required for efficient apical constrictions of ventral furrow cells.
Expression of Reaper leads to a loss of DIAP1 (show DIAPH1 ELISA Kits) inhibition of DTRAF1-mediated JNK (show MAPK8 ELISA Kits) activation in Drosophila cells.
DTRAF1-null mutant showed a remarkable reduction in JNK (show MAPK8 ELISA Kits) activity with an impaired development of imaginal discs and a defective formation of photosensory neuron arrays.
Single nucleotide polymorphisms (SNP) in angiotensin II receptor, type 1 (AGTR1 (show AGTR1 ELISA Kits)), transcription factor AP-2 beta (TFAP2B (show TFAP2B ELISA Kits)), and tumor necrosis factor (show TNF ELISA Kits) receptor-associated factor 1 (TRAF1) have been reported to be associated with the incidence of PDA in preterm infants.
TRAF1 plays a crucial role in the pathogenesis of autoantibodies and may serve as a serologic inflammatory marker of disease activity in rheumatoid arthritis patients.
Helicobacter pylori infection induces the overexpression of TRAF1 in gastric epithelial cells. The upregulation of TRAF1 plays an antiapoptotic role in Helicobacte pylori -infected gastric cells and may contribute to the gastric carcinogenesis.
The increased serum TRAF-1 may be a useful non-invasive indicator of Renal cell carcinoma (RCC (show XRCC1 ELISA Kits)) development.
Data suggest that, during B-cell transformation by Epstein-Barr virus, LMP1 (show PDLIM7 ELISA Kits) (EBV latent membrane protein 1) induces signaling that stimulates Lys63-polyubiquitin (show UBB ELISA Kits) chain attachment to TRAF1 (TNF receptor-associated factor 1) in the B-lymphocytes.
This study did not replicate the association between PTPRC (show PTPRC ELISA Kits) and the response to anti-TNF (show TNF ELISA Kits) treatment in our Southern European population. We found that TRAF1/C5 risk RA variants potentially influence anti-TNF (show TNF ELISA Kits) treatment response.
Rs2900180 in C5-TRAF1 and linked variants in a 66Kb region were associated with radiographic progression in ACPA (show PRTN3 ELISA Kits)-negative RA
TRAF1/C5 rs10818488 polymorphism is not a genetic risk factor for acquired aplastic anemia in a Chinese population.
TRAF1-ALK translocation contributes to neoplastic phenotype in anaplastic large-cell lymphoma.
DNMT3L (show TRDMT1 ELISA Kits) can address DNMT3A (show DNMT3A ELISA Kits)/B to specific sites by directly interacting with TFs that do not directly interact with DNMT3A (show DNMT3A ELISA Kits)/B
NFkappaB anti-apoptotic target genes TNF receptor-associated factor 1 (TRAF1), TNF receptor-associated factor 2 (TRAF2 (show TRAF2 ELISA Kits)), cellular inhibitor of apoptosis (cIAP2 (show BIRC3 ELISA Kits)), and Ferritin heavy chain (FTH1 (show FTH1 ELISA Kits)) were increased following Losartan treatment
TRAF1 is a crucial early mediator of hepatic ischemia/reperfusion injury.
Increased neuronal TRAF1 leads to elevated neuronal death and enlarged ischaemic lesions.
The pathogenesis of spontaneous KRN/I-A(g7) arthritis can largely proceed by TRAF1-independent pathways.
Together, these findings define the importance of the basal phosphorylation state of the TRAF1 Serine 139 residue in coordinating signalling events downstream of 4-1BB (show TNFRSF9 ELISA Kits) in primary T cells.
TRAF1 and LSP1 (show LSP1 ELISA Kits) cooperate downstream of 4-1BB (show TNFRSF9 ELISA Kits) to activate ERK (show EPHB2 ELISA Kits) signaling and down-modulate the levels of Bim (show BCL2L11 ELISA Kits) leading to enhanced T cell survival.
TRAF1 plays a critical role in regulating T cell activation both through restricting the costimulation independent activation of NIK (show MAP4K4 ELISA Kits) in activated T cells and by promoting the 4-1BB (show TNFRSF9 ELISA Kits)-induced classical NF-kappaB (show NFKB1 ELISA Kits) pathway.
These findings identify TRAF1 as a potential biomarker of HIV-specific CD8 (show CD8A ELISA Kits) T cell fitness during the chronic phase of disease and a target for therapy.
combined signaling from the TNF (show TNF ELISA Kits) or IL-1 (show IL1A ELISA Kits) receptors promotes maximal lung inflammation that may contribute to the severity of disease caused by H5N1 virus infection
TRAF1 deficiency attenuates atherogenesis in mice, most likely owing to impaired monocyte recruitment to the vessel wall
The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins\; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. Three transcript variants encoding two different isoforms have been found for this gene.
, TNF receptor associated factor 1
, TNF-receptor-associated factor 1
, Epstein-Barr virus-induced protein 6
, TNF receptor-associated factor 1
, TNF receptor-associated factor 1-like
, Epstein-Bar virus-induced protein 6