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anti-Human TRAF2 Antibodies:
anti-Mouse (Murine) TRAF2 Antibodies:
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Human Monoclonal TRAF2 Primary Antibody for WB - ABIN967631
Arch, Gedrich, Thompson: Translocation of TRAF proteins regulates apoptotic threshold of cells. in Biochemical and biophysical research communications 2000
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Human Monoclonal TRAF2 Primary Antibody for IHC (p), IHC - ABIN252657
van Galen, Muris, Giroth, Vos, Ossenkoppele, Meijer, Oudejans: Expression of TNF-receptor associated factor 2 correlates with poor progression-free survival time in ABC-like primary nodal diffuse large B-cell lymphomas. in Histopathology 2008
Show all 3 Pubmed References
Human Polyclonal TRAF2 Primary Antibody for ICC, FACS - ABIN252172
Döppler, Liou, Storz: Downregulation of TRAF2 mediates NIK-induced pancreatic cancer cell proliferation and tumorigenicity. in PLoS ONE 2013
Show all 3 Pubmed References
Human Polyclonal TRAF2 Primary Antibody for IHC, ELISA - ABIN1003293
Arch, Gedrich, Thompson: Tumor necrosis factor receptor-associated factors (TRAFs)--a family of adapter proteins that regulates life and death. in Genes & development 1998
Show all 4 Pubmed References
Human Polyclonal TRAF2 Primary Antibody for IHC, ELISA - ABIN1003294
van Kooten, Banchereau: CD40-CD40 ligand. in Journal of leukocyte biology 2000
Show all 4 Pubmed References
Human Polyclonal TRAF2 Primary Antibody for IF (p), IHC (p) - ABIN673479
Lei, Bai, Yang, Lai, Qiu, Yang, Lian: Gsdma3 is a new factor needed for TNF-?-mediated apoptosis signal pathway in mouse skin keratinocytes. in Histochemistry and cell biology 2012
The addition of nanomolar concentration of TRAF2 in GUVs also seems to exert a mechanical action.
TRAF2 and OTUD7B (show OTUD7B Antibodies) govern a ubiquitin-dependent switch that regulates mTORC2 (show CRTC2 Antibodies) signalling
destabilization of TRAF2 by miR-17 reduced the ability of TRAF2 to associate with cIAP2 (show BIRC3 Antibodies), resulting in the downregulation of TNF-alpha (show TNF Antibodies)-induced NF-kappaBp65, c-Jun (show JUN Antibodies), and STAT3 (show STAT3 Antibodies) nuclear translocation and the production of IL-6 (show IL6 Antibodies), IL-8 (show IL8 Antibodies), MMP-1 (show MMP1 Antibodies), and MMP-13 (show MMP13 Antibodies) in human rheumatoid arthritis synovial fibroblasts.
HOXA1 (show HOXA1 Antibodies)-mediated activation of NF-kappaB (show NFKB1 Antibodies) is non-transcriptional and the RBCK1 (show RBCK1 Antibodies) and TRAF2 influences on NF-kappaB (show NFKB1 Antibodies) are epistatic to HOXA1 (show HOXA1 Antibodies)
RIPK1 (show RIPK1 Antibodies) collaborates with TRAF2 to inhibit murine and human hepatocarcinogenesis.
Data suggest that TRAF2 (TNF receptor-associated factor 2) negatively regulates (1) TNFR1- (tumor necrosis factor binding protein 1 (show TNFRSF1A Antibodies))-induced apoptosis, (2) TNFR2 (show TNFRSF1B Antibodies)- (tumor necrosis factor (show TNF Antibodies) receptor type 2)-induced non-canonical NFkappaB (show NFKB1 Antibodies) signaling, and (3) TNF- (tumor necrosis factor (show TNF Antibodies))-induced necroptosis. [REVIEW]
Study presents the characterization of the peptide binding preferences of TRAFs 2, 3, and 5 using deep mutational scanning. The three TRAF (show TRAF1 Antibodies) proteins demonstrated different preferences for binding to members of the CD40 (show CD40 Antibodies) library, and three peptides from that library individually showed striking differences in affinity for the three TRAFs.
The data demonstrate a novel and unexpected function of BIG1 (show CNTN3 Antibodies) that regulates TNFR1 (show TNFRSF1A Antibodies) signaling by targeting TRAF2.
TRAF2 expression was increased in gastric cancer patients as a result of DNA hypomethylation.
Data show that when death receptor 5 (DR5 (show TNFRSF10B Antibodies)) is suppressed, caspase-8 (show CASP8 Antibodies) may recruit and stabilize TNF receptor-associated factor 2 (TRAF2) to form a metastasis and invasion signaling complex, resulting in activation of ERK (show EPHB2 Antibodies) signaling.
work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF (show TRAF1 Antibodies)/NF-kappaB (show NFKB1 Antibodies)-regulated apoptosis and the p53 (show TP53 Antibodies)/PCNA (show PCNA Antibodies)- and ATM (show ATM Antibodies)/ATR (show ATR Antibodies)-Chk1 (show CHEK1 Antibodies)/2-controlled DNA-damage response pathways.
Traf2 mediates the pro-survival pathway in the heart by suppressing necroptotic signaling.
Targeting TRAF2 may be useful as a therapeutic approach for immunosuppression-free islet allograft survival that avoids the thromboembolic complications associated with the use of anti-CD40L (show CD40LG Antibodies) antibodies.
Celastrol promotes Nur77 (show NR4A1 Antibodies) migration from the nucleus to mitochondria, where it is ubiquitinated by TRAF2. Ubiquitinated Nur77 (show NR4A1 Antibodies) then interacts with p62/SQSTM1 (show SQSTM1 Antibodies), leading to autophagy of dysfunctional mitochondria and alleviation of inflammation.
this study shows that TRAF2 and TRAF5 (show TRAF5 Antibodies) work as important regulators of the IL-6R signaling needed for Th17 development
Keratinocyte-specific deletion of Traf2, but not Sphk1 (show SPHK1 Antibodies) deficiency, disrupted TNF (show TNF Antibodies) mediated NF-kappaB (show NFKB1 Antibodies) and MAP kinase (show MAPK1 Antibodies) signalling and caused epidermal hyperplasia and psoriatic skin inflammation.
TRAF2 functions as a key activator of MST1 (show MST1 Antibodies) in oxidative stress-induced (show SQSTM1 Antibodies) intracellular signaling processes.
Proinflammatory TLR signalling is regulated by a TRAF2-dependent proteolysis mechanism in macrophages.
NFkappaB anti-apoptotic target genes TNF receptor-associated factor 1 (TRAF1 (show TRAF1 Antibodies)), TNF receptor-associated factor 2 (TRAF2), cellular inhibitor of apoptosis (cIAP2 (show BIRC3 Antibodies)), and Ferritin heavy chain (FTH1 (show FTH1 Antibodies)) were increased following Losartan treatment
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.
, conjugal transfer protein TraF
, E3 ubiquitin-protein ligase TRAF2
, tumor necrosis factor type 2 receptor associated protein 3
, tumor necrosis factor type 2 receptor-associated protein 3
, TRAF family member-associated NFKB activator
, TNF receptor-associated factor 2