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|Antigen||TNF Receptor-Associated Factor 3 (TRAF3) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This TRAF3 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
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Product Details anti-TRAF3 AntibodyTarget Details TRAF3 Application Details Handling Images
|Specificity||This antibody detects TRAF3 / CRAF1 at N-term.|
|Cross-Reactivity (Details)||Species reactivity (tested):Human, mouse, rat|
|Purification||Peptide affinity chromatography|
|Immunogen||TRAF3 antibody was raised against a 15 amino acid peptide from near the amino terminus of human.|
Target Details TRAF3Product Details anti-TRAF3 Antibody Application Details Handling Images back to top
|Alternative Name||TRAF3 / CRAF1 (TRAF3 Antibody Abstract)|
|Background||Tumor necrosis factor (TNF) receptor associated factors (TRAFs) are the major signal transducers for the TNF receptor superfamily and the interleukin-1 receptor/Toll-like receptor (IL-1/TLR) superfamily (1). TRAF3 was first identified by its interaction with CD40 and the Epstein-Barr virus transforming protein LMP1 (2,3). Several TRAF3 mRNA splice variants exist and some of these can activate the transcription factor NF-kappaB (4). Besides CD40, TRAF3 also interacts with the TRFR superfamily member lymphotoxin-beta receptor (LTbetaR) in association with TRAF2 and the apoptosis inhibitors cIAP1 and Smac. It has been suggested that TRAF3 induces mitochondria-mediated apoptosis upon binding of the TNF family cytokine LIGHT by LTbetaR.Synonyms: CAP-1, CAP1, CD40 receptor-associated factor 1, CD40-binding protein, CD40BP, LAP1, LMP1-associated protein, TNF receptor-associated factor 3|
|Pathways||NF-kappaB Signaling, Apoptosis, TLR Signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades|
Application DetailsProduct Details anti-TRAF3 Antibody Target Details TRAF3 Handling Images back to top
ELISA. Western blot: 1 - 2 μg/mL. Immunoflourescence.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-TRAF3 Antibody Target Details TRAF3 Application Details Images back to top
|Buffer||PBS containing 0.02 % sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.|