Browse our TRAF3 Proteins (TRAF3)

Full name:
TNF Receptor-Associated Factor 3 Proteins (TRAF3)
On are 5 TNF Receptor-Associated Factor 3 (TRAF3) Proteins from 3 different suppliers available. Additionally we are shipping TRAF3 Antibodies (138) and TRAF3 Kits (4) and many more products for this protein. A total of 162 TRAF3 products are currently listed.
AI528849, amn, CAP-1, CAP1, CD40bp, CRAF1, IIAE5, LAP1, T-BAM
list all proteins Gene Name GeneID UniProt
TRAF3 7187 Q13114
TRAF3 22031 Q60803
Rat TRAF3 TRAF3 362788  

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TRAF3 Proteins (TRAF3) by Origin

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Human TNF Receptor-Associated Factor 3 (TRAF3) interaction partners

  1. The current investigations identified a subset of HPV-positive HNSCCs with mutations in the genes TRAF3 (tumor necrosis factor (show TNF Proteins) receptor-associated factor 3) and CYLD (show CYLD Proteins) (cylindromatosis lysine 63 deubiquitinase). Defects in TRAF3 and CYLD (show CYLD Proteins) correlated with the activation of transcriptional factor nuclear factor kappaB, episomal HPV status of tumors, and improved patient survival.

  2. NDR1 interacts with TRAF3 and interferes with the association of TRAF3 and IL-17R, resulting in increased formation of the activation complex IL-17R-Act1, which is required for the downstream signaling and production of pro-inflammatory factors

  3. Data suggest that UBR5 down-regulates levels of TRAF3, a key component of Toll (show TLR4 Proteins)-like receptor signaling, via the miRNA pathway; p90RSK (show RPS6KA1 Proteins) is an upstream regulator of UBR5; p90RSK (show RPS6KA1 Proteins) phosphorylates UBR5 as required for translational repression of TRAF3 mRNA. (UBR5 = ubiquitin protein ligase E3 component n-recognin 5 protein; TRAF3 = TNF receptor-associated factor 3; p90RSK (show RPS6KA1 Proteins) = 90 kDa ribosomal protein S6 (show RPS6 Proteins) kinase (show RPS6KB1 Proteins))

  4. The GA genotype and GA+AA genotype of TRAF3 rs12147254 were found to increase the risk of coronary heart disease among T2DM patients. the GACGAC haplotype in TRAF3 had a protective effect on T2DM micro-macrovascular complications.

  5. These data suggest an interplay between CELF2 (show CELF2 Proteins) and hnRNP C (show HNRNPC Proteins) as the mechanistic basis for activation-dependent alternative splicing of TRAF3 exon 8.

  6. DDX3 (show DDX3X Proteins) directly regulates TRAF3 ubiquitination and acts as a scaffold to co-ordinate assembly of signaling complexes downstream from MAVS (show MAVS Proteins).

  7. The NleB effector limited host IFN-beta (show IFNB1 Proteins) production by inhibiting Lys (show LYZ Proteins)(63)-linked ubiquitination of TNF receptor-associated factor 3 (TRAF3). Inhibition was dependent on the glycosyltransferase (show GTDC2 Proteins) activity of NleB.

  8. TRAF3 epigenetics may significantly contribute to the variability of clopidogrel response and recurrence of ischemic events in patients with stroke.

  9. Study presents the characterization of the peptide binding preferences of TRAFs 2, 3, and 5 using deep mutational scanning. The three TRAF (show TRAF1 Proteins) proteins demonstrated different preferences for binding to members of the CD40 (show CD40 Proteins) library, and three peptides from that library individually showed striking differences in affinity for the three TRAFs.

  10. Taken all together, Helicobacter pylori toxin Tip-alpha might activate NF-kappaB (show NFKB1 Proteins) to promote inflammation and carcinogenesis by inhibiting miR (show MLXIP Proteins)-3178 expression, which directly targets TRAF3, during Helicobacter pylori infection in gastric mucosal epithelial cells.

Mouse (Murine) TNF Receptor-Associated Factor 3 (TRAF3) interaction partners

  1. NDR1 interacts with TRAF3 and interferes with the association of TRAF3 and IL-17R, resulting in increased formation of the activation complex IL-17R-Act1, which is required for the downstream signaling and production of pro-inflammatory factors

  2. Data (including data from studies using knockout mice) suggest that RANKL (show TNFSF11 Proteins) enhances TNF (show TNF Proteins)-induced osteoclast formation from precursor spleen cells and enhances bone resorption independently of Traf6 (show TRAF6 Proteins) by degrading Traf3, a known inhibitor of osteoclastogenesis. (RANKL (show TNFSF11 Proteins) = osteoclast differentiation factor (show TNFSF11 Proteins); TNF (show TNF Proteins) = tumor necrosis factor (show TNF Proteins); Traf (show TRAF1 Proteins) = TNF (show TNF Proteins) receptor-associated factor)

  3. Upon stimulation with poly(I:C), malaria parasite-infected red blood cells (iRBCs), or vesicular stomatitis virus (VSV), FOSL1 (show FOSL1 Proteins) "translocated" from the nucleus to the cytoplasm, where it inhibited the interactions between TNF receptor-associated factor 3 (TRAF3), TIR domain-containing adapter inducing IFN-beta (show IFNB1 Proteins) (TRIF (show RNF138 Proteins)), and Tank-binding kinase 1 (TBK1 (show TBK1 Proteins)) via impairing K63-linked polyubiquitination of TRAF3 and TRIF (show RNF138 Proteins).

  4. These findings reveal a novel mechanism that endotoxin tolerance reprograms mitogen-activated protein kinase (show MAPK1 Proteins) signaling by suppressing Pellino 1 (show PELI1 Proteins)-mediated K63-linked ubiquitination of cIAP2 (show BIRC3 Proteins), K48-linked ubiquitination, and degradation of TRAF3.

  5. Findings establish CK1varepsilon as a regulator of antiviral innate immune responses and indicate a novel mechanism of immunoregulation that involves CK1varepsilon-mediated phosphorylation of TRAF3.

  6. Hepatocyte TRAF3 promotes liver steatosis and insulin (show INS Proteins) resistance through targeting TAK1 (show NR2C2 Proteins)-dependent signaling.

  7. findings identify TRAF3 and PTPN22 (show PTPN22 Proteins) as inhibitors of IL-6R signaling in B cells and reveal a previously uncharacterized role for TRAF3 in the regulation of plasma cell differentiation

  8. TRAF3 expressed in myeloid cells regulates immune responses in myeloid cells and acts to inhibit inflammation and tumor development in mice.

  9. The MYSM1 (show MYSM1 Proteins) SWIRM domain interacts with TRAF3 to terminate PRR (show PVRL1 Proteins) pathways for pro-inflammatory and type I interferon (show IFNA Proteins) responses.

  10. Data show that the degradation of TNF receptor-associated factor 3 (TRAF3) and TNF (show TNF Proteins) receptor-associated Ffactor 6 (TRAF6 (show TRAF6 Proteins)) was accelerated in ubiquitin-specific protease 25 (show USP25 Proteins) knockout (USP25 (show USP25 Proteins)-/-) cells after viral infection.

TRAF3 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Several alternatively spliced transcript variants encoding three distinct isoforms have been reported.

Alternative names and synonyms associated with TRAF3

  • TNF receptor-associated factor 3 (TRAF3)
  • TNF receptor-associated factor 3 (Traf3)
  • Tnf receptor-associated factor 3 (Traf3)
  • AI528849 protein
  • amn protein
  • CAP-1 protein
  • CAP1 protein
  • CD40bp protein
  • CRAF1 protein
  • IIAE5 protein
  • LAP1 protein
  • T-BAM protein

Protein level used designations for TRAF3

CD40 associated protein 1 , CD40 binding protein , CD40 receptor associated factor 1 , LMP1-associated protein 1 , CD40 receptor-associated factor 1 , TRAFAMN , TNF receptor-associated factor 3

7187 Homo sapiens
22031 Mus musculus
362788 Rattus norvegicus
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