Browse our TRAF5 Proteins (TRAF5)

Full name:
TNF Receptor-Associated Factor 5 Proteins (TRAF5)
On are 10 TNF Receptor-Associated Factor 5 (TRAF5) Proteins from 6 different suppliers available. Additionally we are shipping TRAF5 Antibodies (63) and TRAF5 Kits (4) and many more products for this protein. A total of 82 TRAF5 products are currently listed.
MGC:39780, RNF84
list all proteins Gene Name GeneID UniProt
TRAF5 7188 O00463
TRAF5 22033 P70191

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Human TNF Receptor-Associated Factor 5 (TRAF5) interaction partners

  1. Study presents the characterization of the peptide binding preferences of TRAFs 2, 3, and 5 using deep mutational scanning. The three TRAF (show TRAF1 Proteins) proteins demonstrated different preferences for binding to members of the CD40 (show CD40 Proteins) library, and three peptides from that library individually showed striking differences in affinity for the three TRAFs.

  2. These findings indicate that miR (show MLXIP Proteins)-26b might influence TRAF5-MAPK (show MAPK1 Proteins) signaling pathways to facilitate the malignant progression of melanoma cells.

  3. findings reveal a direct link between TRAF5-mediated ubiquitination and RORgammat protein regulation

  4. RIG-I (show DDX58 Proteins)-like receptor mediated antiviral innate immune responses in the lower respiratory tract involves TRAF3 (show TRAF3 Proteins) and TRAF5 signaling.

  5. This study provides evidence that TRAF5 and TRAF3IP2 (show TRAF3IP2 Proteins) genes are involved in the development of Behcet's disease (BD) and Vogt-Koyanagi-Harada (VKH) syndrome.

  6. Data indicate that TNF receptor-associated factor 5 (TRAF5) gene is involved in the development of acute anterior uveitis (AAU) and pediatric uveitis.

  7. Data indicate that in monocyte- derived macrophages (MDMs) acutely infected with HIV-1 and treated with HCV rCore and HIV-1 rNef, the HIV-1 replication depends on an upstream signal mediated through TRAF2 (show TRAF2 Proteins), TRAF5 and TRAF6 (show TRAF6 Proteins).

  8. TRAF3 (show TRAF3 Proteins) and TRAF5 are overexpressed in inflammatory bowel disease

  9. Numbl (show NUMBL Proteins) interacted with tumor necrosis factor (show TNF Proteins) receptor-associated factor 5, which signals upstream and is required for the activation of NF-kappaB (show NFKB1 Proteins), and committed it to proteasomal degradation by promoting K48-linked polyubiquitination of TRAF5

  10. Resutls indicate that TRAF5 may be a key molecule in the innate response against viral infection.

Mouse (Murine) TNF Receptor-Associated Factor 5 (TRAF5) interaction partners

  1. this study shows that TRAF2 (show TRAF2 Proteins) and TRAF5 work as important regulators of the IL-6R signaling needed for Th17 development

  2. The results indicated that TRAF5 deficiency significantly aggravated DSS (show PMP22 Proteins)-induced colitis, most likely by regulating Th cell-mediated inflammation.

  3. In conclusion, our results suggest that as an intrinsic cardioprotective factor, TRAF5 plays a crucial role in the development of cardiac hypertrophy through the negative regulation of the MEK-ERK1/2 pathway

  4. TRAF5 negatively regulates TLR signaling in B lymphocytes.

  5. These results provide the first demonstration that TRAF5 is a critical mediator of brain ischemia/reperfusion in an experimental stroke model.

  6. In vitro and cellular experiments showed that forms of TRAF5 with mutation of the corresponding residues to those of TRAF3 (show TRAF3 Proteins) had TRAF3 (show TRAF3 Proteins)-like antiviral activity.

  7. Treatment with IL-17 (show IL17A Proteins) prolongs the half-life of chemokine (show CCL1 Proteins) CXCL1 (show CXCL1 Proteins) mRNA via the adaptor TRAF5 and the splicing-regulatory factor SF2 (ASF (show SRSF1 Proteins)).

  8. TNF receptor-associated factor 5 (TRAF5) deficiency accelerates atherogenesis in mice by increasing inflammatory cell recruitment and foam cell formation.

  9. Study is the first report showing a major requirement for TRAF5 in signaling by a specific receptor both in vitro and in vivo, as well as playing an important role in biological function in B lymphocytes.

  10. role in both RANKL (show TNFSF11 Proteins)- and TNFalpha (show TNF Proteins)-induced osteoclastogenesis

TRAF5 Protein Profile

Protein Summary

The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF) protein family and contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger, and two TRAF-type zinc fingers. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor (TNF) receptor cytoplasmic domains and mediates TNF-induced activation. Alternate transcriptional splice variants have been characterized.

Alternative names and synonyms associated with TRAF5

  • TNF receptor-associated factor 5 (LOC100340005)
  • TNF receptor-associated factor 5 (TRAF5)
  • TNF receptor-associated factor 5 (Traf5)
  • MGC:39780 protein
  • RNF84 protein

Protein level used designations for TRAF5

TNF receptor-associated factor 5 , RING finger protein 84

100340005 Oryctolagus cuniculus
7188 Homo sapiens
22033 Mus musculus
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