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anti-Mouse (Murine) TRAF6 Antibodies:
anti-Human TRAF6 Antibodies:
anti-Rat (Rattus) TRAF6 Antibodies:
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Human Polyclonal TRAF6 Primary Antibody for WB - ABIN1881900
Hinz, Stilmann, Arslan, Khanna, Dittmar, Scheidereit: A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-κB activation. in Molecular cell 2010
Show all 4 Pubmed References
Cow (Bovine) Polyclonal TRAF6 Primary Antibody for IHC (fro), IHC (p) - ABIN537432
Ichii, Otsuka, Sasaki, Namiki, Hashimoto, Kon: Altered expression of microRNA miR-146a correlates with the development of chronic renal inflammation. in Kidney international 2012
Show all 3 Pubmed References
Human Polyclonal TRAF6 Primary Antibody for ICC, ELISA - ABIN1003297
Takeda, Kaisho, Akira: Toll-like receptors. in Annual review of immunology 2003
Show all 4 Pubmed References
Human Polyclonal TRAF6 Primary Antibody for ICC, IHC (fro) - ABIN3044469
Yuan, Zhang, Yang: Ligusticum wallichii Extract Inhibited the Expression of IL-1? after AMI in Rats. in Evidence-based complementary and alternative medicine : eCAM 2014
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Human Polyclonal TRAF6 Primary Antibody for FACS, WB - ABIN4361690
Yoshida, Jono, Kai, Li: The tumor suppressor cylindromatosis (CYLD) acts as a negative regulator for toll-like receptor 2 signaling via negative cross-talk with TRAF6 AND TRAF7. in The Journal of biological chemistry 2005
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Cow (Bovine) Polyclonal TRAF6 Primary Antibody for IHC, IHC (p) - ABIN4361692
Zapata, Krajewska, Krajewski, Kitada, Welsh, Monks, McCloskey, Gordon, Kipps, Gascoyne, Shabaik, Reed: TNFR-associated factor family protein expression in normal tissues and lymphoid malignancies. in Journal of immunology (Baltimore, Md. : 1950) 2000
Human Polyclonal TRAF6 Primary Antibody for ELISA, ICC - ABIN4361694
Doyon, Servant et al.: Tumor necrosis factor receptor-associated factor-6 and ribosomal S6 kinase intracellular pathways link the angiotensin II AT1 receptor to the phosphorylation and activation of the IkappaB kinase ... in The Journal of biological chemistry 2010
Human Polyclonal TRAF6 Primary Antibody for IF (p) - ABIN918441
Qi, Pradipta, Li, Zhao, Lu, Fu, Wei, Hsung, Tanaka, Zhou: Cinchonine induces apoptosis of HeLa and A549 cells through targeting TRAF6. in Journal of experimental & clinical cancer research : CR 2017
we found that reactive oxygen species-induced autophagy acts as a negative feedback regulator of JNK (show MAPK8 Antibodies) activity by dissociating Atg9 (show ATG9A Antibodies)/mAtg9 (show ATG9A Antibodies) from dTRAF2/TRAF6 in Drosophila.
null mutant of DTRAF2 showed immune deficiencies in which NF-kappaB nuclear translocation and antimicrobial gene transcription against microbial infection were severely impaired
this study shows that TRAF6 is necessary for the nontranscriptional priming of NLRP3 (show NLRP3 Antibodies) inflammasome by TLR/IL-1R derived signals
work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF (show TRAF1 Antibodies)/NF-kappaB (show NFKB1 Antibodies)-regulated apoptosis and the p53 (show TP53 Antibodies)/PCNA (show PCNA Antibodies)- and ATM (show ATM Antibodies)/ATR (show ATR Antibodies)-Chk1 (show CHEK1 Antibodies)/2-controlled DNA-damage response pathways.
TRAF6 prevents the mitochondrial translocation of p53 (show TP53 Antibodies) and spontaneous apoptosis by promoting lysine63-linked ubiquitination of p53 (show TP53 Antibodies) in cytosol.
TRAF6 mediates lysine-63 ubiquitination within the SH2 (show MYO15 Antibodies) domain of STAT3 (show STAT3 Antibodies), which is an essential step for STAT3 (show STAT3 Antibodies) membrane recruitment and phosphorylation in response to S Typhimurium infection; results reveal a strategy in which S Typhimurium T3SS effectors broaden their functions through the activation of host proteins in a ubiquitination-dependent manner to manipulate host cells into becoming a Salmonella-friendly zone
this study shows that an interaction of TRAF6 with cullin-5 (show CUL5 Antibodies) promotes TRAF6 polyubiquitination and lipopolysaccharide signaling
Consistent with cellular studies, icaritin downregulated TRAF6 and NFATc1 protein expression in CD11b(+) /Gr-1(-/low) osteoclast precursors
Data (including data from studies using knockout mice) suggest that RANKL (show TNFSF11 Antibodies) enhances TNF (show TNF Antibodies)-induced osteoclast formation from precursor spleen cells and enhances bone resorption independently of Traf6 by degrading Traf3 (show TRAF3 Antibodies), a known inhibitor of osteoclastogenesis. (RANKL (show TNFSF11 Antibodies) = osteoclast differentiation factor (show TNFSF11 Antibodies); TNF (show TNF Antibodies) = tumor necrosis factor (show TNF Antibodies); Traf (show TRAF1 Antibodies) = TNF (show TNF Antibodies) receptor-associated factor)
the SH3 domain (show ITSN1 Antibodies) of NOSTRIN (show NOSTRIN Antibodies) is involved in the NOSTRIN (show NOSTRIN Antibodies)-TRAF6 interaction and is required for NOSTRIN (show NOSTRIN Antibodies)-induced down-regulation of endothelial cell proteins
this study shows that TRAF6 overexpression in hematopoietic stem/progenitor cells results in impaired hematopoiesis and bone marrow failure
TRAF6 and H2AX (show H2AFX Antibodies) overexpression and gammaH2AX (show H2AFX Antibodies)-mediated HIF1alpha (show HIF1A Antibodies) enrichment in the nucleus of cancer cells lead to overactivation of HIF1alpha (show HIF1A Antibodies)-driven tumorigenesis, glycolysis and metastasis.
we have now analyzed the in vivo function of Traf6 in the innate immune response without interference of adaptive immunity
Full-length traf6 was functionally characterized.
CRBN (show CRBN Antibodies) negatively regulates TLR4 (show TLR4 Antibodies) signaling via attenuation of TRAF6 and TAB2 (show TAB2 Antibodies) ubiquitination.
the polymorphisms in TLR-MyD88 (show MYD88 Antibodies)-NF-kappaB (show NFKB1 Antibodies) signaling pathway confer genetic susceptibility to Type 2 diabetes mellitus and diabetic nephropathy.
The E3 ligase TRAF6 binds to DCP1a (show DCP1A Antibodies) and indirectly regulates DCP1a (show DCP1A Antibodies) phosphorylation, expression of decapping factors, and gene-specific mRNA decay.
Study showed that patients without a history of atrial fibrillation who develop postoperative atrial fibrillation have a higher percentage of left atrial fibrosis, increased expression of TRAF6, higher serum Ang II (show AGT Antibodies) levels, and changes in the activities of the MAPKs/TGF-beta1 (show TGFB1 Antibodies)/TRAF6 pathway.
Low TRAF6 expression is associated with graft-versus-host disease.
Results suggest that overexpression of miR (show MLXIP Antibodies)-146a could promote IDD (show COL9A3 Antibodies) through the TRAF (show TRAF1 Antibodies)/NF-kappaB (show NFKB1 Antibodies) pathway.
These findings show that SopB (show IFT122 Antibodies) suppresses host cell apoptosis by binding to TRAF6 and preventing mitochondrial reactive oxygen species generation.
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain. Two alternatively spliced transcript variants, encoding an identical protein, have been reported.
TNF receptor-associated factor 6-B
, E3 ubiquitin-protein ligase TRAF6
, TNF-receptor-associated factor 2
, TNF receptor-associated factor 6
, TNF receptor-associated factor 6-like
, RING finger protein 85
, interleukin-1 signal transducer
, TNF-receptor associated factor 6