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|Application / Reactivity||Rat (Rattus)||Mouse (Murine)|
|ELISA||12 Antibodies||12 Antibodies|
|Enzyme Immunoassay (EIA)||1 Antibodies||1 Antibodies|
|Immunocytochemistry (ICC)||11 Antibodies||10 Antibodies|
|Immunofluorescence (IF)||7 Antibodies||7 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||11 Antibodies||11 Antibodies|
|Immunohistochemistry (IHC)||15 Antibodies||17 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||2 Antibodies||1 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||8 Antibodies|
|Immunoprecipitation (IP)||3 Antibodies|
|Western Blotting (WB)||39 Antibodies|
|Antigen||TNF Receptor-Associated Factor 6 (TRAF6) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This TRAF6 antibody is un-conjugated Alternatives|
Immunocytochemistry (ICC), ELISA, Western Blotting (WB)
|4 references available|
|Supplier||Log in to see|
Product Details anti-TRAF6 AntibodyTarget Details TRAF6 Application Details Handling References for anti-TRAF6 Antibody (ABIN1003297) Images
|Blocking Peptide||Blocking peptide for this product available: ABIN1003904|
|Purification||Ion exchange chromatography purified.|
|Immunogen||Rabbit polyclol TRAF6 antibody was raised against a peptide corresponding to 14 amino acids near the C-terminus of human TRAF6 (GenBank accession no. S71821).|
Target Details TRAF6Product Details anti-TRAF6 Antibody Application Details Handling References for anti-TRAF6 Antibody (ABIN1003297) Images back to top
|Alternative Name||TNF Receptor Associated Factor 6 (TRAF6 Antibody Abstract)|
|Background||Signals from the IL-1 receptor (IL-1R)/Toll-like receptor (TLR) and TNF receptor (TNFR) superfamilies are critical for regulating the function of antigen-presenting cells. Signals transduced by these molecules lead to increased expression and activation of transcription factors such as NF-kappaB. TNF receptor-associated factor 6 (TRAF6) is unique in that it is a signaling adapter molecule common to both families. TRAF6 is important in cytokine production, dendritic cell (DC) maturation, and the T cell stimulatory capacity of DCs in response to TLR and CD40 ligands. It can be activated in the IL-1R/TLR signaling pathway by IL-1 receptor-associated kinase 1 (IRAK-1) or by other TLR adaptor molecules such as TRIF. Also, it has been shown that TRAF6 can interact directly with TNFR family members CD40 and RANK.|
|Pathways||NF-kappaB Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway|
Application DetailsProduct Details anti-TRAF6 Antibody Target Details TRAF6 Handling References for anti-TRAF6 Antibody (ABIN1003297) Images back to top
|Application Notes||TRAF6 antibody can be used for detection of TRAF6 by Western blot at 1 to 2 µg/ml. (Optimal dilution should be determined by user.) Antibody can also be used for immunocytochemistry and ELISA and might be suited for other applications not tested so far.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-TRAF6 Antibody Target Details TRAF6 Application Details References for anti-TRAF6 Antibody (ABIN1003297) Images back to top
|Buffer||Antibody is supplied in PBS containing 0.02% sodium azide.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Antibody can be stored at 4 °C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.|
|Expiry Date||12 months|
References for anti-TRAF6 Antibody (ABIN1003297)Product Details anti-TRAF6 Antibody Target Details TRAF6 Application Details Handling Images back to top
|Product cited in:||
Wu: "Assembly of post-receptor signaling complexes for the tumor necrosis factor receptor superfamily." in: Advances in protein chemistry, Vol. 68, pp. 225-79, 2004 (PubMed).
Wajant, Scheurich: "Analogies between Drosophila and mammalian TRAF pathways." in: Progress in molecular and subcellular biology, Vol. 34, pp. 47-72, 2004 (PubMed).
Kobayashi, Walsh, Walsh et al.: "TRAF6 is a critical factor for dendritic cell maturation and development." in: Immunity, Vol. 19, Issue 3, pp. 353-63, 2003 (PubMed).
Takeda, Kaisho, Akira: "Toll-like receptors." in: Annual review of immunology, Vol. 21, pp. 335-76, 2003 (PubMed).