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|Application / Reactivity||Rat (Rattus)||Mouse (Murine)|
|ELISA||12 Antibodies||12 Antibodies|
|Enzyme Immunoassay (EIA)||1 Antibodies||1 Antibodies|
|Immunocytochemistry (ICC)||11 Antibodies||10 Antibodies|
|Immunofluorescence (IF)||7 Antibodies||7 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||11 Antibodies||11 Antibodies|
|Immunohistochemistry (IHC)||15 Antibodies||17 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||2 Antibodies||1 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||8 Antibodies|
|Immunoprecipitation (IP)||3 Antibodies|
|Western Blotting (WB)||39 Antibodies|
|Antigen||TNF Receptor-Associated Factor 6 (TRAF6) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This TRAF6 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
|1 reference available|
|Supplier||Log in to see|
Product Details anti-TRAF6 AntibodyTarget Details TRAF6 Application Details Handling References for anti-TRAF6 Antibody (ABIN501028) Images
|Specificity||This antibody detects TRAF6 / RNF85 at C-term.|
|Cross-Reactivity (Details)||Species reactivity (tested):Human, mouse, rat|
|Purification||Ion exchange chromatography|
|Immunogen||TRAF6 antibody was raised against a peptide corresponding to 14 amino acids near the C- terminus of human TRAF6.|
Target Details TRAF6Product Details anti-TRAF6 Antibody Application Details Handling References for anti-TRAF6 Antibody (ABIN501028) Images back to top
|Alternative Name||TRAF6 / RNF85 (TRAF6 Antibody Abstract)|
|Background||Signals from the IL-1 receptor (IL-1R)/Toll-like receptor (TLR) and TNF receptor (TNFR) superfamilies are critical for regulating the function of antigen-presenting cells. Signals transduced by these molecules lead to increased expression and activation of transcription factors such as NF-?B (1,2). TNF receptor-associated factor 6 (TRAF6) is unique in that it is a signaling adapter molecule common to both families (3). TRAF6 is important in cytokine production, dendritic cell (DC) maturation, and the T cell stimulatory capacity of DCs in response to TLR and CD40 ligands (4). It can be activated in the IL-1R/TLR signaling pathway by IL-1 receptor-associated kinase 1 (IRAK-1) (5) or by other TLR adaptor molecules such as TRIF (6). Also, it has been shown that TRAF6 can interact directly with TNFR family members CD40 and RANK (7).Synonyms: Interleukin-1 signal transducer, RING finger protein 85, TNF receptor-associated factor 6|
|Pathways||NF-kappaB Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway|
Application DetailsProduct Details anti-TRAF6 Antibody Target Details TRAF6 Handling References for anti-TRAF6 Antibody (ABIN501028) Images back to top
ELISA. Western blot: 1 to 2 μg/mL. Immunflourescence.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-TRAF6 Antibody Target Details TRAF6 Application Details References for anti-TRAF6 Antibody (ABIN501028) Images back to top
|Buffer||PBS containing 0.02 % sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.|
References for anti-TRAF6 Antibody (ABIN501028)Product Details anti-TRAF6 Antibody Target Details TRAF6 Application Details Handling Images back to top
Takeda, Kaisho, Akira: "Toll-like receptors." in: Annual review of immunology, Vol. 21, pp. 335-76, 2003 (PubMed).
ImagesProduct Details anti-TRAF6 Antibody Target Details TRAF6 Application Details Handling References for anti-TRAF6 Antibody (ABIN501028) back to top