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Browse our Tumor Necrosis Factor Proteins (TNF)

Full name:
Tumor Necrosis Factor Proteins (TNF)
On www.antibodies-online.com are 251 Tumor Necrosis Factor (TNF) Proteins from 25 different suppliers available. Additionally we are shipping Tumor Necrosis Factor Antibodies (1672) and Tumor Necrosis Factor Kits (327) and many more products for this protein. A total of 2287 Tumor Necrosis Factor products are currently listed.
Synonyms:
Cachectin, cTNF, DIF, RATTNF, tnf, TNF-a, Tnf-alpha, TNFa, tnfa-like, TNFalpha, Tnfsf1a, TNFSF2, xtnf
list all proteins Gene Name GeneID UniProt
TNF 7124 P01375
Mouse TNF TNF 21926 P06804
Rat TNF TNF 24835 P16599

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Tumor Necrosis Factor Proteins (TNF) by Origin

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Top referenced Tumor Necrosis Factor Proteins

  1. Human Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN2003118 : Black, Rauch, Kozlosky, Peschon, Slack, Wolfson, Castner, Stocking, Reddy, Srinivasan, Nelson, Boiani, Schooley, Gerhart, Davis, Fitzner, Johnson, Paxton, March, Cerretti: A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells. in Nature 1997 (PubMed)
    Show all 9 references for ABIN2003118

  2. Mouse (Murine) Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN2007701 : Chen, Goeddel: TNF-R1 signaling: a beautiful pathway. in Science (New York, N.Y.) 2002 (PubMed)
    Show all 6 references for ABIN2007701

  3. Rat (Rattus) Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN413826 : Muehlbauer, Lima, Goldman, Jacobson, Rivera, Goldberg, Palladino, Casadevall, Brojatsch: Proteasome inhibitors prevent caspase-1-mediated disease in rodents challenged with anthrax lethal toxin. in The American journal of pathology 2010 (PubMed)
    Show all 4 references for ABIN413826

  4. Human Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN2666707 : Beutler, Cerami: Tumor necrosis, cachexia, shock, and inflammation: a common mediator. in Annual review of biochemistry 1988 (PubMed)
    Show all 4 references for ABIN2666707

  5. Human Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN1047828 : Pennica, Nedwin, Hayflick, Seeburg, Derynck, Palladino, Kohr, Aggarwal, Goeddel: Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin. in Nature 1985 (PubMed)
    Show all 4 references for ABIN1047828

  6. Mouse (Murine) Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN1305135 : Hogan, Vogel: Production of tumor necrosis factor by rIFN-gamma-primed C3H/HeJ (Lpsd) macrophages requires the presence of lipid A-associated proteins. in Journal of immunology (Baltimore, Md. : 1950) 1989 (PubMed)
    Show all 3 references for ABIN1305135

  7. Rat (Rattus) Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN1305133 : Jäättelä: Biologic activities and mechanisms of action of tumor necrosis factor-alpha/cachectin. in Laboratory investigation; a journal of technical methods and pathology 1991 (PubMed)
    Show all 2 references for ABIN1305133

  8. Cow (Bovine) Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN1047829 : Mertens, Muriuki, Gaidulis: Cloning of two members of the TNF-superfamily in cattle: CD40 ligand and tumor necrosis factor alpha. in Immunogenetics 1995 (PubMed)
    Show all 2 references for ABIN1047829

  9. Human Tumor Necrosis Factor Protein expressed in HEK-293 Cells - ABIN2181833 : Dowlati, Herrmann, Swardfager, Liu, Sham, Reim, Lanctôt: A meta-analysis of cytokines in major depression. in Biological psychiatry 2010 (PubMed)

  10. Mouse (Murine) Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN413823 : Srivastava, Qin, Wedhas, Arnush, Linkhart, Chadwick, Kumar: Tumor necrosis factor-alpha augments matrix metalloproteinase-9 production in skeletal muscle cells through the activation of transforming growth factor-beta-activated kinase 1 (TAK1)-dependent signaling pathway. in The Journal of biological chemistry 2007 (PubMed)

More Proteins for Tumor Necrosis Factor Interaction Partners

Rainbow Trout (Oncorhynchus mykiss) Tumor Necrosis Factor (TNF) interaction partners

  1. Our findings demonstrate that TNF-alpha plays a pivotal role in HF-mediated neuroinflammation and associated alterations of cortical dendritic spine density and has the potential to reveal novel treatment strategies for HF-associated memory deficits.

  2. the present study assessed the combined impacts of estrogens and bacterial infection on the insulin (show INS Proteins)-like growth factors (IGF) and tumor-necrosis factor (TNF)-alpha.

  3. The expression of miR (show MYLIP Proteins)-125b-1 regulated by NF-kappaB (show NFKB1 Proteins) has been reported in diverse cell types under various stimuli, this study found that its expression was also significantly regulated by NF-kappaB (show NFKB1 Proteins) in TNFalpha-stimulated HeLa and HepG2 cells

  4. In the Han Chinese population, the allele 'A' of TNF-alpha -308 may increase the risk for osteoarthritis (OA), whereas TNF-alpha -238 polymorphisms do not play a role in OA patients.

  5. Letter: serum TNF-alpha was not elevated in chronic spontaneous urticaria.

  6. Metastatic cells can escape the proapoptotic effects of TNF-alpha through increased autocrine IL-6 (show IL6 Proteins)/STAT3 (show STAT3 Proteins) signaling

  7. The predicted 3D structures of IL-1beta (show IL1B Proteins), TNF-alpha, and IL-8 (show IL8 Proteins) from Oncorhynchus mykiss, Dicentrarchus labrax, and Chionodraco hamatus are reported and the differences between them and their mammalian counterparts investigated.

  8. The mitochondrial dysfunction may be caused by increased brain levels of TNFalpha without physiological stress but will be exacerbated after middle cerebral artery occlusion.

  9. TNF-alpha is released rapidly in trout macrophages after stimulation with lipopolysaccharide and zymosan, and its secretion is dependent on TACE (show ADAM17 Proteins)-like activity that is regulated by ERK (show MAPK1 Proteins), JNK (show MAPK8 Proteins) and p38MAPK (show MAPK14 Proteins) signaling pathways.

  10. Recombinant, as well as native trout TNF-alpha, directly stimulates glucose uptake in trout muscle cells and provide evidence, for the first time in nonmammalian vertebrates, for a potential regulatory role of TNF-alpha in skeletal muscle metabolism.

Human Tumor Necrosis Factor (TNF) interaction partners

  1. N-acetyl-seryl-aspartyl-lysyl-proline inhibition of TNF-alpha activation of canonical, i.e., IKK-beta (show IKBKB Proteins)-dependent, NF-kappaB (show NFKB1 Proteins) pathway and subsequent decrease in ICAM-1 (show ICAM1 Proteins) expression is achieved via inhibition of IKK-beta (show IKBKB Proteins).

  2. TNF-alpha impairs adiponectin (show ADIPOQ Proteins)/AdipoR1 (show ADIPOR1 Proteins) signaling, mitochondrial biogenesis, and myogenesis in primary human myotubes cultures obtained from heart failure patients.

  3. These findings indicate that both TNF-alpha -308G/A and -238G/A polymorphisms were associated with increased risks of sepsis but not sepsis-related mortality.

  4. No association was found between TNF-alpha -308G/A polymorphism and idiopathic recurrent miscarriage. [meta-analysis]

  5. TNF-alpha stimulates colonic myofibroblast migration through P38 MAPK (show MAPK14 Proteins)-mediated activation of COX-2 and Hsp27 (show HSPB1 Proteins).

  6. The authors concluded that IL-25 (show IL25 Proteins) provides protection from amebiasis, which is dependent upon intestinal eosinophils and suppression of TNF-alpha.

  7. our results also revealed a significant difference in the genotype/allele frequencies of the rs1800624 and rs1800625 polymorphisms between the sepsis and severe sepsis subtypes, the rs1800624 TT or rs1800625 TT genotype carriers exhibited a significant increase in RAGE (show AGER Proteins) mRNA, sRAGE, TNF-a and IL-6 (show IL6 Proteins) expression compared with the rs1800624 AT/AA or rs1800625 CT/CC carriers in sepsis patients

  8. Data indicate that endogenous tumor necrosis factor-alpha (TNF-alpha) serves as an important pathogenic mediator in the development of Sjogren's syndrome (SS).

  9. In patients with cutaneous leishmaniasis, the A allele in TNFalpha-308G/A SNP was found more frequently in individuals with asymptomatic infection (16% vs 7%), whereas the CC genotype in IL-10 (show IL10 Proteins)-819 C/T SNP was more frequent in patients with chronic disease (34% vs. 27% in asymptomatic individuals). No differences in allele frequencies for TLR4 (show TLR4 Proteins) SNPs were found among groups.

  10. Higher HDL (show HSD11B1 Proteins)-C levels were noted in carriers of genotype GG of polymorphism TNFa rs3093664 that was protective for wheezing Vs AG and AA genotypes (65.3 Vs 51.8 and 53.3 mg/dl, p-value < 0.001 and p-value for trend = 0.028).

Mouse (Murine) Tumor Necrosis Factor (TNF) interaction partners

  1. Results suggest that elevated TNF in the heart, via TNFR1 (show TNFRSF1A Proteins) and TNFR2 (show TNFRSF1B Proteins), restrains cardiomyocyte differentiation of resident cardiac stem cells and may enhance adrenergic activation, both effects that would reduce the effectiveness of endogenous cardiac repair and the response to exogenous stem cell therapy, while promoting adverse cardiac remodeling.

  2. The data demonstrate that cigarette smoke exposure reduces TTP (show ZFP36 Proteins) expression and impairs TTP (show ZFP36 Proteins) function, resulting in significantly increased TNF-alpha mRNA stability and excessive TNF-alpha expression in alveolar macrophages and epithelial cells.

  3. Taken together, these data show that, in adipose tissues, IL-17A (show IL17A Proteins) contributes to exacerbating insulin (show INS Proteins) resistance-enhancing IL-6 (show IL6 Proteins) production and promotes the infiltration of Th17 cells in cooperation with TNFalpha; these findings represent a novel hypothesis for the association between IL-17A (show IL17A Proteins)-producing cells and type 2 diabetes.

  4. these simulations also revealed that the initial cytokine secretion (1-2 h after stimulation) rather than final TNF level (10 h after stimulation) defines the hepatocellular NF-kappaB (show NFKB1 Proteins) response. This raises the question whether the current experimental standard of single high-dose cytokine administration is suitable to mimic in vivo cytokine exposure.

  5. TNF-alpha blockade exerts antiatherosclerotic effects that are dependent on the presence of macrophage LRP1 (show LRP1 Proteins).

  6. Data indicate that infiltrated M1 Mvarphi suppress the induction of thermogenic adipocytes in obese adipose tissues via TNFalpha.

  7. In vivo, GSK621 oral administration inhibited LPS (show TLR4 Proteins)-induced TNFalpha production and endotoxin shock in mice. In summary, GSK621 activates AMPK (show PRKAA1 Proteins) signaling to inhibit LPS (show TLR4 Proteins)-induced TNFalpha production in macrophages/monocytes.

  8. Using in vivo, time-lapse imaging we show that as centrally-projecting pioneer axons from dorsal root ganglia (DRG) enter the spinal cord, they initiate expression of the cytokine TNFalpha. This induction coincides with ensheathment of these axons by associated glia via a TNF receptor 2 (TNFR2 (show TNFRSF1B Proteins))-mediated process.

  9. TNFalpha and IL-1beta (show IL1B Proteins) produced by inflammatory monocytes play a key role in the loss of the intestinal barrier function during Cryptosporidium parvum infection.

  10. These results indicate that TNF-alpha is a major component of the inflammatory response associated with altered neurodevelopment that follows murine cytomegalovirus infection of the developing brain and that a subset of peripheral blood myeloid mononuclear cells represent a key effector cell population in this model of virus-induced inflammatory disease of the developing brain.

Pig (Porcine) Tumor Necrosis Factor (TNF) interaction partners

  1. TNF-alpha, secreted from activated Monocytes, mediates the downregulation of OTX2 (show OTX2 Proteins) and essential retinal pigment epithelium genes.

  2. TNF-alpha induced MMP-13 (show MMP13 Proteins) expression by condylar cells might be involved in the degradation of the juvenile condyle.

  3. TNF-alpha was able to promote theca interna cell proliferation. Our results suggest that TNF-alpha might play a role in hyperandrogenism, cortex thickness, and the increased ovary volume observed in polycystic ovaries.

  4. This study showed that the -791(C-->T) mutation of the TNF-alpha gene could be considered an important potential genetic marker of enterotoxigenic Escherichia coli F18 (show MAMLD1 Proteins) resistance.

  5. Both Nsp1beta and Nsp11 of porcine reproductive and respiratory syndrome virus were demonstrated to be responsible for the inhibitory effect on TNF-alpha production in pulmonary alveolar macrophages.

  6. Study presents evidence demonstrating a single species of exotoxin ApxI, derived from A. pleuropneumoniae serotype 10, induces the expression and production of proinflammatory cytokines IL-1beta (show IL1B Proteins), IL-8 (show IL8 Proteins) and TNF-alpha in porcine alveolar macrophages.

  7. the role of miR (show MYLIP Proteins)-181a in adipocyte differentiation by regulation of TNF-alpha

  8. The NOS inhibitor, L-NMMA, significantly suppressed the combined effects of HT and CORM-2 on TNFalpha-triggered NFkappaBp65 phosphorylation as well as decreased cell viability.

  9. High-volume hemofiltration improves hemodynamics and heart dysfunction in septic shock pigs, which may be attributed to reduction of TNF-alpha in myocardium but not in circulation.

  10. Basal lipogenesis was not affected by tumor necrosis factor alpha (TNFalpha) treatment; however, insulin (show INS Proteins) stimulated lipogenesis was reduced by TNFalpha. Interleukin 6 (show IL6 Proteins) and TNFalpha gene expression were acutely (2-4 h) stimulated by exogenous TNFalpha treatment.

Cow (Bovine) Tumor Necrosis Factor (TNF) interaction partners

  1. Data suggest that luteolytic factors (such as TNFa, interferon gamma (show IFNG Proteins), and PGF2a) control expression of MMP1 (show MMP1 Proteins), other matrix metalloproteinases, and tissue inhibitors of metalloproteinase in cultured luteal cells.

  2. These results suggest that polymorphism of the TNFalpha-824 A>G gene and mTNFalpha protein expression play an important role in the pathogenesis of enzootic bovine leukosis.

  3. These results suggest that the endometrium might lower the TNF concentration in the blastocyst by (1) regulating TNF secretion into the uterine fluid and (2) inducing decreased TNF and TNFR2 (show TNFRSF1B Proteins) mRNA transcription in the embryo.

  4. There was a significant association between the proviral load and a low frequency of the G/G genotype of TNF-alpha at position -824.

  5. SNP in the TNF-alpha gene affects immune function and reproductive performance in dairy cows.

  6. Studied genotypic and expression profiling of partial TNF-alpha gene and its association with mastitis susceptibility in 129 crossbred cattle.

  7. Messenger RNA and protein levels of prostaglandin (PG) E synthase (PGES (show PTGES Proteins)), PGF2alpha receptor (PGFR), tumor necrosis factor-alpha (TNF) and Fas (show FAS Proteins) were found to be higher in the corpus luteum of pregnancy than in corpus luteum of the cycle.

  8. TNF-alpha up-regulates NaV1.7 (show SCN9A Proteins) mRNA in both adrenal chromaffin cells and dorsal root ganglia (DRG) neurons, highlighting the peripheral nociceptive mechanism of TNF-alpha

  9. These results provide evidence for a high prevalence of subclinical endometritis in repeat breeding cows as well as the involvement of TNFalpha and iNOS (show NOS2 Proteins) pathways in the regulation of this pathological condition.

  10. Exposure to follicular fluid transiently increased the transcript levels of IL8 (show IL8 Proteins) and PTGS2 (show PTGS2 Proteins), and decreased the expression of SOD2 (show SOD2 Proteins), GPX3 (show GPX3 Proteins), DAB2 (show DAB2 Proteins), and NR3C1 (show NR3C1 Proteins). TNF and IL6 (show IL6 Proteins) levels were also decreased while those of NAMPT (show NAMPT Proteins) were unaffected.

Horse (Equine) Tumor Necrosis Factor (TNF) interaction partners

  1. The results obtained showed that IL-6 (show IL6 Proteins) expression in adipose tissue biopsies derived from animals with equine metabolic syndrome was enhanced while TNF-alpha levels of both groups were comparable.

  2. Data indicate that tumor necrosis factor-alpha production is closely related to ovarian steroid actions.

  3. These results indicate that in equine corpus luteum, cytokines TNF, IFNG (show IFNG Proteins) and FASL (show FASL Proteins) regulate nitric oxide activity, via eNOS (show NOS3 Proteins) expression modulation.

  4. These data show the presence of cytokines TNF and IFNG (show IFNG Proteins), and their receptors, in the equine corpus luteum and indicate their potential involvement in regulation of luteal function.

  5. The contribution of bronchial epithelium to airway inflammation, with focus on mRNA and protein expression of IL-6 (show IL6 Proteins), IL-10 (show IL10 Proteins) and TNF-alpha, in horses with recurrent airway obstruction during exacerbation and in remission is reported.

Rabbit Tumor Necrosis Factor (TNF) interaction partners

  1. TUNEL staining was positively correlated with TNF-a protein expression. Our findings suggest that apoptosis can be induced in the vocal fold epithelium after 120min of modal intensity phonation. In contrast, shorter durations of vibration exposure do not result in apoptosis signaling.

  2. Inflammatory factors such as TNF-alpha can stimulate MMP-2 (show MMP2 Proteins)/9 activity in corneal epithelium cells. This may be a potential manipulating mechanism of MMP expression in the pathogenesis of corneal diseases.

  3. The JNK (show MAPK8 Proteins) pathway plays an important role in mechanical ventilation-stimulated TNF-alpha expression in alveolar macrophages, but the injury-stimulated IL-8 (show IL8 Proteins) expression may be regulated by other signaling pathways.

  4. The TNFalpha-evoked Cl- current.

  5. IL-1beta (show IL1B Proteins) and TNF-alpha expression increases significantly during acute lung injury. Ambroxol combined with low-dose heparin inhibits teh release of IL-1beta (show IL1B Proteins) and TNF-alpha.

  6. Hypercapnia increased expression of TNFa and decreased expression of NFKB in acute lung injury models.

  7. In the early stages of myocardial ischemia, bone marrow stem cells are mobilized and home to ischemic myocardium with a concomitant increase in expression of cytokines VEGF (show VEGFA Proteins) and TNFalpha.

  8. Ammonium perchlorate can increase gene expressions of types I, III collagens, TGF-beta(1 (show TGFB1 Proteins)) and TNF-alpha in lung of rabbits.

  9. TNFalpha may either be directly or indirectly involved in vascular damage following an embolic stroke. Moreover, TNFalpha may mediate some of the detrimental effects of tPA (show PLAT Proteins) on the vascular compartment

Rhesus Monkey Tumor Necrosis Factor (TNF) interaction partners

  1. These interactions result in the induction of the TNF signaling pathway, activation of apoptosis, and DNA-damage stress response.

  2. Findings showed that both mucosal compartments harbor similar percentages of memory CD4 (show CD4 Proteins)(+) T cells and displayed comparable cytokine TNF-alpha responses to mitogenic stimulations prior to infection.

  3. Primary role for IL-1beta (show IL1B Proteins) and TNF-alpha in the triggering of preterm labor associated with inflammation or infection.

Goat Tumor Necrosis Factor (TNF) interaction partners

  1. Data indicate that three single-nucleotide polymorphisms were identified in tumor necrosis factor-alpha (TNF-alpha) gene.

Zebrafish Tumor Necrosis Factor (TNF) interaction partners

  1. The results reveal a crucial role for TNFalpha/TNFR2 (show TNFRSF1B Proteins) axis in the protection of the skin against DUOX1 (show DUOX1 Proteins)-mediated oxidative stress.

  2. TNF alpha is the first molecule identified that is produced by dying retinal neurons and is necessary to induce Muller glia to proliferate in the zebrafish retinal regeneration response.

  3. The data suggest that Mycobacterium marinum SecA2 modulates adaptive immunity to promote granuloma stability, perhaps through induction of tumor necrosis factor alpha.

  4. TNF is not required for tuberculous granuloma formation, but maintains granuloma integrity indirectly by restricting mycobacterial growth within macrophages and preventing their necrosis.

  5. The main proinflammatory effects of fish TNF-alpha are mediated through the activation of endothelial cells and point to the complexity of the evolution that has taken place in the regulation of innate immunity by cytokines.

Tumor Necrosis Factor (TNF) Protein Profile

Protein Summary

This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.

Alternative names and synonyms associated with Tumor Necrosis Factor (TNF)

  • tumor necrosis factor (TNF superfamily, member 2) (TNF)
  • tumor necrosis factor (tnf)
  • tumour necrosis factor alpha-like (tnf-alpha)
  • tumor necrosis factor alpha (tnf-alpha)
  • lipopolysaccharide-induced TNF factor (LITAF)
  • tumor necrosis factor (TNF)
  • tumor necrosis factor (Tnf)
  • tumor necrosis factor alpha (TNF)
  • tumor necrosis factor b (TNF superfamily, member 2) (tnfb)
  • Cachectin protein
  • cTNF protein
  • DIF protein
  • RATTNF protein
  • tnf protein
  • TNF-a protein
  • Tnf-alpha protein
  • TNFa protein
  • tnfa-like protein
  • TNFalpha protein
  • Tnfsf1a protein
  • TNFSF2 protein
  • xtnf protein

Protein level used designations for Tumor Necrosis Factor Proteins (TNF)

tumor necrosis factor (TNF superfamily, member 2) , tumor necrosis factor alpha , tumor necrosis factor , tumour necrosis factor alpha , putative tumour necrosis factor alpha , LPS-induced TNF-alpha factor homolog , TNF-alpha factor , lipid-induced TNF-alpha factor , lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog , small integral membrane protein of lysosome/late endosome , tissue necrosis factor-alpha , APC1 protein , TNF, macrophage-derived , TNF, monocyte-derived , TNF-a , cachectin , tumor necrosis factor ligand superfamily member 2 , tumor necrosis factor-alpha , TNF-alpha , tumor-necrosis factor , tumour necrosis factor , ATP-binding cassette, sub-family F (GCN20), member 1 , TNF alpha , tumor necrosis factor, alpha , TNF2 , lta

GENE ID SPECIES
744399 Pan troglodytes
100136064 Oncorhynchus mykiss
100304592 Ictalurus punctatus
100134991 Xenopus (Silurana) tropicalis
100136034 Oncorhynchus mykiss
100137091 Salmo salar
374125 Gallus gallus
7124 Homo sapiens
21926 Mus musculus
24835 Rattus norvegicus
397086 Sus scrofa
280943 Bos taurus
443540 Ovis aries
100033834 Equus caballus
403922 Canis lupus familiaris
100135630 Cavia porcellus
100009088 Oryctolagus cuniculus
493755 Felis catus
715467 Macaca mulatta
100397484 Callithrix jacchus
101420445 Dasypus novemcinctus
494186 Pan troglodytes
101318178 Tursiops truncatus
100861232 Capra hircus
554167 Danio rerio
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