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Browse our Tumor Necrosis Factor Proteins (TNF)

Full name:
Tumor Necrosis Factor Proteins (TNF)
On www.antibodies-online.com are 255 Tumor Necrosis Factor (TNF) Proteins from 25 different suppliers available. Additionally we are shipping Tumor Necrosis Factor Antibodies (1180) and Tumor Necrosis Factor Kits (305) and many more products for this protein. A total of 1777 Tumor Necrosis Factor products are currently listed.
Synonyms:
Cachectin, cTNF, DIF, RATTNF, tnf, TNF-a, Tnf-alpha, TNFa, tnfa-like, TNFalpha, Tnfsf1a, TNFSF2, xtnf
list all proteins Gene Name GeneID UniProt
TNF 7124 P01375
Mouse TNF TNF 21926 P06804
Rat TNF TNF 24835 P16599

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Tumor Necrosis Factor Proteins (TNF) by Origin

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Top referenced Tumor Necrosis Factor Proteins

  1. Rat (Rattus) Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN2666709 : Kwon, Chung, Benveniste: Cloning and sequence analysis of the rat tumor necrosis factor-encoding genes. in Gene 1993 (PubMed)
    Show all 4 references for ABIN2666709

  2. Human Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN2666707 : Beutler, Cerami: Tumor necrosis, cachexia, shock, and inflammation: a common mediator. in Annual review of biochemistry 1988 (PubMed)
    Show all 4 references for ABIN2666707

  3. Rat (Rattus) Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN413826 : Muehlbauer, Lima, Goldman, Jacobson, Rivera, Goldberg, Palladino, Casadevall, Brojatsch: Proteasome inhibitors prevent caspase-1-mediated disease in rodents challenged with anthrax lethal toxin. in The American journal of pathology 2010 (PubMed)
    Show all 4 references for ABIN413826

  4. Human Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN1047828 : Pennica, Nedwin, Hayflick, Seeburg, Derynck, Palladino, Kohr, Aggarwal, Goeddel: Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin. in Nature 1985 (PubMed)
    Show all 4 references for ABIN1047828

  5. Human Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN413820 : Bhola, Simon: Determinism and divergence of apoptosis susceptibility in mammalian cells. in Journal of cell science 2009 (PubMed)
    Show all 4 references for ABIN413820

  6. Mouse (Murine) Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN1305135 : Hogan, Vogel: Production of tumor necrosis factor by rIFN-gamma-primed C3H/HeJ (Lpsd) macrophages requires the presence of lipid A-associated proteins. in Journal of immunology (Baltimore, Md. : 1950) 1989 (PubMed)
    Show all 3 references for ABIN1305135

  7. Cow (Bovine) Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN1047829 : Mertens, Muriuki, Gaidulis: Cloning of two members of the TNF-superfamily in cattle: CD40 ligand and tumor necrosis factor alpha. in Immunogenetics 1995 (PubMed)
    Show all 2 references for ABIN1047829

  8. Rat (Rattus) Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN1305133 : Jäättelä: Biologic activities and mechanisms of action of tumor necrosis factor-alpha/cachectin. in Laboratory investigation; a journal of technical methods and pathology 1991 (PubMed)
    Show all 2 references for ABIN1305133

  9. Human Tumor Necrosis Factor Protein expressed in HEK-293 Cells - ABIN2181833 : Dowlati, Herrmann, Swardfager, Liu, Sham, Reim, Lanctôt: A meta-analysis of cytokines in major depression. in Biological psychiatry 2010 (PubMed)

  10. Mouse (Murine) Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN413823 : Srivastava, Qin, Wedhas, Arnush, Linkhart, Chadwick, Kumar: Tumor necrosis factor-alpha augments matrix metalloproteinase-9 production in skeletal muscle cells through the activation of transforming growth factor-beta-activated kinase 1 (TAK1)-dependent signaling pathway. in The Journal of biological chemistry 2007 (PubMed)

More Proteins for Tumor Necrosis Factor Interaction Partners

Rainbow Trout (Oncorhynchus mykiss) Tumor Necrosis Factor (TNF) interaction partners

  1. Our findings demonstrate that TNF-alpha plays a pivotal role in HF-mediated neuroinflammation and associated alterations of cortical dendritic spine density and has the potential to reveal novel treatment strategies for HF-associated memory deficits.

  2. the present study assessed the combined impacts of estrogens and bacterial infection on the insulin (show INS Proteins)-like growth factors (IGF) and tumor-necrosis factor (TNF)-alpha.

  3. The expression of miR (show MYLIP Proteins)-125b-1 regulated by NF-kappaB (show NFKB1 Proteins) has been reported in diverse cell types under various stimuli, this study found that its expression was also significantly regulated by NF-kappaB (show NFKB1 Proteins) in TNFalpha-stimulated HeLa and HepG2 cells

  4. In the Han Chinese population, the allele 'A' of TNF-alpha -308 may increase the risk for osteoarthritis (OA), whereas TNF-alpha -238 polymorphisms do not play a role in OA patients.

  5. Letter: serum TNF-alpha was not elevated in chronic spontaneous urticaria.

  6. Metastatic cells can escape the proapoptotic effects of TNF-alpha through increased autocrine IL-6 (show IL6 Proteins)/STAT3 (show STAT3 Proteins) signaling

  7. The predicted 3D structures of IL-1beta (show IL1B Proteins), TNF-alpha, and IL-8 (show IL8 Proteins) from Oncorhynchus mykiss, Dicentrarchus labrax, and Chionodraco hamatus are reported and the differences between them and their mammalian counterparts investigated.

  8. The mitochondrial dysfunction may be caused by increased brain levels of TNFalpha without physiological stress but will be exacerbated after middle cerebral artery occlusion.

  9. TNF-alpha is released rapidly in trout macrophages after stimulation with lipopolysaccharide and zymosan, and its secretion is dependent on TACE (show ADAM17 Proteins)-like activity that is regulated by ERK (show MAPK1 Proteins), JNK (show MAPK8 Proteins) and p38MAPK (show MAPK14 Proteins) signaling pathways.

  10. Recombinant, as well as native trout TNF-alpha, directly stimulates glucose uptake in trout muscle cells and provide evidence, for the first time in nonmammalian vertebrates, for a potential regulatory role of TNF-alpha in skeletal muscle metabolism.

Human Tumor Necrosis Factor (TNF) interaction partners

  1. Polymorphisms within TNF-alpha are associated with recurrent pregnancy loss. [review]

  2. Findings support a strong evidence of association between the functional TNFA rs1800629 polymorphism and the risk of ulcerative colitis and inflammatory bowel disease susceptibility in Moroccan patients.

  3. Intracellular NAD+ levels are associated with LPS (show IRF6 Proteins)-induced TNF-alpha release in pro-inflammatory macrophages.

  4. Despite the lack of association observed for LEPR (show LEPR Proteins) Q223R and TNF-alpha G-308A, Indian and Chinese subjects with AA risk genotype for LEPR (show LEPR Proteins) Q223R/LEP (show LEP Proteins) G-2548A and TNF-alpha G-308A/LEP (show LEP Proteins) G-2548A, respectively, had increased mean BMI

  5. TNF increased significantly during short-term normobaric hypoxia.

  6. Association between Serum TNF-alpha Levels and Recurrent Spontaneous Miscarriage: A Meta-analysis

  7. Il-6 (show IL6 Proteins) CC genotype was more strongly associated with ischemic stroke than other two polymorphisms TNF-alpha and IL-10 (show IL10 Proteins) in our population.

  8. TNF gene polymorphism are associated with psoriasis.

  9. Serum TNF concentrations were significantly elevated in women with pre-eclampsia versus normotensive controls.

  10. Ultraviolet light-emitting-diode irradiation inhibits TNF-alpha and IFN-gamma-induced (show SAMHD1 Proteins) expression of ICAM-1 (show ICAM1 Proteins) and STAT1 (show STAT1 Proteins) phosphorylation in human keratinocytes.

Mouse (Murine) Tumor Necrosis Factor (TNF) interaction partners

  1. Activation of P2X7 (show P2RX7 Proteins) by ATP induced the release of TNFalpha from microglia which protected neurons from NMDA-induced excitotoxicity, might also account for neuroprotective properties of valproic acid

  2. In the presence of the LentisiTNFalphaOPG vector, the mRNA expression levels of the inflammatory factors and RANKL (show TNFSF11 Proteins) were downregulated, as were the protein levels of TNFalpha

  3. These findings thereby provide new mechanistic insight into the regulation of TXNIP (show TXNIP Proteins) and beta-cell biology and reveal novel links between proinflammatory cytokines, carbohydrate response element binding protein (show MLXIPL Proteins)-mediated transcription, and microRNA signaling.

  4. TLR2 increase the stimulating effect of beta2GP1/anti-beta2GP1 complex on the expression of TNF-alpha in mouse peritoneal macrophages.

  5. autophagy plays a key role in TiAl6V4 particle-induced osteolysis by promoting TNF-alpha expression

  6. Suggest TNF-alpha antagonism as strategy to manage experimental polycystic ovary.

  7. MEK (show MDK Proteins) inhibitors exerted distinct effects; one, CH5126766, potentiated TNF-alpha-induced apoptosis, and the others reduced cell death.

  8. IL-33 (show IL33 Proteins) promotes degranulation of bone marrow-derived mast cells and release of cytokines IL-1beta (show IL1B Proteins), IL-6 (show IL6 Proteins) and TNF-alpha.

  9. results suggest that LPS (show TLR4 Proteins)-stimulated macrophage mediators attenuate both FAK (show PTK2 Proteins) and Src (show SRC Proteins) activations in osteoblast, suggesting a novel role for TNFalpha on osteoblast performance

  10. Results show that excessive tumor necrosis factor (TNF) not only causes polyarthritis, but also heart valve disease.

Pig (Porcine) Tumor Necrosis Factor (TNF) interaction partners

  1. Both Nsp1beta and Nsp11 of porcine reproductive and respiratory syndrome virus were demonstrated to be responsible for the inhibitory effect on TNF-alpha production in pulmonary alveolar macrophages.

  2. Study presents evidence demonstrating a single species of exotoxin ApxI, derived from A. pleuropneumoniae serotype 10, induces the expression and production of proinflammatory cytokines IL-1beta (show IL1B Proteins), IL-8 (show IL8 Proteins) and TNF-alpha in porcine alveolar macrophages.

  3. the role of miR (show MYLIP Proteins)-181a in adipocyte differentiation by regulation of TNF-alpha

  4. The NOS inhibitor, L-NMMA, significantly suppressed the combined effects of HT and CORM-2 on TNFalpha-triggered NFkappaBp65 phosphorylation as well as decreased cell viability.

  5. High-volume hemofiltration improves hemodynamics and heart dysfunction in septic shock pigs, which may be attributed to reduction of TNF-alpha in myocardium but not in circulation.

  6. Basal lipogenesis was not affected by tumor necrosis factor alpha (TNFalpha) treatment; however, insulin (show INS Proteins) stimulated lipogenesis was reduced by TNFalpha. Interleukin 6 (show IL6 Proteins) and TNFalpha gene expression were acutely (2-4 h) stimulated by exogenous TNFalpha treatment.

  7. In swine, IL-8 (show IL8 Proteins), TNF-ALPHA, INOS (show NOS2 Proteins) AND MIP-1BETA (show CCL4 Proteins) were increased during mechanical ventilation in a time-related fashion.

  8. These data demonstrate that CRF (show CRH Proteins) triggers increases in intestinal paracellular permeability via mast cell dependent release of TNF-alpha and proteases.

  9. We identified critical amino acid residues in PRRSV Nsp1alpha and Nsp1beta that are important for TNF-alpha down-regulation and attenuation in vivo.

  10. Porcine reproductive and respiratory syndrome virus infection impaired TNF-alpha production by inhibiting ERK (show MAPK1 Proteins) signaling. pathway.

Cow (Bovine) Tumor Necrosis Factor (TNF) interaction partners

  1. Data suggest that luteolytic factors (such as TNFa, interferon gamma (show IFNG Proteins), and PGF2a) control expression of MMP1 (show MMP1 Proteins), other matrix metalloproteinases, and tissue inhibitors of metalloproteinase in cultured luteal cells.

  2. These results suggest that polymorphism of the TNFalpha-824 A>G gene and mTNFalpha protein expression play an important role in the pathogenesis of enzootic bovine leukosis.

  3. These results suggest that the endometrium might lower the TNF concentration in the blastocyst by (1) regulating TNF secretion into the uterine fluid and (2) inducing decreased TNF and TNFR2 (show TNFRSF1B Proteins) mRNA transcription in the embryo.

  4. There was a significant association between the proviral load and a low frequency of the G/G genotype of TNF-alpha at position -824.

  5. SNP in the TNF-alpha gene affects immune function and reproductive performance in dairy cows.

  6. Studied genotypic and expression profiling of partial TNF-alpha gene and its association with mastitis susceptibility in 129 crossbred cattle.

  7. Messenger RNA and protein levels of prostaglandin (PG) E synthase (PGES (show PTGES Proteins)), PGF2alpha receptor (PGFR), tumor necrosis factor-alpha (TNF) and Fas (show FAS Proteins) were found to be higher in the corpus luteum of pregnancy than in corpus luteum of the cycle.

  8. TNF-alpha up-regulates NaV1.7 (show SCN9A Proteins) mRNA in both adrenal chromaffin cells and dorsal root ganglia (DRG) neurons, highlighting the peripheral nociceptive mechanism of TNF-alpha

  9. These results provide evidence for a high prevalence of subclinical endometritis in repeat breeding cows as well as the involvement of TNFalpha and iNOS (show NOS2 Proteins) pathways in the regulation of this pathological condition.

  10. Exposure to follicular fluid transiently increased the transcript levels of IL8 (show IL8 Proteins) and PTGS2 (show PTGS2 Proteins), and decreased the expression of SOD2 (show SOD2 Proteins), GPX3 (show GPX3 Proteins), DAB2 (show DAB2 Proteins), and NR3C1 (show NR3C1 Proteins). TNF and IL6 (show IL6 Proteins) levels were also decreased while those of NAMPT (show NAMPT Proteins) were unaffected.

Horse (Equine) Tumor Necrosis Factor (TNF) interaction partners

  1. The results obtained showed that IL-6 (show IL6 Proteins) expression in adipose tissue biopsies derived from animals with equine metabolic syndrome was enhanced while TNF-alpha levels of both groups were comparable.

  2. Data indicate that tumor necrosis factor-alpha production is closely related to ovarian steroid actions.

  3. These results indicate that in equine corpus luteum, cytokines TNF, IFNG (show IFNG Proteins) and FASL (show FASL Proteins) regulate nitric oxide activity, via eNOS (show NOS3 Proteins) expression modulation.

  4. These data show the presence of cytokines TNF and IFNG (show IFNG Proteins), and their receptors, in the equine corpus luteum and indicate their potential involvement in regulation of luteal function.

  5. The contribution of bronchial epithelium to airway inflammation, with focus on mRNA and protein expression of IL-6 (show IL6 Proteins), IL-10 (show IL10 Proteins) and TNF-alpha, in horses with recurrent airway obstruction during exacerbation and in remission is reported.

Rabbit Tumor Necrosis Factor (TNF) interaction partners

  1. Inflammatory factors such as TNF-alpha can stimulate MMP-2 (show MMP2 Proteins)/9 activity in corneal epithelium cells. This may be a potential manipulating mechanism of MMP expression in the pathogenesis of corneal diseases.

  2. The JNK (show MAPK8 Proteins) pathway plays an important role in mechanical ventilation-stimulated TNF-alpha expression in alveolar macrophages, but the injury-stimulated IL-8 (show IL8 Proteins) expression may be regulated by other signaling pathways.

  3. The TNFalpha-evoked Cl- current.

  4. IL-1beta (show IL1B Proteins) and TNF-alpha expression increases significantly during acute lung injury. Ambroxol combined with low-dose heparin inhibits teh release of IL-1beta (show IL1B Proteins) and TNF-alpha.

  5. Hypercapnia increased expression of TNFa and decreased expression of NFKB in acute lung injury models.

  6. In the early stages of myocardial ischemia, bone marrow stem cells are mobilized and home to ischemic myocardium with a concomitant increase in expression of cytokines VEGF (show VEGFA Proteins) and TNFalpha.

  7. Ammonium perchlorate can increase gene expressions of types I, III collagens, TGF-beta(1 (show TGFB1 Proteins)) and TNF-alpha in lung of rabbits.

  8. TNFalpha may either be directly or indirectly involved in vascular damage following an embolic stroke. Moreover, TNFalpha may mediate some of the detrimental effects of tPA (show PLAT Proteins) on the vascular compartment

Rhesus Monkey Tumor Necrosis Factor (TNF) interaction partners

  1. These interactions result in the induction of the TNF signaling pathway, activation of apoptosis, and DNA-damage stress response.

  2. Findings showed that both mucosal compartments harbor similar percentages of memory CD4 (show CD4 Proteins)(+) T cells and displayed comparable cytokine TNF-alpha responses to mitogenic stimulations prior to infection.

  3. Primary role for IL-1beta (show IL1B Proteins) and TNF-alpha in the triggering of preterm labor associated with inflammation or infection.

Goat Tumor Necrosis Factor (TNF) interaction partners

  1. Data indicate that three single-nucleotide polymorphisms were identified in tumor necrosis factor-alpha (TNF-alpha) gene.

Zebrafish Tumor Necrosis Factor (TNF) interaction partners

  1. The results reveal a crucial role for TNFalpha/TNFR2 (show TNFRSF1B Proteins) axis in the protection of the skin against DUOX1 (show DUOX1 Proteins)-mediated oxidative stress.

  2. TNF alpha is the first molecule identified that is produced by dying retinal neurons and is necessary to induce Muller glia to proliferate in the zebrafish retinal regeneration response.

  3. The data suggest that Mycobacterium marinum SecA2 modulates adaptive immunity to promote granuloma stability, perhaps through induction of tumor necrosis factor alpha.

  4. TNF is not required for tuberculous granuloma formation, but maintains granuloma integrity indirectly by restricting mycobacterial growth within macrophages and preventing their necrosis.

  5. The main proinflammatory effects of fish TNF-alpha are mediated through the activation of endothelial cells and point to the complexity of the evolution that has taken place in the regulation of innate immunity by cytokines.

Tumor Necrosis Factor (TNF) Protein Profile

Protein Summary

This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.

Alternative names and synonyms associated with Tumor Necrosis Factor (TNF)

  • tumor necrosis factor (TNF superfamily, member 2) (TNF)
  • tumor necrosis factor (tnf)
  • tumour necrosis factor alpha-like (tnf-alpha)
  • tumor necrosis factor alpha (tnf-alpha)
  • lipopolysaccharide-induced TNF factor (LITAF)
  • tumor necrosis factor (TNF)
  • tumor necrosis factor (Tnf)
  • tumor necrosis factor alpha (TNF)
  • tumor necrosis factor b (TNF superfamily, member 2) (tnfb)
  • Cachectin protein
  • cTNF protein
  • DIF protein
  • RATTNF protein
  • tnf protein
  • TNF-a protein
  • Tnf-alpha protein
  • TNFa protein
  • tnfa-like protein
  • TNFalpha protein
  • Tnfsf1a protein
  • TNFSF2 protein
  • xtnf protein

Protein level used designations for Tumor Necrosis Factor Proteins (TNF)

tumor necrosis factor (TNF superfamily, member 2) , tumor necrosis factor alpha , tumor necrosis factor , tumour necrosis factor alpha , putative tumour necrosis factor alpha , LPS-induced TNF-alpha factor homolog , TNF-alpha factor , lipid-induced TNF-alpha factor , lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog , small integral membrane protein of lysosome/late endosome , tissue necrosis factor-alpha , APC1 protein , TNF, macrophage-derived , TNF, monocyte-derived , TNF-a , cachectin , tumor necrosis factor ligand superfamily member 2 , tumor necrosis factor-alpha , TNF-alpha , tumor-necrosis factor , tumour necrosis factor , ATP-binding cassette, sub-family F (GCN20), member 1 , TNF alpha , tumor necrosis factor, alpha , TNF2 , lta

GENE ID SPECIES
744399 Pan troglodytes
100136064 Oncorhynchus mykiss
100304592 Ictalurus punctatus
100134991 Xenopus (Silurana) tropicalis
100136034 Oncorhynchus mykiss
100137091 Salmo salar
374125 Gallus gallus
7124 Homo sapiens
21926 Mus musculus
24835 Rattus norvegicus
397086 Sus scrofa
280943 Bos taurus
443540 Ovis aries
100033834 Equus caballus
403922 Canis lupus familiaris
100135630 Cavia porcellus
100009088 Oryctolagus cuniculus
493755 Felis catus
715467 Macaca mulatta
100397484 Callithrix jacchus
101420445 Dasypus novemcinctus
494186 Pan troglodytes
101318178 Tursiops truncatus
100861232 Capra hircus
554167 Danio rerio
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