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Browse our ADAM10 Proteins (ADAM10)

Full name:
ADAM Metallopeptidase Domain 10 Proteins (ADAM10)
On are 20 ADAM Metallopeptidase Domain 10 (ADAM10) Proteins from 9 different suppliers available. Additionally we are shipping ADAM10 Antibodies (142) and ADAM10 Kits (43) and many more products for this protein. A total of 209 ADAM10 products are currently listed.
1700031C13Rik, ad10, ADAM-10, ADAM 10, Adam10, cd156c, HsT18717, kuz, kuzbanian, LOC100219653, madm, wu:fc03d12, xadam10
list all proteins Gene Name GeneID UniProt
ADAM10 11487 O35598
ADAM10 102 O14672
ADAM10 29650  

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ADAM10 Proteins (ADAM10) by Origin

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More Proteins for ADAM10 Interaction Partners

Mouse (Murine) ADAM Metallopeptidase Domain 10 (ADAM10) interaction partners

  1. this study shows that during positive selection in the spleen, B-cell receptor signaling causes immature type 1 transitional B cells to become receptive to Notch (show NOTCH1 Proteins) ligands via Taok3 (show TAOK3 Proteins)-mediated surface expression of ADAM10

  2. Thus, Leda-1/Pianp (show C12orf53 Proteins) is constitutively processed by proprotein convertases, sheddases including MMPs and ADAM10/17 and intramembrane protease gamma-secretase.

  3. ADAM10 was dispensable for alpha-toxin (show PLC Proteins)-dependent xenophagic targeting of S. aureus, whereas a role for alpha-toxin (show PLC Proteins) attack on the plasma membrane was confirmed.

  4. ADAM10 was essentially involved in maxillofacial bone development. ADAM10 conditional knock-out KO mice present craniofacial dysmorphia and bone defects. Impaired osteoblast differentiation,proliferation and apoptosis underlie the bone deformity.

  5. Newborn mice deficient in ADAM10 exhibited organ-specific vascular defects.

  6. Findings demonstrate the direct requirement of ADAM10 in cortical radial migration and reveal the underlying mechanism by linking ADAM10-initiated regulated intramembrane proteolysis of Notch (show NOTCH1 Proteins) to the regulation of microtubule cytoskeleton through transcriptional control of Dcx (show DCX Proteins) expression

  7. our data afford the new insight that miR (show MLXIP Proteins)-103a inhibited abdominal aortic aneurysm (AAA (show AAAS Proteins)) growth via targeting ADAM10, which might be a promising therapeutic strategy to alleviate AAA (show AAAS Proteins).

  8. ADAM10 gene was predominantly expressed in the neurons of the cerebral cortex, hippocampus, thalamus and cerebellar granular cells in adult mouse CNS.

  9. Matrix metalloproteases ADAM10 and TACE (ADAM17) cleave AXL receptor tyrosine (show AXL Proteins)kinase (Axl) in lupus-prone leukocytes.

  10. Loss of ADAM10 in murine liver results in hepatocyte necrosis and concomitant liver fibrosis. ADAM10 directly regulates expression of bile acid transporters but is dispensable for Notch2 (show NOTCH2 Proteins)-dependent formation of the biliary system. Differentiation of liver progenitor cells to hepatocytes is augmented in the absence of ADAM10.

Human ADAM Metallopeptidase Domain 10 (ADAM10) interaction partners

  1. 1,25D3 causes ectodomain shedding of TLR4 (show TLR4 Proteins) and thereby decreases the responsiveness of cells to LPS (show IRF6 Proteins). ADAM10, activated by extracellular Ca2 (show CA2 Proteins)+ influx, was implicated in the ectodomain cleavage of TLR4 (show TLR4 Proteins).

  2. The overexpression of MTERF4 induced a significant increase in the levels of APP protein and secreted Abeta 42 in HEK293-APPswe cells compared with control cells these results suggest that MTERF4 promotes the amyloidogenic processing of APP by inhibiting ADAM10 in HEK293-APPswe cells; therefore, MTERF4 may play an important role in the pathogenesis of Alzheimer's disease.

  3. Pre-incubation with simvastatin prior to treatment with IL-1beta (show IL1B Proteins) + Oncostatin M (show OSM Proteins) decreased the level of CD44 (show CD44 Proteins) fragmentation, decreased the proportion of CD44 (show CD44 Proteins) that transits into the lipid raft fractions, decreased ADAM10 activity and diminished the interaction between CD44 (show CD44 Proteins) and ADAM10.

  4. ADAM17 (show ADAM17 Proteins) and ADAM10 cleave Nectin-4 (show PVRL4 Proteins) and release soluble Nectin-4 (show PVRL4 Proteins) (sN4).

  5. Data show that mononuclear leukocytes (PBMC) AXL receptor tyrosine kinase (Axl (show AXL Proteins)) is rescued by combined matrix metalloproteases ADAM10 and TACE (ADAM17 (show ADAM17 Proteins)) inhibition.

  6. we found that ADAM10 expression was associated with a more rapid metastatic progression confirming its role in uveal melanoma metastasis.

  7. the TLR4 (show TLR4 Proteins)/Gal-1 (show LGALS1 Proteins) signaling pathway regulates lactate-mediated EMT (show ITK Proteins) processes through the activation of ADAM10 and ADAM17 (show ADAM17 Proteins) in colon cancer cells.

  8. Studies demonstrate a role for ADAM10 in the ectodomain shedding of LRP1 (show LRP1 Proteins) in the brain and the clearance of Abeta (show APP Proteins) across the blood-brain barrier, which may provide a novel strategy for attenuating Abeta (show APP Proteins) accumulation in the AD brain

  9. In response to trastuzumab, both HER3 (show ERBB3 Proteins) and the metalloprotease (show ADAM8 Proteins) ADAM10 are simultaneously upregulated. The proteolytic activity of the latter then releases the HER3 (show ERBB3 Proteins) ligand heregulin (show NRG1 Proteins) from the cell surface to activate HER3 (show ERBB3 Proteins) and confer resistance to trastuzumab by inducing compensatory growth factor receptor (show RYK Proteins) signaling.

  10. Active ADAM10 promotes the carcinogenesis, invasion, metastasis and proliferation of ESCC and controls invasion and metastasis at least in part through the shedding of E-cadherin (show CDH1 Proteins) activity.

Xenopus laevis ADAM Metallopeptidase Domain 10 (ADAM10) interaction partners

  1. A dramatic decline in ephrinB2 (show EFNB2 Proteins) protein levels on the absence of flotillin-1 (show FLOT1 Proteins) expression is specific, and is partly the result of an increased susceptibility to cleavage by the metalloprotease (show ADAM8 Proteins) ADAM10.

Pig (Porcine) ADAM Metallopeptidase Domain 10 (ADAM10) interaction partners

  1. significantly increased expression of ADAM10 in the ISR versus non-ISR segment in diabetic minipigs

Cow (Bovine) ADAM Metallopeptidase Domain 10 (ADAM10) interaction partners

  1. Data show that ADAM10 and APLP2 (show APLP2 Proteins) are expressed in proximal tubule cells, and that ADAM10 activity has a pronounced effect on expression of specific brush-border proteins.

  2. Intracellular trafficking of ADAM10 critically requires a novel sorting signal within its cytoplasmic domain.

  3. N-glycosylation is crucial for ADAM10 processing and resistance to proteolysis, and results suggest that it is required for full-enzyme activity.

ADAM10 Protein Profile

Protein Summary

Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin.

Alternative names and synonyms associated with ADAM10

  • a disintegrin and metalloprotease domain 10a (adam10a)
  • ADAM metallopeptidase domain 10 (ADAM10)
  • ADAM metallopeptidase domain 10 (LOC100219653)
  • ADAM metallopeptidase domain 10 (Adam10)
  • a disintegrin and metallopeptidase domain 10 (Adam10)
  • ADAM metallopeptidase domain 10 (adam10)
  • ADAM10 (LOC100101614)
  • 1700031C13Rik protein
  • ad10 protein
  • ADAM-10 protein
  • ADAM 10 protein
  • Adam10 protein
  • cd156c protein
  • HsT18717 protein
  • kuz protein
  • kuzbanian protein
  • LOC100219653 protein
  • madm protein
  • wu:fc03d12 protein
  • xadam10 protein

Protein level used designations for ADAM10

a disintegrin and metalloprotease domain 10a , ADAM metallopeptidase domain 10 , disintegrin and metalloproteinase domain-containing protein 10 , ADAM10 metallopeptidase , disintegrin and metalloproteinase domain-containing protein 10-like , ADAM 10 , a disintegrin and metalloprotease domain (ADAM) 10 , a disintegrin and metalloprotease domain 10 , kuzbanian protein homolog , mammalian disintegrin-metalloprotease , CDw156 , a disintegrin and metalloproteinase domain 10 , metalloprotease/disintegrin , xKuz , a disintegrin and metallopeptidase domain 10 , disintegrin-metalloproteinase , myelin-associated metalloproteinase

566044 Danio rerio
701355 Macaca mulatta
746942 Pan troglodytes
100068314 Equus caballus
100169741 Pongo abelii
100219653 Taeniopygia guttata
100313545 Saccoglossus kowalevskii
100476350 Ailuropoda melanoleuca
100606667 Nomascus leucogenys
11487 Mus musculus
102 Homo sapiens
399187 Xenopus laevis
29650 Rattus norvegicus
374113 Gallus gallus
478321 Canis lupus familiaris
397345 Sus scrofa
282132 Bos taurus
100718999 Cavia porcellus
100101614 Oryctolagus cuniculus
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