Browse our ADAM10 Proteins (ADAM10)

Full name:
ADAM Metallopeptidase Domain 10 Proteins (ADAM10)
On are 21 ADAM Metallopeptidase Domain 10 (ADAM10) Proteins from 10 different suppliers available. Additionally we are shipping ADAM10 Antibodies (168) and ADAM10 Kits (44) and many more products for this protein. A total of 237 ADAM10 products are currently listed.
1700031C13Rik, ad10, ADAM-10, ADAM 10, Adam10, cd156c, HsT18717, kuz, kuzbanian, LOC100219653, madm, wu:fc03d12, xadam10
list all proteins Gene Name GeneID UniProt
ADAM10 11487 O35598
ADAM10 102 O14672
ADAM10 29650  

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ADAM10 Proteins (ADAM10) by Origin

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More Proteins for ADAM10 Interaction Partners

Mouse (Murine) ADAM Metallopeptidase Domain 10 (ADAM10) interaction partners

  1. these results show that ADAM10-Notch (show NOTCH1 Proteins) signaling in ovarian somatic cells governs the primordial follicle formation by controlling the development of ovarian pregranulosa cells.

  2. Findings provide evidence that ADAM10, and not ADAM17 (show ADAM17 Proteins), is indispensable for proper retinal development as a regulator of NOTCH (show NOTCH1 Proteins) signaling.

  3. this study shows that during positive selection in the spleen, B-cell receptor signaling causes immature type 1 transitional B cells to become receptive to Notch (show NOTCH1 Proteins) ligands via Taok3 (show TAOK3 Proteins)-mediated surface expression of ADAM10

  4. Thus, Leda-1/Pianp (show C12orf53 Proteins) is constitutively processed by proprotein convertases, sheddases including MMPs and ADAM10/17 and intramembrane protease gamma-secretase.

  5. ADAM10 was dispensable for alpha-toxin (show PLC Proteins)-dependent xenophagic targeting of S. aureus, whereas a role for alpha-toxin (show PLC Proteins) attack on the plasma membrane was confirmed.

  6. ADAM10 was essentially involved in maxillofacial bone development. ADAM10 conditional knock-out KO mice present craniofacial dysmorphia and bone defects. Impaired osteoblast differentiation,proliferation and apoptosis underlie the bone deformity.

  7. Newborn mice deficient in ADAM10 exhibited organ-specific vascular defects.

  8. Findings demonstrate the direct requirement of ADAM10 in cortical radial migration and reveal the underlying mechanism by linking ADAM10-initiated regulated intramembrane proteolysis of Notch (show NOTCH1 Proteins) to the regulation of microtubule cytoskeleton through transcriptional control of Dcx (show DCX Proteins) expression

  9. our data afford the new insight that miR (show MLXIP Proteins)-103a inhibited abdominal aortic aneurysm (AAA (show AAAS Proteins)) growth via targeting ADAM10, which might be a promising therapeutic strategy to alleviate AAA (show AAAS Proteins).

  10. ADAM10 gene was predominantly expressed in the neurons of the cerebral cortex, hippocampus, thalamus and cerebellar granular cells in adult mouse CNS.

Human ADAM Metallopeptidase Domain 10 (ADAM10) interaction partners

  1. Regulation of ADAM10 by the TspanC8 subgroup of tetraspanins, namely Tspan5 (show TSPAN5 Proteins), 10, 14, 15, 17 and 33 is reviewed.

  2. active ADAM10 form marks cancer stem-like cells with active Notch (show NOTCH1 Proteins) signaling, known to mediate chemoresistance.

  3. Data show that tetraspanin 33 (tspan33 (show TSPAN33 Proteins)) is an early activation marker, and that disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) protein expression does not correlate with Tspan33 (show TSPAN33 Proteins) expression in B cells.

  4. High ADAM10 expression is associated with metastasis of hepatocellular carcinoma.

  5. The dysregulation of ADAM10, Fas (show FAS Proteins) and FasL (show FASL Proteins) could be useful indicators of the progression and severity of OSCC.

  6. 1,25D3 causes ectodomain shedding of TLR4 (show TLR4 Proteins) and thereby decreases the responsiveness of cells to LPS (show IRF6 Proteins). ADAM10, activated by extracellular Ca2 (show CA2 Proteins)+ influx, was implicated in the ectodomain cleavage of TLR4 (show TLR4 Proteins).

  7. The overexpression of MTERF4 induced a significant increase in the levels of APP protein and secreted Abeta 42 in HEK293-APPswe cells compared with control cells these results suggest that MTERF4 promotes the amyloidogenic processing of APP by inhibiting ADAM10 in HEK293-APPswe cells; therefore, MTERF4 may play an important role in the pathogenesis of Alzheimer's disease.

  8. Pre-incubation with simvastatin prior to treatment with IL-1beta (show IL1B Proteins) + Oncostatin M (show OSM Proteins) decreased the level of CD44 (show CD44 Proteins) fragmentation, decreased the proportion of CD44 (show CD44 Proteins) that transits into the lipid raft fractions, decreased ADAM10 activity and diminished the interaction between CD44 (show CD44 Proteins) and ADAM10.

  9. ADAM17 (show ADAM17 Proteins) and ADAM10 cleave Nectin-4 (show PVRL4 Proteins) and release soluble Nectin-4 (show PVRL4 Proteins) (sN4).

  10. Data show that mononuclear leukocytes (PBMC) AXL receptor tyrosine kinase (Axl (show AXL Proteins)) is rescued by combined matrix metalloproteases ADAM10 and TACE (ADAM17 (show ADAM17 Proteins)) inhibition.

Xenopus laevis ADAM Metallopeptidase Domain 10 (ADAM10) interaction partners

  1. A dramatic decline in ephrinB2 (show EFNB2 PLURAL_@34830@) protein levels on the absence of flotillin-1 (show FLOT1 PLURAL_@34830@) expression is specific, and is partly the result of an increased susceptibility to cleavage by the metalloprotease (show ADAM8 PLURAL_@34830@) ADAM10.

Pig (Porcine) ADAM Metallopeptidase Domain 10 (ADAM10) interaction partners

  1. significantly increased expression of ADAM10 in the ISR versus non-ISR segment in diabetic minipigs

Cow (Bovine) ADAM Metallopeptidase Domain 10 (ADAM10) interaction partners

  1. Data show that ADAM10 and APLP2 (show APLP2 Proteins) are expressed in proximal tubule cells, and that ADAM10 activity has a pronounced effect on expression of specific brush-border proteins.

  2. Intracellular trafficking of ADAM10 critically requires a novel sorting signal within its cytoplasmic domain.

  3. N-glycosylation is crucial for ADAM10 processing and resistance to proteolysis, and results suggest that it is required for full-enzyme activity.

ADAM10 Protein Profile

Protein Summary

Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin.

Alternative names and synonyms associated with ADAM10

  • a disintegrin and metalloprotease domain 10a (adam10a)
  • ADAM metallopeptidase domain 10 (ADAM10)
  • ADAM metallopeptidase domain 10 (LOC100219653)
  • ADAM metallopeptidase domain 10 (Adam10)
  • a disintegrin and metallopeptidase domain 10 (Adam10)
  • ADAM metallopeptidase domain 10 (adam10)
  • ADAM10 (LOC100101614)
  • 1700031C13Rik protein
  • ad10 protein
  • ADAM-10 protein
  • ADAM 10 protein
  • Adam10 protein
  • cd156c protein
  • HsT18717 protein
  • kuz protein
  • kuzbanian protein
  • LOC100219653 protein
  • madm protein
  • wu:fc03d12 protein
  • xadam10 protein

Protein level used designations for ADAM10

a disintegrin and metalloprotease domain 10a , ADAM metallopeptidase domain 10 , disintegrin and metalloproteinase domain-containing protein 10 , ADAM10 metallopeptidase , disintegrin and metalloproteinase domain-containing protein 10-like , ADAM 10 , a disintegrin and metalloprotease domain (ADAM) 10 , a disintegrin and metalloprotease domain 10 , kuzbanian protein homolog , mammalian disintegrin-metalloprotease , CDw156 , a disintegrin and metalloproteinase domain 10 , metalloprotease/disintegrin , xKuz , a disintegrin and metallopeptidase domain 10 , disintegrin-metalloproteinase , myelin-associated metalloproteinase

566044 Danio rerio
701355 Macaca mulatta
746942 Pan troglodytes
100068314 Equus caballus
100169741 Pongo abelii
100219653 Taeniopygia guttata
100313545 Saccoglossus kowalevskii
100476350 Ailuropoda melanoleuca
100606667 Nomascus leucogenys
11487 Mus musculus
102 Homo sapiens
399187 Xenopus laevis
29650 Rattus norvegicus
374113 Gallus gallus
478321 Canis lupus familiaris
397345 Sus scrofa
282132 Bos taurus
100718999 Cavia porcellus
100101614 Oryctolagus cuniculus
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