Browse our anti-ADAM17 (ADAM17) Antibodies

Full name:
anti-ADAM Metallopeptidase Domain 17 Antibodies (ADAM17)
On www.antibodies-online.com are 265 ADAM Metallopeptidase Domain 17 (ADAM17) Antibodies from 34 different suppliers available. Additionally we are shipping ADAM17 Kits (33) and ADAM17 Proteins (15) and many more products for this protein. A total of 322 ADAM17 products are currently listed.
Synonyms:
adam17, ADAM18, CD156B, CSVP, NISBD, si:dkey-81b15.2, Tace
list all antibodies Gene Name GeneID UniProt
ADAM17 11491 Q9Z0F8
ADAM17 6868 P78536
ADAM17 57027 Q9Z1K9

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Most Popular Reactivities for anti-ADAM17 (ADAM17) Antibodies

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anti-Mouse (Murine) ADAM17 Antibodies:

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Top referenced anti-ADAM17 Antibodies

  1. Human Polyclonal ADAM17 Primary Antibody for WB - ABIN264994 : Giegel, Chaplin: Targets in cytokine activation. in Agents and actions. Supplements 1998 (PubMed)
    Show all 6 references for 264994

  2. Human Monoclonal ADAM17 Primary Antibody for FACS - ABIN4897862 : Kermarrec, Selloum, Plantefeve, Chosidow, Paoletti, Lopez, Mantz, Desmonts, Gougerot-Pocidalo, Chollet-Martin: Regulation of peritoneal and systemic neutrophil-derived tumor necrosis factor-alpha release in patients with severe peritonitis: role of tumor necrosis factor-alpha converting enzyme cleavage. in Critical care medicine 2005 (PubMed)
    Show all 5 references for 4897862

  3. Human Monoclonal ADAM17 Primary Antibody for FACS - ABIN4897863 : Moreira-Tabaka, Peluso, Vonesch, Hentsch, Kessler, Reimund, Dumont, Muller: Unlike for human monocytes after LPS activation, release of TNF-α by THP-1 cells is produced by a TACE catalytically different from constitutive TACE. in PLoS ONE 2012 (PubMed)
    Show all 3 references for 4897863

  4. Human Polyclonal ADAM17 Primary Antibody for ELISA, WB - ABIN1531481 : Bilousova, Taylor, Emirzian, Gylys, Frautschy, Cole, Teng: Parallel age-associated changes in brain and plasma neuronal pentraxin receptor levels in a transgenic APP/PS1 rat model of Alzheimer's disease. in Neurobiology of disease 2015 (PubMed)
    Show all 3 references for 1531481

  5. Human Polyclonal ADAM17 Primary Antibody for FACS, WB - ABIN388309 : Tellier, Canault, Poggi, Bonardo, Nicolay, Alessi, Nalbone, Peiretti: HDLs activate ADAM17-dependent shedding. in Journal of cellular physiology 2007 (PubMed)
    Show all 2 references for 388309

  6. Human Polyclonal ADAM17 Primary Antibody for WB - ABIN388310 : Takamune, Ikebe, Nagano, Shinohara: Involvement of NF-kappaB-mediated maturation of ADAM-17 in the invasion of oral squamous cell carcinoma. in Biochemical and biophysical research communications 2007 (PubMed)
    Show all 2 references for 388310

  7. Human Polyclonal ADAM17 Primary Antibody for ELISA, WB - ABIN1536098 : Moss, Jin, Milla, Bickett, Burkhart, Carter, Chen, Clay, Didsbury, Hassler, Hoffman, Kost, Lambert, Leesnitzer, McCauley, McGeehan, Mitchell, Moyer, Pahel, Rocque, Overton, Schoenen, Seaton, Su et al.: Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha. ... in Nature 1997 (PubMed)
    Show all 2 references for 1536098

  8. Human Polyclonal ADAM17 Primary Antibody for ELISA, WB - ABIN184721 : Black, Rauch, Kozlosky, Peschon, Slack, Wolfson, Castner, Stocking, Reddy, Srinivasan, Nelson, Boiani, Schooley, Gerhart, Davis, Fitzner, Johnson, Paxton, March, Cerretti: A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells. in Nature 1997 (PubMed)

More Antibodies against ADAM17 Interaction Partners

Mouse (Murine) ADAM Metallopeptidase Domain 17 (ADAM17) interaction partners

  1. These results show that TACE is a target of, and is downregulated by, soluble TNF (show TNF Antibodies)-induced AP-2alpha (show TFAP2A Antibodies) transcription factor in dendritic cells

  2. the critical role of the transmembrane domains of ADAM17 and Rhbdf2 (show RHBDF2 Antibodies) in the regulation of the ADAM17 and EGFR (show EGFR Antibodies), and ADAM17 and TNFalpha (show TNF Antibodies) signaling pathways, was examined.

  3. Findings provide evidence that ADAM10 (show ADAM10 Antibodies), and not ADAM17, is indispensable for proper retinal development as a regulator of NOTCH (show NOTCH1 Antibodies) signaling.

  4. this study shows that the iRhom2 (show RHBDF2 Antibodies)/ADAM17 pathway plays an important role in regulating CSF1R (show CSF1R Antibodies) expression in the myeloid cell compartment at steady state, and in modulating development of monocytes/macrophages during their repopulation

  5. Suggest an atheroprotective role of ADAM17, which might be mediated by cleaving membrane-bound TNFalpha (show TNF Antibodies) and TNFR2 (show TNFRSF1B Antibodies), thereby preventing overactivation of endogenous TNFR2 (show TNFRSF1B Antibodies) signaling in cells of the vasculature.

  6. Aging and obesity cooperatively reduce caveolin-1 (show CAV1 Antibodies) expression and increase vascular endothelial ADAM17 activity and soluble TNF (show TNF Antibodies) release in adipose tissue, which may contribute to the development of remote coronary microvascular dysfunction in older obese patients.

  7. Thus, Leda-1/Pianp (show C12orf53 Antibodies) is constitutively processed by proprotein convertases, sheddases including MMPs and ADAM10 (show ADAM10 Antibodies)/17 and intramembrane protease gamma-secretase.

  8. Matrix metalloproteases ADAM10 and TACE (ADAM17) cleave AXL receptor tyrosine (show AXL Antibodies)kinase (Axl) in lupus-prone leukocytes.

  9. These findings suggest that maintaining ADAM17-EGFR (show EGFR Antibodies) epithelial signaling is necessary for the recovery from UC and would be beneficial to therapeutic strategies targeting ADAM17-mediated TNF-a (show TNF Antibodies) shedding.

  10. Data show that caveolin 1 (CAV1 (show CAV1 Antibodies)) is required for transforming growth factor-beta (TGF-beta)-induced reactive oxygen species production, mediated by NADPH oxidase (show NOX1 Antibodies) NOX1 (show NOX1 Antibodies), that is necessary for a disintegrin and metalloproteinase 17 (ADAM17) activation.

Human ADAM Metallopeptidase Domain 17 (ADAM17) interaction partners

  1. TNF-alpha-converting enzyme -mediated cleavage of soluble RANKL (show TNFSF11 Antibodies) from activated lymphocytes, especially B cells, can promote osteoclastogenesis in periodontitis.

  2. Cell stimulation can downregulate expression of mature ADAM17 from the cell surface and induce release of exosomal ADAM17, which can then distribute and contribute to substrate shedding on more distant cells.

  3. Aging and obesity cooperatively reduce caveolin-1 (show CAV1 Antibodies) expression and increase vascular endothelial ADAM17 activity and soluble TNF (show TNF Antibodies) release in adipose tissue, which may contribute to the development of remote coronary microvascular dysfunction in older obese patients.

  4. Our data demonstrated that elevated serum Semaphorin5A (Sema5A (show SEMA5A Antibodies)) in SLE patients correlated with disease activity and are involved in kidney and blood system damage; ADAM17 might be involved in the release of secreted Sema5A (show SEMA5A Antibodies).

  5. ADAM17 and ADAM10 (show ADAM10 Antibodies) cleave Nectin-4 (show PVRL4 Antibodies) and release soluble Nectin-4 (show PVRL4 Antibodies) (sN4).

  6. ADAM17 promotes epithelial-mesenchymal transition via the TGF-beta (show TGFB1 Antibodies)/Smad (show SMAD1 Antibodies) pathway. the present study demonstrates that ADAM17 plays a critical role in the development of gastric cancer and provides a potential therapeutic target for gastric cancer.

  7. FHL2 (show FHL2 Antibodies) interacts with ADAM-17 in normal, dysplastic and malignant colon epithelial cells. Colocalisation of these proteins is more frequent in malignant than in normal and dysplastic cells, suggesting a role for ADAM-17/FHL2 (show FHL2 Antibodies) complex in the development of colorectal cancer.

  8. The present study suggests that ADAM17-siRNA inhibits MCF-7 breast cancer and is activated through the EGFR (show EGFR Antibodies)-PI3K (show PIK3CA Antibodies)-AKT (show AKT1 Antibodies) signaling pathway

  9. Data show that mononuclear leukocytes (PBMC) AXL receptor tyrosine kinase (Axl (show AXL Antibodies)) is rescued by combined matrix metalloproteases ADAM10 (show ADAM10 Antibodies) and TACE (ADAM17) inhibition.

  10. the TLR4 (show TLR4 Antibodies)/Gal-1 (show LGALS1 Antibodies) signaling pathway regulates lactate-mediated EMT (show ITK Antibodies) processes through the activation of ADAM10 (show ADAM10 Antibodies) and ADAM17 in colon cancer cells.

Pig (Porcine) ADAM Metallopeptidase Domain 17 (ADAM17) interaction partners

  1. ADAM17 was involved in porcine CD16 (show CD16 Antibodies) shedding in porcine reproductive and respiratory syndrome virus-infected pigs.

  2. Overexpression of ADAM17 induced downregulation of CD163 (show CD163 Antibodies) expression and a reduction in reproductive and respiratory syndrome virus infection.

  3. activation of TACE/ADAM17 via a PKC (show FYN Antibodies)-induced c-Src (show SRC Antibodies)-dependent manner mediates proteolytic activation of the EGF (show EGF Antibodies)-like factors that are involved in the induction of granulosa cell differentiation, cumulus expansion, and meiotic maturation of porcine oocytes

  4. Data indicate that TNF-alpha (show TNF Antibodies) stimulates Rac (show AKT1 Antibodies), ADAM17/TACE, and RhoA (show RHOA Antibodies) through the guanine nucleotide exchange factor (show ARHGEF12 Antibodies) (GEF)-H1 (show ARHGEF2 Antibodies).

  5. progesterone-induced TACE/ADAM17 leads to production of soluble EGF (show EGF Antibodies) domain from cumulus cells, which enhances functional changes of cumulus cells and progresses meiotic maturation of oocytes

ADAM17 Antigen Profile

Antigen Summary

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme\; binds mitotic arrest deficient 2 protein\; and also plays a prominent role in the activation of the Notch signaling pathway.

Alternative names and synonyms associated with ADAM17

  • ADAM metallopeptidase domain 17 (ADAM17) antibody
  • a disintegrin and metallopeptidase domain 17b (adam17b) antibody
  • ADAM metallopeptidase domain 17 (adam17) antibody
  • a disintegrin and metallopeptidase domain 17 (Adam17) antibody
  • ADAM metallopeptidase domain 17 (Adam17) antibody
  • adam17 antibody
  • ADAM18 antibody
  • CD156B antibody
  • CSVP antibody
  • NISBD antibody
  • si:dkey-81b15.2 antibody
  • Tace antibody

Protein level used designations for ADAM17

ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) , a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme) , disintegrin and metalloproteinase domain-containing protein 17 , tumor necrosis factor alpha converting enzyme , a disintegrin and metallopeptidase domain 17 , ADAM metallopeptidase domain 17 , a disintegrin and metalloprotease domain 17 , disintegrin metalloproteinase , disintegrin and metalloproteinase domain-containing protein 17-like , ADAM 17 , TNF-alpha convertase , TNF-alpha converting enzyme , TNF-alpha-converting enzyme , a disintegrin and metalloprotease domain 17; TNF-alpha converting enzyme , a disintegrin and metalloproteinase domain 17 , ADAM metallopeptidase domain 18 , snake venom-like protease , tumor necrosis factor, alpha, converting enzyme

GENE ID SPECIES
421931 Gallus gallus
459018 Pan troglodytes
560657 Danio rerio
694429 Macaca mulatta
733430 Xenopus laevis
100072496 Equus caballus
100406520 Callithrix jacchus
100482770 Ailuropoda melanoleuca
11491 Mus musculus
6868 Homo sapiens
57027 Rattus norvegicus
475662 Canis lupus familiaris
397343 Sus scrofa
517541 Bos taurus
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