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Browse our anti-ADAM17 (ADAM17) Antibodies

Full name:
anti-ADAM Metallopeptidase Domain 17 Antibodies (ADAM17)
On are 255 ADAM Metallopeptidase Domain 17 (ADAM17) Antibodies from 33 different suppliers available. Additionally we are shipping ADAM17 Kits (32) and ADAM17 Proteins (15) and many more products for this protein. A total of 310 ADAM17 products are currently listed.
adam17, ADAM18, CD156B, CSVP, NISBD, si:dkey-81b15.2, Tace
list all antibodies Gene Name GeneID UniProt
ADAM17 11491 Q9Z0F8
ADAM17 6868 P78536
ADAM17 57027 Q9Z1K9

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Most Popular Reactivities for anti-ADAM17 (ADAM17) Antibodies

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anti-Mouse (Murine) ADAM17 Antibodies:

anti-Human ADAM17 Antibodies:

anti-Rat (Rattus) ADAM17 Antibodies:

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Top referenced anti-ADAM17 Antibodies

  1. Human Polyclonal ADAM17 Primary Antibody for WB - ABIN264994 : Giegel, Chaplin: Targets in cytokine activation. in Agents and actions. Supplements 1998 (PubMed)
    Show all 6 references for ABIN264994

  2. Human Polyclonal ADAM17 Primary Antibody for EIA, IF - ABIN500861 : Black, Rauch, Kozlosky, Peschon, Slack, Wolfson, Castner, Stocking, Reddy, Srinivasan, Nelson, Boiani, Schooley, Gerhart, Davis, Fitzner, Johnson, Paxton, March, Cerretti: A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells. in Nature 1997 (PubMed)
    Show all 6 references for ABIN500861

  3. Human Polyclonal ADAM17 Primary Antibody for ELISA, WB - ABIN1531481 : Bilousova, Taylor, Emirzian, Gylys, Frautschy, Cole, Teng: Parallel age-associated changes in brain and plasma neuronal pentraxin receptor levels in a transgenic APP/PS1 rat model of Alzheimer's disease. in Neurobiology of disease 2015 (PubMed)
    Show all 3 references for ABIN1531481

  4. Human Polyclonal ADAM17 Primary Antibody for FACS, WB - ABIN388309 : Tellier, Canault, Poggi, Bonardo, Nicolay, Alessi, Nalbone, Peiretti: HDLs activate ADAM17-dependent shedding. in Journal of cellular physiology 2007 (PubMed)
    Show all 2 references for ABIN388309

  5. Human Polyclonal ADAM17 Primary Antibody for WB - ABIN388310 : Takamune, Ikebe, Nagano, Shinohara: Involvement of NF-kappaB-mediated maturation of ADAM-17 in the invasion of oral squamous cell carcinoma. in Biochemical and biophysical research communications 2007 (PubMed)
    Show all 2 references for ABIN388310

  6. Human Polyclonal ADAM17 Primary Antibody for ELISA, WB - ABIN1536098 : Moss, Jin, Milla, Bickett, Burkhart, Carter, Chen, Clay, Didsbury, Hassler, Hoffman, Kost, Lambert, Leesnitzer, McCauley, McGeehan, Mitchell, Moyer, Pahel, Rocque, Overton, Schoenen, Seaton, Su et al.: Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha. ... in Nature 1997 (PubMed)
    Show all 2 references for ABIN1536098

More Antibodies against ADAM17 Interaction Partners

Mouse (Murine) ADAM Metallopeptidase Domain 17 (ADAM17) interaction partners

  1. Matrix metalloproteases ADAM10 and TACE (ADAM17) cleave AXL receptor tyrosine (show AXL Antibodies)kinase (Axl) in lupus-prone leukocytes.

  2. These findings suggest that maintaining ADAM17-EGFR (show EGFR Antibodies) epithelial signaling is necessary for the recovery from UC and would be beneficial to therapeutic strategies targeting ADAM17-mediated TNF-a (show TNF Antibodies) shedding.

  3. Data show that caveolin 1 (CAV1 (show CAV1 Antibodies)) is required for transforming growth factor-beta (TGF-beta)-induced reactive oxygen species production, mediated by NADPH oxidase (show NOX1 Antibodies) NOX1 (show NOX1 Antibodies), that is necessary for a disintegrin and metalloproteinase 17 (ADAM17) activation.

  4. ADAM12 (show ADAM12 Antibodies) and ADAM17 are essential molecules for the impairment of barrier function of retinal vasculature under hypoxia.

  5. 4-Hydroxyisoleucine improved insulin (show INS Antibodies) resistant-like state in 3T3-L1 adipocytes by targeting TACE/TIMP3 (show TIMP3 Antibodies) and the insulin (show INS Antibodies) signaling pathway.

  6. Hypercapnic acidosis blocks stretch-mediated activation of ADAM17. ADAM17 is an important proximal mediator of ventilator-induced lung injury.

  7. Lrig2 has a role in negative regulation of ectodomain shedding of axon guidance receptors by ADAM17 protease

  8. Overexpression of ADAM17 increases shed ACE2 (show ACE2 Antibodies) and decreases cellular ACE2 (show ACE2 Antibodies) levels in pancreatic islets. Whereas ADAM17 has the ability to shed ACE2 (show ACE2 Antibodies), ADAM17 does not deplete ACE2 (show ACE2 Antibodies) from pancreatic islets in diabetic db/db (show LEPR Antibodies) mice.

  9. established that endogenous IL-6R of both human and murine origin is shed by ADAM17 in an induced manner, whereas constitutive release of endogenous IL-6R is largely mediated by ADAM10 (show ADAM10 Antibodies)

  10. These data demonstrated that ADAM17 contributed to microglial cell survival, predominantly by EGFR (show EGFR Antibodies) signalling, following spinal cord injury

Human ADAM Metallopeptidase Domain 17 (ADAM17) interaction partners

  1. Our data demonstrated that elevated serum Semaphorin5A (Sema5A (show SEMA5A Antibodies)) in SLE patients correlated with disease activity and are involved in kidney and blood system damage; ADAM17 might be involved in the release of secreted Sema5A (show SEMA5A Antibodies).

  2. ADAM17 and ADAM10 (show ADAM10 Antibodies) cleave Nectin-4 (show PVRL4 Antibodies) and release soluble Nectin-4 (show PVRL4 Antibodies) (sN4).

  3. ADAM17 promotes epithelial-mesenchymal transition via the TGF-beta (show TGFB1 Antibodies)/Smad (show SMAD1 Antibodies) pathway. the present study demonstrates that ADAM17 plays a critical role in the development of gastric cancer and provides a potential therapeutic target for gastric cancer.

  4. FHL2 (show FHL2 Antibodies) interacts with ADAM-17 in normal, dysplastic and malignant colon epithelial cells. Colocalisation of these proteins is more frequent in malignant than in normal and dysplastic cells, suggesting a role for ADAM-17/FHL2 (show FHL2 Antibodies) complex in the development of colorectal cancer.

  5. The present study suggests that ADAM17-siRNA inhibits MCF-7 breast cancer and is activated through the EGFR (show EGFR Antibodies)-PI3K (show PIK3CA Antibodies)-AKT (show AKT1 Antibodies) signaling pathway

  6. Data show that mononuclear leukocytes (PBMC) AXL receptor tyrosine kinase (Axl (show AXL Antibodies)) is rescued by combined matrix metalloproteases ADAM10 (show ADAM10 Antibodies) and TACE (ADAM17) inhibition.

  7. the TLR4 (show TLR4 Antibodies)/Gal-1 (show LGALS1 Antibodies) signaling pathway regulates lactate-mediated EMT (show ITK Antibodies) processes through the activation of ADAM10 (show ADAM10 Antibodies) and ADAM17 in colon cancer cells.

  8. The HNE-TACE signalling pathway has an important role in the process of MUC5AC overexpression in chronic rhinosinusitis.

  9. The inhibition of cell proliferation and invasion was observed in the ADAM17 knockdown cells, which was associated with modulation of the EGFR (show EGFR Antibodies) signalling pathway.

  10. ADAM17 expression was increased in the sepsis patients with the rs12692386 GA/GG genotypes, accompanied by up-regulation of expression of the ADAM17 substrates (TNF-alpha (show TNF Antibodies), IL-6R and CX3CL1 (show CX3CL1 Antibodies)) and pro-inflammatory cytokines (IL-1beta (show IL1B Antibodies) and IL-6 (show IL6 Antibodies)).

Pig (Porcine) ADAM Metallopeptidase Domain 17 (ADAM17) interaction partners

  1. ADAM17 was involved in porcine CD16 (show CD16 Antibodies) shedding in porcine reproductive and respiratory syndrome virus-infected pigs.

  2. Overexpression of ADAM17 induced downregulation of CD163 (show CD163 Antibodies) expression and a reduction in reproductive and respiratory syndrome virus infection.

  3. activation of TACE/ADAM17 via a PKC (show FYN Antibodies)-induced c-Src (show SRC Antibodies)-dependent manner mediates proteolytic activation of the EGF (show EGF Antibodies)-like factors that are involved in the induction of granulosa cell differentiation, cumulus expansion, and meiotic maturation of porcine oocytes

  4. Data indicate that TNF-alpha (show TNF Antibodies) stimulates Rac (show AKT1 Antibodies), ADAM17/TACE, and RhoA (show RHOA Antibodies) through the guanine nucleotide exchange factor (show ARHGEF12 Antibodies) (GEF)-H1 (show ARHGEF2 Antibodies).

  5. progesterone-induced TACE/ADAM17 leads to production of soluble EGF (show EGF Antibodies) domain from cumulus cells, which enhances functional changes of cumulus cells and progresses meiotic maturation of oocytes

ADAM17 Antigen Profile

Antigen Summary

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme\; binds mitotic arrest deficient 2 protein\; and also plays a prominent role in the activation of the Notch signaling pathway.

Alternative names and synonyms associated with ADAM17

  • ADAM metallopeptidase domain 17 (ADAM17) antibody
  • a disintegrin and metallopeptidase domain 17b (adam17b) antibody
  • ADAM metallopeptidase domain 17 (adam17) antibody
  • a disintegrin and metallopeptidase domain 17 (Adam17) antibody
  • ADAM metallopeptidase domain 17 (Adam17) antibody
  • adam17 antibody
  • ADAM18 antibody
  • CD156B antibody
  • CSVP antibody
  • NISBD antibody
  • si:dkey-81b15.2 antibody
  • Tace antibody

Protein level used designations for ADAM17

ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) , a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme) , disintegrin and metalloproteinase domain-containing protein 17 , tumor necrosis factor alpha converting enzyme , a disintegrin and metallopeptidase domain 17 , ADAM metallopeptidase domain 17 , a disintegrin and metalloprotease domain 17 , disintegrin metalloproteinase , disintegrin and metalloproteinase domain-containing protein 17-like , ADAM 17 , TNF-alpha convertase , TNF-alpha converting enzyme , TNF-alpha-converting enzyme , a disintegrin and metalloprotease domain 17; TNF-alpha converting enzyme , a disintegrin and metalloproteinase domain 17 , ADAM metallopeptidase domain 18 , snake venom-like protease , tumor necrosis factor, alpha, converting enzyme

421931 Gallus gallus
459018 Pan troglodytes
560657 Danio rerio
694429 Macaca mulatta
733430 Xenopus laevis
100072496 Equus caballus
100406520 Callithrix jacchus
100482770 Ailuropoda melanoleuca
11491 Mus musculus
6868 Homo sapiens
57027 Rattus norvegicus
475662 Canis lupus familiaris
397343 Sus scrofa
517541 Bos taurus
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