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anti-Mouse (Murine) ADAM17 Antibodies:
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Human Monoclonal ADAM17 Primary Antibody for CyTOF, FACS - ABIN4900516
Breshears, Schlievert, Peterson: A disintegrin and metalloproteinase 17 (ADAM17) and epidermal growth factor receptor (EGFR) signaling drive the epithelial response to Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1). in The Journal of biological chemistry 2012
Show all 8 Pubmed References
Human Monoclonal ADAM17 Primary Antibody for CyTOF, FACS - ABIN4900517
Zingoni, Cecere, Vulpis, Fionda, Molfetta, Soriani, Petrucci, Ricciardi, Fuerst, Amendola, Mytilineos, Cerboni, Paolini, Cippitelli, Santoni: Genotoxic Stress Induces Senescence-Associated ADAM10-Dependent Release of NKG2D MIC Ligands in Multiple Myeloma Cells. in Journal of immunology (Baltimore, Md. : 1950) 2015
Show all 8 Pubmed References
Human Monoclonal ADAM17 Primary Antibody for FACS - ABIN4897862
Kermarrec, Selloum, Plantefeve, Chosidow, Paoletti, Lopez, Mantz, Desmonts, Gougerot-Pocidalo, Chollet-Martin: Regulation of peritoneal and systemic neutrophil-derived tumor necrosis factor-alpha release in patients with severe peritonitis: role of tumor necrosis factor-alpha converting enzyme cleavage. in Critical care medicine 2005
Show all 5 Pubmed References
Human Polyclonal ADAM17 Primary Antibody for IHC - ABIN965510
Rabie, Strehl, Ludwig, Nieswandt: Evidence for a role of ADAM17 (TACE) in the regulation of platelet glycoprotein V. in The Journal of biological chemistry 2005
Show all 12 Pubmed References
Human Monoclonal ADAM17 Primary Antibody for FACS - ABIN4897863
Moreira-Tabaka, Peluso, Vonesch, Hentsch, Kessler, Reimund, Dumont, Muller: Unlike for human monocytes after LPS activation, release of TNF-α by THP-1 cells is produced by a TACE catalytically different from constitutive TACE. in PLoS ONE 2012
Show all 3 Pubmed References
Human Polyclonal ADAM17 Primary Antibody for ICC, ELISA - ABIN1003300
Moss, Jin, Milla, Bickett, Burkhart, Carter, Chen, Clay, Didsbury, Hassler, Hoffman, Kost, Lambert, Leesnitzer, McCauley, McGeehan, Mitchell, Moyer, Pahel, Rocque, Overton, Schoenen, Seaton, Su et al.: Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha. ... in Nature 1997
Show all 4 Pubmed References
Human Polyclonal ADAM17 Primary Antibody for FACS, IF (p) - ABIN705671
Li, Xie, He, Wang, Duan, Yang, Wang: Identification of ADAM10 and ADAM17 with potential roles in the spermatogenesis of the Chinese mitten crab, Eriocheir sinensis. in Gene 2015
Human Polyclonal ADAM17 Primary Antibody for ELISA, WB - ABIN249487
Black, Rauch, Kozlosky, Peschon, Slack, Wolfson, Castner, Stocking, Reddy, Srinivasan, Nelson, Boiani, Schooley, Gerhart, Davis, Fitzner, Johnson, Paxton, March, Cerretti: A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells. in Nature 1997
Human Polyclonal ADAM17 Primary Antibody for ELISA, WB - ABIN1531481
Bilousova, Taylor, Emirzian, Gylys, Frautschy, Cole, Teng: Parallel age-associated changes in brain and plasma neuronal pentraxin receptor levels in a transgenic APP/PS1 rat model of Alzheimer's disease. in Neurobiology of disease 2015
Show all 3 Pubmed References
Human Polyclonal ADAM17 Primary Antibody for ICC, ELISA - ABIN1003301
Rosendahl, Ko, Long, Brewer, Rosenzweig, Hedl, Anderson, Pyle, Moreland, Meyers, Kohno, Lyons, Lichenstein: Identification and characterization of a pro-tumor necrosis factor-alpha-processing enzyme from the ADAM family of zinc metalloproteases. in The Journal of biological chemistry 1997
Show all 3 Pubmed References
Xenoestrogens biphenol-A and nonylphenol stimulate the release of EGFR (show EGFR Antibodies)-ligands by differentially activating ADAM17 or ADAM10 (show ADAM10 Antibodies).
Fhl2 (show FHL2 Antibodies) anticipates the emerging inflammation and specifically the development of psoriatic arthritis by impeding the Adam17-mediated release of TNF (show TNF Antibodies)
most defects in formation of the postnatal epidermal barrier upon keratinocyte-specific ADAM17 deletion are mediated via EGFR (show EGFR Antibodies)
ADAM17 is either not required in T cells under homoeostatic conditions and for control of listeria infection or can be effectively compensated by other mechanisms
In a clinically relevant CADASIL (show NOTCH3 Antibodies) mouse model, we show that exogenous ADAM17 or HB-EGF (show HBEGF Antibodies) restores cerebral arterial tone and blood flow responses, and identify upregulated voltage-dependent potassium channel (show KCNAB2 Antibodies) (KV) number in cerebral arterial myocytes as a heretofore-unrecognized downstream effector of TIMP3 (show TIMP3 Antibodies)-induced deficits.
Conditional ADAM17 knockout mice lacking ADAM17 in all leukocytes had a significant survival advantage during severe polymicrobial sepsis induced by CLP, associated with enhanced neutrophil recruitment at the infectious locus along with decreased bacterial spread and circulating levels of proinflammatory factors. Its induction during sepsis may tip the balance between efficient and impaired neutrophil recruitment.
These results demonstrate a novel physiologic role for a disintegrin and metalloprotease 17 in regulating murine IL-6 (show IL6 Antibodies) signals during inflammatory processes.
These results show that TACE is a target of, and is downregulated by, soluble TNF (show TNF Antibodies)-induced AP-2alpha (show TFAP2A Antibodies) transcription factor in dendritic cells
the critical role of the transmembrane domains of ADAM17 and Rhbdf2 (show RHBDF2 Antibodies) in the regulation of the ADAM17 and EGFR (show EGFR Antibodies), and ADAM17 and TNFalpha (show TNF Antibodies) signaling pathways, was examined.
Findings provide evidence that ADAM10 (show ADAM10 Antibodies), and not ADAM17, is indispensable for proper retinal development as a regulator of NOTCH (show NOTCH1 Antibodies) signaling.
FoxM1 (show FOXM1 Antibodies) regulates the expression of ADAM-17, which is upregulated in gastric carcinoma.
Glypican-1 (show GPC1 Antibodies) was validated as a novel substrate for ADAM17, with important function in adhesion, proliferation and migration of carcinoma cells.
the chaperone 78-kDa glucose-regulated protein (GRP78 (show HSPA5 Antibodies)) protects the MPD (show MVD Antibodies) against PDI (show PADI1 Antibodies)-dependent disulfide-bond isomerization by binding to this domain and, thereby, preventing ADAM17 inhibition.
The ADAM17 messenger RNA (mRNA) and protein levels were significantly higher in the inferior turbinate than in nasal polyps (p < 0.05). The ADAM10 (show ADAM10 Antibodies) mRNA and protein levels did not differ significantly between NPs (show NPS Antibodies) and inferior turbinates (p > 0.05). ADAM10 (show ADAM10 Antibodies) and ADAM17 were expressed primarily in inflammatory cells, submucosal glandular cells, and lining epithelial cells.
The iRhom2 (show RHBDF2 Antibodies) N-terminus stabilizes mature ADAM17 at the cell surface where it cleaves TNF (show TNF Antibodies) and EGFR (show EGFR Antibodies) in inflammatory and innate immune responses. (Review)
inhibition of ADAM17 enhanced the purity of expanded NK cells and the antibody-dependent cellular cytotoxicity activity of these cells against trastuzumab treated breast cancer cell lines.
hypoxia instigates the RSK1 (show RPS6KA1 Antibodies)-dependent C/EBPbeta (show CEBPB Antibodies) signaling pathway, which in turn initiates binding of C/EBPbeta (show CEBPB Antibodies) to the ADAM 17 promoter and ultimately induces ADAM 17 expression in human lung fibroblasts.
TNF-alpha-converting enzyme -mediated cleavage of soluble RANKL (show TNFSF11 Antibodies) from activated lymphocytes, especially B cells, can promote osteoclastogenesis in periodontitis.
Cell stimulation can downregulate expression of mature ADAM17 from the cell surface and induce release of exosomal ADAM17, which can then distribute and contribute to substrate shedding on more distant cells.
Aging and obesity cooperatively reduce caveolin-1 (show CAV1 Antibodies) expression and increase vascular endothelial ADAM17 activity and soluble TNF (show TNF Antibodies) release in adipose tissue, which may contribute to the development of remote coronary microvascular dysfunction in older obese patients.
these findings provide the direct evidence that ADAM17 cleaves porcine TNFalpha (show TNF Antibodies), which represents a new view for identifying potential therapeutic targets in anti-porcine reproductive and respiratory syndrome virus therapy
ADAM17 was involved in porcine CD16 (show CD16 Antibodies) shedding in porcine reproductive and respiratory syndrome virus-infected pigs.
Overexpression of ADAM17 induced downregulation of CD163 (show CD163 Antibodies) expression and a reduction in reproductive and respiratory syndrome virus infection.
activation of TACE/ADAM17 via a PKC (show FYN Antibodies)-induced c-Src (show SRC Antibodies)-dependent manner mediates proteolytic activation of the EGF (show EGF Antibodies)-like factors that are involved in the induction of granulosa cell differentiation, cumulus expansion, and meiotic maturation of porcine oocytes
Data indicate that TNF-alpha (show TNF Antibodies) stimulates Rac (show AKT1 Antibodies), ADAM17/TACE, and RhoA (show RHOA Antibodies) through the guanine nucleotide exchange factor (show ARHGEF12 Antibodies) (GEF)-H1 (show ARHGEF2 Antibodies).
progesterone-induced TACE/ADAM17 leads to production of soluble EGF (show EGF Antibodies) domain from cumulus cells, which enhances functional changes of cumulus cells and progresses meiotic maturation of oocytes
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme\; binds mitotic arrest deficient 2 protein\; and also plays a prominent role in the activation of the Notch signaling pathway.
ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme)
, a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme)
, disintegrin and metalloproteinase domain-containing protein 17
, tumor necrosis factor alpha converting enzyme
, a disintegrin and metallopeptidase domain 17
, ADAM metallopeptidase domain 17
, a disintegrin and metalloprotease domain 17
, disintegrin metalloproteinase
, disintegrin and metalloproteinase domain-containing protein 17-like
, ADAM 17
, TNF-alpha convertase
, TNF-alpha converting enzyme
, TNF-alpha-converting enzyme
, a disintegrin and metalloprotease domain 17; TNF-alpha converting enzyme
, a disintegrin and metalloproteinase domain 17
, ADAM metallopeptidase domain 18
, snake venom-like protease
, tumor necrosis factor, alpha, converting enzyme