Browse our anti-ADAM17 (ADAM17) Antibodies

On www.antibodies-online.com are 272 ADAM Metallopeptidase Domain 17 (ADAM17) Antibodies from 34 different suppliers available. Additionally we are shipping ADAM17 Kits (34) and ADAM17 Proteins (17) and many more products for this protein. A total of 332 ADAM17 products are currently listed.
Synonyms:
adam17, ADAM18, CD156B, CSVP, NISBD, si:dkey-81b15.2, Tace
list all antibodies Gene Name GeneID UniProt
ADAM17 11491 Q9Z0F8
ADAM17 6868 P78536
ADAM17 57027 Q9Z1K9

Most Popular Reactivities for anti-ADAM17 (ADAM17) Antibodies

anti-Mouse (Murine) ADAM17 Antibodies:

anti-Human ADAM17 Antibodies:

anti-Rat (Rattus) ADAM17 Antibodies:

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More Antibodies against ADAM17 Interaction Partners

Mouse (Murine) ADAM Metallopeptidase Domain 17 (ADAM17) interaction partners

  1. Conditional ADAM17 knockout mice lacking ADAM17 in all leukocytes had a significant survival advantage during severe polymicrobial sepsis induced by CLP, associated with enhanced neutrophil recruitment at the infectious locus along with decreased bacterial spread and circulating levels of proinflammatory factors. Its induction during sepsis may tip the balance between efficient and impaired neutrophil recruitment.

  2. These results demonstrate a novel physiologic role for a disintegrin and metalloprotease 17 in regulating murine IL-6 (show IL6 Antibodies) signals during inflammatory processes.

  3. These results show that TACE is a target of, and is downregulated by, soluble TNF (show TNF Antibodies)-induced AP-2alpha (show TFAP2A Antibodies) transcription factor in dendritic cells

  4. the critical role of the transmembrane domains of ADAM17 and Rhbdf2 (show RHBDF2 Antibodies) in the regulation of the ADAM17 and EGFR (show EGFR Antibodies), and ADAM17 and TNFalpha (show TNF Antibodies) signaling pathways, was examined.

  5. Findings provide evidence that ADAM10 (show ADAM10 Antibodies), and not ADAM17, is indispensable for proper retinal development as a regulator of NOTCH (show NOTCH1 Antibodies) signaling.

  6. this study shows that the iRhom2 (show RHBDF2 Antibodies)/ADAM17 pathway plays an important role in regulating CSF1R (show CSF1R Antibodies) expression in the myeloid cell compartment at steady state, and in modulating development of monocytes/macrophages during their repopulation

  7. Suggest an atheroprotective role of ADAM17, which might be mediated by cleaving membrane-bound TNFalpha (show TNF Antibodies) and TNFR2 (show TNFRSF1B Antibodies), thereby preventing overactivation of endogenous TNFR2 (show TNFRSF1B Antibodies) signaling in cells of the vasculature.

  8. Aging and obesity cooperatively reduce caveolin-1 (show CAV1 Antibodies) expression and increase vascular endothelial ADAM17 activity and soluble TNF (show TNF Antibodies) release in adipose tissue, which may contribute to the development of remote coronary microvascular dysfunction in older obese patients.

  9. Thus, Leda-1/Pianp (show C12orf53 Antibodies) is constitutively processed by proprotein convertases, sheddases including MMPs and ADAM10 (show ADAM10 Antibodies)/17 and intramembrane protease gamma-secretase.

  10. Matrix metalloproteases ADAM10 and TACE (ADAM17) cleave AXL receptor tyrosine (show AXL Antibodies)kinase (Axl) in lupus-prone leukocytes.

Human ADAM Metallopeptidase Domain 17 (ADAM17) interaction partners

  1. TNF-alpha-converting enzyme -mediated cleavage of soluble RANKL (show TNFSF11 Antibodies) from activated lymphocytes, especially B cells, can promote osteoclastogenesis in periodontitis.

  2. Cell stimulation can downregulate expression of mature ADAM17 from the cell surface and induce release of exosomal ADAM17, which can then distribute and contribute to substrate shedding on more distant cells.

  3. Aging and obesity cooperatively reduce caveolin-1 (show CAV1 Antibodies) expression and increase vascular endothelial ADAM17 activity and soluble TNF (show TNF Antibodies) release in adipose tissue, which may contribute to the development of remote coronary microvascular dysfunction in older obese patients.

  4. Our data demonstrated that elevated serum Semaphorin5A (Sema5A (show SEMA5A Antibodies)) in SLE patients correlated with disease activity and are involved in kidney and blood system damage; ADAM17 might be involved in the release of secreted Sema5A (show SEMA5A Antibodies).

  5. ADAM17 and ADAM10 (show ADAM10 Antibodies) cleave Nectin-4 (show PVRL4 Antibodies) and release soluble Nectin-4 (show PVRL4 Antibodies) (sN4).

  6. ADAM17 promotes epithelial-mesenchymal transition via the TGF-beta (show TGFB1 Antibodies)/Smad (show SMAD1 Antibodies) pathway. the present study demonstrates that ADAM17 plays a critical role in the development of gastric cancer and provides a potential therapeutic target for gastric cancer.

  7. FHL2 (show FHL2 Antibodies) interacts with ADAM-17 in normal, dysplastic and malignant colon epithelial cells. Colocalisation of these proteins is more frequent in malignant than in normal and dysplastic cells, suggesting a role for ADAM-17/FHL2 (show FHL2 Antibodies) complex in the development of colorectal cancer.

  8. The present study suggests that ADAM17-siRNA inhibits MCF-7 breast cancer and is activated through the EGFR (show EGFR Antibodies)-PI3K (show PIK3CA Antibodies)-AKT (show AKT1 Antibodies) signaling pathway

  9. Data show that mononuclear leukocytes (PBMC) AXL receptor tyrosine kinase (Axl (show AXL Antibodies)) is rescued by combined matrix metalloproteases ADAM10 (show ADAM10 Antibodies) and TACE (ADAM17) inhibition.

  10. the TLR4 (show TLR4 Antibodies)/Gal-1 (show LGALS1 Antibodies) signaling pathway regulates lactate-mediated EMT (show ITK Antibodies) processes through the activation of ADAM10 (show ADAM10 Antibodies) and ADAM17 in colon cancer cells.

Pig (Porcine) ADAM Metallopeptidase Domain 17 (ADAM17) interaction partners

  1. ADAM17 was involved in porcine CD16 (show CD16 Antibodies) shedding in porcine reproductive and respiratory syndrome virus-infected pigs.

  2. Overexpression of ADAM17 induced downregulation of CD163 (show CD163 Antibodies) expression and a reduction in reproductive and respiratory syndrome virus infection.

  3. activation of TACE/ADAM17 via a PKC (show FYN Antibodies)-induced c-Src (show SRC Antibodies)-dependent manner mediates proteolytic activation of the EGF (show EGF Antibodies)-like factors that are involved in the induction of granulosa cell differentiation, cumulus expansion, and meiotic maturation of porcine oocytes

  4. Data indicate that TNF-alpha (show TNF Antibodies) stimulates Rac (show AKT1 Antibodies), ADAM17/TACE, and RhoA (show RHOA Antibodies) through the guanine nucleotide exchange factor (show ARHGEF12 Antibodies) (GEF)-H1 (show ARHGEF2 Antibodies).

  5. progesterone-induced TACE/ADAM17 leads to production of soluble EGF (show EGF Antibodies) domain from cumulus cells, which enhances functional changes of cumulus cells and progresses meiotic maturation of oocytes

ADAM17 Antigen Profile

Antigen Summary

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme\; binds mitotic arrest deficient 2 protein\; and also plays a prominent role in the activation of the Notch signaling pathway.

Alternative names and synonyms associated with ADAM17

  • ADAM metallopeptidase domain 17 (ADAM17) antibody
  • a disintegrin and metallopeptidase domain 17b (adam17b) antibody
  • ADAM metallopeptidase domain 17 (adam17) antibody
  • a disintegrin and metallopeptidase domain 17 (Adam17) antibody
  • ADAM metallopeptidase domain 17 (Adam17) antibody
  • adam17 antibody
  • ADAM18 antibody
  • CD156B antibody
  • CSVP antibody
  • NISBD antibody
  • si:dkey-81b15.2 antibody
  • Tace antibody

Protein level used designations for ADAM17

ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) , a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme) , disintegrin and metalloproteinase domain-containing protein 17 , tumor necrosis factor alpha converting enzyme , a disintegrin and metallopeptidase domain 17 , ADAM metallopeptidase domain 17 , a disintegrin and metalloprotease domain 17 , disintegrin metalloproteinase , disintegrin and metalloproteinase domain-containing protein 17-like , ADAM 17 , TNF-alpha convertase , TNF-alpha converting enzyme , TNF-alpha-converting enzyme , a disintegrin and metalloprotease domain 17; TNF-alpha converting enzyme , a disintegrin and metalloproteinase domain 17 , ADAM metallopeptidase domain 18 , snake venom-like protease , tumor necrosis factor, alpha, converting enzyme

GENE ID SPECIES
421931 Gallus gallus
459018 Pan troglodytes
560657 Danio rerio
694429 Macaca mulatta
733430 Xenopus laevis
100072496 Equus caballus
100406520 Callithrix jacchus
100482770 Ailuropoda melanoleuca
11491 Mus musculus
6868 Homo sapiens
57027 Rattus norvegicus
475662 Canis lupus familiaris
397343 Sus scrofa
517541 Bos taurus
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