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Browse our Aph 1b (aph1b) ELISA Kits

Full name:
Anterior Pharynx Defective 1 Homolog B (C. Elegans) ELISA Kits (aph1b)
On www.antibodies-online.com are 0 Anterior Pharynx Defective 1 Homolog B (C. Elegans) (aph1b) ELISA Kits from different suppliers available. A total of 0 Aph 1b products are currently listed.
Synonyms:
0610008A10Rik, 2310057K14Rik, APH-1B, APH-1B', Aph1b, Aph1c, PRO1328, PSFL, TAAV688
list all ELISA KIts Gene Name GeneID UniProt
Rat aph1b aph1b 300802  
Mouse aph1b aph1b 208117 Q8C7N7
Human aph1b aph1b 83464 Q8WW43

Show all synonyms

More ELISA Kits for Aph 1b Interaction Partners

Mouse (Murine) Anterior Pharynx Defective 1 Homolog B (C. Elegans) (aph1b) interaction partners

  1. Abeta (show APP ELISA Kits) oligomers in the cerebrospinal fluid (CSF (show CSF2 ELISA Kits)) further promoted the expression of APH-1alpha (show APH1A ELISA Kits)/-1beta (by >2.5-fold), which enhances the gamma-cleavage of APP (show APP ELISA Kits) and Abeta (show APP ELISA Kits) deposition during AD progression

  2. analysis of hippocampal circuitry via Aph1b-gamma-secretase/neuregulin 1 (show NRG1 ELISA Kits) signalling

  3. Upregulation of PS1 (show PSEN1 ELISA Kits)/gamma-secretase activity may be a risk factor for late onset sporadic Alzheimer's disease.

  4. the Aph1B/C-gamma-secretase complex is expressed in brain areas relevant to schizophrenia pathogenesis and that Aph1B/C deficiency causes pharmacological and behavioral abnormalities that can be reversed by antipsychotic drugs

  5. study shows gamma-secretase complexes containing different Aph1 (show APH1A ELISA Kits) subunits have heterogeneous properties; inactivation of Aph1B gamma-secretase in an Alzheimer disease model led to improvement of disease-relevant features without Notch (show NOTCH1 ELISA Kits)-related side effects

Human Anterior Pharynx Defective 1 Homolog B (C. Elegans) (aph1b) interaction partners

  1. Expression of APH-1b increases amyloid beta peptide levels and gamma-secretase activity.

  2. both APH-1a (show APH1A ELISA Kits) splice forms and APH-1b are expressed in peripheral and neuronal cells. APH (show APEH ELISA Kits)-1aS, APH (show APEH ELISA Kits)-1aL, and APH-1b form separate, proteolytically active gamma-secretase complexes containing either one of the two presenilins.

  3. dimeric (NCSTN (show NCSTN ELISA Kits)/APH-1 (show APH1A ELISA Kits)) and trimeric (NCSTN (show NCSTN ELISA Kits)/APH-1 (show APH1A ELISA Kits)/PS1 (show PSEN1 ELISA Kits)) intermediates of gamma-secretase complex assembly are retained within the ER and incorporation of the fourth binding partner (PEN-2 (show PSENEN ELISA Kits)) also occurs on immature NCSTN (show NCSTN ELISA Kits) (APH-1 (show APH1A ELISA Kits))

  4. knock down of APH-1a (show APH1A ELISA Kits), but not APH-1b, resulted in impaired maturation of nicastrin (show NCSTN ELISA Kits) and reduced expression of presenilin 1 (show PSEN1 ELISA Kits), presenilin 2 (show PSEN2 ELISA Kits), and PEN-2 (show PSENEN ELISA Kits) proteins

  5. APH-1b variant protein is destabilized, and the fourth transmembrane domain plays an important role in the protein stability and function of APH-1 (show APH1A ELISA Kits).

  6. These results collectively indicate that the three forms of APH-1 (show APH1A ELISA Kits) can replace each other in presenilin (PS) complexes and that the transmembrane GxxxG region is essential for the stability of the APH-1 (show APH1A ELISA Kits) protein as well as the assembly of PS complexes.

  7. These data suggest that a cooperative mechanism involving APOE (show APOE ELISA Kits) and APH-1b plays a role in the susceptibility to develop AD.

  8. A non-synonymous SNP in the gamma-secretase component APH1B (Phe217Leu; rs1047552)is significantly associated with premature coronary atherosclerosis in Dutch males.

Aph 1b (aph1b) Antigen Profile

Antigen Summary

This gene encodes a multi-pass transmembrane protein that is a functional component of the gamma-secretase complex, which also contains presenilin and nicastrin. This protein represents a stabilizing cofactor for the presenilin holoprotein in the complex. The gamma-secretase complex catalyzes the cleavage of integral proteins such as notch receptors and beta-amyloid precursor protein.

Alternative names and synonyms associated with Aph 1b (aph1b)

  • anterior pharynx defective 1 homolog B (C. elegans) (APH1B) Elisa Kit
  • anterior pharynx defective 1 homolog B (C. elegans) (Aph1b) Elisa Kit
  • anterior pharynx defective 1b homolog (C. elegans) (Aph1b) Elisa Kit
  • anterior pharynx defective 1c homolog (C. elegans) (Aph1c) Elisa Kit
  • APH1B gamma secretase subunit (APH1B) Elisa Kit
  • 0610008A10Rik Elisa Kit
  • 2310057K14Rik Elisa Kit
  • APH-1B Elisa Kit
  • APH-1B' Elisa Kit
  • Aph1b Elisa Kit
  • Aph1c Elisa Kit
  • PRO1328 Elisa Kit
  • PSFL Elisa Kit
  • TAAV688 Elisa Kit

Protein level used designations for aph1b

anterior pharynx defective 1c homolog , gamma-secretase subunit APH-1B , anterior pharynx defective 1b homolog , APH-1b , aph-1beta , APH1B homolog , anterior pharynx defective 1b , putative gamma-secretase subunit APH-1C , anterior pharynx defective 1 homolog B

GENE ID SPECIES
487589 Canis lupus familiaris
530913 Bos taurus
300802 Rattus norvegicus
100171910 Pongo abelii
208117 Mus musculus
68318 Mus musculus
83464 Homo sapiens
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