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This study show that the undifferentiated CNS expresses Crb1, Crb2a, and Crb2b in distinct spatial and temporal patterns.
Data suggest that the Crb (show MYBL2 ELISA Kits)/Moe (show EPB41L5 ELISA Kits) complex and Notch (show NOTCH1 ELISA Kits) play roles in a positive feedback loop to maintain the apicobasal polarity in neuroepithelial cells.
Two novel variants were detected: c.2536G>T (p.G846X) in the CRB1 gene and c.4929delA (p.Lys1643fsX2) in the CEP290 (show CEP290 ELISA Kits) gene.
CRB1 mutations may be associated with intraretinal cystoid spaces. The use of carbonic anhydrase inhibitors can result in improved visual acuity in some patients.
Comprehensive retinal dystrophy (show MERTK ELISA Kits) panel revealed a homozygous mutation in CRB1 (p.Pro836Thr:c.2506C>A) in both twins.
Removal of this side chain enhances the binding affinity by more than fivefold, suggesting that access of Crb to Pals1 (show MPP5 ELISA Kits) may be regulated by intradomain contacts or by protein-protein interaction.
The phenotypic spectrum of recessive CRB1 mutation includes childhood cone-rod dystrophy with macular cystic degeneration and the associated ERG (show ERG ELISA Kits) can be electronegative.
The phenotypes of these novel mutations for early-onset retinal dystrophy (show MERTK ELISA Kits) (EORD) are typical of CRB1-associated EORD
Study showed that CRB1 and CRB2 in human retinas have an opposite pattern of expression in Muller glia and photoreceptor cells compared with mouse retinas, and that Crb2 influences the severity of the murine Crb1-linked retinal dystrophies.
the mammalian apical CRB1 complex might control retinogenesis and prevents onset of Leber congenital amaurosis or retinitis pigmentosa.
Macular nummular pigmentation is a gene-specific indication for CRB1associated retinal dystrophy (show MERTK ELISA Kits).
This report illustrates a novel presentation of a macular dystrophy caused by CRB1 mutations affecting 2 siblings exhibiting a relatively well-developed retinal structure and preservation of generalized retinal function.
This study showed that The geographic distribution of subretinal microglia/macrophages changes with age in both Crb1 rd8/rd8 and C57BL mice, but the total number of microglia only increases in Crb1 rd8/rd8 mice,and pro-inflamatory phenotype.
The retinal phenotype of Grk1 (show GRK1 ELISA Kits)-/- mice is compromised by a Crb1 rd8 mutation.
Presence of rd8 (Crb1) mutation does not alter the ocular phenotype of late-onset retinal degeneration mouse model carrying the Ctrp5 (show C1QTNF5 ELISA Kits) mutation.
These findings suggest that CRB1 and CRB2 suppress late progenitor pool expansion by regulating multiple proliferative signaling pathways.
The C57BL/6NJ-Crb1(rd8) mutation and its associated retinal phenotypes were corrected efficiently by TALEN-mediated homology-directed repair.
This study demonistrated that the Rd8 mutation in the Crb1 gene of CD11c (show ITGAX ELISA Kits)-eYFP transgenic reporter mice results in abnormal numbers of CD11c (show ITGAX ELISA Kits)-positive cells in the retina.
Data show the deletion of Pals1 (show MPP5 ELISA Kits) leads to the disruption of the apical localization of Crb polarity complex proteins Crb1, Crb2 and Crb3 (show CRB3 ELISA Kits) in retinal progenitors and the adult retina.
CRB1 mutations lead to early-onset severe loss of vision with thickened, disorganized, nonseeing retina. Impaired peripheral vision can persist in late disease stages.
Isolation of Crb1, a mouse homologue of Drosophila crumbs, and analysis of its expression pattern in eye and brain.
This gene encodes a protein which is similar to the Drosophila crumbs protein and localizes to the inner segment of mammalian photoreceptors. In Drosophila crumbs localizes to the stalk of the fly photoreceptor and may be a component of the molecular scaffold that controls proper development of polarity in the eye. Mutations in this gene are associated with a severe form of retinitis pigmentosa, RP12, and with Leber congenital amaurosis. Alternate splicing results in multiple transcript variants, some protein coding and some non-protein coding.
crumbs homolog 1 (Drosophila)
, crumbs homolog 1
, crumbs-like 1
, crumbs homolog 1-like
, protein crumbs homolog 1