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we report for the first time that CRB3 acts as an upstream regulator of the Hippo pathway to regulate contact inhibition by recruiting other Hippo molecules, such as Kibra (show WWC1 ELISA Kits) and/or FRMD6 (show FRMD6 ELISA Kits), in mammary epithelial cells.
CRB3A recruits p114RhoGEF (show ARHGEF18 ELISA Kits) and its activator Ehm2 to the cell periphery using both functional motifs of its cytoplasmic tail and increases RhoA (show RHOA ELISA Kits) activation levels.
our data demonstrated that CRB3 may be used as a new independent favorable prognostic factor for human ccRCC
Morg1 (show wdr83 ELISA Kits) facilitates Par6 (show PARD6A ELISA Kits)-aPKC binding to Crb3 for definition of apical identity of epithelial cells.
the Crumbs3-Pals1 (show MPP5 ELISA Kits) complex has a role in development of polarity in mammalian epithelial cells
CRB3, through its cytoplasmic domain and its interactors, plays a role in apical membrane morphogenesis and tight junction regulation.
Data show that a novel Crumbs3 isoform regulates cell division and ciliogenesis via importin beta1 interactions.
overexpression of human CRB1 (show CRB1 ELISA Kits) and related isoforms, CRB2 and CRB3, had no effect on the levels of presenilin complex components, on NCT (show NCSTN ELISA Kits) maturation or on PS endoproteolysis
Crb3, a Crumbs isoform that determines epithelial apical domain identity, is required for airway differentiation by controlling the localization of the transcriptional regulator Yap (show YAP1 ELISA Kits).
The presence of Crb3 in many organs and the regularity of Crb3 distribution in the process of mouse embryonic development indicate that Crb3 protein plays an important role in establishing and maintaining the polarity of mouse embryos.
Data indicate that Crb3 (Crumbs3) is crucial for epithelial morphogenesis and plays a role in linking the apical membrane to the underlying ezrin (show EZR ELISA Kits)-containing cytoskeleton.
the presence of CRB3 protein in the mouse retina
Data show the deletion of Pals1 (show MPP5 ELISA Kits) leads to the disruption of the apical localization of Crb polarity complex proteins Crb1 (show CRB1 ELISA Kits), Crb2 and Crb3 in retinal progenitors and the adult retina.
This gene encodes a member of the Crumbs family of proteins. This protein may play a role in epithelial cell polarity and is associated with tight junctions at the apical surface of epithelial cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
crumbs protein homolog 3
, protein crumbs homolog 3