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anti-Mouse (Murine) Deltex Homolog 1 Antibodies:
anti-Human Deltex Homolog 1 Antibodies:
anti-Rat (Rattus) Deltex Homolog 1 Antibodies:
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Human Polyclonal Deltex Homolog 1 Primary Antibody for WB - ABIN2780591
Takeyama, Aguiar, Gu, He, Freeman, Kutok, Aster, Shipp: The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity. in The Journal of biological chemistry 2003
Dog (Canine) Polyclonal Deltex Homolog 1 Primary Antibody for ELISA - ABIN4268617
Gupta-Rossi, Storck, Griebel, Reynaud, Weill, Dahan: Specific over-expression of deltex and a new Kelch-like protein in human germinal center B cells. in Molecular immunology 2003
exerts one level of control on regulatory T-cell stability by sustaining the expression of Foxp3 (show FOXP3 Antibodies) protein
DTX1, similar to Cbl-b and Itch, participates in T cell anergy-induced PKC-theta degradation. there is a coupling of DTX1 to Cbl-b in T cell anergy.
NB-3 (show CNTN6 Antibodies)/Notch1 (show NOTCH1 Antibodies) pathway promotes neural progenitor cell differentiation into
Deltex selectively suppresses T-cell activation through degradation of a key signaling molecule, MEKK1 (show MAP2K1 Antibodies).
Deltex-1 ubiquitin ligase activity is dispensable for mouse development and immune function.
Deltex can act as a negative regulator of Notch (show NOTCH1 Antibodies) signals in T cells but that endogenous levels of Deltex1 and Deltex2 (show DTX2 Antibodies) are not important for regulating Notch (show NOTCH1 Antibodies) signals during thymocyte development[Deltex1]
Data show that Deltex1 ablation enabled Id1 (show ID1 Antibodies)-expressing progenitors to differentiate to the DN3 (CD44 (show CD44 Antibodies)(-) CD25 (show IL2RA Antibodies)(+)) stage, which was accompanied by enhanced Notch1 (show NOTCH1 Antibodies) expression in T-cell progenitors.
deficiency of DTX1 augmented T cell activation, conferred resistance to anergy induction, enhanced autoantibody generation, and increased inflammation
Two SNPs (rs2384077 and rs10744794) in an intron of DTX1 and the linkage disequilibrium (LD) block are significantly associated with the immune response to HBV vaccination.
this study reports the identification of two new hGIP-interacting partners, DTX1 and STAU1 (show STAU1 Antibodies).
characterization of two genes expressed in centroblasts of human tonsils: deltex (Drosophila) homolog 1 (DTX1), which is related to the Notch (show NOTCH1 Antibodies) pathway and a new Kelch-like protein, KLHL6 (show KLHL7 Antibodies)
It is reported that BBAP (show DTX3L Antibodies) and the human family of DTX proteins (DTX1, DTX2 (show DTX2 Antibodies), and DTX3 (show DTX3 Antibodies)) function as E3 ligases based on their capacity for self-ubiquitination.
Studies in Drosophila have identified this gene as encoding a positive regulator of the Notch-signaling pathway. The human gene encodes a protein of unknown function\; however, it may play a role in basic helix-loop-helix transcription factor activity.
, deltex homolog 1 (Drosophila)
, deltex 4 homolog
, E3 ubiquitin-protein ligase DTX1
, fractionated x-irradiation induced transcript 1