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exerts one level of control on regulatory T-cell stability by sustaining the expression of Foxp3 (show FOXP3 Proteins) protein
DTX1, similar to Cbl-b and Itch, participates in T cell anergy-induced PKC-theta degradation. there is a coupling of DTX1 to Cbl-b in T cell anergy.
NB-3 (show CNTN6 Proteins)/Notch1 (show NOTCH1 Proteins) pathway promotes neural progenitor cell differentiation into
Deltex selectively suppresses T-cell activation through degradation of a key signaling molecule, MEKK1 (show MAP2K1 Proteins).
Deltex-1 ubiquitin ligase activity is dispensable for mouse development and immune function.
Deltex can act as a negative regulator of Notch (show NOTCH1 Proteins) signals in T cells but that endogenous levels of Deltex1 and Deltex2 (show DTX2 Proteins) are not important for regulating Notch (show NOTCH1 Proteins) signals during thymocyte development[Deltex1]
Data show that Deltex1 ablation enabled Id1 (show ID1 Proteins)-expressing progenitors to differentiate to the DN3 (CD44 (show CD44 Proteins)(-) CD25 (show IL2RA Proteins)(+)) stage, which was accompanied by enhanced Notch1 (show NOTCH1 Proteins) expression in T-cell progenitors.
deficiency of DTX1 augmented T cell activation, conferred resistance to anergy induction, enhanced autoantibody generation, and increased inflammation
Data indicate that decreased expression of deltex E3 ubiquitin ligase (show MUL1 Proteins) 1 (DTX1) in head and neck squamous cell carcinoma (HNSCC) tumors maybe associated with NOTCH (show NOTCH1 Proteins) pathway activation and increased migration potential.
Two SNPs (rs2384077 and rs10744794) in an intron of DTX1 and the linkage disequilibrium (LD) block are significantly associated with the immune response to HBV vaccination.
this study reports the identification of two new hGIP-interacting partners, DTX1 and STAU1 (show STAU1 Proteins).
characterization of two genes expressed in centroblasts of human tonsils: deltex (Drosophila) homolog 1 (DTX1), which is related to the Notch (show NOTCH1 Proteins) pathway and a new Kelch-like protein, KLHL6 (show KLHL7 Proteins)
It is reported that BBAP (show DTX3L Proteins) and the human family of DTX proteins (DTX1, DTX2 (show DTX2 Proteins), and DTX3 (show DTX3 Proteins)) function as E3 ligases based on their capacity for self-ubiquitination.
Studies in Drosophila have identified this gene as encoding a positive regulator of the Notch-signaling pathway. The human gene encodes a protein of unknown function\; however, it may play a role in basic helix-loop-helix transcription factor activity.
, deltex homolog 1 (Drosophila)
, deltex 4 homolog
, E3 ubiquitin-protein ligase DTX1
, fractionated x-irradiation induced transcript 1