Browse our FURIN Proteins (FURIN)

Full name:
Furin (Paired Basic Amino Acid Cleaving Enzyme) Proteins (FURIN)
On are 20 Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN) Proteins from 8 different suppliers available. Additionally we are shipping FURIN Antibodies (114) and FURIN Kits (24) and many more products for this protein. A total of 162 FURIN products are currently listed.
9130404I01Rik, Fur, furin, LOC100220259, MGC82710, Pace, Pcsk3, si:dkey-281a24.5, SPC1, xfurin
list all proteins Gene Name GeneID UniProt
FURIN 5045 P09958
FURIN 18550 P23188
Rat FURIN FURIN 54281 P23377

Show all synonyms

FURIN Proteins (FURIN) by Origin

Select your origin of interest

Top referenced FURIN Proteins

  1. Human FURIN Protein expressed in Wheat germ - ABIN1354517 : Heng, Dynon, Li, Edgell, Walton, Rombauts, Vollenhoven, Nie: Development of a high-throughput assay for human proprotein convertase 5/6 for detecting uterine receptivity. in Analytical biochemistry 2015 (PubMed)

More Proteins for FURIN Interaction Partners

Zebrafish Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN) interaction partners

  1. Silencing furin genes reduced the survival of M. marinum-infected zebrafish embryos. A mycobacterial infection upregulated furinA in adult zebrafish.

  2. Genetic analysis of fin development in zebrafish identifies furin as potential novel fraser syndrome disease genes

  3. furin genes may function partially redundantly to activate Endothelin1 signaling in craniofacial patterning

Human Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN) interaction partners

  1. Furin plays an important role in the malignant phenotype of rhabdomyosarcoma cells by activating proteins involved in tumor growth, vascularization, metastasis and invasion.

  2. Furin promotes epithelial-mesenchymal transition in pancreatic cancer cells probably via Hippo-YAP (show YAP1 Proteins) pathway and may be a potential target for anti-pancreatic cancer.

  3. Results suggest that (pro)renin receptor (show ATP6AP2 Proteins) (s(P)RR (show ATP6AP2 Proteins)) is generated by sequential processing by site-1 protease (S1P (show MBTPS1 Proteins)) and furin protein.

  4. our study provides evidence that furin activity and epithelial-mesenchymal transition are potential indicators of the aggressive phenotype in recurrent laryngeal cancer after irradiation and that furin is a potentially useful target against laryngeal cancer

  5. Data show that both furin and brain type natriuretic peptide (BNP) were more sensitive than corin (show CORIN Proteins) in predicting cardiovascular complications in type 2 diabetes mellitus (T2DM) patients.

  6. The authors show that Human papillomavirus type 16 L2 is cleaved during virion morphogenesis in differentiated tissue and that tissue-derived native virus initiates infection independent of cellular furin.

  7. Data suggest that the full Crimean-Congo hemorrhagic fever virus can be reproduced by reverse genetics; in this system, furin cleavage of the nonstructural glycoprotein reveals mature GP38 (show PDPN Proteins).

  8. we could not confirm an effect of the SNP on FURIN expression in vitro and no correlations could be found in vivo with FURIN expression or outcome.

  9. the plasma level of FURIN does not predict the severity of infectious disease, it may be of use in the diagnostics of autoimmune diseases.

  10. These data highlight a positive-feedback loop whereby Notch1 (show NOTCH1 Proteins)-dependent furin expression can induce Notch1 (show NOTCH1 Proteins) signaling by increasing Notch1 (show NOTCH1 Proteins) processing and by potentiating the activity of ADAM10 (show ADAM10 Proteins) and Membrane Type 1 Matrix Metalloproteinase (show MMP14 Proteins).

Mouse (Murine) Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN) interaction partners

  1. Furin plays an important role in the malignant phenotype of rhabdomyosarcoma cells by activating proteins involved in tumor growth, vascularization, metastasis and invasion.

  2. Studied the impact of Furin inhibition on the development and progression of hepatocellular carcinoma.

  3. PC7 (show PCSK7 Proteins) and the related proteases Furin and Pace4 regulate E-cadherin (show CDH1 Proteins) function during blastocyst formation.

  4. work confirms the hypothesis that the TCR-regulated protease FURIN plays an important role in T cell activation and that it can specifically modulate TCR-activated transactivation

  5. the role of serpinB8 (show SERPINB8 Proteins)/furin in obesity-associated chronic inflammation

  6. Furin has a role as the primary in vivo convertase of ANGPTL3 (show ANGPTL3 Proteins) and endothelial lipase (show LIPG Proteins) in hepatocytes

  7. overexpression of PCs, furin and PC5 (show PCSK5 Proteins), but not PC7 (show PCSK7 Proteins), which are all expressed in SMC (show DYM Proteins), increase PKGI (show PRKG1 Proteins) cleavage in a dose-dependent manner

  8. we observed an increased susceptibility to UV in single furin transgenic mice that was not substantially enhanced in the double furin/PACE4 transgenic mice.

  9. These data suggest that obesity states facilitate the cleavage of adipolin presumably through upregulation of furin in adipose tissue.

  10. Furin-cleaved proprotein convertase subtilisin/kexin type 9 (PCSK9 (show PCSK9 Proteins)) is active and modulates low density lipoprotein receptor (show LDLR Proteins) and serum cholesterol levels.

Pig (Porcine) Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN) interaction partners

  1. Point mutation of the furin cleavage site at the S2' position of the S protein enables the virus to infect cultured cells independently of trypsin.

FURIN Protein Profile

Protein Summary

The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can efficiently cleave precursor proteins at their paired basic amino acid processing sites. Some of its substrates are: proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene is thought to play a role in tumor progression. The use of alternate polyadenylation sites has been found for this gene.

Alternative names and synonyms associated with FURIN

  • furin (paired basic amino acid cleaving enzyme) (FURIN)
  • furin (paired basic amino acid cleaving enzyme) a (furina)
  • furin (paired basic amino acid cleaving enzyme) b (furinb)
  • furin (paired basic amino acid cleaving enzyme) (LOC100220259)
  • furin (paired basic amino acid cleaving enzyme) (furin)
  • furin (paired basic amino acid cleaving enzyme) (Furin)
  • furin-like (LOC100156882)
  • 9130404I01Rik protein
  • Fur protein
  • furin protein
  • LOC100220259 protein
  • MGC82710 protein
  • Pace protein
  • Pcsk3 protein
  • si:dkey-281a24.5 protein
  • SPC1 protein
  • xfurin protein

Protein level used designations for FURIN

furin (paired basic amino acid cleaving enzyme) , furin A , stu , sturgeon , furin B , furin , furin-like , FES upstream region , dibasic processing enzyme , dibasic-processing enzyme , furin, membrane associated receptor protein , paired basic amino acid residue-cleaving enzyme , proprotein convertase subtilisin/kexin type 3 , paired basic amino acid residue cleaving enzyme , prohormone convertase 3 , subtilisin pro-protein processing enzyme , paired basic amino acid cleaving enzyme , trans Golgi network protease furin , Paired basic amino acid cleaving enzyme (furin) , Proprotein convertase subtilisin/kexin type 3 (paired basic amino acid cleaving enzyme, furin, membrane associated receptor protein) , proprotein convertase subtilisin/kexin type3

453652 Pan troglodytes
566557 Danio rerio
566591 Danio rerio
780454 Ovis aries
100220259 Taeniopygia guttata
100327238 Xenopus (Silurana) tropicalis
398345 Xenopus laevis
100014434 Monodelphis domestica
100396662 Callithrix jacchus
100448725 Pongo abelii
100475645 Ailuropoda melanoleuca
100591992 Nomascus leucogenys
5045 Homo sapiens
488746 Canis lupus familiaris
18550 Mus musculus
281374 Bos taurus
100068931 Equus caballus
54281 Rattus norvegicus
395457 Gallus gallus
100156882 Sus scrofa
Selected quality suppliers for FURIN Proteins (FURIN)
Did you look for something else?