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Human FURIN Protein expressed in Wheat germ - ABIN1354517
Heng, Dynon, Li, Edgell, Walton, Rombauts, Vollenhoven, Nie: Development of a high-throughput assay for human proprotein convertase 5/6 for detecting uterine receptivity. in Analytical biochemistry 2015
Silencing furin genes reduced the survival of M. marinum-infected zebrafish embryos. A mycobacterial infection upregulated furinA in adult zebrafish.
Genetic analysis of fin development in zebrafish identifies furin as potential novel fraser syndrome disease genes
furin genes may function partially redundantly to activate Endothelin1 signaling in craniofacial patterning
findings uncover a role of ERK1 (show MAPK3 Proteins) in the regulation of furin activity by supporting a self-sustaining loop for high TGF-beta (show TGFB1 Proteins) activity in glioma-initiating cells.
Divers studies have confirmed the expression of furin in a large spectrum of cancers. Functional studies modulating its activity uncovered its importance for the processing of many cancer-related substrates and strongly indicate that high furin activity promotes the malignant phenotype of cancer cells. [review]
Furin plays an important role in the malignant phenotype of rhabdomyosarcoma cells by activating proteins involved in tumor growth, vascularization, metastasis and invasion.
Furin promotes epithelial-mesenchymal transition in pancreatic cancer cells probably via Hippo-YAP (show YAP1 Proteins) pathway and may be a potential target for anti-pancreatic cancer.
Results suggest that (pro)renin receptor (show ATP6AP2 Proteins) (s(P)RR (show ATP6AP2 Proteins)) is generated by sequential processing by site-1 protease (S1P (show MBTPS1 Proteins)) and furin protein.
our study provides evidence that furin activity and epithelial-mesenchymal transition are potential indicators of the aggressive phenotype in recurrent laryngeal cancer after irradiation and that furin is a potentially useful target against laryngeal cancer
Data show that both furin and brain type natriuretic peptide (BNP) were more sensitive than corin (show CORIN Proteins) in predicting cardiovascular complications in type 2 diabetes mellitus (T2DM) patients.
The authors show that Human papillomavirus type 16 L2 is cleaved during virion morphogenesis in differentiated tissue and that tissue-derived native virus initiates infection independent of cellular furin.
Data suggest that the full Crimean-Congo hemorrhagic fever virus can be reproduced by reverse genetics; in this system, furin cleavage of the nonstructural glycoprotein reveals mature GP38 (show PDPN Proteins).
we could not confirm an effect of the SNP on FURIN expression in vitro and no correlations could be found in vivo with FURIN expression or outcome.
Studied the impact of Furin inhibition on the development and progression of hepatocellular carcinoma.
PC7 (show PCSK7 Proteins) and the related proteases Furin and Pace4 regulate E-cadherin (show CDH1 Proteins) function during blastocyst formation.
work confirms the hypothesis that the TCR-regulated protease FURIN plays an important role in T cell activation and that it can specifically modulate TCR-activated transactivation
the role of serpinB8 (show SERPINB8 Proteins)/furin in obesity-associated chronic inflammation
Furin has a role as the primary in vivo convertase of ANGPTL3 (show ANGPTL3 Proteins) and endothelial lipase (show LIPG Proteins) in hepatocytes
overexpression of PCs, furin and PC5 (show PCSK5 Proteins), but not PC7 (show PCSK7 Proteins), which are all expressed in SMC (show DYM Proteins), increase PKGI (show PRKG1 Proteins) cleavage in a dose-dependent manner
we observed an increased susceptibility to UV in single furin transgenic mice that was not substantially enhanced in the double furin/PACE4 transgenic mice.
These data suggest that obesity states facilitate the cleavage of adipolin presumably through upregulation of furin in adipose tissue.
Furin-cleaved proprotein convertase subtilisin/kexin type 9 (PCSK9 (show PCSK9 Proteins)) is active and modulates low density lipoprotein receptor (show LDLR Proteins) and serum cholesterol levels.
Point mutation of the furin cleavage site at the S2' position of the S protein enables the virus to infect cultured cells independently of trypsin.
The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can efficiently cleave precursor proteins at their paired basic amino acid processing sites. Some of its substrates are: proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene is thought to play a role in tumor progression. The use of alternate polyadenylation sites has been found for this gene.
furin (paired basic amino acid cleaving enzyme)
, furin A
, furin B
, FES upstream region
, dibasic processing enzyme
, dibasic-processing enzyme
, furin, membrane associated receptor protein
, paired basic amino acid residue-cleaving enzyme
, proprotein convertase subtilisin/kexin type 3
, paired basic amino acid residue cleaving enzyme
, prohormone convertase 3
, subtilisin pro-protein processing enzyme
, paired basic amino acid cleaving enzyme
, trans Golgi network protease furin
, Paired basic amino acid cleaving enzyme (furin)
, Proprotein convertase subtilisin/kexin type 3 (paired basic amino acid cleaving enzyme, furin, membrane associated receptor protein)
, proprotein convertase subtilisin/kexin type3