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Browse our JAG2 Proteins (JAG2)

Full name:
Jagged 2 Proteins (JAG2)
On www.antibodies-online.com are 15 Jagged 2 (JAG2) Proteins from 4 different suppliers available. Additionally we are shipping JAG2 Antibodies (98) and JAG2 Kits (9) and many more products for this protein. A total of 127 JAG2 products are currently listed.
Synonyms:
D12Ggc2e, HJ2, jag2, mJagged2-1, SER2, serB, Serh, sm, zgc:152855
list all proteins Gene Name GeneID UniProt
JAG2 16450 Q9QYE5
JAG2 3714 Q9Y219
Rat JAG2 JAG2 29147  

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JAG2 Proteins (JAG2) by Origin

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More Proteins for JAG2 Interaction Partners

Mouse (Murine) Jagged 2 (JAG2) interaction partners

  1. silencing prevents Notch2 (show NOTCH2 Proteins)-driven osteoclast development and bone destruction in multiple myeloma

  2. Although Jag1 (show JAG1 Proteins) shares a high degree of homology with Jag2 in the ectodomain region, BACE1 (show BACE Proteins) fails to cleave Jag2 effectively, indicating a selective cleavage of Jag1 (show JAG1 Proteins).

  3. Reducing Jagged 1 (show JAG1 Proteins) and 2 levels prevents cerebral arteriovenous malformations in matrix Gla protein (show MGP Proteins) deficiency.

  4. these findings suggest that Jagged2 signaling can affect graft acceptance by upregulation of IL-6 (show IL6 Proteins) and consequent resistance to Treg-cell suppression.

  5. results demonstrate that maternal P4 levels during midpregnancy can inhibit the expression of Jagged2 and Notch1 (show NOTCH1 Proteins), which are involved in primordial folliculogenesis, in the mouse fetal ovary

  6. These data suggest that Notch (show NOTCH1 Proteins) ligands are differentially regulated in DCs: Delta-like (show DLK1 Proteins) 4 is regulated by T helper cells and by pathogen-derived Th1 (show HAND1 Proteins) stimuli, whereas Jagged 2 is regulated by Th2 cells and pathogen-derived Th2-promoting stimuli.

  7. novel Jagged2/miR (show MLXIP Proteins)-200-dependent pathway that mediates lung adenocarcinoma epithelial-to-mesenchymal transition and metastasis

  8. Loss of Jagged2 is associated with craniofacial, limb, and T cell development.

  9. Notch (show NOTCH1 Proteins) ligands, including Delta-like1 and 3 and Jagged1 (show JAG1 Proteins) and Jagged2, show distinct expression patterns in the developing and adult brain overlapping that of Notch1 (show NOTCH1 Proteins)

  10. Jagged2 stimulates the development of natural killer cells from Lin(-) Sca-1(+) c-kit(+) hematopoietic stem cells

Human Jagged 2 (JAG2) interaction partners

  1. Immunohistochemistry showed a reverse correlation between MUC2 and Notch3 or Jagged1 (P = 0.033 and P = 0.005, respectively) and between MUC5AC and Jagged1 or Hes1

  2. Jagged-2 enhances immunomodulatory activity in adipose derived mesenchymal stem cells

  3. Increased expression of JAG2, a target of miR (show MLXIP Proteins)-1280, is associated with high metastatic dissemination at diagnosis and a poor outcome in medulloblastoma.

  4. Results show that tumor cell migration, invasion, and metastasis are dependent on JAGGED2 independently of NOTCH (show NOTCH1 Proteins) activation.

  5. silencing prevents Notch2 (show NOTCH2 Proteins)-driven osteoclast development and bone destruction in multiple myeloma

  6. Although Jag1 (show JAG1 Proteins) shares a high degree of homology with Jag2 in the ectodomain region, BACE1 (show BACE Proteins) fails to cleave Jag2 effectively, indicating a selective cleavage of Jag1 (show JAG1 Proteins).

  7. This study demonistrated that NOTCH (show NOTCH1 Proteins) ligands JAG1 (show JAG1 Proteins) and JAG2 as critical pro-survival factors in childhood medulloblastoma.

  8. Jagged2 expression status was closely correlated with important histopathologic characteristics (grades and stages) and the recurrence and metastasis of bladder urothelial carcinomas.

  9. Notch-1 (show NOTCH1 Proteins) and Jagged-2 are not expressed in spastic colon segments, which may be associated with the pathogenesis of Hirschsprung disease.

  10. JAG2-mediated Notch (show NOTCH1 Proteins) activation confers phenotypic and functional aspects of Langerhans cell histiocytosis to dendritic cells.

Zebrafish Jagged 2 (JAG2) interaction partners

  1. Expression of both jagged2 and jagged1b mRNA in the central nervous system suggested that they might be involved in control of differentiating neural progenitors.

  2. Mice homozygous for a deletion in the Notch (show NOTCH1 Proteins)-interaction domain of Jag2 presented a variety of severe dental abnormalities.

  3. Jagged and Delta ligands are functionally redundant or required in specific combinations in many differentiation processes

  4. Jag2-mediated Notch (show NOTCH1 Proteins) signaling maintains proliferating neural progenitors and regulates cell diversity in the ventral spinal cord.

JAG2 Protein Profile

Protein Summary

The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with JAG2

  • jagged 2 (JAG2)
  • jagged 2 (jag2)
  • jagged 2 (Jag2)
  • jagged 2b (jag2b)
  • D12Ggc2e protein
  • HJ2 protein
  • jag2 protein
  • mJagged2-1 protein
  • SER2 protein
  • serB protein
  • Serh protein
  • sm protein
  • zgc:152855 protein

Protein level used designations for Jagged 2 Proteins (JAG2)

jagged 2 , protein jagged-2-like , protein jagged-2 , syndactylism , C-Serrate-2 , notch ligand , serrate-2 , serrateB , unp1068

GENE ID SPECIES
100014054 Monodelphis domestica
100447370 Pongo abelii
100497180 Xenopus (Silurana) tropicalis
100552963 Anolis carolinensis
16450 Mus musculus
3714 Homo sapiens
29147 Rattus norvegicus
776138 Gallus gallus
490882 Canis lupus familiaris
100522743 Sus scrofa
517405 Bos taurus
140422 Danio rerio
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