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A deficiency of KLF2 (show KLF2 Proteins) increased the expression of Notch ligand Jagged2 via hypoxia-inducible factor 1alpha (HIF-1alpha (show HIF1A Proteins)), which led to Th2 amplification.
silencing prevents Notch2 (show NOTCH2 Proteins)-driven osteoclast development and bone destruction in multiple myeloma
Although Jag1 (show JAG1 Proteins) shares a high degree of homology with Jag2 in the ectodomain region, BACE1 (show BACE Proteins) fails to cleave Jag2 effectively, indicating a selective cleavage of Jag1 (show JAG1 Proteins).
Reducing Jagged 1 (show JAG1 Proteins) and 2 levels prevents cerebral arteriovenous malformations in matrix Gla protein (show MGP Proteins) deficiency.
these findings suggest that Jagged2 signaling can affect graft acceptance by upregulation of IL-6 (show IL6 Proteins) and consequent resistance to Treg-cell suppression.
results demonstrate that maternal P4 levels during midpregnancy can inhibit the expression of Jagged2 and Notch1 (show NOTCH1 Proteins), which are involved in primordial folliculogenesis, in the mouse fetal ovary
These data suggest that Notch (show NOTCH1 Proteins) ligands are differentially regulated in DCs: Delta-like (show DLK1 Proteins) 4 is regulated by T helper cells and by pathogen-derived Th1 (show HAND1 Proteins) stimuli, whereas Jagged 2 is regulated by Th2 cells and pathogen-derived Th2-promoting stimuli.
novel Jagged2/miR (show MLXIP Proteins)-200-dependent pathway that mediates lung adenocarcinoma epithelial-to-mesenchymal transition and metastasis
Loss of Jagged2 is associated with craniofacial, limb, and T cell development.
Notch (show NOTCH1 Proteins) ligands, including Delta-like1 and 3 and Jagged1 (show JAG1 Proteins) and Jagged2, show distinct expression patterns in the developing and adult brain overlapping that of Notch1 (show NOTCH1 Proteins)
these results show that the Notch (show NOTCH1 Proteins) signaling pathway in T cells is crucial for the induction of TH2-mediated allergic airway inflammation in an house dust mite -driven asthma model but that expression of Jagged 1 (show JAG1 Proteins) or Jagged 2 on DCs is not required
The authors present novel structures of human ligands Jagged2 and Delta-like4 and human Notch2 (show NOTCH2 Proteins), together with functional assays, which suggest that ligand-mediated coupling of membrane recognition and Notch (show NOTCH1 Proteins) binding is likely to be critical in establishing the optimal context for Notch (show NOTCH1 Proteins) signalling.
Immunohistochemistry showed a reverse correlation between MUC2 and Notch3 or Jagged1 (P = 0.033 and P = 0.005, respectively) and between MUC5AC and Jagged1 or Hes1
Jagged-2 enhances immunomodulatory activity in adipose derived mesenchymal stem cells
Increased expression of JAG2, a target of miR (show MLXIP Proteins)-1280, is associated with high metastatic dissemination at diagnosis and a poor outcome in medulloblastoma.
Results show that tumor cell migration, invasion, and metastasis are dependent on JAGGED2 independently of NOTCH (show NOTCH1 Proteins) activation.
This study demonistrated that NOTCH (show NOTCH1 Proteins) ligands JAG1 (show JAG1 Proteins) and JAG2 as critical pro-survival factors in childhood medulloblastoma.
Jagged2 expression status was closely correlated with important histopathologic characteristics (grades and stages) and the recurrence and metastasis of bladder urothelial carcinomas.
Expression of both jagged2 and jagged1b mRNA in the central nervous system suggested that they might be involved in control of differentiating neural progenitors.
Mice homozygous for a deletion in the Notch (show NOTCH1 Proteins)-interaction domain of Jag2 presented a variety of severe dental abnormalities.
Jagged and Delta ligands are functionally redundant or required in specific combinations in many differentiation processes
Jag2-mediated Notch (show NOTCH1 Proteins) signaling maintains proliferating neural progenitors and regulates cell diversity in the ventral spinal cord.
The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene.
, protein jagged-2-like
, protein jagged-2
, notch ligand