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Our results reveal a novel mechanism of upregulation of NEDD4 expression in pancreatic adenocarcinoma
Describe an autoinhibitory mechanism for NEDD4-1 ubiquitin ligase involving a linker-HECT domain interaction. This intramolecular interaction traps the HECT enzyme in its inactive state and can be relieved by linker phosphorylation.
Insights into links between autophagy and the ubiquitin system showed that LC3B-binding can steer intrinsic NEDD4 E3 ligase activity.
NEDD4-1 recognizes SERTA domain containing proline rich region of p34SEI-1 (show SERTAD1 Proteins). Residues of NEDD4-1 responsible for direct interaction with p34SEI-1 (show SERTAD1 Proteins) are identified by NMR titration experiments.
Our results demonstrate that NEDD4 may promote the acquired resistance of non-small-cell lung cancer cells to erlotinib by decreasing phosphatase and tensin homolog deleted on chromosome 10 protein expression. Targeted decrease in NEDD4 expression may be a potential therapeutic strategy for tyrosine kinase (show TXK Proteins) inhibitor-resistant non-small-cell lung cancer.
this is the first demonstration that Nedd4-1 regulates hOAT1 (show SLC22A6 Proteins) ubiquitination, expression, and transport activity through its WW2 and WW3 domains
both Nedd4-1 and Nedd4-2 (show NEDD4L Proteins) are important regulators for hOAT1 (show SLC22A6 Proteins) ubiquitination, expression, and function
Nedd4-1 inhibited Rap2a (show RAP2A Proteins) activity, and promoted the migration and invasion of glioma cells.
We concluded that USP15 (show USP15 Proteins) attenuates IGF-I (show IGF1 Proteins) signaling by antagonizing Nedd4-induced IRS-2 (show IRS2 Proteins) ubiquitination.
Data suggest a possible molecular mechanism might be that NEDD4 silence led to an increase in PTEN (phosphatase and tensin homologue) expression.
Nedd4-1 is required for efficient internalization of major growth factor receptors involved in liver regeneration and their downstream mitogenic signaling.
NPM1 (show GJA1 Proteins)-dependent nucleolar PIDDosome is a key initiator of the caspase-2 (show CASP2 Proteins) activation cascade.
these results suggest that Nedd4 suppresses colonic WNT (show WNT2 Proteins) signaling and tumor growth, at least in part, by suppressing the transcription factors LEF1 (show LEF1 Proteins) and YY1 (show YY1 Proteins).
Findings indicate that reducing Nedd4 protein by 50% significantly impairs long-term potentiation and long-term memory thereby demonstrating an important role for Nedd4 in these processes.
Upregulation of long non-coding RNA PAPAS (show PSTPIP1 Proteins) in response to hypoosmotic stress does not increase H4K20me3 because of Nedd4-dependent ubiquitinylation and proteasomal degradation of Suv4-20h2 (show SUV420H2 Proteins).
we propose that Nedd4 functions as a novel Pax7 (show PAX7 Proteins) regulator, which activity is temporally and spatially controlled to modulate the Pax7 (show PAX7 Proteins) protein levels and therefore satellite cell fate.
PDLIM7 (show PDLIM7 Proteins) is a bona fide skeletal muscle substrate of Nedd4-1.
show that absence of Nedd4 in pre-osteoblasts results in decreased cell proliferation and altered osteogenic differentiation
Nedd4 overexpression accelerates zebrafish embryonic growth through IRS-2 (show IRS2 Proteins) in vivo.
Nedd4 co-injection was found to have no affect on Gag- or Env (show ERVW-1 Proteins)-specific IFNgamma but had a trend of increased Gag-specific IL-6 (show IL6 Proteins), IL-17A (show IL17A Proteins) and TNFalpha (show TNF Proteins) that was not seen following Env (show ERVW-1 Proteins) stimulation.
miR-1-mediated regulation of Nedd4/Nedd4L (show NEDD4L Proteins) expression may serve to broadly modulate the trafficking or degradation of Nedd4/Nedd4L (show NEDD4L Proteins) substrates in the heart
Nedd4Lo destabilizes Amph (show AMPH Proteins) in muscles, leading to impaired T-tubule formation and muscle function.
NEDD4 controls the Hippo pathway leading to coordinated cell proliferation and apoptosis
data in two evolutionarily distant model organisms strongly suggest that Nedd4 is a modifier of alpha-synuclein pathobiology and thus a potential target for neuroprotective therapies
Nedd4, another E3 ubiquitin ligase that may have a role in PD, is functionally related to Sep4 and could be involved in regulating Sep4 subcellular localization/trafficking.
splice isoforms of the same dNedd4 gene can lead to opposite effects on neuromuscular synaptogenesis
Nedd4 regulates endocytosis of notch (show NOTCH1 Proteins) and suppresses its ligand-independent activation.
These studies provide insights into the specific regulation of dNedd4-mediated ubiquitination of Comm and subsequent internalization of Comm or the Comm/Roundabout (show ROBO1 Proteins) complex, critical for CNS and muscle development.
dNedd4 and ubiquitination are required for Commissureless endocytosis and proper neuromuscular synaptogenesis.
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Involved in ubiquitination of ERBB4 intracellular domain E4ICD1 (PubMed:19193720). Predominantly involved in ubiquitination of membrane bound forms of ERBB4 rather than processed precursors and intermediate membrane-anchored 80 kDa fragments (m80HER4), with a lesser role in ubiquitination of ERBB4 intracellular domain E4ICD1 (PubMed:19047365). Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2 (By similarity).
E3 ubiquitin-protein ligase NEDD4
, cell proliferation-inducing gene 53 protein
, neural precursor cell expressed developmentally down-regulated protein 4
, receptor-potentiating factor 1
, neural precursor cell expressed, developmentally down-regulated gene 4
, neural precursor cell expressed, developmentally down-regulated gene 4a
, neural precursor cell expressed, developmentally down-regulted gene 4
, neural precursor cell expressed, developmentally down-regulated 4
, ubiquitin-protein ligase Nedd4
, E3 ubiquitin-protein ligase NEDD4-like
, e3 ubiquitin-protein ligase NEDD4-like
, neural precursor cell expressed, developmentally down-regulated gene 4A