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Browse our NEDD4 Proteins (NEDD4)

Full name:
Neural Precursor Cell Expressed, Developmentally Down-Regulated 4, E3 Ubiquitin Protein Ligase Proteins (NEDD4)
On www.antibodies-online.com are 5 Neural Precursor Cell Expressed, Developmentally Down-Regulated 4, E3 Ubiquitin Protein Ligase (NEDD4) Proteins from 4 different suppliers available. Additionally we are shipping NEDD4 Antibodies (75) and many more products for this protein. A total of 83 NEDD4 products are currently listed.
Synonyms:
AA959633, AL023035, AU019897, E430025J12Rik, mKIAA0093, NEDD4-1, Nedd4a, RPF1
list all proteins Gene Name GeneID UniProt
NEDD4 17999 P46935
NEDD4 4734 P46934
NEDD4 25489 Q62940

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NEDD4 Proteins (NEDD4) by Origin

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Mouse (Murine) Neural Precursor Cell Expressed, Developmentally Down-Regulated 4, E3 Ubiquitin Protein Ligase (NEDD4) interaction partners

  1. we propose that Nedd4 functions as a novel Pax7 (show PAX7 Proteins) regulator, which activity is temporally and spatially controlled to modulate the Pax7 (show PAX7 Proteins) protein levels and therefore satellite cell fate.

  2. PDLIM7 (show PDLIM7 Proteins) is a bona fide skeletal muscle substrate of Nedd4-1.

  3. show that absence of Nedd4 in pre-osteoblasts results in decreased cell proliferation and altered osteogenic differentiation

  4. Nedd4 overexpression accelerates zebrafis (show IRS2 Proteins)h embryonic growth through IRS-2 in vivo.

  5. Nedd4 co-injection was found to have no affect on Gag- or Env (show ERVW-1 Proteins)-specific IFNgamma but had a trend of increased Gag-specific IL-6 (show IL6 Proteins), IL-17A (show IL17A Proteins) and TNFalpha (show TNF Proteins) that was not seen following Env (show ERVW-1 Proteins) stimulation.

  6. NEDD4 is a previously unknown component of the CD40 (show CD40 Proteins) signalling complex necessary for AKT (show AKT1 Proteins) activation.

  7. Brucella infection inhibits macrophages apoptosis via Nedd4-dependent degradation of calpain2.

  8. Data show that NEDD4-1 E3 ligase as a novel component of the tumor suppressor protein p53 (show TP53 Proteins)/proto-oncogene (show RAB1A Proteins) proteins c-mdm2 (show MDM2 Proteins) regulatory feedback loop that controls p53 (show TP53 Proteins) activity during stress responses.

  9. PTEN limits Nedd4-1 protein levels by modulating the activity of mTORC1, a protein complex that controls protein synthesis and cell growth.

  10. Rsp5 and its mammalian homologue Nedd4 are important E3 ligases responsible for the increased ubiquitylation induced by heat stress.

Human Neural Precursor Cell Expressed, Developmentally Down-Regulated 4, E3 Ubiquitin Protein Ligase (NEDD4) interaction partners

  1. Elevated NEDD4 is implicated as the responsible ubiquitin E3 ligase for HSF1 (show HSF1 Proteins) degradation through ubiquitin-proteasome system. Aberrant HSF1 (show HSF1 Proteins) degradation is a key neurodegenerative mechanism underlying alpha-synucleinopathy.

  2. LRAD3 is a component of pathways that function effectively to modulate Itch and Nedd4 auto-ubiquitination and levels.

  3. Data show that human ABCB1 (show ABCB1 Proteins) is a substrate for human NEDD4-1 and identified 8 lysine residues that were ubiquitinated by NEDD4-1.

  4. we demonstrate that the E3 ubiquitin ligase (show MUL1 Proteins) NEDD4 ubiquitinates IFITM3 (show IFITM3 Proteins) in cells and in vitro.

  5. Data show that silencing of PMEPA1 (show PMEPA1 Proteins) protein facilitates the growth of prostate cancer cells and modulates androgen receptor (AR (show AR Proteins)) through NEDD4 ubiquitin protein ligase (show UBE2K Proteins) and PTEN protein.

  6. Nedd4-induced monoubiquitination of IRS-2 (show IRS2 Proteins) enhances IGF signalling and mitogenic activity.

  7. NEDD4 controls the Hippo pathway leading to coordinated cell proliferation and apoptosis

  8. Study identifies NEDD4 as a putative oncogene (show RAB1A Proteins) in endometrial cancer that may augment activation of the IGF-1R (show IGF1R Proteins)/PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) signaling pathway.

  9. HUWE1 (show HUWE1 Proteins) and NEDD4-1 are two E3 ligases that are fundamental enzymes in the post-translational regulation of ABCG1 (show ABCG1 Proteins) and ABCG4 (show ABCG4 Proteins) protein levels and cellular cholesterol export activity

  10. Studies on Smurf2 and Nedd4 show that the C2 domain has the potential to regulate E3 activity by maintaining the HECT domain in a low-activity state where its ability for transthiolation and noncovalent Ubiquitin binding are impaired.

NEDD4 Protein Profile

Protein Summary

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Involved in ubiquitination of ERBB4 intracellular domain E4ICD1 (PubMed:19193720). Predominantly involved in ubiquitination of membrane bound forms of ERBB4 rather than processed precursors and intermediate membrane-anchored 80 kDa fragments (m80HER4), with a lesser role in ubiquitination of ERBB4 intracellular domain E4ICD1 (PubMed:19047365). Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2 (By similarity).

Alternative names and synonyms associated with NEDD4

  • neural precursor cell expressed, developmentally down-regulated 4 (Nedd4)
  • neural precursor cell expressed, developmentally down-regulated 4 (NEDD4)
  • neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase (NEDD4)
  • neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase (Nedd4)
  • AA959633 protein
  • AL023035 protein
  • AU019897 protein
  • E430025J12Rik protein
  • mKIAA0093 protein
  • NEDD4-1 protein
  • Nedd4a protein
  • RPF1 protein

Protein level used designations for NEDD4

E3 ubiquitin-protein ligase NEDD4 , NEDD-4 , neural precursor cell expressed developmentally down-regulated protein 4 , neural precursor cell expressed, developmentally down-regulated gene 4 , neural precursor cell expressed, developmentally down-regulated gene 4a , neural precursor cell expressed, developmentally down-regulted gene 4 , cell proliferation-inducing gene 53 protein , receptor-potentiating factor 1 , neural precursor cell expressed, developmentally down-regulated gene 4A , ubiquitin-protein ligase Nedd4

GENE ID SPECIES
17999 Mus musculus
415406 Gallus gallus
4734 Homo sapiens
25489 Rattus norvegicus
467689 Pan troglodytes
608738 Canis lupus familiaris
100054735 Equus caballus
100009418 Oryctolagus cuniculus
507781 Bos taurus
100152466 Sus scrofa
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