Browse our NEDD4 Proteins (NEDD4)

Full name:
Neural Precursor Cell Expressed, Developmentally Down-Regulated 4, E3 Ubiquitin Protein Ligase Proteins (NEDD4)
On www.antibodies-online.com are 5 Neural Precursor Cell Expressed, Developmentally Down-Regulated 4, E3 Ubiquitin Protein Ligase (NEDD4) Proteins from 4 different suppliers available. Additionally we are shipping NEDD4 Antibodies (78) and many more products for this protein. A total of 86 NEDD4 products are currently listed.
Synonyms:
AA959633, AL023035, AU019897, E430025J12Rik, mKIAA0093, NEDD4-1, Nedd4a, RPF1
list all proteins Gene Name GeneID UniProt
NEDD4 17999 P46935
NEDD4 4734 P46934
NEDD4 25489 Q62940

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Mouse (Murine) Neural Precursor Cell Expressed, Developmentally Down-Regulated 4, E3 Ubiquitin Protein Ligase (NEDD4) interaction partners

  1. Findings indicate that reducing Nedd4 protein by 50% significantly impairs long-term potentiation and long-term memory thereby demonstrating an important role for Nedd4 in these processes.

  2. Upregulation of long non-coding RNA PAPAS (show PSTPIP1 Proteins) in response to hypoosmotic stress does not increase H4K20me3 because of Nedd4-dependent ubiquitinylation and proteasomal degradation of Suv4-20h2 (show SUV420H2 Proteins).

  3. we propose that Nedd4 functions as a novel Pax7 (show PAX7 Proteins) regulator, which activity is temporally and spatially controlled to modulate the Pax7 (show PAX7 Proteins) protein levels and therefore satellite cell fate.

  4. PDLIM7 (show PDLIM7 Proteins) is a bona fide skeletal muscle substrate of Nedd4-1.

  5. show that absence of Nedd4 in pre-osteoblasts results in decreased cell proliferation and altered osteogenic differentiation

  6. Nedd4 overexpression accelerates zebrafis (show IRS2 Proteins)h embryonic growth through IRS-2 in vivo.

  7. Nedd4 co-injection was found to have no affect on Gag- or Env (show ERVW-1 Proteins)-specific IFNgamma but had a trend of increased Gag-specific IL-6 (show IL6 Proteins), IL-17A (show IL17A Proteins) and TNFalpha (show TNF Proteins) that was not seen following Env (show ERVW-1 Proteins) stimulation.

  8. NEDD4 is a previously unknown component of the CD40 (show CD40 Proteins) signalling complex necessary for AKT (show AKT1 Proteins) activation.

  9. Brucella infection inhibits macrophages apoptosis via Nedd4-dependent degradation of calpain2.

  10. Data show that NEDD4-1 E3 ligase as a novel component of the tumor suppressor protein p53 (show TP53 Proteins)/proto-oncogene (show RAB1A Proteins) proteins c-mdm2 (show MDM2 Proteins) regulatory feedback loop that controls p53 (show TP53 Proteins) activity during stress responses.

Human Neural Precursor Cell Expressed, Developmentally Down-Regulated 4, E3 Ubiquitin Protein Ligase (NEDD4) interaction partners

  1. Insights into links between autophagy and the ubiquitin system showed that LC3B-binding can steer intrinsic NEDD4 E3 ligase activity.

  2. NEDD4-1 recognizes SERTA domain containing proline rich region of p34SEI-1 (show SERTAD1 Proteins). Residues of NEDD4-1 responsible for direct interaction with p34SEI-1 (show SERTAD1 Proteins) are identified by NMR titration experiments.

  3. Our results demonstrate that NEDD4 may promote the acquired resistance of non-small-cell lung cancer cells to erlotinib by decreasing phosphatase and tensin homolog deleted on chromosome 10 protein expression. Targeted decrease in NEDD4 expression may be a potential therapeutic strategy for tyrosine kinase (show TXK Proteins) inhibitor-resistant non-small-cell lung cancer.

  4. this is the first demonstration that Nedd4-1 regulates hOAT1 (show SLC22A6 Proteins) ubiquitination, expression, and transport activity through its WW2 and WW3 domains

  5. both Nedd4-1 and Nedd4-2 (show NEDD4L Proteins) are important regulators for hOAT1 (show SLC22A6 Proteins) ubiquitination, expression, and function

  6. Nedd4-1 inhibited Rap2a (show RAP2A Proteins) activity, and promoted the migration and invasion of glioma cells.

  7. We concluded that USP15 (show USP15 Proteins) attenuates IGF-I (show IGF1 Proteins) signaling by antagonizing Nedd4-induced IRS-2 (show IRS2 Proteins) ubiquitination.

  8. Data suggest a possible molecular mechanism might be that NEDD4 silence led to an increase in PTEN (phosphatase and tensin homologue) expression.

  9. we found that Ndfipl binds to Nedd4-1, and that increased expression of Ndfipl significantly reduced Itch expression. We also found that increased ubiquitination played a role in Ndfipl-mediated processes, and that Ndfipl and a-synuclein interact

  10. Upregulation of long non-coding RNA PAPAS (show PSTPIP1 Proteins) in response to hypoosmotic stress does not increase H4K20me3 because of Nedd4-dependent ubiquitinylation and proteasomal degradation of Suv4-20h2 (show SUV420H2 Proteins).

NEDD4 Protein Profile

Protein Summary

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Involved in ubiquitination of ERBB4 intracellular domain E4ICD1 (PubMed:19193720). Predominantly involved in ubiquitination of membrane bound forms of ERBB4 rather than processed precursors and intermediate membrane-anchored 80 kDa fragments (m80HER4), with a lesser role in ubiquitination of ERBB4 intracellular domain E4ICD1 (PubMed:19047365). Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2 (By similarity).

Alternative names and synonyms associated with NEDD4

  • neural precursor cell expressed, developmentally down-regulated 4 (Nedd4)
  • neural precursor cell expressed, developmentally down-regulated 4 (NEDD4)
  • neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase (NEDD4)
  • neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase (Nedd4)
  • AA959633 protein
  • AL023035 protein
  • AU019897 protein
  • E430025J12Rik protein
  • mKIAA0093 protein
  • NEDD4-1 protein
  • Nedd4a protein
  • RPF1 protein

Protein level used designations for NEDD4

E3 ubiquitin-protein ligase NEDD4 , NEDD-4 , neural precursor cell expressed developmentally down-regulated protein 4 , neural precursor cell expressed, developmentally down-regulated gene 4 , neural precursor cell expressed, developmentally down-regulated gene 4a , neural precursor cell expressed, developmentally down-regulted gene 4 , cell proliferation-inducing gene 53 protein , receptor-potentiating factor 1 , neural precursor cell expressed, developmentally down-regulated gene 4A , ubiquitin-protein ligase Nedd4

GENE ID SPECIES
17999 Mus musculus
415406 Gallus gallus
4734 Homo sapiens
25489 Rattus norvegicus
467689 Pan troglodytes
608738 Canis lupus familiaris
100054735 Equus caballus
100009418 Oryctolagus cuniculus
507781 Bos taurus
100152466 Sus scrofa
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