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Down-regulation of the ATP-binding cassette transporter 2 (Abca2 (show ABCA2 ELISA Kits)) reduces amyloid-beta production by altering Nicastrin maturation and intracellular localization.
Co-expression of Drosophila Pen-2 (show PSENEN ELISA Kits) with Aph-1 (show APH1A ELISA Kits) and nicastrin increases the formation of Psn fragments as well as gamma-secretase activity
Aph-1 (show APH1A ELISA Kits) and Nct may form a subcomplex that stabilizes the Psn holoprotein at an early step in gamma-secretase assembly.
the proper assembly of the Aph-1 (show APH1A ELISA Kits).nicastrin subcomplex with presenilin is the prerequisite for the trafficking as well as the enzymatic activity of the gamma-secretase complex and Aph-1 (show APH1A ELISA Kits) functions as a stabilizing scaffold in the assembly of this complex
presenilin, nicastrin, APH-1 (show APH1A ELISA Kits), and PEN-2 (show PSENEN ELISA Kits), are present and enriched on phagosome membranes from both murine macrophages and Drosophila S2 phagocytes
Nicastrin is essential to early photoreceptor neuron development
Zebrafish have an orthologue of human NCSTN, transcripts of the zebrafish ncstn gene are provided maternally, and the gene is then transcribed throughout embryogenesis and in adult zebrafish. Zebrafish ncstn transcripts are present in ventricular cells of the developing brain, Ncstn protein likely plays a role in Notch (show NOTCH1 ELISA Kits) signaling within the proliferative ventricular zone.
haploinsufficiency of the NCSTN gene caused by the nonsense mutation c.1258C>T (p.Q420X) contributes to the occurrence of hidradenitis suppurativa in this family.
The "Lid" domain of nicastrin is not essential for regulating gamma-secretase activity.
SNPs in Notch (show NOTCH1 ELISA Kits) pathway genes may be predictors of cutaneous melanoma disease-specific survival.
Tumor necrosis factor-alpha (show TNF ELISA Kits) and interleukin-10 (show IL10 ELISA Kits) levels were elevated in acne inversa patients with nicastrin or presenilin enhancer (show PSENEN ELISA Kits) mutation.
A strategy focused on MAPT (show MAPT ELISA Kits), APP (show APP ELISA Kits), NCSTN and BACE1 (show BACE ELISA Kits) to build blood classifiers for Alzheimer's disease.
Akt1 (show AKT1 ELISA Kits) phosphorylates NCT at Ser437, significantly reducing NCT stability. A phospho-deficient mutation in NCT at Ser437 stabilized its protein levels.
We suggest that this is the first description of an NCSTN nonsense mutation causing autosomal dominant hidradenitis suppurativa in an African American family.
analysis of how the conformation of presenilin, Pen-2 (show PSENEN ELISA Kits), Aph-1 (show APH1A ELISA Kits), and nicastrin affect the function and mechanism of gamma-secretase
High nicastrin expression is associated with invasive breast cancer.
Analysis of nicastrin structure provides insights into the assembly and architecture of the gamma-secretase complex.
PS1 (show PSEN1 ELISA Kits)(exon8) interacts with nicastrin, participating in the gamma-secretase complex formation.
nicastrin plays essential roles in the regulation of short- and long-term synaptic plasticity, highlighting the importance of gamma-secretase in the function of mature synapses
These results reveal a key role for ncstn in modulating amyloid beta production and amyloid plaque formation.
Upregulation of PS1 (show PSEN1 ELISA Kits)/gamma-secretase activity may be a risk factor for late onset sporadic Alzheimer's disease.
Pen-2 (show PSENEN ELISA Kits), as well as nicastrin and Aph-1alpha (show APH1A ELISA Kits), is dispensable for presenilin endoproteolysis
SGK1 (show SGK1 ELISA Kits) is a gamma-secretase regulator presumably effective through phosphorylation and degradation of NCT.
We propose a model that identifies critical TMDs of Aph-1 (show APH1A ELISA Kits) for associations with Nct and PS for the stepwise assembly of gamma-secretase components.
we found gamma-secretase components, including nicastrin, to cleave BCG (show SLC11A1 ELISA Kits)-derived Ag85B to produce a peptide epitope
single residues in a gamma-secretase component besides presenilin are able to differentially affect amyloid precursor protein (show APP ELISA Kits) and Notch (show NOTCH1 ELISA Kits) processing.
This gene encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease\; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Alternatively spliced transcript variants have been described, but their full-length nature has not been determined.
, anterior pharynx-defective 2
, membrane protein