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Browse our anti-NOTCH3 (NOTCH3) Antibodies

Full name:
anti-Notch 3 Antibodies (NOTCH3)
On are 201 Notch 3 (NOTCH3) Antibodies from 22 different suppliers available. Additionally we are shipping NOTCH3 Proteins (10) and NOTCH3 Kits (6) and many more products for this protein. A total of 221 NOTCH3 products are currently listed.
AW229011, CADASIL, CASIL, fa14b08, hpbk, IMF2, N3, notch5, wu:fa14b08
list all antibodies Gene Name GeneID UniProt
NOTCH3 4854 Q9UM47
NOTCH3 18131 Q61982
NOTCH3 56761 Q9R172

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anti-Human NOTCH3 Antibodies:

anti-Mouse (Murine) NOTCH3 Antibodies:

anti-Rat (Rattus) NOTCH3 Antibodies:

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Top referenced anti-NOTCH3 Antibodies

  1. Human Monoclonal NOTCH3 Primary Antibody for ELISA, WB - ABIN562028 : Park, Shih, Wang: Identification of Pbx1, a potential oncogene, as a Notch3 target gene in ovarian cancer. in Cancer research 2008 (PubMed)
    Show all 7 references for ABIN562028

  2. Mouse (Murine) Monoclonal NOTCH3 Primary Antibody for FACS - ABIN2663860 : Bellavia, Checquolo, Campese, Felli, Gulino, Screpanti: Notch3: from subtle structural differences to functional diversity. in Oncogene 2008 (PubMed)
    Show all 6 references for ABIN2663860

  3. Mouse (Murine) Monoclonal NOTCH3 Primary Antibody for FACS - ABIN2657987 : Louvi, Arboleda-Velasquez, Artavanis-Tsakonas: CADASIL: a critical look at a Notch disease. in Developmental neuroscience 2006 (PubMed)
    Show all 5 references for ABIN2657987

  4. Human Polyclonal NOTCH3 Primary Antibody for EIA, IHC (p) - ABIN358709 : Suwanwela, Srikiatkhachorn, Tangwongchai, Phanthumchina, Suwanwela: Mutation of the Notch 3 gene in a Thai cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy family. in Journal of the Medical Association of Thailand = Chotmaihet thangphaet 2003 (PubMed)
    Show all 2 references for ABIN358709

  5. Human Polyclonal NOTCH3 Primary Antibody for IHC, ELISA - ABIN185524 : Dang, Fan, Chaudhry, Wang, Gaiano, Eberhart: Notch3 signaling initiates choroid plexus tumor formation. in Oncogene 2006 (PubMed)

  6. Human Monoclonal NOTCH3 Primary Antibody for FACS - ABIN4900322 : Soriani, Iannitto, Ricci, Fionda, Malgarini, Morrone, Peruzzi, Ricciardi, Petrucci, Cippitelli, Santoni: Reactive oxygen species- and DNA damage response-dependent NK cell activating ligand upregulation occurs at transcriptional levels and requires the transcriptional factor E2F1. in Journal of immunology (Baltimore, Md. : 1950) 2014 (PubMed)

  7. Human Polyclonal NOTCH3 Primary Antibody for IHC (fro), IHC - ABIN408754 : Soylu, Acar, Ozbey, Unal, Koksal, Bassorgun, Ciftcioglu, Ustunel: Characterization of Notch Signalling Pathway Members in Normal Prostate, Prostatic Intraepithelial Neoplasia (PIN) and Prostatic Adenocarcinoma. in Pathology oncology research : POR 2015 (PubMed)

More Antibodies against NOTCH3 Interaction Partners

Human Notch 3 (NOTCH3) interaction partners

  1. Kaplan-Meier curves suggested that a high expression of Notch3 was a significant risk factor for shortened survival time. We also showed that inhibition of Notch3 had an antiinvasion role in PDAC cells. In vitro, the inhibition of Notch3 reduced the migration and invasion capabilities of PDAC cells

  2. Data support a crucial role of Notch3 in the increase of stem-like property in NSCLC cells that might be associated with upregulation of ALDH1A1 (show ALDH1A1 Antibodies) and CD44 (show CD44 Antibodies) and activation of autophagy.

  3. Jagged1 (show JAG1 Antibodies) activation of Notch3 resulted in a significant decrease in cell proliferation while concomitantly promoting Hemangioma-pericyte maturation.

  4. Macrophage notch1 (show NOTCH1 Antibodies) may play a more important role than notch2 (show NOTCH2 Antibodies) and notch 3 in the regulation of NF-kappaB (show NFKB1 Antibodies) signaling pathway in atherosclerosis.

  5. Results found new NOTCH3 missenses mutations in patients with pulmonary hypertension that were predicted to be likely pathogenic.

  6. We present a Polish family with a previously unreported novel mutation in exon 12 c.1851C>C/G of the NOTCH3 gene and varying disease expression. One of the two family members with the confirmed mutation presented with all the main CADASIL symptoms; while, his affected father was nearly asymptomatic.

  7. Overexpressing Notch3 protein upregulated Cdh1 expression and resulted in p27(Kip) accumulation by accelerating Skp2 degradation.

  8. Notch2 (show NOTCH2 Antibodies) and Notch3 inhibited both cell proliferation and cell apoptosis in BeWo and JAR (show MYO6 Antibodies) trophoblast cell lines.

  9. A rare 2182C>T mutation in exon 14 of the NOTCH3 gene was identified in all available cases

  10. Loss of Notch3 expression is associated with small cell lung carcinoma.

Mouse (Murine) Notch 3 (NOTCH3) interaction partners

  1. Notch3 is an important protective factor for cardiac fibrosis in a myocardial infarction model, and the protective effect of Notch3 is attributable to its action on TGF-beta1 (show TGFB1 Antibodies)/Smad3 (show SMAD3 Antibodies) signaling.

  2. Data indicate that Notch (show NOTCH1 Antibodies) receptors Notch1 (show NOTCH1 Antibodies) and Notch3 deficiency compromises pericyte function and contributes to vascular pathologies.

  3. In this study, authors use a smooth muscle-specific (show EIF3K Antibodies) deletion of Notch2 (show NOTCH2 Antibodies) together with a global Notch3 deletion to produce mice with combinations of mutant and wild-type Notch2 (show NOTCH2 Antibodies)/3 alleles in vascular smooth muscle cells

  4. Elevated levels of TIMP3 (show TIMP3 Antibodies) and vitronectin (show VTN Antibodies), acting downstream of Notch3(ECD (show ECD Antibodies)) deposition, play a role in CADASIL, producing divergent influences on early CBF (show CEBPZ Antibodies) deficits and later white matter lesions.

  5. Mutant Notch3 accumulates in pericytes and causes progressive pericyte loss and BBB (show ALMS1 Antibodies) leakage in the cerebral cortex in CADASIL mouse model.

  6. Relative to air-exposed controls, ozone increased bronchoalveolar lavage fluid protein, a marker of lung permeability, in all genotypes, but significantly greater concentrations were found in Notch4 (show NOTCH4 Antibodies)-/- compared with wild-type and Notch3-/- mice.

  7. The mechanism of Oncostatin M (show OSM Antibodies) on cardiac ischemia/reperfusion injury is partly mediated by the Notch3/Akt (show AKT1 Antibodies) pathway.

  8. miR (show MLXIP Antibodies)-7a regulates the differentiation of Muller glia through the suppression of Notch3 expression.

  9. Study showed Notch3 expressed in proliferating hippocampal precursor cells and down-regulates their activation and proliferation; adult neurogenesis in CADASIL transgenic mice was altered prior to vascular abnormalities due to deficits in Notch3 signaling

  10. NOTCH3, but not NOTCH2 (show NOTCH2 Antibodies) protects vascular smooth muscle cell from apoptosis.

Zebrafish Notch 3 (NOTCH3) interaction partners

  1. The Notch3 receptor is required earlier within the developing somite to regulate hematopoietic stem cell (HSC (show FUT1 Antibodies)) emergence in a non-cell-autonomous manner.

  2. 90 % of proliferating radial glia express notch1a (show NOTCH1A Antibodies), notch1b and notch3. In contrast, the proliferating non-glial populations of the dorsal telencephalon and hypothalamus rarely express notch3 and about half express notch1a (show NOTCH1A Antibodies)/1b.

  3. Notch3 regulates oligodendrocyte precursor cells development and mbp (show MBP Antibodies) gene expression in larvae, and maintains vascular integrity in adults.

  4. new role for Notch (show NOTCH1 Antibodies) signaling in brain vascular development whereby Notch3 signaling promotes expansion of the brain pericyte population

  5. Notch3 activity gates neural stem cell activation in the adult pallium.

  6. Cellular correlates of Notch (show NOTCH1 Antibodies)-delta gene expression in the regenerating zebrafish retina.

  7. knockdown of notch3 function in notch1a (show NOTCH1A Antibodies) mutants leads to the loss of rhombomere boundary cells and causes neuronal hyperplasia

NOTCH3 Antigen Profile

Antigen Summary

This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).

Alternative names and synonyms associated with NOTCH3

  • notch 3 (NOTCH3) antibody
  • notch 3 (Notch3) antibody
  • notch homolog 3 (notch3) antibody
  • AW229011 antibody
  • CADASIL antibody
  • CASIL antibody
  • fa14b08 antibody
  • hpbk antibody
  • IMF2 antibody
  • N3 antibody
  • notch5 antibody
  • wu:fa14b08 antibody

Protein level used designations for anti-Notch 3 (NOTCH3) Antibodies

Notch homolog 3 , neurogenic locus notch homolog protein 3 , Notch gene homolog 3

4854 Homo sapiens
18131 Mus musculus
56761 Rattus norvegicus
58066 Danio rerio
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