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Browse our anti-Presenilin Enhancer 2 Homolog (C. Elegans) (PSENEN) Antibodies

Full name:
anti-Presenilin Enhancer 2 Homolog (C. Elegans) Antibodies (PSENEN)
On www.antibodies-online.com are 65 Presenilin Enhancer 2 Homolog (C. Elegans) (PSENEN) Antibodies from 14 different suppliers available. Additionally we are shipping Presenilin Enhancer 2 Homolog (C. Elegans) Kits (4) and Presenilin Enhancer 2 Homolog (C. Elegans) Proteins (4) and many more products for this protein. A total of 81 Presenilin Enhancer 2 Homolog (C. Elegans) products are currently listed.
Synonyms:
1700023M09Rik, ACYPI006208, anon-AE003800.1, CG33198, Dmel\\CG33198, dPen-2, MSTP064, PEN-2, PEN2, Psenen, RGD1312037, T5E8.110, T5E8_110
list all antibodies Gene Name GeneID UniProt
PSENEN 55851 Q9NZ42
PSENEN 66340 Q9CQR7
PSENEN 292788 Q6QI68

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Most Popular Reactivities for anti-Presenilin Enhancer 2 Homolog (C. Elegans) (PSENEN) Antibodies

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All available anti-Presenilin Enhancer 2 Homolog (C. Elegans) Antibodies

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Top referenced anti-Presenilin Enhancer 2 Homolog (C. Elegans) Antibodies

  1. Human Polyclonal PSENEN Primary Antibody for EIA, IF - ABIN500471 : Selkoe: Translating cell biology into therapeutic advances in Alzheimer's disease. in Nature 1999 (PubMed)
    Show all 4 references for ABIN500471

  2. Human Polyclonal PSENEN Primary Antibody for EIA, IHC (p) - ABIN500473 : Weihofen, Martoglio: Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides. in Trends in cell biology 2003 (PubMed)
    Show all 4 references for ABIN500473

  3. Human Polyclonal PSENEN Primary Antibody for IF, WB - ABIN181530 : Francis, McGrath, Zhang, Ruddy, Sym, Apfeld, Nicoll, Maxwell, Hai, Ellis, Parks, Xu, Li, Gurney, Myers, Himes, Hiebsch, Ruble, Nye, Curtis: aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation. in Developmental cell 2002 (PubMed)

More Antibodies against Presenilin Enhancer 2 Homolog (C. Elegans) Interaction Partners

Fruit Fly (Drosophila melanogaster) Presenilin Enhancer 2 Homolog (C. Elegans) (PSENEN) interaction partners

  1. APH-1 (show APH1A Antibodies) stabilizes the presenilin holoprotein in the complex, whereas PEN-2 is required for endoproteolytic processing of presenilin and conferring gamma-secretase activity to the complex.

  2. presenilin, nicastrin (show NCSTN Antibodies), APH-1 (show APH1A Antibodies), and PEN-2, are present and enriched on phagosome membranes from both murine macrophages and Drosophila S2 phagocytes

Arabidopsis thaliana Presenilin Enhancer 2 Homolog (C. Elegans) (PSENEN) interaction partners

  1. All gamma-secretase subunits: PS1/PS2, APH-1, PEN-2, and NCT colocalize and interact with each other in Arabidopsis thaliana protoplasts. [AtPEN-2]

Human Presenilin Enhancer 2 Homolog (C. Elegans) (PSENEN) interaction partners

  1. TRPC6 (show TRPC6 Antibodies) specifically interacts with APP (show APP Antibodies) leading to inhibition of its cleavage by gamma-secretase and reduction in Abeta (show APP Antibodies) production.

  2. secondary mutations in presenilin 1 (show PSEN1 Antibodies) alone activated the gamma-secretase activity.

  3. Data indicate that familial Alzheimer's disease (FAD (show BRCA2 Antibodies)) and control brain samples had similar overall gamma-secretase activity levels, and therefore, loss of overall (endopeptidase) gamma-secretase function cannot be an essential part of the pathogenic mechanism.

  4. We for the first time identify PEN-2 as the causative gene of familial comedones.

  5. The first hydrophobic domain of Pen-2 forms a structure similar to a reentrant loop while the second hydrophobic domain spans the lipid bilayer.

  6. shedding of BCMA (show TNFRSF17 Antibodies) by gamma-secretase controls plasma cells in the bone marrow and yields a potential biomarker for B-cell involvement in human autoimmune diseases

  7. Tumor necrosis factor-alpha (show TNF Antibodies) and interleukin-10 (show IL10 Antibodies) levels were elevated in acne inversa patients with nicastrin (show NCSTN Antibodies) or presenilin enhancer mutation.

  8. SLC2A13 (show SLC2A13 Antibodies) is a novel gamma-secretase associated protein that regulates amyloid beta production without affecting Notch (show NOTCH1 Antibodies) cleavage.

  9. A complete inhibition of PS1 (show PSEN1 Antibodies)-induced apoptosis was achieved by knockdown of PS1 (show PSEN1 Antibodies)-associated protein (PSAP (show PSAP Antibodies)), a mitochondrial proapoptotic protein that forms a complex with Bax (show BAX Antibodies) upon induction of apoptosis, in the presence of gamma-secretase inhibitor.

  10. analysis of how the conformation of presenilin, Pen-2, Aph-1 (show APH1A Antibodies), and nicastrin (show NCSTN Antibodies) affect the function and mechanism of gamma-secretase

Mouse (Murine) Presenilin Enhancer 2 Homolog (C. Elegans) (PSENEN) interaction partners

  1. the G206D mutation reduced presenilin-1 (show PSEN1 Antibodies)-presenilin enhancer 2 interaction, but did not abolish gamma-secretase formation and presenilin-1 (show PSEN1 Antibodies) endoproteolysis

  2. Data show that the expression level of presenilin enhancer-2 (Pen-2) is relatively high in central nervous system at the early stages of postnatal development, but declines, gradually in adult mice.

  3. rather than solely being a catalyst for gamma-secretase endoproteolysis, Pen-2 may also stabilize the complex prior to PS1 (show PSEN1 Antibodies) endoproteolysis, allowing time for full assembly and proper trafficking.

  4. Pen-2, as well as nicastrin (show NCSTN Antibodies) and Aph-1alpha (show APH1A Antibodies), is dispensable for presenilin endoproteolysis

  5. Nct (show NCSTN Antibodies) has a critical role in the stability and proper intracellular trafficking of other components of the PS1 (show PSEN1 Antibodies)/ gamma-secretase complex but not in maintaining the association of PEN-2, APH-1 (show APH1A Antibodies), and full-length PS1 (show PSEN1 Antibodies)

Cow (Bovine) Presenilin Enhancer 2 Homolog (C. Elegans) (PSENEN) interaction partners

  1. The PSENEN gene is down-regulated in bovine intramuscular fibroblast cells during differentiation into adipocytes.

Presenilin Enhancer 2 Homolog (C. Elegans) (PSENEN) Antigen Profile

Antigen Summary

Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase.

Alternative names and synonyms associated with Presenilin Enhancer 2 Homolog (C. Elegans) (PSENEN)

  • presenilin enhancer (pen-2) antibody
  • hypothetical protein (AT5G09310) antibody
  • presenilin enhancer 2 (PEN2) antibody
  • presenilin enhancer 2 (Psenen) antibody
  • presenilin enhancer 2 homolog (C. elegans) (PSENEN) antibody
  • presenilin enhancer 2 homolog (C. elegans) (Psenen) antibody
  • Protein PEN-2 (pen-2) antibody
  • 1700023M09Rik antibody
  • ACYPI006208 antibody
  • anon-AE003800.1 antibody
  • CG33198 antibody
  • Dmel\\CG33198 antibody
  • dPen-2 antibody
  • MSTP064 antibody
  • PEN-2 antibody
  • PEN2 antibody
  • Psenen antibody
  • RGD1312037 antibody
  • T5E8.110 antibody
  • T5E8_110 antibody

Protein level used designations for PSENEN

CG33198-PA , pen-2-PA , presenilin enhancer 2 , gamma-secretase subunit PEN-2 , hematopoietic stem/progenitor cells protein MDS033 , presenilin enhancer protein 2 , LRRGT00140 mRNA , liver regeneration-related protein LRRGT00140

GENE ID SPECIES
251430 Drosophila melanogaster
830790 Arabidopsis thaliana
5726417 Chlamydomonas reinhardtii
100165248 Acyrthosiphon pisum
55851 Homo sapiens
66340 Mus musculus
493993 Bos taurus
292788 Rattus norvegicus
176565 Caenorhabditis elegans
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