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APP (show APP ELISA Kits) substrate occupancy of these three pockets of gamma-secretase occurs after initial substrate binding but precedes catalysis, suggesting a conformational change in substrate may be required for cleavage.
PSENEN mutations can indeed cause a comanifestation of Dowling-Degos disease and acne inversa (AI) that is likely triggered by predisposing factors for AI.
zinc, copper inhibited Abeta (show APP ELISA Kits) production by directly targeting the subunits presenilin and nicastrin (show NCSTN ELISA Kits) in the gamma-secretase complex
PSENEN may play a crucial role in the progression of atopic dermatitis by participating in the Notch (show NOTCH1 ELISA Kits) signaling pathway.
Remarkably, PEN-2 was identified besides nicastrin (show NCSTN ELISA Kits) as additional substrate-binding subunit.
TRPC6 (show TRPC6 ELISA Kits) specifically interacts with APP (show APP ELISA Kits) leading to inhibition of its cleavage by gamma-secretase and reduction in Abeta (show APP ELISA Kits) production.
secondary mutations in presenilin 1 (show PSEN1 ELISA Kits) alone activated the gamma-secretase activity.
Data indicate that familial Alzheimer's disease (FAD (show BRCA2 ELISA Kits)) and control brain samples had similar overall gamma-secretase activity levels, and therefore, loss of overall (endopeptidase) gamma-secretase function cannot be an essential part of the pathogenic mechanism.
We for the first time identify PEN-2 as the causative gene of familial comedones.
The first hydrophobic domain of Pen-2 forms a structure similar to a reentrant loop while the second hydrophobic domain spans the lipid bilayer.
The PSENEN gene is down-regulated in bovine intramuscular fibroblast cells during differentiation into adipocytes.
Cleavage of the Interleukin-11 receptor (show IL11RA ELISA Kits) induces processing of its C-terminal fragments by the gamma-secretase and the proteasome.
the G206D mutation reduced presenilin-1 (show PSEN1 ELISA Kits)-presenilin enhancer 2 interaction, but did not abolish gamma-secretase formation and presenilin-1 (show PSEN1 ELISA Kits) endoproteolysis
Data show that the expression level of presenilin enhancer-2 (Pen-2) is relatively high in central nervous system at the early stages of postnatal development, but declines, gradually in adult mice.
rather than solely being a catalyst for gamma-secretase endoproteolysis, Pen-2 may also stabilize the complex prior to PS1 (show PSEN1 ELISA Kits) endoproteolysis, allowing time for full assembly and proper trafficking.
Pen-2, as well as nicastrin (show NCSTN ELISA Kits) and Aph-1alpha (show APH1A ELISA Kits), is dispensable for presenilin endoproteolysis
Nct (show NCSTN ELISA Kits) has a critical role in the stability and proper intracellular trafficking of other components of the PS1 (show PSEN1 ELISA Kits)/ gamma-secretase complex but not in maintaining the association of PEN-2, APH-1 (show APH1A ELISA Kits), and full-length PS1 (show PSEN1 ELISA Kits)
APH-1 (show APH1A ELISA Kits) stabilizes the presenilin holoprotein in the complex, whereas PEN-2 is required for endoproteolytic processing of presenilin and conferring gamma-secretase activity to the complex.
presenilin, nicastrin (show NCSTN ELISA Kits), APH-1 (show APH1A ELISA Kits), and PEN-2, are present and enriched on phagosome membranes from both murine macrophages and Drosophila S2 phagocytes
Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase.
gamma-secretase subunit PEN-2
, hematopoietic stem/progenitor cells protein MDS033
, presenilin enhancer protein 2
, presenilin enhancer 2
, LRRGT00140 mRNA
, liver regeneration-related protein LRRGT00140
, Presenilin enhancer protein 2 homolog
, presenilin enhancer 2 homolog
, presenilin enhancer protein 2 homolog