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Histone demethylases KDM3A, KDM4A, and KDM4C were expressed before and after embryonic genome activation, whereas KDM5B was mainly expressed during the blastocyst period.
histone H3 (show HIST3H3 ELISA Kits) lysine 9 methylation reduction, which may be due to the downregulation of methyltransferase SUV39H2 (show SUV39H2 ELISA Kits) and the upregulation of demethylase (show MBD2 ELISA Kits) KDM4C, was found in CD4 (show CD4 ELISA Kits)(+) T lymphocytes of Latent autoimmune diabetes in adult patients
KDM4C recognition of H3K4me3 stimulates demethylation of H3K9me3 in cis (show CISH ELISA Kits) on peptide and mononucleosome substrates.
Pharmacological inhibition of KDM4C/PRMT1 (show PRMT1 ELISA Kits) suppresses transcription and transformation ability of MLL (show MLL ELISA Kits) fusions
JMJD2B and JMJD2C play an important role in the pathology of osteosarcoma via the up-regulation of FGF2 (show FGF2 ELISA Kits).
Data suggest that D396N polymorphism of JmjC domain-containing histone demethylase (show MBD2 ELISA Kits) JMJD2C affects the prognosis of breast cancer by altering caspase-3 (show CASP3 ELISA Kits) cleavage and the ability of double strand DNA break repair which may contribute to therapy resistance.
GASC1 expression is higher in adenocarcinoma than squamous cell carcinoma. Smoking decreases GASC1 expression in tumor cells, indicating that tobacco smoke may influence the methylation of histone 3 lysine residues in lung cancer.
KDM4C promotes transcriptional activation by removing the repressive histone mark, H3K9me3, from its target genes. Variation in its expression leads to differences in the growth of normal and some cancer cells.
KDM4C maintains the sphere-forming capacity in CRCs by mediating the beta-catenin (show CTNNB1 ELISA Kits)-dependent transcription of JAG1 (show JAG1 ELISA Kits) in a feed-forward manner.
analysis of the nickel-induced inhibition of truncated constructs of JMJD2A (show KDM4A ELISA Kits) and JMJD2C histone demethylases using X-ray absorption spectroscopy
Patients with GASC1 positive tumors have better breast cancer specific survival and respond better to radiotherapy and hormonal treatment
Jmjd2c and G9a (show EHMT2 ELISA Kits) are novel enhancer-associated factors; Jmjd2c is a molecular scaffold for the assembly of essential enhancer-protein complexes with an impact on timely gene activation
The authors show that Jmjd2a (show KDM4A ELISA Kits) and Jmjd2c both localize to H3K4me3-positive promoters, where they have widespread and redundant roles in preventing accumulation of H3K9me3 and H3K36me3.
Number of GFAP (show GFAP ELISA Kits)-positive astrocytes in the brain of Gasc1 hypomorphic mutant mice is increased at 2-3 months of age.
GASC1 has an oncogenic role in mouse skin carcinogenesis.
These findings together demonstrate the essential role of KDM4A (show KDM4A ELISA Kits) and KDM4C in orchestrating mESC differentiation to endothelial cells through the activation of Flk1 (show KDR ELISA Kits) and VE-cadherin (show CDH5 ELISA Kits) promoters, respectively
Jmjd2C increases MyoD (show MYOD1 ELISA Kits) transcriptional activity to facilitate skeletal muscle differentiation by increasing MyoD (show MYOD1 ELISA Kits) stability through inhibiting G9a (show EHMT2 ELISA Kits)-dependent MyoD (show MYOD1 ELISA Kits) degradation.
Jmjd2b unique, Jmjd2c unique, and Jmjd2b-Jmjd2c common target sites belong to functionally separable Core, Polycomb (show CBX2 ELISA Kits) repressive complex (PRC (show PPRC1 ELISA Kits)), and Myc (show MYC ELISA Kits) regulatory modules, respectively.
Inositol pyrophosphates regulate JMJD2C-dependent histone demethylation.
stage-specifically expressed during preimplantation development (show MTA2 ELISA Kits), with the highest activity being observed from the two-cell to the eight-cell stage
This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein with one JmjC domain, one JmjN domain, two PHD-type zinc fingers, and two Tudor domains. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form. Chromosomal aberrations and increased transcriptional expression of this gene are associated with esophageal squamous cell carcinoma. Alternative splicing results in multiple transcript variants.
jumonji domain containing 2C
, lysine (K)-specific demethylase 4C
, jumonji domain containing 2c
, lysine-specific demethylase 4C
, lysine-specific demethylase 4C-like
, GASC-1 protein
, JmjC domain-containing histone demethylation protein 3C
, gene amplified in squamous cell carcinoma 1 protein
, jumonji domain-containing protein 2C
, tudor domain containing 14C
, gene amplified in squamous cell carcinoma 1
, jmjC domain-containing histone demethylation protein 3C