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PP2A/striatin complex modulates microtubule dynamics by regulating MAP2 phosphorylation
the rapid, nongenomic mineralocorticoid receptor (show NR3C2 Proteins) pathway (mediated via striatin) has a role in modulating the interaction between salt intake and blood pressure.
A recurrent STRN/ALK fusion found in thyroid carcinomas.
Our data demonstrate that STRN-ALK fusion occurs in a subset of patients with highly aggressive types of thyroid cancer and provide initial evidence suggesting that it may represent a therapeutic target for these patients.
Striatin orchestrates the regulation of Mst3 (show STK24 Proteins) by PP2A (show PPP2R4 Proteins).
identify striatin as a molecular scaffold required for rapid, nongenomic estrogen-mediated activation of downstream signaling pathways
Taken together, splicing variation of SG2NA might have some critical roles in differentiation and maturation in metazoan cells.
striatin deficiency is associated with salt sensitivity of blood pressure, enhanced vasoconstriction, and decreased vascular relaxation, suggesting a critical role for striatin in regulation of vascular function and BP during changes in sodium intake.
these results provide evidence that increased striatin levels is a component of MR activation in the vasculature and suggest that regulation of striatin by ALDO may modulate estrogen's nongenomic effects.
striatin, calmodulin binding protein
, striatin, calmodulin-binding protein