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Human Polyclonal TOB2 Primary Antibody for EIA, IHC (p) - ABIN358776
Ikematsu, Yoshida, Kawamura-Tsuzuku, Ohsugi, Onda, Hirai, Fujimoto, Yamamoto: Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases. in Oncogene 2000
Show all 4 references for ABIN358776
Results show reduced Tob2 expression in primary hepatocellular Carcinoma cells (HCC (show FAM126A Antibodies)) and that dysregulation of miR (show MLXIP Antibodies)-362 and Tob2 may contribute to HCC (show FAM126A Antibodies) malignancy.
The antiproliferative and the mRNA deadenylation/decay-promoting effects of TOB1 and TOB2 proteins are linked.
study identifies miR-378-TOB2-cyclin D1 as a functional module to mediate the cross talk between Myc and Ras signaling in cellular transformation
TNFalpha (show TNF Antibodies) is able to transactivate ErbB-2 (show ERBB2 Antibodies) and use it as an obligatory downstream signaling molecule in the generation of mitogenic signals.
Haploinsufficiency of the MLL (show MLL Antibodies) and TOB2 genes in lymphoid malignancy.
Antiproliferative proteins of the BTG/Tob (show TDO2 Antibodies) family are degraded by the ubiquitin-proteasome system. the C-terminal regions are necessary and sufficient to control the stabilities of BTG1 (show BTG1 Antibodies), BTG2 (show BTG2 Antibodies), Tob (show TDO2 Antibodies), and Tob2 proteins.
Tob1(-/-), Tob2(-/-), and Tob1/2 double knockout (DKO, Tob1(-/-) & Tob2(-/-)) embryonic stem cells (ESCs (show NR2E3 Antibodies)) grew faster than wild type (WT) ESCs (show NR2E3 Antibodies) without losing pluripotency.
miR (show MLXIP Antibodies)-322 and its target protein Tob2 modulate Osx (show SP7 Antibodies) mRNA stability
Tob2 protein suppresses PPARgamma2 (show PPARG Antibodies) transcription by inhibiting BMP2 (show BMP2 Antibodies)-induced Smad1 (show SMAD1 Antibodies)/5 phosphorylation through its interaction with Smad6 (show SMAD6 Antibodies) and by sequestering C/EBPalpha (show CEBPA Antibodies) from the PPARgamma2 (show PPARG Antibodies) promoter.
Tob2 negatively regulates formation of osteoclasts by suppressing RANKL (show TNFSF11 Antibodies) expression through its interaction with vitamin D receptor (show VDR Antibodies)
TOB2 belongs to the TOB (see TOB1\; MIM 605523)/BTG1 (MIM 109580) family of antiproliferative proteins, which are involved in the regulation of cell cycle progression.
, transducer of ERBB2, 2
, protein Tob4
, transducer of erbB-2 2